Effects of bisoprolol: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Major Research Findings

Bisoprolol is a beta blocker that selectively targets beta 1 receptors in the heart, used to treat conditions like high blood pressure and angina. These studies explore bisoprolol’s pharmacological effects and clinical benefits, comparing it to other beta blockers like atenolol and carvedilol.

5 compares the beta 1 receptor selectivity, hemodynamic effects, and biochemical changes of bisoprolol and atenolol. Both bisoprolol and atenolol were found to be beta 1 receptor selective antagonists, with bisoprolol showing slightly more potency and selectivity for beta 1 receptors than atenolol at the doses used.

9 investigates the relationship between acute and chronic effects of bisoprolol in healthy volunteers. The research indicates that the beta-blocking effect of bisoprolol is directly related to plasma concentration, and can be predicted by a single intravenous dose administration.

13 contrasts the effects of bisoprolol and carvedilol in patients with chronic heart failure. Bisoprolol demonstrated more protective effects against myocardial injury and pulmonary dysfunction compared to carvedilol.

7 compares the effects of two different doses of bisoprolol on exercise tolerance in patients with stable angina. The study shows that bisoprolol improves exercise tolerance, and this improvement is dose-dependent.

6 explores the antihypertensive effects of bisoprolol in patients with essential hypertension at different dosages. The study found that bisoprolol effectively lowers blood pressure, and this effect is stronger with higher doses.

11 examines the relationship between bisoprolol-induced hemodynamic effects and survival in heart failure patients, utilizing data from the Cardiac Insufficiency BIsoprolol Study (CIBIS). The study suggests a connection between hemodynamic effects of bisoprolol and survival in heart failure patients.

2 assesses the beta 1 receptor selectivity of bisoprolol through metabolic responses. The study found that bisoprolol exhibits beta 1 receptor selectivity compared to atenolol, but this selectivity decreases with higher doses.

8 compares the effects of bisoprolol and metoprolol on blood pressure and heart rate reduction in hypertensive patients. The study indicates that bisoprolol provides more persistent reduction in exercise blood pressure and heart rate throughout the 24-hour dosage interval compared to metoprolol.

3 investigates the dose-effect relationship and long-term effects of bisoprolol in patients with mild to moderate hypertension. The study suggests that bisoprolol lowers blood pressure in a dose-dependent manner and these effects persist with long-term treatment.

12 compares the beta-blocking effects of bisoprolol, carvedilol, and nebivolol, all effective in treating heart failure. The study highlights that the beta-blocking effects of these drugs differ.

4 compares the antihypertensive efficacy and tolerability of bisoprolol and atenolol in patients with essential hypertension. The study shows that bisoprolol provides slightly but significantly greater blood pressure reduction than atenolol.

1 investigates the effects of bisoprolol on sexual functioning in men with hypertension. The study suggests that bisoprolol may potentially impact sexual function.

10 explores the effects of low-dose bisoprolol on blood pressure and lipoprotein concentrations in newly diagnosed hypertensive patients. The study found that low-dose bisoprolol effectively lowers blood pressure and may influence lipoprotein concentrations.

Benefits and Risks

Benefit Summary

Bisoprolol, a selective beta 1 receptor-targeting beta blocker, is used to treat high blood pressure and angina. It effectively lowers blood pressure and reduces heart rate. It has also shown potential in improving exercise tolerance and slowing the progression of heart failure. Compared to atenolol, bisoprolol might be more potent and selective, and its effects on lowering blood pressure and heart rate during exercise could persist longer. Studies also suggest that even low doses of bisoprolol might effectively lower blood pressure.

Risk Summary

While generally safe, bisoprolol can cause side effects. Common side effects include fatigue, dizziness, headache, and digestive problems. In rarer cases, it may worsen conditions like asthma, heart failure, or diabetes. Bisoprolol may also impact sexual function, as some studies suggest. When taking bisoprolol, it's crucial to follow your doctor’s instructions and promptly report any side effects.

Comparison Between Studies

Commonalities

These studies share the goal of evaluating bisoprolol’s pharmacological effects and clinical benefits. They consistently suggest that bisoprolol is a beta blocker that selectively targets beta 1 receptors in the heart, and is an effective treatment for conditions like high blood pressure and angina.

