Side Effects of brivaracetam: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Main Research Findings

Multiple studies have suggested that brivaracetam is a safe and effective option for the treatment of partial seizures in adults and children. 3 reported that brivaracetam demonstrated efficacy, safety, and tolerability in the treatment of partial seizures. 17 suggested that brivaracetam may have improved tolerability and efficacy in patients who previously failed levetiracetam treatment. 8 conducted a prospective audit to understand how to best use the anti-seizure medication in everyday clinical practice.

Reasons for Side Effects

The side effects of brivaracetam may be related to its mechanism of action. Brivaracetam, like levetiracetam, binds to synaptic vesicle protein 2A (SV2A). SV2A is involved in the release of neurotransmitters. Brivaracetam is thought to inhibit the release of neurotransmitters by binding to SV2A, thereby suppressing seizures. However, binding to SV2A may affect the release of other neurotransmitters, which may be the cause of side effects.

Common Side Effects

Somnolence

The most common side effect of brivaracetam is somnolence. 19 , 27 , 25 , 9 and many other studies have reported somnolence. This side effect may be related to the mechanism of action of brivaracetam. Brivaracetam inhibits the release of neurotransmitters by binding to SV2A, which may suppress neural activity and lead to side effects such as somnolence.

Dizziness

Another common side effect of brivaracetam is dizziness. It has been reported in 19 , 27 , 25 , 9 . Dizziness is thought to be caused by the effects of brivaracetam on the central nervous system. Brivaracetam suppresses seizures by inhibiting neural activity in the brain, but this effect can lead to side effects such as dizziness.

Fatigue

Fatigue has also been reported as a side effect of brivaracetam. 19 , 27 , 25 , 9 listed fatigue as a side effect of brivaracetam. Fatigue is thought to be caused by the suppressive effect of brivaracetam on neural activity. Suppression of neural activity may reduce the body's energy consumption, which may lead to fatigue.

Other Side Effects

In addition to somnolence, dizziness, and fatigue, various other side effects have been reported for brivaracetam. 21 , 11 , 4 etc. have reported side effects such as decreased appetite, weight loss, aggression, mood swings, and depression. These side effects are thought to be caused by the suppressive effect of brivaracetam on neural activity or the effect of binding to SV2A on the release of other neurotransmitters.

Side Effect Management

Somnolence

Adjusting the time of brivaracetam administration is important to reduce somnolence caused by the drug. 14 suggests that adjusting the time of brivaracetam administration may reduce somnolence. If somnolence is severe, you should consult a doctor to adjust the dosage or switch to another medication.

Dizziness

To reduce dizziness caused by brivaracetam, it is important to get up slowly when standing. 14 recommends getting up slowly when standing to reduce dizziness. If dizziness is severe, you should consult a doctor to adjust the dosage or switch to another medication.

Fatigue

To reduce fatigue caused by brivaracetam, it is important to get enough rest. 14 recommends getting enough rest to reduce fatigue caused by brivaracetam. If fatigue is severe, you should consult a doctor to adjust the dosage or switch to another medication.

Other Side Effects

In addition to somnolence, dizziness, and fatigue, various other side effects have been reported for brivaracetam. If you are concerned about these side effects, you should consult a doctor to adjust the dosage or switch to another medication.

Comparison Between Studies

Commonalities Between Studies

In multiple studies, brivaracetam has been reported to demonstrate efficacy and tolerability in the treatment of partial seizures. 3 , 17 , 8 , 19 , 13 , 20 , 6 etc. many studies reported that brivaracetam demonstrated efficacy in the treatment of partial seizures.

Differences Between Studies

There are differences in the frequency and types of side effects reported in different studies of brivaracetam. 20 suggests that brivaracetam may be less likely to cause behavioral problems such as aggression compared to levetiracetam. However, 14 reports aggression and depression as side effects of brivaracetam. These differences may be due to differences in study design and subjects. Further research on the side effects of brivaracetam is needed.

