Effective treatment of breast diseases: A Synthesis of Findings from 16 Studies

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Original Abstract of the Article

Main Research Findings

Research on effective treatments for breast diseases has yielded various findings. Studies have shown that cognitive behavioral therapy ( 2 ) can be effective in reducing pain intensity and frequency in children with recurrent abdominal pain, a common condition affecting 10-20% of schoolchildren. Furthermore, antidepressants, specifically citalopram, have shown a trend towards effectiveness in treating childhood functional abdominal pain ( 9 ). Other treatments explored include hypnotherapy ( 11 ), which has demonstrated noninferiority to individual hypnotherapy for pediatric irritable bowel syndrome and functional abdominal pain. Additionally, therapeutic ultrasound and local anesthetic injections have been investigated as treatments for chronic pelvic pain associated with abdominal myofascial syndrome ( 15 ).

Treatment Summary

Based on the research, several treatments have emerged for breast diseases, including cognitive behavioral therapy ( 2 ), antidepressants ( 9 ), hypnotherapy ( 11 ), therapeutic ultrasound ( 15 ), local anesthetic injections ( 15 ), and ashi acupuncture ( 12 ). It's crucial to remember that these are just some of the potential treatment options and may not be suitable for everyone.

Benefits and Risks

Benefit Summary

These treatments offer potential benefits for managing various symptoms associated with breast diseases, including pain reduction and improved quality of life. For example, cognitive behavioral therapy has been shown to reduce pain frequency and intensity in children with recurrent abdominal pain ( 2 ). Antidepressants like citalopram have shown a trend towards effectiveness in reducing pain associated with functional abdominal pain in children ( 9 ). Hypnotherapy, particularly home-based self-exercises, offers a viable alternative for pediatric patients with irritable bowel syndrome and functional abdominal pain ( 11 ). Furthermore, therapeutic ultrasound and local anesthetic injections have been explored as potential treatments for chronic pelvic pain caused by abdominal myofascial syndrome ( 15 ).

Risk Summary

It's important to note that each treatment carries potential risks and side effects. For instance, antidepressants can cause side effects like nausea and drowsiness ( 9 ). Hypnotherapy may not be effective for everyone and could potentially worsen symptoms in some cases ( 11 ). Therapeutic ultrasound and local anesthetic injections can lead to pain and swelling ( 15 ), and ashi acupuncture carries risks of infection and bleeding ( 12 ).

Comparison of Studies

Commonalities of Studies

All of these studies aim to investigate the effectiveness of different treatments for various breast diseases. While the specific focus, participant demographics, treatments, and evaluation metrics vary, the overarching goal is to alleviate symptoms and improve quality of life for those affected by these conditions.

Differences of Studies

The studies differ significantly in terms of participant characteristics, treatments investigated, evaluation methods, and study designs. For example, studies on cognitive behavioral therapy have varied in the age range and specific symptoms of the participants ( 2 ). Similarly, research on antidepressants has explored different medications and dosages ( 9 ).

Consistency and Inconsistencies of Results

The research findings exhibit both consistency and inconsistencies. For instance, cognitive behavioral therapy consistently shows promise in reducing symptoms associated with breast diseases ( 2 , 14 ). However, research on hypnotherapy has yielded mixed results, with some studies demonstrating effectiveness and others finding no significant benefit ( 11 ). These inconsistencies can be attributed to differences in study designs, participant characteristics, evaluation methods, and other factors.

Practical Considerations

It's essential to approach these research findings with a critical eye and consider them within the context of individual circumstances. These studies were conducted under specific conditions and may not be universally applicable. Moreover, treatment effectiveness varies greatly from person to person. Before starting any new treatment, it's crucial to consult with a doctor to discuss potential options and determine the best approach for your specific needs.

Current Research Limitations

Research on effective treatments for breast diseases is still ongoing and has limitations. For example, long-term effectiveness and safety data remain insufficient. Additionally, potential factors influencing treatment effectiveness, such as age, symptoms, and lifestyle habits, haven't been fully explored. Addressing these limitations requires further research.

Future Research Directions

Future research on effective treatments for breast diseases should focus on the following areas: * Long-term effectiveness and safety evaluations * Investigating combined treatment approaches * Identifying factors influencing treatment effectiveness * Tailoring treatments to individual needs

Conclusion

Research on effective treatments for breast diseases is growing, offering various potential options for managing symptoms. Treatments like cognitive behavioral therapy, antidepressants, hypnotherapy, therapeutic ultrasound, local anesthetic injections, and ashi acupuncture show promise in reducing pain and improving quality of life. However, it's important to remember that each treatment has its own benefits, risks, and effectiveness may vary among individuals. Always consult with a healthcare professional to determine the best course of action for your specific situation.

