Effects of barium sulfate: A Synthesis of Findings from 12 Studies

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Original Abstract of the Article

Main Research Findings

Barium sulfate is widely used in various fields, including medical imaging and industrial applications. Studies have investigated the effects of barium sulfate on human health, revealing both potential benefits and risks. Some studies have shown that barium sulfate can cause pulmonary inflammation and tissue damage, especially when inhaled in the form of dust or nanoparticles. 5 Additionally, allergic reactions have been reported following barium sulfate-based colon radiography. However, other research has shown that barium sulfate, when used appropriately, can be a safe and effective contrast agent for medical imaging, without causing significant inflammation in human volunteers. 4 Furthermore, barium sulfate has been found to enhance tissue granulation in cases of enterocutaneous fistulas, leading to faster healing and improved quality of life for patients. 10

Benefits and Risks

Benefit Summary

Barium sulfate is a valuable contrast agent in medical imaging, enabling visualization of internal structures for diagnostic purposes. 9 It is widely used in industrial applications, including polymers and paints, showcasing its potential for safe use in various settings. 6

Risk Summary

Barium sulfate poses potential risks, including pulmonary effects, allergic reactions, and adverse effects on the biliary tract. 8 Understanding these risks and implementing appropriate precautions is crucial for the safe use of barium sulfate.

Comparison of Studies

Similarities between Studies

Many studies explore the safety and efficacy of barium sulfate across various applications, including medical imaging and industrial products. 6

Differences between Studies

Studies vary in their methodology, including the method of administration, the purpose of barium sulfate use, and the assessment methods employed. For instance, research examining pulmonary effects of barium sulfate may involve different administration routes, such as inhalation or direct injection into the lungs. 5 Additionally, studies may utilize different animal models and observation periods.

Consistency and Contradictions in Findings

While barium sulfate can be safely used when appropriate methods are followed, some research suggests potential risks, including pulmonary effects and allergic reactions. These findings highlight the need for further research to comprehensively assess the safety and efficacy of barium sulfate.

Considerations for Real-World Applications

Barium sulfate is widely used in medical imaging, including X-rays and barium enema examinations. It is essential to understand the potential risks and take appropriate precautions when using barium sulfate. Individuals with a history of allergies or those with respiratory or digestive issues should consult their physician before undergoing procedures involving barium sulfate.

Limitations of Current Research

Further research is necessary to comprehensively understand the long-term effects of barium sulfate on human health. Additionally, data on the specific effects of barium sulfate on human subjects remains limited.

Future Research Directions

Future research should focus on investigating the long-term effects of barium sulfate on humans, particularly its impact on different organs and systems. Research should also aim to optimize the dosage and administration methods of barium sulfate to maximize its effectiveness and minimize potential risks.

Conclusion

Barium sulfate plays a crucial role in medical imaging and industrial applications. While it holds significant potential for safe use, research has highlighted potential risks associated with its exposure, particularly in the form of dust or nanoparticles. 6 Therefore, it is essential to use barium sulfate responsibly, adhering to appropriate guidelines and precautions to ensure safety and minimize potential risks.

Literature analysis of 12 papers
Positive Content
8
Neutral Content
0
Negative Content
4
Article Type
0
1
1
0
12
1.

Efficacy and safety of baricitinib for the treatment of hospitalized adults with COVID-19: a systematic review and meta-analysis.

Author: SunJing, WangShufang, MaXin, WeiQingqing, PengYujuan, BaiYing, MiaoGuobin, MengChang, LiuPeng

COVID-19 treatment

This meta-analysis evaluated the efficacy and safety of baricitinib in treating COVID-19. The analysis found that baricitinib improved clinical outcomes in patients with COVID-19, particularly in those with severe illness.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Differential Effects of Laxatives on Barium Sulfate Coating and Image Quality in Double-Contrast Barium Enema.

Author: LaiCheng-Shih, TsaiHong-Ming, TingChien-Yi, WangBow

Improved diagnostic accuracy
None reported

This retrospective study evaluated the effects of three laxatives on barium sulfate coating efficiency in the large intestine, sigmoid colon, and hepatic flexure in double-contrast barium enema (DCBE). Dulcolax® (DC) had a better barium sulfate coating efficiency in the hepatic flexure compared with Klean-Prep® (KP) and Fleet® enema.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

No inflammatory effects after acute inhalation of barium sulfate particles in human volunteers.

Author: MonséChristian, WestphalGötz, RaulfMonika, JettkantBirger, van KampenVera, KendziaBenjamin, SchürmeyerLeonie, SeifertChristoph Edzard, MarekEike-Maximilian, WiegandFelicitas, RosenkranzNina, WegenerChristopher, MergetRolf, BrüningThomas, BüngerJürgen

Inhalation safety assessment

This study explored whether the inflammatory effects of particles observed in animal models could be confirmed in humans. Researchers compared the effects of barium sulfate particles (BaSO<sub>4</sub>), considered inert, with zinc oxide (ZnO) which has known inflammatory activity. They found that BaSO<sub>4</sub> did not cause significant inflammatory responses in humans, while ZnO resulted in local and systemic inflammation, confirming the findings from animal studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats.

Author: SchwotzerDaniela, ErnstHeinrich, SchaudienDirk, KockHeiko, PohlmannGerhard, DasenbrockClemens, CreutzenbergOtto

Pulmonary effects

This study investigated the pulmonary effects of CeO<sub>2</sub>NM-212 and BaSO<sub>4</sub>NM-220 nanoparticles in a 90-day exposure setup in mice. The study found that both nanoparticles accumulated in the lungs, but BaSO<sub>4</sub>NM-220 nanoparticles accumulated at higher levels. Both nanoparticles induced inflammatory responses in the lungs, but no significant overload-related effects were observed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Biokinetics and effects of barium sulfate nanoparticles.

Author: KonduruNagarjun, KellerJana, Ma-HockLan, GrötersSibylle, LandsiedelRobert, DonagheyThomas C, BrainJoseph D, WohllebenWendel, MolinaRamon M

Novel applications

This study examines the biokinetics and pulmonary responses to barium sulfate nanoparticles (BaSO₄ NPs) in rats, following previous short-term inhalation studies.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Effects of nitrate and water on the oxygen isotopic analysis of barium sulfate precipitated from water samples.

Author: HannonJanet E, BöhlkeJohn Karl, MroczkowskiStanley J

Errors in O isotope measurements

This study found that BaSO(4) precipitated for SO(4) (2-) isotopic analysis may contain H(2)O and NO(3) (-), introducing errors in O isotope measurements. The study provides methods to reduce these errors and discusses their implications for SO(4) (2-) studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

8.

Adverse effects of barium sulfate in the biliary tract.

Author: WalshamAnna, LarsenJörg

Stent occlusion

This article discusses the rare occurrence of barium sulfate reflux into the biliary tract, highlighting potential complications such as stent occlusion. A case illustrating this occurrence is presented.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Effects of sterilized micropulverized barium sulfate suspension and meglumine iothalamate solution on the genitourinary tract of healthy male dogs after retrograde urethrocystography.

Author: FeeneyD A, JohnstonG R, TomlinsonM J, OsborneC A

Bladder distention
Urethral inflammation

Barium sulfate infusion into the urinary tract of dogs induced vesicoureteral reflux. While barium persisted in the urinary tract for up to 30 days, no significant kidney lesions were observed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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