Main Research Findings

This study reports a case of a 62-year-old Japanese woman who developed acute ischemic colitis after taking baloxavir marboxil for influenza A. The patient experienced abdominal pain, diarrhea, and nausea the day after taking baloxavir (day 2), and developed hematochezia on day 3. She was diagnosed with ischemic colitis after abdominal echography, computed tomography, and colonoscopy. This case highlights the potential for baloxavir marboxil to induce ischemic colitis, emphasizing the need for further research on the drug’s side effects, particularly regarding ischemic colitis. 1

Reasons for Side Effects

While the exact mechanism by which baloxavir marboxil may cause ischemic colitis is unknown, the study notes that influenza A itself can cause the condition. This suggests a complex interaction between the virus and the medication, requiring further investigation. 1

Common Side Effects

Ischemic Colitis

This study reports ischemic colitis as a potential side effect of baloxavir marboxil. Ischemic colitis is an inflammatory condition of the intestines caused by inadequate blood flow. Symptoms include abdominal pain, diarrhea, and hematochezia (bloody stools). 1

Countermeasures for Side Effects

Ischemic Colitis

Treatment for ischemic colitis depends on the severity of symptoms. Mild cases often improve with fluid replacement and dietary modifications, while severe cases may require hospitalization. 1

Comparison Between Studies

Commonalities in Studies

This study, along with others, highlights the potential for anti-influenza medications to cause ischemic colitis. 1

Differences in Studies

This study focuses on the potential for baloxavir marboxil to induce ischemic colitis, whereas other studies have investigated the same risk associated with oseltamivir. 1

Precautions for Applying to Real Life

If you experience abdominal pain, diarrhea, or bloody stools while taking baloxavir marboxil, it is crucial to seek medical attention promptly. 1

Limitations of Current Research

This study is a single case report and does not definitively prove a causal relationship between baloxavir marboxil and ischemic colitis. 1

Future Research Directions

Further research is necessary to fully understand the mechanisms by which baloxavir marboxil might induce ischemic colitis. Additionally, strategies for mitigating the risk of this adverse event should be investigated. 1

Conclusion

This study suggests a possible association between baloxavir marboxil use and the development of ischemic colitis. It is important to be aware of the potential for this side effect and seek prompt medical attention if you experience relevant symptoms while taking the drug. 1