Differences

These studies vary in terms of the patient population, research design, and evaluated metrics. For example, 5 is a pharmacological evaluation using healthy volunteers, while 7 is a clinical trial involving patients with stable angina.

Consistency and Contradictions in Findings

These studies generally indicate that bisoprolol is a safe and effective drug. However, the beta 1 receptor selectivity and duration of blood pressure and heart rate reduction during exercise can differ depending on the dosage and patient population. Some studies have reported a potential impact on sexual function with bisoprolol use, requiring further investigation.

Real-World Application Notes

Bisoprolol is used to treat high blood pressure and angina. Follow your doctor’s instructions for taking bisoprolol and report any side effects immediately. Remember, bisoprolol can interact with other medications, so consult your doctor before starting this medication. Pregnant or breastfeeding women should not take bisoprolol. Be cautious, as bisoprolol may affect alcohol consumption and driving ability.

Limitations of Current Research

These studies have limitations, such as a limited patient population, research design, and evaluation metrics, which necessitate further research to fully understand bisoprolol’s pharmacological and clinical effects. Particularly, more research is needed regarding long-term effects and side effects of bisoprolol.

Future Research Directions

Further research is needed regarding long-term effects, side effects, impact on sexual function, interactions with other medications, optimal dosage, and delivery methods of bisoprolol.

Conclusion

Bisoprolol is a beta blocker that selectively targets beta 1 receptors in the heart, used to treat high blood pressure and angina. It effectively lowers blood pressure and reduces heart rate. It has also shown potential in improving exercise tolerance and slowing the progression of heart failure. While generally safe, bisoprolol can cause side effects. Follow your doctor’s instructions for taking bisoprolol and report any side effects immediately.

These studies suggest that bisoprolol is a safe and effective drug. However, there are still unanswered questions regarding bisoprolol, warranting further research. If you are considering taking bisoprolol, consult your doctor.

Literature analysis of 13 papers
Positive Content
13
Neutral Content
0
Negative Content
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Article Type
13
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13
1.

Bisoprolol and hypertension: effects on sexual functioning in men.

Author: BroekmanC P, HaenselS M, Van de VenL L, SlobA K

Improved sexuality

Bisoprolol is an effective antihypertensive drug with no detrimental effects on sexuality in newly diagnosed men with hypertension. In men already on antihypertensive medication, bisoprolol improved certain aspects of sexuality.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

A metabolic assessment of the beta 1 selectivity of bisoprolol.

Author: HaffnerC A, HortonR C, LewisH M, HughesB, KendallM J

Effective antianginal
Effective antihypertensive
Minimal effect on beta 2 receptors
Decreasing beta 1 selectivity

Bisoprolol, a beta-blocker, had comparable beta1 selectivity to atenolol as measured by metabolic response. At a dose of 5 mg, bisoprolol had minimal effect on beta2 receptors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Dose-effect relationship and long-term effects of bisoprolol in mild to moderate hypertension.

Author: WeinerL, FrithzG

Blood pressure reduction
Heart rate reduction
Cold extremities

Bisoprolol, a new beta 1-selective beta-blocking agent, was effective in reducing blood pressure and heart rate in 48 hypertensive patients. The 20 mg dose was more effective than the 5 or 10 mg doses. The effects were sustained over 10 months of treatment. Side effects were common but mild.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Double-blind comparison of the cardioselective beta-blockers bisoprolol and atenolol in hypertension: the Bisoprolol International Multicenter Study (BIMS).

Author: BühlerF R, BerglundG, AndersonO K, BrunnerH R, ScherrerU, van BrummelenP, DistlerA, PhilippT, FogariR, MimranA

Blood pressure reduction
Well-being

Bisoprolol was found to be slightly but significantly more effective than atenolol in lowering blood pressure in 94 patients with essential hypertension. Bisoprolol also resulted in higher rates of achieving diastolic target pressures of less than or equal to 95 mm Hg. Both drugs were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Beta 1-adrenoceptor selectivity of single oral doses of bisoprolol and atenolol.

