Effects of bethanechol: A Synthesis of Findings from 23 Studies

  1. Home
  2. Effects of bethanechol
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of bethanechol: A Synthesis of Findings from 23 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of bethanechol: A Synthesis of Findings from 23 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Bethanechol, a cholinergic agonist, has been shown to have diverse effects on various organs and tissues in multiple studies. 21 suggests that bethanechol, in combination with cimetidine, can be effective in improving esophageal motor function and reducing symptoms in patients with esophagitis and Barrett's esophagus. 16 investigated the neuropharmacodynamics of bethanechol chloride on the external urethral sphincter in spinal cord injury patients, highlighting its potential in urinary tract rehabilitation. 22 delves into the effects of bethanechol on colonic smooth muscle in cats, demonstrating its influence on intestinal motility. 4 explores the effects of bethanechol on equine gastrointestinal contractility, showcasing its potential in treating gastrointestinal disorders in horses. Further, examines the impact of bethanechol on the electrical activity of the cat colon, indicating its role in regulating intestinal function. In addition, 17 demonstrates the influence of bethanechol on gastric acid secretion in dogs and the effectiveness of H2-receptor antagonists in inhibiting this effect. highlights the effects of bethanechol on intestinal ion transport in rats, suggesting its involvement in regulating fluid and electrolyte balance. explores the effects of bethanechol on renal electrolyte excretion in rats and chickens, indicating its potential role in renal function. Other studies like and 20 showcase bethanechol's influence on pancreatic polypeptide and gastrin release in dogs and urethral closure pressure in women with urinary stress incontinence respectively. 7 emphasizes the risk of hypothermia associated with bethanechol and adrenoblockers in spinal cord injury patients. 13 highlights the effects of bethanechol on esophageal motor function in infants with gastroesophageal reflux, suggesting its potential therapeutic use. 11 delves into the effects of bethanechol on gastric acid secretion in mice. 15 compares the effects of bethanechol on gastric and salivary secretion in dogs with H2-receptor antagonists and anticholinoceptor drugs. 1 examines the effects of bethanechol on smooth muscle preparations from the abomasal antrum and duodenum of dairy cows. 18 explores the trophic effects of chronic bethanechol on the pancreas, stomach, and duodenum in rats. 3 investigates the effects of bethanechol and cisapride on urodynamic parameters in patients undergoing radical hysterectomy for cervical cancer. 12 explores the effects of anoxia on the biphasic response of isolated strips of rabbit bladder to field stimulation, bethanechol, methoxamine, and KCl. 2 discusses the potential use of topical diltiazem and bethanechol in reducing anal sphincter pressure without side effects. 19 describes the in vitro effects of bethanechol on specimens of intestinal smooth muscle from the duodenum and jejunum of healthy dairy cows. investigates the effects of atropine, glucagon, and bethanechol on the urodynamics of continent cecal urinary reservoirs in dogs. examines the effects of bethanechol on canine urinary bladder smooth muscle function. 6 studies the effects of racemic bethanechol and its (R)- and (S)-enantiomers on pre- and postjunctional muscarine receptors in the guinea-pig ileum. suggests the potential of bethanechol in treating anticholinergic side effects. 14 examines the effects of bethanechol, metoclopramide, and domperidone on antral contractions in cats and dogs. 9 investigates the role of the vagus nerve and cholinergic mechanisms in controlling rabbit jejunal mucin and protein release. 8 studies the effects of the sympathetic nervous system on bethanechol-induced elevation of gastric acid secretion and mucosal blood flow in rats. 10 compares the twitch-response enhancing potencies of substance P, bethanechol, 4-aminopyridine, and potassium chloride in the field-stimulated guinea-pig vas deferens. These research findings collectively point towards bethanechol's multifaceted effects on physiological functions, particularly those related to smooth muscle contraction and nerve signaling.

Benefits and Risks

Benefit Summary

Bethanechol has shown potential benefits in improving esophageal motor function, aiding in urinary tract rehabilitation, enhancing intestinal motility, improving gastric emptying, promoting pancreatic growth, and treating anticholinergic side effects. It also holds potential for treating gastrointestinal disorders in horses and improving bladder function in patients undergoing surgery.

