Effects of calcium acetate: A Synthesis of Findings from 23 Studies

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Original Abstract of the Article

Main Research Findings

Calcium acetate has shown potential benefits in various fields, from treating hyperphosphatemia in kidney disease patients to improving food quality as a food additive. It has also been found to promote microbial growth and enhance material strength, indicating its versatility in multiple areas.

For instance, suggests that calcium acetate might improve vascular function in patients with chronic kidney disease. Moreover, 17 highlights the ability of calcium acetate-containing polymers to transition from soft gels to rigid plastics upon heating. This property has implications for the development of novel materials for athletic protective gear and other applications.

Furthermore, 20 demonstrates that calcium acetate can enhance the properties of calcium phosphate coatings formed on magnesium alloys. This has potential applications in the development of biomaterials and artificial bones. Therefore, calcium acetate holds promise for various applications in medicine, engineering, food science, and more.

Benefits and Risks

Benefits Summary

Calcium acetate may effectively manage hyperphosphatemia and, as suggested by , potentially improve vascular function compared to sevelamer. It serves as a food additive, enhancing food quality and nutritional value. Additionally, 20 and 17 indicate potential applications in developing biomaterials and innovative materials.

Risks Summary

Calcium acetate poses risks if consumed in excess, highlighting the importance of adhering to recommended dosages. 12 notes changes in color and texture of shrimp chips when calcium acetate is added, which should be considered when using it as a food additive. Additionally, 3 warns of potential gastrointestinal issues with excessive intake. Therefore, the use of calcium acetate requires careful consideration of its potential benefits and risks.

Comparison Across Studies

Commonalities

Multiple studies suggest that calcium acetate can be beneficial for treating hyperphosphatemia and serves as a food additive. Its potential for use in biomaterials and new materials development is also evident. These studies collectively suggest the value of calcium acetate across various fields.

Differences

The effectiveness of calcium acetate may vary depending on the study subject, dosage, and evaluation methods. For example, suggests improved vascular function, while 12 highlights its impact on the color and texture of shrimp chips. Therefore, carefully assessing both the benefits and risks is crucial when using calcium acetate in real-world scenarios.

Consistency and Discrepancies in Results

While calcium acetate exhibits numerous benefits across various fields, it also comes with potential risks, such as adverse health effects with excessive intake or impacts on food quality. Therefore, a balanced consideration of both its benefits and risks is essential when using it.

Considerations for Real-World Applications

Calcium acetate is already widely used in treating hyperphosphatemia and as a food additive. However, 12 highlights the potential impact of its addition to foods on color and texture. Furthermore, 3 suggests that excessive intake could lead to gastrointestinal issues, emphasizing the need to avoid excessive consumption.

Limitations of Current Research

Research on the effects of calcium acetate is not yet comprehensive. Further studies are needed to understand its long-term impacts on humans and its safety across diverse situations.

Future Directions for Research

Large-scale clinical trials involving human participants are necessary to establish the long-term safety and efficacy of calcium acetate. Additionally, further fundamental research is needed to explore its potential applications in various fields.

Conclusion

Calcium acetate holds potential as a valuable substance for treating hyperphosphatemia, enhancing food quality, and contributing to advancements in biomaterials and innovative materials. However, its use should be carefully considered, balancing its benefits against potential risks, such as adverse effects from excessive intake or impacts on food quality. Further research is crucial to clarify the safety and efficacy of calcium acetate for long-term use and in diverse contexts.

Literature analysis of 23 papers
Positive Content
22
Neutral Content
1
Negative Content
0
Article Type
3
1
1
5
23
1.

Liposomal formulation of Galbanic acid improved therapeutic efficacy of pegylated liposomal Doxorubicin in mouse colon carcinoma.

Author: NikMaryam Ebrahimi, Malaekeh-NikoueiBizhan, AminMohamadreza, HatamipourMahdi, TeymouriManouchehr, SadeghniaHamid Reza, IranshahiMehrdad, JaafariMahmoud Reza

Cancer treatment

A pegylated liposomal galbanic acid (PLGba) with an integrin-targeting ligand (RGD peptide) showed improved integrin-mediated cellular uptake in vitro and in vivo. PLGba co-treatment with pegylated liposomal doxorubicin (PLD) had a synergistic antiproliferative effect on C26 tumor cells and an antagonistic effect on normal HUVECs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Diet-induced oxalate nephropathy.

Author: ClarkBarbara, BaqdunesMohammad Wisam, KunkelGregory M

Renal recovery
Oxalate nephropathy

Oxalate nephropathy is a rare condition that can be overlooked. This case report describes an 81-year-old man who developed oxalate nephropathy after consuming a high amount of oxalate precursors.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Clinical Evaluation of the Safety, Efficacy and Tolerability of Lanthanum Carbonate in the Management of Hyperphosphatemia in Patients with End-Stage Renal Disease.

Author: CernaroValeria, CalimeriSebastiano, LaudaniAlfredo, SantoroDomenico

Hyperphosphatemia treatment
Improved nutritional status
Reduced cardiovascular risk
Fecal impaction
Gastrointestinal obstruction
Nausea
Reduced drug absorption

This review summarizes recent literature data concerning the safety, efficacy, and tolerability of lanthanum carbonate in patients with end-stage renal disease and hyperphosphatemia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Pharmacokinetics of Roxadustat: A Population Analysis of 2855 Dialysis- and Non-Dialysis-Dependent Patients with Chronic Kidney Disease.