Treatment List

Cognitive behavioral therapy, antidepressants, hypnotherapy, therapeutic ultrasound, local anesthetic injections, ashi acupuncture.

Literature analysis of 16 papers
Positive Content
15
Neutral Content
0
Negative Content
1
Article Type
5
7
10
9
16
1.

Analgesia in patients with acute abdominal pain.

Author: ManterolaC, AstudilloP, LosadaH, PinedaV, SanhuezaA, VialM

Improved acute abdominal pain treatment
Acute abdominal pain

For a long time, pain medication was withheld for people with acute abdominal pain until a diagnosis was made, out of concern that it might mask symptoms, alter physical findings, and delay diagnosis and treatment. However, recent studies have shown that giving pain medication early on significantly reduces pain without affecting the accuracy of diagnosis. In fact, reducing pain may make it easier to diagnose the problem.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

[Cognitive behavioural therapy of functional recurrent abdominal pain in children].

Author: RaskCharlotte Ulrikka, ThomsenPer Hove

Improved functional abdominal pain treatment
Recurrent abdominal pain

Recurrent abdominal pain is common in school-aged children, causing a significant number of doctor visits. In most cases, the pain is functional, meaning there is no identifiable cause, and medical treatments offer limited relief. Cognitive behavioral therapy (CBT) is a newer approach to treating functional abdominal pain in children. Five studies have shown that CBT reduces pain intensity and frequency in children with this condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Danish

3.

Psychosocial interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood.

Author: Huertas-CeballosA, LoganS, BennettC, MacarthurC

Recurrent abdominal pain management

This review summarizes the evidence for various psychosocial interventions recommended for children with recurrent abdominal pain (RAP) of unknown cause.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Analgesia in patients with acute abdominal pain.

Author: ManterolaCarlos, VialManuel, MoragaJavier, AstudilloPaula

AAP treatment

Traditionally, pain medication for acute abdominal pain (AAP) was withheld until a diagnosis was made, fearing it might hide symptoms or interfere with diagnosis. However, recent studies suggest that providing pain relief early on in patients with AAP significantly reduces pain without affecting the accuracy of diagnosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain-related functional gastrointestinal disorders in childhood.

Author: HorvathA, DziechciarzP, SzajewskaH

Abdominal pain relief

Lactobacillus rhamnosus GG (LGG) supplementation was associated with a significant increase in the rate of treatment responders (defined as no pain or a decrease in pain intensity) in children with abdominal pain-related functional gastrointestinal disorders (3 RCTs, n = 290; RR 1.31, 95% CI 1.08-1.59, NNT 7, 95% CI 4-22). This effect was even stronger in the irritable bowel syndrome (IBS) subgroup (3 RCTs, n = 167; RR 1.70, 95% CI 1.27-2.27, NNT 4, 95% CI 3-8).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Antidepressants for the treatment of abdominal pain-related functional gastrointestinal disorders in children and adolescents.

Author: KaminskiAngela, KamperAdrian, ThalerKylie, ChapmanAndrea, GartlehnerGerald

Limited evidence for antidepressants

This review examines the evidence on the benefits and harms of antidepressants for the treatment of abdominal pain-related functional gastrointestinal disorders (FGIDs) in children and adolescents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Treatment of acute abdominal pain in the emergency room: a systematic review of the literature.

Author: FalchC, VicenteD, HäberleH, KirschniakA, MüllerS, NissanA, BrücherB L D M

Acute abdominal pain treatment

While recent studies show that pain medication doesn't interfere with diagnosing or treating acute abdominal pain, it's still common practice to withhold pain relief until a diagnosis is made. This review examines the use of pain medication for acute abdominal pain, summarizing different types of pain, common causes of abdominal pain, appropriate pain medications, and ethical considerations. The review recommends using paracetamol, dipyrone, or piritramide intravenously for pain relief. Combining non-opioid and opioid medications might be necessary for moderate to severe pain, with frequent pain assessments to adjust treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Stop the pain: study protocol for a randomized-controlled trial.

Author: WarschburgerPetra, CalvanoClaudia, BeckerSebastian, FriedtMichael, HudertChristian, PosovszkyCarsten, SchierMaike, WegscheiderKarl

Cognitive behavioral treatment
Functional abdominal pain

This study highlights the prevalence and impact of functional abdominal pain (FAP) in children, which can persist into adulthood and increase the risk of mental health problems. While cognitive behavioral therapy (CBT) has shown promise, the study points out the need for larger, longer-term studies that include more rigorous controls and consider the impact on social and emotional well-being.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Citalopram for pediatric functional abdominal pain: a randomized, placebo-controlled trial.