Risk Summary

Bethanechol can have side effects, including nausea, vomiting, diarrhea, abdominal pain, sweating, increased heart rate, and low blood pressure. It can be dangerous for individuals with pre-existing conditions such as heart disease, asthma, glaucoma, bladder blockage, and enlarged prostate. Bethanechol should not be used during pregnancy or breastfeeding. Consultation with a healthcare professional is essential before using bethanechol.

Research Comparison

Research Similarities

These studies consistently demonstrate that bethanechol can significantly influence the functions of various organs and tissues. The common thread across these research findings is the impact of bethanechol on smooth muscle contraction and nerve signaling, particularly in the gastrointestinal and urinary tracts.

Research Differences

The effects of bethanechol vary significantly depending on the specific organ or tissue being studied. For example, bethanechol can stimulate muscle contractions in the esophagus and bladder but may inhibit contractions in the colon. The diverse responses highlight the complexity of bethanechol's action and its dependence on the specific cellular environment.

Consistency and Contradictions

Research findings show both consistency and contradictions regarding bethanechol's effects. While many studies point to its influence on smooth muscle contraction, the specific nature of this influence varies. The mechanism of action of bethanechol is not completely understood, and its potential interactions with other drugs require further investigation.

Practical Applications and Precautions

Bethanechol should be used only under the guidance of a healthcare professional. Self-medication with bethanechol is dangerous. It is important to consult with a doctor before taking bethanechol. It is crucial to avoid bethanechol during pregnancy and breastfeeding and exercise caution if you have pre-existing conditions.

Limitations of Current Research

Further research is required to comprehensively understand the mechanism of action of bethanechol, its long-term effects, and potential interactions with other medications. Studies regarding the safety and efficacy of bethanechol in specific populations, such as those with pre-existing conditions, are also essential.

Future Research Directions

Future research should focus on elucidating the mechanism of action of bethanechol, investigating its long-term effects, and assessing its safety and efficacy in various patient populations. Further studies on its interactions with other medications and its potential use in treating specific conditions are also crucial.

Conclusion

Bethanechol is a versatile drug with a range of effects on various organs and tissues. While it holds potential benefits for treating various conditions, it's crucial to be aware of its potential side effects and use it only under the supervision of a healthcare professional. Continued research is essential to gain a better understanding of its mechanism of action, long-term effects, and safety, paving the way for its more effective and safe use in clinical practice.

Literature analysis of 23 papers
Positive Content
20
Neutral Content
2
Negative Content
1
Article Type
2
0
0
0
23
1.

In vitro effects of cisapride, metoclopramide and bethanechol on smooth muscle preparations from abomasal antrum and duodenum of dairy cows.

Author: MichelA, MevissenM, BurkhardtH W, SteinerA

Gastric emptying enhancement

This study investigates the effects of cisapride, metoclopramide, and bethanechol on contractility parameters in smooth muscle preparations of the abomasal antrum and proximal duodenum of cows. The results suggest that bethanechol can enhance abomasal emptying.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects.

Author: CarapetiE A, KammM A, EvansB K, PhillipsR K

Anal fissure treatment
Headache

Topical nitrates lower anal sphincter pressure and heal anal fissures, but a majority of patients experience headache. It may therefore be possible to lower anal sphincter pressure using calcium channel blockers and cholinergic agonists without side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

The effects of bethanechol and cisapride on urodynamic parameters in patients undergoing radical hysterectomy for cervical cancer. A randomized, double-blind, placebo-controlled study.

Author: MadeiroAlberto P, RufinoAndréa C, SartoriMarair G F, BaracatEdmund C, LimaGeraldo Rodrigues De, GirãoManoel J B C

More efficient detrusor function

Bethanechol and cisapride are drugs that improve bladder function. Studies show that these drugs can positively modify urodynamic parameters in patients undergoing radical hysterectomy, leading to a more efficient detrusor function.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

The effects of racemic bethanechol and its (R)- and (S)-enantiomers on pre- and postjunctional muscarine receptors in the guinea-pig ileum.

Author: SchwörerH, LambrechtG, MutschlerE, KilbingerH

The (S)-enantiomer of bethanechol was a more potent agonist than the (R)-enantiomer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Effects of bethanechol and adreno-blockers on thermoregulation in spinal cord injury.

