Main Research Findings

Several recent studies have described the benefits of fenfluramine for the symptomatic treatment of infantile autism. . However, no large surveys of side effects of this drug have been reported in autistic children. . This study systematically evaluated the untoward effects of fenfluramine in 12 children with autism. .

Reasons for Side Effects

Fenfluramine can cause side effects because it affects the levels of neurotransmitters in the brain, such as serotonin and dopamine. These neurotransmitters are involved in regulating mood, appetite, sleep, and movement. While fenfluramine may improve some autism symptoms by altering these neurotransmitter levels, it can also lead to unintended side effects. .

Common Side Effects

Drowsiness

Drowsiness was frequently observed during the first two weeks of fenfluramine treatment. .

Loss of Appetite

Loss of appetite was a common side effect during the initial two weeks of treatment and persisted in the final 14 weeks of fenfluramine therapy. .

Upset Stomach

Stomach upset was frequently reported in the initial two weeks of fenfluramine administration. .

Irritability

Irritability was observed in the final 14 weeks of fenfluramine treatment. .

Agitation

Agitation was reported in the final 14 weeks of fenfluramine treatment. .

Crying

Crying was observed in the final 14 weeks of fenfluramine treatment. .

Weight Loss

Participants in the study experienced a 2.1% weight loss during the active drug phase, but this weight loss was regained during the subsequent placebo phase. .

Measures for Side Effects

Drowsiness

To alleviate drowsiness, it is recommended to get sufficient rest. .

Loss of Appetite

To address loss of appetite, it is suggested to eat small, frequent meals. . Also, prioritize nutritious foods and ensure adequate hydration. .

Upset Stomach

To mitigate stomach upset, it is advised to consume easily digestible foods. . Also, consider reducing portion sizes and incorporating snacks throughout the day. .

Irritability

To lessen irritability, it is recommended to create a calming environment. . Engage in relaxing activities to reduce stress. .

Agitation

To manage agitation, focus on relaxing activities. . Also, limit consumption of caffeine and alcohol. .

Crying

To address crying, provide comfort and reassurance to the child. . Ensure a safe and secure environment for the child. .

Comparison Between Studies

Similarities Between Studies

Several recent studies have described the benefits of fenfluramine for the symptomatic treatment of infantile autism. .

Differences Between Studies

No large surveys of side effects of this drug have been reported in autistic children. .

Cautions Regarding Application to Real Life

While fenfluramine may offer potential benefits for treating autism symptoms, it is important to acknowledge the risk of side effects. . If considering fenfluramine, it is crucial to follow your doctor's instructions closely and monitor for any adverse reactions. . Remember, fenfluramine may not be effective for all autism symptoms. . Consulting with a doctor is essential to determine if fenfluramine is appropriate for an autistic child. .

Limitations of Current Research

The research on fenfluramine's side effects is still insufficient. . Further research is particularly needed to understand the long-term effects of fenfluramine in autistic children. .

Future Research Directions

Large-scale studies are required to thoroughly investigate the side effects of fenfluramine. . Additionally, research focused on the long-term effects of fenfluramine is necessary. .

Conclusion

Fenfluramine may offer potential benefits for treating autism symptoms, but it is important to acknowledge the risk of side effects. . If considering fenfluramine, it is crucial to follow your doctor's instructions closely and monitor for any adverse reactions. . Remember, fenfluramine may not be effective for all autism symptoms. . Consulting with a doctor is essential to determine if fenfluramine is appropriate for an autistic child. .