Precautions for Real-Life Application

Brivaracetam is an effective drug for the treatment of partial seizures. However, brivaracetam can cause side effects such as somnolence, dizziness, and fatigue, so caution is necessary when performing tasks that require attention, such as driving or operating machinery. Brivaracetam can also interact with other medications, so it is important to avoid taking other medications without consulting a doctor.

Limitations of Current Research

There is still limited research on brivaracetam. Further research is needed, especially on long-term safety and efficacy. There are also differences in the frequency and types of side effects reported in different studies. Further research is expected to clarify the frequency and types of side effects of brivaracetam.

Future Research Directions

Further research is needed on the long-term safety and efficacy of brivaracetam. More detailed studies are also needed on the frequency and types of side effects. In addition, further research is needed on the potential for interactions between brivaracetam and other medications.

Conclusion

Brivaracetam is an effective drug for the treatment of partial seizures, but caution is needed due to side effects such as somnolence, dizziness, and fatigue. When taking brivaracetam, it is important to consult a doctor to determine the appropriate dosage and administration time.

Literature analysis of 27 papers
Positive Content
24
Neutral Content
2
Negative Content
1
Article Type
1
1
0
11
25
2.

A review of cognitive and behavioral outcomes of Brivaracetam.

Author: LiKuan-Ying, HsuChung-Yao, YangYuan-Han

Fewer cognitive adverse events
Less behavioral disturbance
Limited cognitive impact

This literature review examined the impact of brivaracetam (BRV), a newer anti-seizure medication (ASM), on cognition and behavior compared to other ASMs. BRV was associated with fewer cognitive adverse events and less behavioral disturbance compared to other ASMs, suggesting potential benefits for patients with levetiracetam intolerance or behavioral side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

BRIVEST: A 'real-world' observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam.

Author: NaddellSophie, ManuelMegan, CavillRebecca, WhitePaul, SieradzanKatarzyna

BRV efficacy
BRV tolerability
BRV withdrawal

A study of 109 patients with epilepsy, 87.2% of whom had drug-resistant epilepsy, found that Brivaracetam was effective in reducing seizures and was well-tolerated, even in patients with previous levetiracetam use, psychiatric comorbidities, learning disabilities, or older age. The study found a ≥50% responder rate of 30.8%, with 12.1% seizure-free. The most common side effects were fatigue, irritability, and depression/low mood, which were experienced by 91.7% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Brivaracetam in treating epileptic encephalopathy and refractory focal epilepsies in patients under 14 years of age.

Author: RussoAngelo, CuteriVittoria, BansalLalit, BonanniPaolo, DanieliAlberto, PiniAntonella, GobbiGiuseppe

Improved sleep quality
Reduced seizure frequency

Brivaracetam was effective and well-tolerated in pediatric patients with epileptic encephalopathy or unresponsive focal epilepsy, particularly for those with an epilepsy onset greater than 12 months and a duration less than 6 years. The drug was particularly effective in managing status epilepticus during sleep.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

5.

Epilepsy in adults with neurodevelopmental disability - what every neurologist should know.

Author: WatkinsLance V, LinehanChristine, BrandtChristian, Snoeijen-SchouwenaarsFrancesca, McGowanPaula, ShankarRohit

Epilepsy treatment
Side effects

This seminar provides an overview of the special needs of persons with epilepsy and neurodevelopmental disorders (NDDs). The seminar explores the complexity of seizures in association with NDDs, focusing on intellectual disability, autism spectrum disorder, and attention deficit hyperactivity disorder. The seminar considers epidemiology, co-morbidities, risk factors, mortality, and the diagnostic and treatment challenges for these conditions.

CongressA conference or meeting where experts in a specific field gather. It provides opportunities for presentations, discussions, and networking, and serves as a place to share expertise and learn about the latest trends in the industry.

Language : English

6.

Efficacy of Brivaracetam in children with epilepsy.