Author: BerardE J, BoucandM H, DepassioJ, FyonJ P

Hypothermia risk

This report describes two cases of hypothermia in patients receiving both bethanechol, a parasympathomimetic, and beta-blockers. The authors suggest that the hypothermia is likely due to a combination of heat loss mediated by bethanechol and the prevention of heat preservation by beta-blockers. Patients on this combination of drugs require careful monitoring for hypothermia.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Effects of the sympathetic nervous system on bethanechol-induced elevation of gastric acid secretion and mucosal blood flow in rats.

Author: YokotaniK, MuramatsuI, FujiwaraM

Stimulation of the sympathetic nervous system reduced bethanechol-induced gastric acid secretion in anesthetized rats without affecting mucosal blood flow. This effect was mediated by alpha adrenoceptors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Mucin and protein release in the rabbit jejunum: effects of bethanechol and vagal nerve stimulation.

Author: GreenwoodB, MantleM

None mentioned
Increased intestinal permeability

The vagus nerve does not regulate rabbit jejunal mucin secretion, but cholinergic stimulation increased both mucin and protein output. This suggests that cholinergic control of intestinal goblet cells is implemented by the intrinsic enteric nervous system.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Differential effects of Na+, K(+)-ATPase inhibition by ouabain on acid secretory responses to histamine and bethanechol in the mouse isolated stomach.

Author: HorieS, YanoS, WatanabeK

Inhibits acid secretion

This study investigated the effect of ouabain, a Na+,K(+)-ATPase inhibitor, on gastric acid secretion. Ouabain caused a transient enhancement followed by inhibition of histamine-induced acid secretion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effects of anoxia on the biphasic response of isolated strips of rabbit bladder to field stimulation, bethanechol, methoxamine and KCl.

Author: BilgenA, WeinA J, ZhaoY, LevinR M

None mentioned
Anoxia-induced inhibition of bladder contraction

Anoxia inhibited the plateau phase of bladder contractions more than the peak phase. This suggests that the two phases of bladder contraction have different energy requirements.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

13.

Early effects of bethanechol on the esophageal motor function of infants with gastroesophageal reflux.

Author: SondheimerJ M, ArnoldG L

Improved esophageal acid clearance
Increased LES pressure

Bethanechol was effective in increasing lower esophageal sphincter pressure in infants with gastroesophageal reflux.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Effects of bethanechol, metoclopramide, and domperidone on antral contractions in cats and dogs.

Author: MangelA W, StavorskiJ R, PendletonR G

No blood pressure changes with domperidone
Stimulates antral contractions

Bethanechol, metoclopramide, and domperidone stimulate antral contractions in dogs and cats, but domperidone is ineffective in cats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Effects of four H2 histamine antagonists on bethanechol-stimulated acid and pepsin secretion in the dog.

Author: HirschowitzB I, MolinaE

Four H2-receptor antagonists inhibited acid secretion but had varying effects on pepsin secretion and gastrin release.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

18.

Trophic effects of chronic bethanechol on pancreas, stomach, and duodenum in rats.

Author: MorissetJ, JolicoeurL, CaussignacY, SolomonT E

Pancreatic growth

Bethanechol, a cholinergic agonist, caused pancreatic hyperplasia and increased protein and enzyme content in rats after long-term treatment. No significant effects were seen on the stomach or duodenum.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

The effects of norephedrine and bethanechol on the human urethral closure pressure profile.

Author: EkA, AnderssonK E, UlmstenU

Increased MUCP

Norephedrine was effective in increasing maximum urethral closure pressure in women with urinary stress incontinence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Effects of bethanechol and the octapeptide of cholecystokinin on colonic smooth muscle in the cat.

Author: SnapeW J, TanS T, KaoH W

CCK-OP, an octapeptide of cholecystokinin, was found to have a different mechanism of action compared to bethanechol, a cholinergic agonist, in regulating colonic smooth muscle activity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

23.

Effects of bethanechol on canine urinary bladder smooth muscle function.

Author: BuranakarlC, KijtawornratA, AngkanapornK, KomolvanichS, BoveeK C

Bladder contraction

This study investigates the effects of bethanechol, a muscarinic receptor agonist, on bladder contraction. It suggests that bethanechol induces contraction through muscarinic receptors and calcium influx, with potential down-regulation mechanisms related to calcium influx interference.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.