Effects of buprenorphine transdermal patch: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Main Research Findings

Buprenorphine transdermal patch has been shown to be effective in managing chronic pain, especially in patients who are opioid-naïve, elderly, or have impaired renal function. 9 , 22 , 15

It is also effective for post-operative pain management. 11 , 5 , 3 , 10

Buprenorphine transdermal patch has a lower risk of dependence and abuse compared to other opioids. 12 , 23

However, buprenorphine transdermal patch can cause side effects such as skin reactions. 2 , 18

Benefits and Risks

Benefit Summary

Buprenorphine transdermal patch has been shown to be effective in managing chronic pain and post-operative pain. 9 , 22 , 15 , 11 , 5 , 3 , 10

It also has a lower risk of dependence and abuse compared to other opioids. 12 , 23

Risk Summary

Buprenorphine transdermal patch can cause side effects such as skin reactions. 2 , 18

Comparison of Studies

Commonalities

Many studies have shown that buprenorphine transdermal patch is effective in managing chronic pain and post-operative pain. 9 , 22 , 15 , 11 , 5 , 3 , 10

Differences

The effectiveness of buprenorphine transdermal patch may vary depending on the patient and type of pain. 21 , 25

Consistency and Contradictions in Results

Buprenorphine transdermal patch has been shown to be effective in managing chronic pain and post-operative pain in many studies. However, its effectiveness may vary depending on the patient and type of pain. 21 , 25

Cautions Regarding Real-World Application

Buprenorphine transdermal patch can be effective in managing chronic pain and post-operative pain, but it is important to use it under the guidance of a physician. 21 , 25

Limitations of Current Research

Research on the effects of buprenorphine transdermal patch is still insufficient. 6 , 14 , 19 , 8

Future Research Directions

More research is needed to investigate the effects of buprenorphine transdermal patch in more detail. 6 , 14 , 19 , 8

Conclusion

Buprenorphine transdermal patch can be effective in managing chronic pain and post-operative pain. However, its effectiveness may vary depending on the patient and type of pain. It is important to use it under the guidance of a physician. 21 , 25

More research is needed to investigate the effects of buprenorphine transdermal patch. 6 , 14 , 19 , 8

Literature analysis of 25 papers
Positive Content
23
Neutral Content
0
Negative Content
2
Article Type
5
0
0
3
24
1.

Pharmacogenomics and Drug-Induced Phenoconversion Informed Medication Safety Review in the Management of Pain Control and Quality of Life: A Case Report.

Author: MuhnSelina, AminNishita Shah, BardoliaChandni, Del Toro-PagánNicole, PizzolatoKatie, ThackerDavid, TurgeonJacques, TomainoCrystal, MichaudVeronique

Improved opioid therapy response
Reduced ADEs

This case report highlights the successful use of pharmacogenomics (PGx) to improve opioid therapy in a 69-year-old female with chronic pain. PGx testing identified several drug-gene and drug-drug-gene interactions, leading to medication adjustments. Switching from tramadol to buprenorphine, discontinuing amitriptyline, and optimizing pregabalin resulted in improved pain control and quality of life for the patient.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

3.

Comparative evaluation of analgesic efficacy of buprenorphine transdermal patch and fentanyl patch in management of postoperative pain after arthroscopic lower limb surgery: A randomized controlled trial.

Author: KhandelwalHariom, NegiAnoop, GovilNishith, SinghAshutosh, ParagKumar, BhardwajBharat Bhushan

Postoperative pain relief

This study evaluates the effectiveness of buprenorphine and fentanyl patches in controlling pain after arthroscopic surgery on the lower limbs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Analgesic impact of buprenorphine transdermal patch in total hip arthroplasty: A randomized controlled trial protocol.

Author: LiWen-Min, LiFeng-Dao, XuHua, SunLi-Chen

Pain relief

This prospective, randomized, controlled study aims to evaluate the effectiveness and safety of the buprenorphine transdermal patch (BTP) for postoperative analgesia in total hip arthroplasty.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Efficacy and Safety of Buprenorphine Transdermal Patch for Immediate Postoperative Analgesia After Total Knee Arthroplasty Surgery.

Author: LondheSanjay, PatwardhanMeghana, ShahRavi, OakMugdha

Postoperative pain relief

This study compared the safety and efficacy of a transdermal buprenorphine (TDB) patch to conventional analgesics after total knee arthroplasty surgery. TDB is widely used for chronic pain management, but it has been rarely studied in acute postoperative settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

A Scoping Review of Transdermal Buprenorphine Use for Non-surgical Pain in the Pediatric Population.

Author: HauptThomas S, SmythMichael, GregoireMarie-Claude

Pain reduction

This study reviews the evidence surrounding the use of transdermal buprenorphine for pain management in children. While buprenorphine is approved for adults, there is limited data on its use in children. The researchers found some promising results from small studies, but highlighted the need for more research to confirm its safety and efficacy in this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

A Novel Application of Buprenorphine Transdermal Patch to Relieve Pain in the Knee Joint of Knee Osteoarthritis Patients: A Retrospective Case-Control Study.

Author: GilHo Young, ParkSungchul, KimNa Eun, ChoiYi Hwa, KimJae Hyung, ChoiSooil, KimHyun Joong, KohJae Chul, LeeByung Ho, LeeSook Young, MinSang Kee, KimBora, LeeHye Seon, JeongHae Won, ParkJi Hyun, ParkBumhee, ChoiJong Bum

OA treatment

This study evaluated a novel method of applying buprenorphine transdermal patches (BTDP) directly to the painful knee joint of osteoarthritis (OA) patients. The knee application resulted in lower pain scores, fewer adverse effects, and higher compliance compared to conventional chest application.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Application of a buprenorphine transdermal patch for the perioperative analgesia in patients who underwent simple lumbar discectomy.

