Effects of belladonna alkaloid combinations and phenobarbital: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Main Research Findings

Several studies have shown that combinations of belladonna alkaloids and phenobarbital can be effective for a variety of symptoms. 4 found that these combinations were effective in relieving bronchospasm. demonstrated that this combination was superior to placebo in treating symptoms of anxiety and tension states associated with functional gastrointestinal disorders. Moreover, revealed that combining meprobamate with this combination resulted in a greater relaxing effect than meprobamate alone. On the other hand, indicated potential risks of side effects when ingesting a massive quantity of this combination. Additionally, 6 demonstrated the effectiveness of this combination in treating acute myocardial infarction. However, 8 highlighted the need for caution when administering this combination to infants. Furthermore, showed that this combination can affect electroshock seizures in rats. 2 reported a potential association of this combination with anticonvulsant hypersensitivity syndrome. Moreover, 7 suggested that this combination could contribute to cardiorespiratory instability and gastroesophageal reflux in vulnerable infants. 5 showed that this combination was effective in treating troublesome symptoms of premenstrual syndrome. 1 suggested that this combination could be effective in treating hot flashes during menopause. 3 demonstrated that this combination could be effective in improving climacteric complaints. suggested that this combination has fewer side effects than the antipsychotic drug thioridazine.

Benefits and Risks

Benefits Summary

Combinations of belladonna alkaloids and phenobarbital have the potential to be effective in improving symptoms such as bronchospasm, anxiety and tension states, functional gastrointestinal disorders, premenstrual syndrome, hot flashes during menopause, and may also be effective in treating acute myocardial infarction.

Risks Summary

Combinations of belladonna alkaloids and phenobarbital pose risks of side effects when ingested in large quantities. Caution is advised for infants and patients with anticonvulsant hypersensitivity. Additionally, this combination has been reported to cause respiratory arrest and cyanosis. Moreover, this combination has been shown to affect electroshock seizures in rats.

Comparison Across Studies

Commonalities Across Studies

Multiple studies have indicated the effectiveness of belladonna alkaloid and phenobarbital combinations for various symptoms. These studies consistently demonstrate that this combination can be effective in alleviating bronchospasm, anxiety and tension states, functional gastrointestinal disorders, premenstrual syndrome, hot flashes during menopause, and may also be effective in treating acute myocardial infarction.

Differences Across Studies

The studies vary in terms of administration methods, dosages, and the specific symptoms targeted for treatment. Some studies have also highlighted the potential risks of side effects.

Consistency and Contradictions in Findings

Multiple studies consistently show that belladonna alkaloid and phenobarbital combinations are effective for various symptoms. However, some studies have indicated potential risks of side effects, emphasizing the need for caution when using this combination.

Considerations for Real-World Application

Combinations of belladonna alkaloids and phenobarbital should be used under the guidance of a healthcare professional, with appropriate dosages. Particular caution is required for infants and patients with anticonvulsant hypersensitivity. If symptoms such as respiratory arrest or cyanosis occur, immediate medical attention is crucial.

Limitations of Current Research

Research on combinations of belladonna alkaloids and phenobarbital is still limited, especially regarding long-term safety. Further studies are needed to evaluate the long-term safety of this combination.

Future Research Directions

Future research should focus on the long-term safety of belladonna alkaloid and phenobarbital combinations. Further investigations are also necessary to comprehensively assess the effectiveness and side effects of this combination for various symptoms.

Conclusion

Combinations of belladonna alkaloids and phenobarbital show potential for effectiveness in addressing various symptoms, but also carry risks of side effects. It is crucial to use this combination under the guidance of a healthcare professional, exercising caution and seeking immediate medical attention if any adverse reactions occur.

Literature analysis of 8 papers
Positive Content
5
Neutral Content
0
Negative Content
3
Article Type
2
0
0
0
8
1.

Centrally active nonhormonal hot flash therapies.

Author: LoprinziCharles L, StearnsVered, BartonDebra

Improves Mood
Treats Hot Flashes
Fluid Retention
Mastalgia
Vaginal Discharge
Weight Gain

Newer antidepressants and gabapentin were effective in reducing hot flashes in women.

Consensus Development Conference, NIHA conference organized by the NIH (National Institutes of Health) to develop consensus and recommendations on medical issues.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms.

Author: TurnerRyan B, KimCaroline Choi, StreamsBrian N, CulpepperKeliegh, HaynesHarley A

Anticonvulsant hypersensitivity syndrome

A case report describes a postmenopausal woman who developed anticonvulsant hypersensitivity syndrome (AHS) while taking Bellamine S, a medication containing phenobarbital, for hot flashes. This report emphasizes the importance of considering AHS as a potential adverse reaction to phenobarbital-containing medications, particularly in women seeking alternative treatments for menopausal symptoms.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Effect of Bellergal Retard on climacteric complaints: a double-blind, placebo-controlled study.

Author: BergmansM G, MerkusJ M, CorbeyR S, SchellekensL A, UbachsJ M

Relief of climacteric complaints

Bellergal Retard (BR) was compared to placebo for treating climacteric complaints. While BR was initially more effective, the difference disappeared after 8 weeks. The study concluded that studies on medication for climacteric complaints should be at least 8 to 12 weeks long.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

[Bronchospasmolytic effectiveness of controlled drug combinations].

Author: ForcheG, ZenkerG, HarnoncourtK

Bronchospasmolytic effect
Cardiovascular side effects

A combined medication consisting of theophyllin, etophyllin, papaverine, and atropine methylnitrate was more effective than theophyllinethylendiamine in treating chronic obstructive pulmonary disease. The combined medication worked faster, longer, and more effectively, while its cardiovascular side effects were considered slight.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

5.

Treatment of the premenstrual syndrome.

Author: RobinsonK, HuntingtonK M, WallaceM G

Premenstrual syndrome relief

A study of women with premenstrual syndrome found that a combination of belladonna alkaloids, ergotamine tartrate, and phenobarbitone (Bellergal) significantly improved symptoms of fatigue, breast tenderness, nervousness, irritability, lethargy, and listlessness. The drug was well-tolerated with no reported side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Colic medication and apparent life-threatening events.

Author: HardoinR A, HensleeJ A, ChristensonC P, ChristensonP J, WhiteM

Colic treatment
Cardiorespiratory instability
GER

This study suggests a potential link between colic medications containing dimenhydrinate and Donnatal and cardiorespiratory instability and gastroesophageal reflux in vulnerable infants. Further evaluation is recommended.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Infants and atropine: a dangerous mixture.

Author: PickfordE J, HansonR M, O'HalloranM T, FenwickD, NobleP, McDonaldJ D

Colic treatment
Serious side effects

A case report highlights the potential for serious side effects from using an atropine-containing mixture for treating infant colic, emphasizing the need for alternative treatment methods due to the risk of toxicity.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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