Author: RekićDinko, Kerbusch-HerbenVirginie, NågårdMats, ChouJames, HuangJiayin, BradleyCharles, ÅstrandMagnus, TannenbaumStacey, HamrénBengt

Anemia treatment
Erythropoiesis stimulation

This study investigates the effect of intrinsic and extrinsic factors on the pharmacokinetics of roxadustat, a novel therapeutic that stimulates erythropoiesis by inhibiting hypoxia-inducible factor prolyl hydroxylase enzymes. Roxadustat is in clinical development for the treatment of anemia in patients with chronic kidney disease.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Effect of chemical additives on Bacillus thuringiensis (Bacillales: Bacillaceae) against Plutella xylostella (Lepidoptera: Pyralidae).

Author: ZhangL, QiuS, HuangT, HuangZ, XuL, WuC, GelbicI, GuanX

Insect control

The study examined the effect of chemical additives on Bacillus thuringiensis against Plutella xylostella.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin.

Author: KaysMichael B, OverholserBrian R, MuellerBruce A, MoeSharon M, SowinskiKevin M

Ciprofloxacin bioavailability

The study examined the effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin. The oral bioavailability of ciprofloxacin is significantly reduced when administered with calcium carbonate. Sevelamer hydrochloride, a phosphate-binding cationic polymer without calcium, was found to have no significant effect on ciprofloxacin bioavailability.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

Metabolic and skeletal effects of low and high doses of calcium acetate in patients with preterminal chronic renal failure.

Author: PhelpsKenneth R, SternMarc, SlingerlandAlice, HeraviMahin, StrogatzDavid S, HaqqieSyed S

Bone mineral density increase

Calcium acetate, prescribed at a dose of 1,521 mg calcium/day with meals, reduces parathyroid hormone and 1,25-dihydroxyvitamin D concentrations, and increases lumbar bone mineral density (BMD) in men with preterminal chronic renal failure. Lower doses of calcium acetate have no significant effect on metabolism or skeletal parameters.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Current and potential treatment options for hyperphosphatemia.

Author: CarfagnaFabio, Del VecchioLucia, PontorieroGiuseppe, LocatelliFrancesco

Lowered serum phosphorus
Hyperphosphatemia
Safety concerns
Tolerability issues

This abstract discusses the challenges associated with hyperphosphatemia in late-stage chronic kidney disease. While oral phosphate binders are effective in lowering serum phosphorus, they come with safety, tolerability, and compliance issues. The abstract highlights the need for careful consideration when selecting a phosphate binder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review.

Author: SkelinMarko, LucijanićTomo, Amidžić KlarićDaniela, RešićArnes, BakulaMiro, Liberati-ČizmekAna-Marija, GharibHossein, RahelićDario

Drug interaction

Levothyroxine, a medication used to treat hypothyroidism, has a narrow therapeutic index, meaning that small variations in dosage can lead to significant changes in therapeutic effects. This review discusses factors that affect the gastrointestinal absorption of levothyroxine, emphasizing the importance of understanding these factors to optimize patient outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Sucroferric Oxyhydroxide as Part of Combination Phosphate Binder Therapy among Hemodialysis Patients.

Author: MolonyDonald A, ParameswaranVidhya, FicocielloLinda H, MullonClaudy, KossmannRobert J

Low pill burden
sP reduction

Sucroferric oxyhydroxide (SO) is an iron-based phosphate binder effective for reducing serum phosphorus in hemodialysis patients. While monotherapy is well-studied, the effects of SO-containing combination therapy are not well understood and require further research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Ultrasound-responsive thrombus treatment with zinc-stabilized gelatin nano-complexes of tissue-type plasminogen activator.

Author: UesugiYoshiko, KawataHiroyuki, SaitoYoshihiko, TabataYasuhiko

Thrombolytic therapy
Cytotoxicity

This study developed a new delivery system for tissue-type plasminogen activator (t-PA), a medication used to dissolve blood clots. The system uses zinc-stabilized gelatin nano-complexes that can be activated by ultrasound irradiation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Development of liposomal pemetrexed for enhanced therapy against multidrug resistance mediated by ABCC5 in breast cancer.

Author: BaiFang, YinYou, ChenTing, ChenJihui, GeMeixin, LuYunshu, XieFangyuan, ZhangJian, WuKejin, LiuYan

Overcome drug resistance

Liposomal pemetrexed was developed to overcome multidrug resistance to pemetrexed in breast cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Effects of phosphates on microstructure and bioactivity of micro-arc oxidized calcium phosphate coatings on Mg-Zn-Zr magnesium alloy.

Author: PanY K, ChenC Z, WangD G, ZhaoT G

Bioactivity
Corrosion prevention

This study investigated the development of calcium phosphate coatings on magnesium alloy using a micro-arc oxidation process. The coatings were found to have excellent bioactivity and biocompatibility.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Comparison of calcium acetate and sevelamer on vascular function and fibroblast growth factor 23 in CKD patients: a randomized clinical trial.

Author: YilmazMahmut Ilker, SonmezAlper, SaglamMutlu, YamanHalil, KilicSelim, EyiletenTayfun, CaglarKayser, OguzYusuf, VuralAbdulgaffar, YenicesuMujdat, MallamaciFrancesca, ZoccaliCarmine

Sevelamer was shown to have effects on FGF-23 level and endothelial function independently of its phosphate-lowering action.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Dietary interventions for mineral and bone disorder in people with chronic kidney disease.

Author: LiuZhuangzhu, SuGuobin, GuoXinfeng, WuYifan, LiuXusheng, ZouChuan, ZhangLei, YangQianchun, XuYuan, MaWeizhong

CKD-MBD treatment

Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a condition that affects people with chronic kidney disease. Phosphate retention plays a significant role in the development of CKD-MBD. This review discusses the potential benefits and limitations of dietary interventions for phosphate retention in people with CKD-MBD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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