Author: TangJian, FanJin, YaoYilun, CaiWeihua, YinGuoyong, ZhouWei

Perioperative analgesia
Adverse effects

A buprenorphine transdermal patch was found to be more effective in reducing pain after simple lumbar discectomy than intravenous parecoxib or oral celecoxib.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Comparison of abuse, suspected suicidal intent, and fatalities related to the 7-day buprenorphine transdermal patch versus other opioid analgesics in the National Poison Data System.

Author: CoplanPaul M, SesslerNelson E, HarikrishnanVenkatesh, SinghRicha, PerkelCharles

Hypoglycemia

This study compared the rates of poison center calls related to abuse, suicide, or fatality for buprenorphine transdermal systems/patches with other extended-release and long-acting opioids.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Stochastic Pharmacokinetic-Pharmacodynamic Analysis of the Effect of Transdermal Buprenorphine on Electroencephalogram and Analgesia.

Author: OlesenAnne Estrup, OlofsenErik, AndresenTrine, GraversenCarina, DrewesAsbjørn Mohr, DahanAlbert

Pain relief

This study investigated the pharmacokinetic-pharmacodynamic (PKPD) properties of the buprenorphine transdermal patch on resting electroencephalography (EEG) and pain tolerance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

[Long-term treatment of chronic pain with low-dose 7-day buprenorphine transdermal patch. Observational data from elderly patients of pain relief and quality of life].

Author: UberallM A, Müller-SchwefeG H H

Improved quality of life
Pain relief

Long-term treatment with low-dose 7-day buprenorphine transdermal patch in elderly patients with chronic pain resulted in fast, effective, and sustained pain relief accompanied by marked improvements in daily life participation and quality of life.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : German

16.

US practitioner prescribing practices and patient characteristics of those newly treated with a buprenorphine transdermal patch system.

Author: PergolizziJoseph V, Ben-JosephRami, ChangChun-Lan, HessGregory

Transdermal buprenorphine therapy

This study assessed how doctors prescribed the transdermal buprenorphine system (BTDS) for opioid dependence, comparing their choices with recommended prescribing information. The study also investigated how patient factors influenced the initial dose of BTDS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Is buprenorphine transdermal patch equally safe and effective in younger and elderly patients with osteoarthritis-related pain? Results of an age-group controlled study.

Author: KarlssonJ, SöderströmA, AugustiniB G, BerggrenA C

Effective for OA pain
Similar exposure in elderly

This study investigated the efficacy and safety of buprenorphine patches in patients with chronic osteoarthritis (OA) pain. The study found that buprenorphine patches provided similar systemic exposure in patients aged ≥75 and 50-60 years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

[Buprenorphine transdermal patch (Norspan tape)].

Author: HamaguchiShinsuke, IkedaTomohito

Fewer psychological side effects
Strong analgesia
Addiction
Constipation
Drug abuse
Erythema
Itching
Loss of appetite
Nausea
Vomiting

Transdermal buprenorphine patches are effective analgesics for chronic non-cancer pain, but they may cause side effects such as nausea, vomiting, and constipation. It is crucial to carefully assess patients' pain and history of drug dependence before administering the patches.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

19.

Rifampin reduces oral morphine absorption: a case of transdermal buprenorphine selection based on morphine pharmacokinetics.

Author: FudinJeffrey, FontenelleDania Vanesta, PayneAnnette

Pain relief

This case report describes a patient with endocarditis and chronic pain whose serum morphine levels decreased due to rifampin-mediated intestinal P-glycoprotein induction.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

21.

[Application of a seven-day buprenorphine transdermal patch in multimorbid patients on long-term ibuprofen or diclofenac].

Author: BöhmeK, HeckesB, ThomitzekK

Musculoskeletal pain treatment

A seven-day buprenorphine transdermal patch significantly reduced pain intensity in patients with chronic musculoskeletal pain who were previously treated with ibuprofen or diclofenac alone. The patch was well-tolerated and improved daily functioning in patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : German

22.

Transdermal buprenorphine for the treatment of moderate to severe chronic pain: results from a large multicenter, non-interventional post-marketing study in Poland.

Author: Przeklasa-MuszynskaAnna, DobrogowskiJan

Improved sleep
Reduced pain
Skin reactions
Vomiting

Transdermal buprenorphine was effective and generally well-tolerated in patients with chronic moderate to severe cancer pain or chronic severe non-malignant pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Opioid detoxification via single 7-day application of a buprenorphine transdermal patch: an open-label evaluation.

Author: LanierRyan K, UmbrichtAnnie, HarrisonJoseph A, NuwayserElie S, BigelowGeorge E

Detoxification
Opioid withdrawal suppression
Opioid dependence

Transdermal buprenorphine patch was found to be safe and clinically effective in suppressing opioid withdrawal. It reduced compliance concerns and was less likely to be diverted to illicit use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

24.

Transdermal buprenorphine patches applied in a 4-day regimen versus a 3-day regimen: a single-site, Phase III, randomized, open-label, crossover comparison.

Author: LikarRudolf, LorenzVioletta, Korak-LeiterMaria, KagerIngo, SittlReinhard

Buprenorphine efficacy
Cancer pain treatment
Patch duration
Side effects

This study discusses the use of transdermal buprenorphine patches for the treatment of moderate to severe cancer pain. The prescribing information recommends wearing patches for 3 days before applying a new one. The study highlights the importance of adhering to these recommendations.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Transdermal buprenorphine in the treatment of chronic pain.

Author: SittlReinhard

Improved sleep
Pain management
Local reactions
Opioid side effects

The transdermal matrix patch formulation of buprenorphine is an effective treatment for moderate-to-severe cancer pain. It is well-tolerated and has a low incidence of tolerance development.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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