Author: Ferragut FerretjansFernando, Soto InsugaVíctor, Bernardino CuestaBeatriz, Cantarín ExtremeraVerónica, Duat RodriguezAnna, LegidoMaría Jiménez, González AlguacilElena, Furones GarcíaMarta, Gutiérrez SolanaLuis, Moreno CanteroTeresa, Ruiz FalcóMaria-Luz, García PeñasJuan José

Reduced seizure frequency
Drowsiness
Irritability

This retrospective study evaluated the efficacy, tolerance, and safety of brivaracetam (BRV) in 66 children with epilepsy. BRV was effective in reducing seizure frequency in 30.3% of cases, with greater efficacy observed in patients who received higher doses and when a direct switch from levetiracetam (LEV) to BRV was performed. BRV was well-tolerated, with the most frequent side effects being irritability and drowsiness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Adjunctive brivaracetam - A prospective audit of outcomes from an epilepsy clinic.

Author: StephenLinda, BrodieMartin J

Focal seizure treatment

Brivaracetam (BRV) is a drug used to treat focal seizures. This audit aimed to understand how to use BRV effectively in clinical practice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Potential role of brivaracetam in pediatric epilepsy.

Author: VerrottiAlberto, GrassoEleonora A, CacciatoreMarta, MatricardiSara, StrianoPasquale

Effective for focal seizures
Useful for pediatric epilepsies
Aggression
Decreased appetite
Drowsiness
Irritability
Somnolence

This review examines the efficacy and tolerability of brivaracetam (BRV) in pediatric patients with focal onset seizures. BRV, a new antiseizure medication, has demonstrated efficacy and safety in adults, and while there is limited evidence in children, it appears promising for pediatric focal epilepsies. BRV is being investigated for use in other forms of epilepsy and as monotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?

Author: KleinPavel, FriedmanAlon, HameedMustafa Q, KaminskiRafal M, Bar-KleinGuy, KlitgaardHenrik, KoeppMathias, JozwiakSergiusz, PrinceDavid A, RotenbergAlexander, TwymanRoy, VezzaniAnnamaria, WongMichael, LöscherWolfgang

Epilepsy prevention

Preventing epilepsy after acute central nervous system insults such as traumatic brain injury (TBI) or cerebrovascular accidents (CVA) is a significant unmet need. This review explores the potential of repurposing existing medications to prevent or modify post-injury epilepsy, based on promising preclinical data in animal models.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Treatment with brivaracetam in children - The experience of a pediatric epilepsy center.

Author: NissenkornAndreea, TzadokMichal, Bar-YosefOmer, Ben-ZeevBruria

Reduced seizures
Tolerability

This study describes the effectiveness and tolerability of brivaracetam, a new anticonvulsant, in pediatric patients with epilepsy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Brivaracetam: First Canadian Experience in an Intractable Epilepsy Population.

Author: LafortuneJeanne, DeaconCharles, ClémentJean-François

BRV for epilepsy
Psychiatric AEs

Brivaracetam was effective in reducing seizures in patients with refractory epilepsy but was associated with a high rate of psychiatric side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Timing use of novel anti-epileptic drugs: is earlier better?

Author: de BiaseStefano, NiloAnnacarmen, BernardiniAndrea, GigliGian Luigi, ValenteMariarosaria, MerlinoGiovanni

Epilepsy treatment
Improved tolerability

Third-generation antiepileptic drugs (AEDs) like lacosamide, eslicarbazepine, perampanel, and brivaracetam may offer better tolerability, fewer side effects, and improved pharmacokinetic properties compared to conventional AEDs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Novel drugs and early polypharmacotherapy in status epilepticus.

Author: Amengual-GualMarta, Sánchez FernándezIván, WainwrightMark S

Outcomes improvement
Seizure control

This review summarizes the evidence for the efficacy of novel drugs and early polypharmacotherapy for status epilepticus (SE). New drugs and treatment strategies aim to target the pathophysiology of SE in order to improve seizure control and outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Cognitive and fatigue side effects of anti-epileptic drugs: an analysis of phase III add-on trials.

Author: SarkisRani A, GoksenYazel, MuYi, RosnerBernard, LeeJong Woo

Cognitive side effects
Fatigue

This study analyzes the terms used to refer to cognitive and fatigue-related side effects in phase III add-on clinical trials of anti-epileptic drugs (AEDs). The findings indicate a significant dose-response effect for most AEDs, suggesting that physicians should consider aiming for lower drug loads to improve tolerability.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Brivaracetam in the Treatment of Patients with Epilepsy-First Clinical Experiences.

