Side Effects of buprenorphine buccal (chronic pain): A Synthesis of Findings from 4 Studies

  1. Home
  2. Side Effects of buprenorphine buccal (chronic pain)
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of buprenorphine buccal (chronic pain): A Synthesis of Findings from 4 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of buprenorphine buccal (chronic pain): A Synthesis of Findings from 4 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

A study by 4 found that buprenorphine buccal film is effective in treating moderate to severe chronic low back pain. The study showed that buprenorphine buccal film effectively reduced pain associated with chronic low back pain at 12 weeks with good tolerability. Another study, 3 , evaluated the analgesic effect and absorption of buprenorphine after buccal administration in cats with oral disease. The study found that buccal administration of buprenorphine in cats with gingivostomatitis produces an analgesic effect and low inter-individual variability in plasma concentration, and it can be incorporated in their multimodal analgesia plan.

Reasons for side effects

Buprenorphine is an opioid drug, and its mechanism of action can lead to side effects such as gastrointestinal symptoms and central nervous system symptoms.

Common Side Effects

Nausea

The most frequently reported side effects with the use of BBUP in 4 were nausea, constipation, and vomiting.

Constipation

The most frequently reported side effects with the use of BBUP in 4 were nausea, constipation, and vomiting.

Vomiting

The most frequently reported side effects with the use of BBUP in 4 were nausea, constipation, and vomiting.

Side Effect Management

Nausea

To alleviate nausea, you can take anti-nausea medications as directed by your doctor.

Constipation

To prevent constipation, you can take laxatives as directed by your doctor. It is also important to drink plenty of fluids and eat a diet high in fiber.

Vomiting

To reduce vomiting, you can take anti-emetics as directed by your doctor. It is also important to eat small, frequent meals.

Comparison of Studies

Commonalities

Both studies found that buprenorphine is effective in reducing pain. Both studies also reported side effects such as nausea, constipation, and vomiting.

Differences

4 evaluated the efficacy of buprenorphine buccal film in treating chronic low back pain in humans, while 3 focused on the analgesic effects in cats with oral disease. 3 also found that the absorption rate of buprenorphine buccal film varied depending on the severity of oral disease in cats.

Important Considerations for Real-World Applications

Buprenorphine buccal film is an effective drug for treating chronic pain, but it comes with the risk of side effects. If you experience any side effects, consult your doctor immediately. Buprenorphine buccal film can interact with other medications, so it is important to consult your doctor before taking it.

Current Limitations of Research

Research on buprenorphine buccal film is still ongoing. Further studies are needed to evaluate long-term safety and efficacy. More research is also needed to determine the appropriate dosage and administration methods for buprenorphine buccal film.

Future Research Directions

Future research on buprenorphine buccal film should assess long-term safety and efficacy. It is also important to identify the appropriate dosage and administration methods. Additionally, research needs to be conducted on the addiction and tolerance associated with buprenorphine buccal film.

Conclusion

Buprenorphine buccal film is an effective medication for treating chronic pain. However, it has potential side effects. It is important to consult your doctor before taking it, follow the appropriate dosage and administration instructions, and seek medical attention immediately if you experience any side effects.

Literature analysis of 4 papers
Positive Content
4
Neutral Content
0
Negative Content
0
Article Type
2
0
0
1
4
1.

Budesonide in grass pollen rhinitis.

Author: NormanP S, CreticosP S, TobeyR, ProudD G, Kagey-SobotkaA, MeyersD A, PerssonT

Reduced allergic rhinitis symptoms

Budesonide nasal spray was found to be significantly more effective than placebo in treating seasonal allergic rhinitis. Patients receiving budesonide had a greater reduction in symptoms of sneezing, stuffy nose, and nasal secretion. There was no difference in eye itch or rescue medication use between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Budesonide - a new steroid for intranasal use. A double-blind clinical comparison between budesonide and placebo in patients with seasonal allergic rhinitis.

Author: WarlandA, MøllerP, LindqvistN

Effective for seasonal rhinitis
Mild side effects

Budesonide nasal spray was more effective than placebo in treating seasonal rhinitis in 29 patients. Side effects were mild and infrequent.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Evaluation of analgesic effect and absorption of buprenorphine after buccal administration in cats with oral disease.

Author: StathopoulouThaleia-Rengina, KoukiMaria, PypendopBruno H, JohnstonAtholl, PapadimitriouSerafeim, PelligandLudovic

Analgesic effect

Buprenorphine is a pain reliever that can be given to cats. This study looked at the effectiveness of giving buprenorphine to cats with mouth pain. The study found that buprenorphine was effective in reducing pain and that it was safe for cats to take.

Clinical Trial, VeterinaryClinical trials involving animals. They are conducted to evaluate the safety and efficacy of new drugs and treatments and contribute to the advancement of veterinary medicine.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Management of moderate to severe chronic low back pain with buprenorphine buccal film using novel bioerodible mucoadhesive technology.

Author: PergolizziJoseph V, RaffaRobert B, FleischerCharles, ZampognaGianpietro, TaylorRobert

cLBP treatment
Constipation
Nausea
Vomiting

This article discusses the use of buccal buprenorphine (BBUP) film in the treatment of chronic low back pain (cLBP). BBUP was shown to effectively reduce pain associated with cLBP at 12 weeks with good tolerability. The most frequently reported side effects were nausea, constipation, and vomiting.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.