Effects of beclomethasone nasal spray: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Major Research Findings

Beclomethasone nasal spray has been studied extensively for its effectiveness in treating allergic rhinitis. 11 、 8 、 10 、 2 、 5 、 1 Studies have shown that beclomethasone nasal spray can effectively reduce symptoms of allergic rhinitis, such as sneezing, runny nose, nasal congestion, and eye symptoms. 11 、 8 、 10 、 2 、 5 、 1 Furthermore, some studies have found beclomethasone nasal spray to be superior to other treatments in alleviating allergic rhinitis symptoms. 11 、 8 、 5 The mechanism of action of beclomethasone is thought to be its ability to reduce inflammation in the nasal mucosa. 1 Beclomethasone works by reducing the number of basophils in the nasal mucosa, thereby inhibiting the release of histamine and leukotrienes, which are involved in allergic reactions. 1 In addition, beclomethasone is believed to decrease nasal congestion and runny nose by reducing the permeability of blood vessels in the nasal mucosa.

Benefits and Risks

Benefit Summary

Beclomethasone nasal spray may be effective in reducing the symptoms of allergic rhinitis. 11 、 8 、 10 、 2 、 5 、 1 Some studies have found that beclomethasone nasal spray is more effective than other treatments in relieving allergic rhinitis symptoms. 11 、 8 、 5

Risk Summary

Side effects of beclomethasone nasal spray include dry nose, nosebleeds, and altered taste. 11 、 8 These side effects are usually mild and tend to disappear when the treatment is discontinued.

Comparison Between Studies

Commonalities Among Studies

These studies all indicate that beclomethasone nasal spray is effective in treating allergic rhinitis. 11 、 8 、 10 、 2 、 5 、 1

Differences Between Studies

These studies differ in terms of their research subjects, methodologies, and outcome measures. For instance, some studies included patients with seasonal allergic rhinitis. 11 、 8 、 2 、 5 Conversely, other studies targeted patients with perennial allergic rhinitis. 4 Additionally, some studies compared the effectiveness of beclomethasone nasal spray to other treatments. 11 、 8 、 5 While other studies evaluated the effectiveness of beclomethasone nasal spray alone. 1 、 10 、 2

Consistency and Contradictions in Results

The findings from these studies suggest that beclomethasone nasal spray is effective in treating allergic rhinitis. 11 、 8 、 10 、 2 、 5 、 1 However, some studies have yielded divergent results regarding the effectiveness of beclomethasone nasal spray. 11 、 8 、 5 This discrepancy might be attributed to variations in study subjects, methodologies, and outcome measures. Consequently, it is important to understand that beclomethasone nasal spray may not be effective for all patients. Additionally, it is essential to remember that beclomethasone nasal spray carries a risk of side effects. 11 、 8 When using beclomethasone nasal spray, it is crucial to follow the doctor's instructions carefully and seek medical advice immediately if any side effects arise.

Practical Considerations and Precautions

Use beclomethasone nasal spray as directed by your doctor to alleviate allergic rhinitis symptoms. 11 、 8 Keep in mind that beclomethasone nasal spray may not be effective for everyone. 11 、 8 Moreover, be aware that beclomethasone nasal spray carries a risk of side effects. 11 、 8 When using beclomethasone nasal spray, it is crucial to adhere closely to your doctor's instructions and seek medical advice promptly if any adverse effects occur.

Limitations of Current Research

The limitations of these studies include the limited scope of research subjects, the short study duration, and variations in research methodologies. 11 、 8 、 10 、 2 、 5 、 1 As a result, these study findings cannot be used to draw general conclusions about the effectiveness of beclomethasone nasal spray. 11 、 8 、 10 、 2 、 5 、 1

Future Research Directions

Further research is needed to investigate the effectiveness of beclomethasone nasal spray. 11 、 8 、 10 、 2 、 5 、 1 In particular, research is needed to examine the long-term safety and efficacy of beclomethasone nasal spray. 11 、 8 、 10 、 2 、 5 、 1 Additionally, research is needed to compare the effectiveness of beclomethasone nasal spray to other treatments. 11 、 8 、 10 、 2 、 5 、 1

Conclusion

Beclomethasone nasal spray may be effective in reducing the symptoms of allergic rhinitis. 11 、 8 、 10 、 2 、 5 、 1 However, it is important to note that beclomethasone nasal spray may not be effective for all patients. 11 、 8 Additionally, beclomethasone nasal spray carries a risk of side effects. 11 、 8 When using beclomethasone nasal spray, it is essential to follow your doctor's instructions carefully and seek medical advice immediately if any side effects occur. It is crucial to consult with a healthcare professional to determine if beclomethasone nasal spray is the right treatment option for you.

Literature analysis of 13 papers
Positive Content
12
Neutral Content
0
Negative Content
1
Article Type
11
0
0
1
13
1.

Intranasal beclomethasone: mode of action in nasal allergy.

Author: OkudaM, SakaguchiK, OhtsukaH

Reduced allergic response

Beclomethasone nasal spray inhibited basophilic cell accumulation in the nasal mucosa, suggesting that this is its primary mechanism of action in allergic rhinitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Onset of action of aqueous beclomethasone dipropionate nasal spray in seasonal allergic rhinitis.