Author: ZahnertFelix, KrauseKristina, ImmischIlka, HabermehlLena, GornyIris, ChmielewskaIzabella, MöllerLeona, WeyandAnna M, MrossPeter M, WagnerJan, MenzlerKatja, KnakeSusanne

Broad therapeutic spectrum
Epilepsy treatment
Safe and effective

Brivaracetam is a safe and effective treatment option for epilepsy, especially for patients with psychiatric comorbidities. It offers a broader therapeutic spectrum and allows for personalized treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Favorable adverse effect profile of brivaracetam vs levetiracetam in a preclinical model.

Author: SanonNathalie T, GagnéJonathan, WolfDaniele C, AboulamerSoumia, BosoiCiprian M, SimardAlexe, MessietEstelle, DesgentSébastien, CarmantLionel

seizure treatment
aggressiveness

This study investigated the behavioral effects of levetiracetam (LEV) and brivaracetam (BRV), two seizure medications, in rats. The study found that BRV, compared to LEV, had less effect on aggressive behaviors in rats, suggesting that it may be a better option for patients experiencing aggression as a side effect of LEV.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Comparing Safety and Efficacy of "Third-Generation" Antiepileptic Drugs: Long-Term Extension and Post-marketing Treatment.

Author: KwokCharlotte S, JohnsonEmily L, KraussGregory L

Refractory focal onset seizures treatment
Hyponatremia

Four 'third-generation' antiepileptic drugs (AEDs) - lacosamide, perampanel, eslicarbazepine acetate, and brivaracetam - were approved for adjunctive treatment of refractory focal onset seizures. Long-term efficacy and safety data from extension studies suggest that these AEDs provide new options in efficacy and tolerability.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Human abuse potential of brivaracetam in healthy recreational central nervous system depressant users.

Author: SchoedelKerri A, StockisArmel, SellersEdward M

Abuse potential

Brivaracetam is a new antiepileptic drug indicated for adjunctive treatment of focal seizures in adults. This study evaluated the abuse potential of brivaracetam compared with alprazolam, placebo, and levetiracetam.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review.

Author: PalleriaCaterina, CozzaGiuseppe, KhengarRajeshree, LibriVincenzo, De SarroGiovambattista

Adverse drug reactions

While there are new antiepileptic drugs (AEDs) available, many people with epilepsy still struggle with their condition and its treatment. While some new AEDs have been approved recently, we still don’t know much about how safe they are to use long-term.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

Treatment of refractory and super-refractory status epilepticus with brivaracetam: A cohort study from two German university hospitals.

Author: StrzelczykAdam, SteinigIsabel, WillemsLaurent M, ReifPhilipp S, SenftChristian, VossMartin, GaidaBernadette, von PodewilsFelix, RosenowFelix

No serious side effects
SE resolution

Brivaracetam (BRV) may prove useful in status epilepticus (SE) treatment, with cessation of SE in the first 24h of BRV in 3 of 11 patients. No serious side effects were seen while taking BRV.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

Brivaracetam as adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy: the current evidence base.

Author: BrandtChristian, MayTheodor W, BienChristian G

Epilepsy treatment
Dizziness
Somnolence

Brivaracetam (BRV) is a new antiepileptic drug licensed for partial epilepsy. This article reviews the efficacy and safety of BRV, highlighting its potential advantages over levetiracetam, including a higher SV2A affinity and faster brain penetration.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

[Brivaracetam for add-on treatment in focal epilepsy].

Author: StrzelczykA, SteinigI, KleinK M, WillemsL M, KnakeS, RosenowF, BauerS

Fast onset of action
Rapid brain penetration
Reduced seizures
Dizziness
Fatigue
Somnolence

Brivaracetam is a new antiepileptic drug that has been shown to be effective in reducing seizures in patients with focal epilepsy. It is generally well-tolerated, with fatigue, dizziness, and somnolence being the most common side effects. Brivaracetam may be useful in emergency situations due to its rapid absorption into brain tissue and faster onset of action than levetiracetam.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

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