Author: RoohafzaH, PourmoghaddasZ, SaneianH, GholamrezaeiA

FAP treatment

This randomized controlled trial of 115 children with functional abdominal pain (FAP) found a trend towards effectiveness of citalopram in reducing pain and global severity scores. However, the study was underpowered and larger studies are required to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

The efficacy of adhesiolysis on chronic abdominal pain: a systematic review.

Author: Gerner-RasmussenJonas, BurcharthJakob, GögenurIsmail

Pain relief

Laparoscopic adhesiolysis shows promising but preliminary results as a treatment of chronic abdominal pain. The evidence for laparoscopic adhesiolysis is not sufficient to make definitive conclusions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Home-Based Hypnotherapy Self-exercises vs Individual Hypnotherapy With a Therapist for Treatment of Pediatric Irritable Bowel Syndrome, Functional Abdominal Pain, or Functional Abdominal Pain Syndrome: A Randomized Clinical Trial.

Author: RuttenJuliette M T M, VliegerArine M, FrankenhuisCarla, GeorgeElvira K, GroenewegMichael, NorbruisObbe F, Tjon A TenWalther, van WeringHerbert M, DijkgraafMarcel G W, MerkusMaruschka P, BenningaMarc A

Effective IBS treatment
Improved quality of life

This study compared the effectiveness of home-based hypnotherapy (HT) with a CD to individual HT performed by therapists in children with irritable bowel syndrome (IBS) or functional abdominal pain. The study found that home-based HT with a CD was noninferior to individual HT in terms of long-term effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Ashi Acupuncture Versus Local Anesthetic Trigger Point Injections in the Treatment of Abdominal Myofascial Pain Syndrome: A Randomized Clinical Trial.

Author: MitidieriAndreia Moreira de Souza, BaltazarMaria Carolina Dalla Vecchia, da SilvaAna Paula Moreira, GurianMaria Beatriz Ferreira, Poli-NetoOmero Benedicto, Candido-Dos-ReisFrancisco Jose, NogueiraAntonio Alberto, Rosa-E-SilvaJulio Cesar

AMPS treatment

This study emphasized the importance of considering abdominal myofascial syndrome (AMPS) in the management of chronic pelvic pain (CPP), highlighting the potential role of musculoskeletal dysfunction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Analgesia in patients with adhesion-related chronic abdominal and pelvic pain after surgery: a systematic review.

Author: van den BeukelB A W, de ReeR, van GoorH, van der WalS E I, Ten BroekR P G

Analgesic treatments for chronic pain related to adhesions

This study looks at pain relief options for chronic abdominal pain caused by adhesions, which are scar tissue that can form after surgery. While surgery to remove adhesions (adhesiolysis) can help some people, many still need other treatments. This study investigates different pain relief options besides surgery.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Psychosocial Interventions for the Treatment of Functional Abdominal Pain Disorders in Children: A Systematic Review and Meta-analysis.

Author: GordonMorris, SinopoulouVassiliki, TabbersMerit, RexwinkelRobyn, de BruijnClara, DoveyTerence, GasparettoMarco, VankerHelen, BenningaMarc

Pain reduction
Treatment success

Cognitive behavioral therapy and hypnotherapy may be considered as treatments for functional abdominal pain disorders in childhood. Future research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Therapeutic ultrasound versus injection of local anesthetic in the treatment of women with chronic pelvic pain secondary to abdominal myofascial syndrome: a randomized clinical trial.

Author: BaltazarMaria Carolina Dalla Vecchia, RussoJéssica Aparecida de Oliveira, De LuccaVictória, MitidieriAndréia Moreira de Souza, da SilvaAna Paula Moreira, GurianMaria Beatriz Ferreira, Poli-NetoOmero Benedicto, Rosa-E-SilvaJúlio César

CPP treatment

This study focuses on abdominal myofascial pain syndrome (AMPS), a type of chronic pelvic pain (CPP) that is often overlooked. While many women with CPP have muscle and tissue issues, this study highlights the need for more research on AMPS, which is characterized by deep pain in the abdomen caused by sensitive trigger points in muscles and surrounding tissues.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Rare causes of abdominal pain: a primer for the admitting general surgeon.

Author: HamiltonJordan, MilenkovskiNicole, MartinKatherine, TullyEmma, PengCalvin, HayesIan

Efficient management
Prompt diagnosis
Misdiagnosis

Patients with non-specific abdominal pain (NSAP) may be misdiagnosed, and this article highlights uncommon conditions that could be mistaken for NSAP. Early diagnosis and treatment planning are crucial for these patients.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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