Author: ChangP C, van VeenS, van der KrogtJ A, VermeijP, van BrummelenP

More potent than atenolol
Selective beta 1 antagonists

Bisoprolol and atenolol were both selective beta 1 antagonists, with bisoprolol showing slightly more potency and selectivity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Antihypertensive effects of bisoprolol during once daily administration in patients with essential hypertension. A dose-ranging study with parallel groups.

Author: WeinerL, FrithzG

Effective for hypertension
Well-tolerated

Bisoprolol, a new beta 1-selective beta-blocking agent, was effective in treating essential hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Comparison of the effects of two doses of bisoprolol on exercise tolerance in exercise-induced stable angina pectoris.

Author: de MuinckE, WagnerG, vd VenL L, LieK I

Improved exercise tolerance
Longer duration of action

Bisoprolol, a beta-blocker, was found to improve exercise tolerance in patients with coronary heart disease. A 10mg dose was more effective than a 5mg dose, but both doses had a duration of action lasting over 24 hours.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Exercise blood pressure and heart rate reduction 24 and 3 hours after drug intake in hypertensive patients following 4 weeks of treatment with bisoprolol and metoprolol: a randomized multicentre double-blind study (BISOMET).

Author: HaasisR, BethgeH

Lower blood pressure
Lower heart rate
Persistent reduction in blood pressure

Bisoprolol and metoprolol, two beta-blockers, were compared for their effects on blood pressure and heart rate during exercise. Bisoprolol showed significantly stronger and more persistent effects on blood pressure and heart rate throughout the 24-hour dosage interval compared to metoprolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Relationships between acute and chronic beta-blocking effects of bisoprolol in healthy volunteers: a practical approach to predict intensity of beta-blockade.

Author: JaminP, LeCozF, Funck-BrentanoC, PoirierJ M, JaillonP

Beta-blockade prediction
Chronic ischemia treatment

Bisoprolol-induced beta-blockade after repeated oral dosing can be predicted by single-test i.v. dose administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Effects of small doses of bisoprolol on blood pressure and lipoprotein concentrations in hypertensive patients.

Author: LithellH, WeinerL, VessbyB, NordströmM L

Blood pressure reduction
Cholesterol reduction
Hypertension treatment

Bisoprolol is a drug that is used to treat high blood pressure. This study found that bisoprolol, at a low dose (2.5 mg per day), was equally effective as a higher dose (5 mg per day) at lowering blood pressure. Both doses had small effects on lipid levels, with an unexpected decrease in LDL cholesterol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Prognostic value of bisoprolol-induced hemodynamic effects in heart failure during the Cardiac Insufficiency BIsoprolol Study (CIBIS).

Author: LechatP, EscolanoS, GolmardJ L, LardouxH, WitchitzS, HennemanJ A, MaischB, HetzelM, JaillonP, BoisselJ P, MalletA

Improved survival
Preserved left ventricular function

Preservation of left ventricular function played a key role in the beneficial effects of bisoprolol therapy in heart failure, with heart rate change and left ventricular fractional shortening change over time being predictive of survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol.

Author: StoschitzkyKurt, StoschitzkyGergana, BrusseeHelmut, BonelliClaudia, DobnigHarald

Improved QOL
Reduced heart rate
Sleep disturbances

Bisoprolol, carvedilol, and nebivolol all effectively reduce heart rate, but they have distinct effects on peak and trough beta-blocking activity and nocturnal melatonin release. Bisoprolol exhibits stronger peak beta-blocking effects, while nebivolol has the highest trough-to-peak ratio. Only bisoprolol significantly reduced nocturnal melatonin release, potentially leading to sleep disturbances.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Protective effects of bisoprolol against myocardial injury and pulmonary dysfunction in patients with chronic heart failure.

Author: ToyodaShigeru, HaruyamaAkiko, InamiShu, AmanoHirohisa, ArikawaTakuo, SakumaMasashi, AbeShichiro, TanakaAtsushi, NodeKoichi, InoueTeruo

Myocardial protection
Preserved pulmonary function
None reported

In 67 patients with chronic systolic heart failure, bisoprolol showed possible superiority to carvedilol in protecting against myocardial injury and preserving pulmonary function. Bisoprolol lowered troponin T levels and improved forced expiratory volume compared to carvedilol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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