Side Effects of butterbur: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Main Research Findings

Butterbur (Petasites hybridus) is a traditional herb that has been used for treating headaches and allergies. Recent research has shown that petasin, a component of butterbur, inhibits testosterone secretion in testicular interstitial cells of male rats. Butterbur also shows potential to be effective for preventing migraine and other types of headache. 7 Butterbur is also suggested to be effective for treating allergic rhinitis.

Reasons for Side Effects

Side effects of butterbur are thought to be caused by petasin or other components. Petasin not only inhibits testosterone secretion, but also has the potential to adversely affect the liver.

Common Side Effects

Liver Damage

Long-term ingestion of butterbur can cause liver damage.

Gastrointestinal Symptoms

Butterbur ingestion can cause gastrointestinal symptoms.

Countermeasures for Side Effects

Liver Damage

It is important to consult with a doctor before taking butterbur. If you have a history of liver disease, you should avoid taking butterbur. It is also important to follow the prescribed dosage when taking butterbur.

Gastrointestinal Symptoms

When taking butterbur, start with a small amount and gradually increase the amount.

Comparison Between Studies

Common Points of Studies

Multiple studies have shown that butterbur may have therapeutic effects for headaches and allergies. 7 , , 9

Differences in Studies

Research on butterbur's side effects has shown varying results. , Some studies have shown that long-term ingestion of butterbur can cause liver damage. However, the incidence and severity of side effects may vary depending on the amount and duration of butterbur intake, as well as individual constitutions.

Precautions for Applying to Real Life

Butterbur has been traditionally used to treat headaches and allergies, but it carries the risk of side effects and should be used under the guidance of a doctor. 7 , Especially if you have a history of liver disease, you should avoid taking butterbur.

Limitations of Current Research

There is still insufficient research on the side effects of butterbur. , Further research is needed, especially on the side effects of long-term ingestion. Also, research considering the possibility of varying incidence and severity of side effects depending on the amount and duration of butterbur intake, as well as individual constitutions, is needed.

Future Research Directions

Further research is needed to clarify the safety and efficacy of butterbur. , Specifically, it is necessary to research the side effects of long-term ingestion and how the components of butterbur act on the body. Also, research considering the possibility of varying incidence and severity of side effects depending on the amount and duration of butterbur intake, as well as individual constitutions, is needed.

Conclusion

Butterbur shows potential to be effective for headaches and allergies, but it also carries the risk of side effects. 7 , , It is important to consult with a doctor and follow the prescribed dosage when taking butterbur. Especially if you have a history of liver disease, you should avoid taking butterbur.

Literature analysis of 13 papers
Positive Content
12
Neutral Content
0
Negative Content
1
Article Type
1
0
1
8
13
1.

Cardiovascular Effects of Medical Marijuana: A Systematic Review.

Author: PashaAhmed K, ClementsCharlene Y, ReynoldsCharity A, LopezMaegan K, LugoCiara A, GonzalezYulisa, ShiraziFarshad M, AbidovAiden

Cardiovascular side effects
Lack of regulation

Medical marijuana use is becoming increasingly popular, with 25 states legalizing it for medical purposes. However, evidence suggests potential cardiovascular risks associated with marijuana use, including rhythm abnormalities, syncope/dizziness, and myocardial infarction. Further research is needed to assess the safety and efficacy of medical marijuana products.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Non-Pharmacological Approaches to Headaches: Non-Invasive Neuromodulation, Nutraceuticals, and Behavioral Approaches.

Author: GrazziLicia, ToppoClaudia, D'AmicoDomenico, LeonardiMatilde, MartellettiPaolo, RaggiAlberto, GuastafierroErika

Headache relief

This paper presents the main approaches reported in the literature for managing headache disorders, specifically focusing on non-invasive neuromodulation, nutraceuticals, and behavioral therapies. The review highlights the increasing use of these approaches as valid treatment options, especially for patients with medication overuse or contraindications to drug treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Usefulness of nutraceuticals in migraine prophylaxis.

Author: D'OnofrioFlorindo, RaimoSimona, SpitaleriDaniele, CasucciGerardo, BussoneGennaro

Migraine prevention
Nutraceutical side effects

This overview summarizes randomized controlled trials investigating the efficacy and side effects of commonly used nutraceutical treatments for migraine, including magnesium, coenzyme Q10, riboflavin, petasites, and feverfew. These alternative therapies are often sought by individuals dissatisfied with conventional medical treatments for migraine prophylaxis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Allergies and Natural Alternatives.

Author: JongbloedWalter M, BrownSeth M

AR treatment
Allergy treatment
Ephedra risks

Complementary and integrative medicine therapies for allergy and allergic rhinitis vary in efficacy and safety. Manuka honey, butterbur, and Sinupret have the strongest evidence for effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Preventive Migraine Treatment.

Author: SilbersteinStephen D

Migraine prevention

This review of evidence-based guidelines for the preventive treatment of migraine found that strong evidence exists to support the use of metoprolol, timolol, propranolol, divalproex sodium, sodium valproate, and topiramate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Evidenced-based use of botanicals, minerals, and vitamins in the prophylactic treatment of migraines.

Author: RiosJuanita, PasseMegan M

Migraine prophylaxis
Limited research

This study reviewed evidence-based information about alternative prophylactic migraine treatments, such as feverfew, butterbur, magnesium, and riboflavin. The study found that current clinical data support the use of these treatments for migraine prophylaxis, but that more research is needed to confirm their safety and efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Herbal treatment of headache.

Author: LevinMorris

Headache relief

Herbal therapy has a long history of being used to treat headache disorders. While evidence for most herbal treatments is limited, butterbur and feverfew have shown promise for migraine and other headache types. More research is needed to further evaluate the effectiveness of herbal treatments for headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Recent Patents of Complementary and Alternative Medicine for Allergic Rhinitis.

Author: HonKam L, FungChing K, LeungAlexander K C, LamHung S, LeeSo L

Allergen avoidance
Improved quality of life
Symptomatic relief

This review discusses complementary and alternative medicine (CAM) for allergic rhinitis (AR), noting that some methods such as acupuncture and herbal medicine show promise, but further research is needed to assess their efficacy and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study.

Author: Oelkers-AxRieke, LeinsAnne, ParzerPeter, HilleckeThomas, BolayHans V, FischerJochen, BenderStephan, HermannsUta, ReschFranz

Migraine prophylaxis

Butterbur root extract and music therapy might be superior to placebo and may represent promising treatment approaches in the prophylaxis of paediatric migraine.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Treatment of migraine with prophylactic drugs.

Author: EversStefan

Improved quality of life
Reduced migraine frequency
Side effects of medication

Beta-blockers, flunarizine, valproic acid, and topiramate are the first-choice drugs for migraine prophylaxis. These medications have been shown to reduce migraine frequency and severity, and improve quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

A Standardized Extract of <i>Petasites hybridus</i> L., Containing the Active Ingredients Petasins, Acts as a Pro-Oxidant and Triggers Apoptosis through Elevating of NF-&#954;B in a Highly Invasive Human Breast Cancer Cell Line.

Author: ApostolovaSonia, OreshkovaTsvetelina, UzunovaVeselina, GeorgievaIrina, MaslenkovaLiliana, TzonevaRumiana

Cancer treatment

This study examines the activity of a standardized Bulgarian Petasites hybridus L. root extract on breast cancer cells and non-cancerous cells, focusing on cell death, oxidative stress, and NF-κB signaling.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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