Author: SelnerJ C, WeberR W, RichmondG W, StrickerW E, NortonJ D

Allergic rhinitis relief
Rapid onset of action
Minor adverse events

The study assessed the onset of action, level of relief, and efficacy of beclomethasone dipropionate nasal spray in patients with seasonal allergic rhinitis. Beclomethasone dipropionate nasal spray produced significant relief of symptoms within 24 hours, with sustained improvement throughout the 7-day study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Intranasal beclomethasone: mode of action in nasal allergy.

Author: OkudaM, SakaguchiK, OhtsukaH

Reduced allergic response

Beclomethasone nasal spray inhibited basophilic cell accumulation in the nasal mucosa, suggesting that this is its primary mechanism of action in allergic rhinitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Ipratropium bromide nasal spray 0.03% and beclomethasone nasal spray alone and in combination for the treatment of rhinorrhea in perennial rhinitis.

Author: DockhornR, AaronsonD, BronskyE, ChervinskyP, CohenR, EhtessabianR, FinnA, GrossmanJ, HowlandW, KaiserH, PearlmanD, SublettJ, RatnerP, SettipaneG, SimT, StormsW, WebbR, DrdaK, WoodC

Rhinitis treatment

Perennial rhinitis is a common condition, often requiring multiple agents for complete relief. This study discusses the importance of studies assessing the benefit/risk of combined therapy, particularly for newly approved agents like ipratropium bromide nasal spray 0.03% for rhinorrhea in perennial rhinitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

A placebo controlled study comparing the efficacy of intranasal azelastine and beclomethasone in the treatment of seasonal allergic rhinitis.

Author: Newson-SmithG, PowellM, BaehreM, GarnhamS P, MacMahonM T

Effective treatment
Rapid symptom relief

Azelastine nasal spray provided rapid onset of symptom relief for seasonal rhinitis compared to beclomethasone, although beclomethasone showed greater improvement over time. Both were effective compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Role of leukotriene inhibitors in the postoperative management of nasal polyps.

Author: MostafaBadr E, Abdel HayHossam, MohammedHussam E, YamaniMohammed

Reduced polyp symptoms

This study compared the effects of montelukast and beclomethasone nasal spray on post-operative symptoms in patients with sinonasal polyps. Both treatments were effective, with montelukast showing a greater reduction in itching, post-nasal discharge, and headache.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Effect of beclomethasone nasal spray on intraocular pressure in ocular hypertension or controlled glaucoma.

Author: YuenDarana, BuysYvonne M, JinYa-Ping, AlasbaliTariq, TropeGraham E

No IOP elevation

This study found that patients with ocular hypertension and primary open-angle glaucoma showed no evidence of IOP elevation after 6 weeks use of beclomethasone nasal spray.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Comparative efficacy of steroid nasal spray versus antihistamine nasal spray in allergic rhinitis.

Author: GhimireAnand, DasBalabhadra Prasad, MishraSubhash Chandra

Allergic rhinitis relief
Azelastine efficacy
Drug side effects

Azelastine nasal spray was found to be as effective as beclomethasone nasal spray in treating allergic rhinitis symptoms. The study included 75 patients and found that both treatments reduced the Total Rhinitis Symptom Complex (TSC) score by 84% after 4 weeks. No significant adverse effects were observed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Effect of Beconase nasal spray on olfactory function in post-nasal polypectomy patients: a prospective controlled trial.

Author: el NaggarM, KaleS, AldrenC, MartinF

No olfactory improvement

Topical beclomethasone did not improve olfaction in 29 patients with bilateral nasal polyps who underwent intranasal polypectomy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Oral antihistamine/decongestant treatment compared with intranasal corticosteroids in seasonal allergic rhinitis.

Author: NegriniA C, TroiseC, VoltoliniS, HorakF, BachertC, JanssensM

Astemizole-D effective
Astemizole-D safe

Astemizole-D (astemizole + pseudoephedrine) was at least as effective and well tolerated as intranasal beclomethasone in treating seasonal allergic rhinitis. Astemizole-D provided greater relief from ocular symptoms than the topical steroid.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Astemizole: a long-acting, nonsedating antihistamine.

Author: KrstenanskyP M, CluxtonR J

Effective treatment
Long acting
Minimal side effects
Once daily dosing
Selective
Increased appetite
Weight gain

Astemizole, a long-acting antihistamine, was found to be effective in treating chronic allergic conditions, with a lower incidence of sedation compared to conventional antihistamines, suggesting its potential for managing allergies in patients sensitive to sedative effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Double-blind trials of azelastine nasal spray monotherapy versus combination therapy with loratadine tablets and beclomethasone nasal spray in patients with seasonal allergic rhinitis. Rhinitis Study Groups.

Author: BergerW E, FinemanS M, LiebermanP, MilesR M

Seasonal allergic rhinitis treatment

Azelastine hydrochloride is an H1-receptor antagonist with antiinflammatory properties. It can be used for the treatment of seasonal allergic rhinitis, either as monotherapy or in combination with intranasal corticosteroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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