Effects of candesartan: A Synthesis of Findings from 11 Studies

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Original Abstract of the Article

Main Research Findings

Candesartan is a medication that blocks the effects of angiotensin II, a substance that causes blood vessels to narrow, leading to increased blood pressure. Several studies have shown that candesartan is effective in treating high blood pressure. 3 , 1 , 2 , 5 Candesartan has been shown to be more effective at lowering blood pressure than losartan, another medication that blocks the effects of angiotensin II. 5 Candesartan has also been shown to be effective in treating heart failure, particularly in patients who cannot tolerate ACE inhibitors. 7 Candesartan is well-tolerated and does not have many side effects. 1 , 2 , 5 Additionally, candesartan has been shown to improve vascular health and may have protective effects on the kidneys. 6 , 11 Furthermore, candesartan has been shown to be effective in combination with other high blood pressure medications. 8 While it is generally well-tolerated, there are some potential side effects associated with candesartan. 4 It is important to consult with a doctor before starting any new medication, including candesartan.

Benefits and Risks

Benefit Summary

Candesartan is an effective medication for treating high blood pressure. It has been shown to be more effective than losartan, another medication that blocks the effects of angiotensin II. Candesartan has also been shown to improve vascular health and may have protective effects on the kidneys. Additionally, it is well-tolerated and does not have many side effects. However, it is important to consult with a doctor before starting any new medication, including candesartan.

Risk Summary

While generally safe, candesartan may cause side effects such as headache, dizziness, fatigue, and cough. In rare cases, more serious side effects may occur. It is important to discuss any concerns with your doctor before taking candesartan.

Comparison of Studies

Commonalities

Several studies have shown that candesartan is effective in treating high blood pressure. 3 , 1 , 2 , 5 Candesartan has been shown to be more effective at lowering blood pressure than losartan. 5 Furthermore, these studies suggest that candesartan is well-tolerated and does not have many side effects. 1 , 2 , 5

Differences

While most studies suggest that candesartan is effective and safe, some discrepancies exist in the findings. For example, the effectiveness of candesartan may vary depending on the individual patient's age, gender, and other factors. Similarly, the occurrence and severity of side effects may differ between individuals.

Consistency and Contradictions

Research findings on the effects of candesartan show both consistency and contradictions. While multiple studies confirm its effectiveness in lowering blood pressure and its generally safe profile, some conflicting results regarding its specific effects compared to other medications and variations in individual responses highlight the need for further investigation and personalized care.

Considerations for Real-World Application

Candesartan is a valuable tool in managing high blood pressure. However, it is crucial to adhere to prescribed dosages and consult with a doctor before starting the medication. Additionally, be mindful of potential interactions with other medications and inform your doctor about any other conditions or medications you are taking. If experiencing side effects, reach out to your healthcare provider for advice.

Limitations of Current Research

The current research on candesartan, though extensive, still has some limitations. More research is needed to fully understand the effectiveness and potential side effects of candesartan in different patient populations and the impact of long-term use.

Future Research Directions

Future research on candesartan should focus on the following areas: • Further investigate the individual factors that may influence the effectiveness and side effects of candesartan. • Conduct long-term studies to assess the safety and effectiveness of candesartan over time. • Explore the potential interactions of candesartan with other medications and conditions. • Investigate the potential benefits of candesartan in managing other cardiovascular conditions beyond high blood pressure.

Conclusion

Candesartan is a medication that effectively lowers blood pressure and is generally well-tolerated. However, its effects may vary between individuals, and potential side effects exist. Remember, consult with your healthcare provider to determine if candesartan is the right medication for you and to discuss any concerns or questions you may have. Continued research will provide a deeper understanding of candesartan’s full potential and its role in managing cardiovascular health.

Literature analysis of 11 papers
Positive Content
10
Neutral Content
1
Negative Content
0
Article Type
10
1
0
0
11
1.

Effects of candesartan cilexetil in patients with systemic hypertension. Candesartan Cilexetil Study Investigators.

Author: ReifM, WhiteW B, FaganT C, OparilS, FlanaganT L, EdwardsD T, CushingD J, MichelsonE L

Hypertension treatment

Candesartan cilexetil, an angiotensin II receptor blocker, effectively reduces blood pressure in a dose-related manner while maintaining safety and tolerability. Doses of 16 and 32 mg are most effective for treatment of hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Effective dose range of candesartan cilexetil for systemic hypertension. Candesartan Cilexetil Study Investigators.

Author: BellT P, DeQuattroV, LasseterK C, RuffD, HardisonJ D, CushingD, KezerA E, MichelsonE L

Lower blood pressure

This study found that candesartan cilexetil has clinically meaningful, dose-related blood pressure-lowering effects in hypertensive patients, with maximum reduction achieved at doses of 16 and 32 mg once daily.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Comparative pharmacodynamics and pharmacokinetics of candesartan and losartan in man.

Author: FuchsB, Breithaupt-GröglerK, BelzG G, RollS, MalerczykC, HerrmannV, Spahn-LangguthH, MutschlerE

Blood pressure control

This double-blind, crossover study compared the in-vivo angiotensin II antagonistic effects of candesartan and losartan. Candesartan showed a greater antagonistic effect than losartan, despite similar plasma activity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

[Change from ACE inhibitor, Ca-antagonist or beta-blocker to candesartan cilexetil: better efficacy and tolerance. SWITCH study (German study segment)].

Author: BaumgartP, ReismannJ, PohlmeyerH, DüsingR

Blood pressure reduction
Hypertension treatment

This study compared the efficacy and tolerability of direct switching to the Angiotensin II-antagonist candesartan cilexetil at its maximal dose with starting therapy at a lower dose and up-titrating.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

5.

Comparative effects of candesartan cilexetil and losartan in patients with systemic hypertension. Candesartan Versus Losartan Efficacy Comparison (CANDLE) Study Group.

Author: GradmanA H, LewinA, BowlingB T, TonkonM, DeedwaniaP C, KezerA E, HardisonJ D, CushingD J, MichelsonE L

Improved tolerability
Reduced blood pressure
Lack of efficacy
Side effects

This study compared the antihypertensive efficacy and tolerability of candesartan cilexetil and losartan in patients with systemic hypertension and found that candesartan was significantly more effective than losartan in reducing blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients.

Author: KohKwang Kon, AhnJeong Yeal, HanSeung Hwan, KimDae Sung, JinDong Kyu, KimHyung Sik, ShinMi-Seung, AhnTae Hoon, ChoiIn Suck, ShinEak Kyun

Endothelial dysfunction reversal
Fibrinolysis improvement
Oxidant stress reduction

Candesartan reversed endothelial dysfunction in hypertensive patients, suggesting that AT1 receptor blocker therapy has antiatherogenic effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

ACE inhibitor intolerance and lessons learned from the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) trials.

Author: SicaDomenic A

Heart failure treatment
Glomerular filtration rate reduction
Hyperkalemia
Hypotension

Candesartan, an angiotensin receptor blocker, was found to be effective in reducing heart failure events and death in patients who were unable to tolerate ACE inhibitors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Antihypertensive efficacy of candesartan-lisinopril in combination vs. up-titration of lisinopril: the AMAZE trials.

Author: IzzoJoseph L, WeinbergMarc S, HainerJames W, KerkeringJoseph, TouConrad K P,

Reduced blood pressure

This study compared the effects of adding candesartan, an angiotensin receptor blocker, to lisinopril, an ACE inhibitor, to the effects of increasing the dose of lisinopril. Both treatments were effective in lowering blood pressure, but adding candesartan to lisinopril resulted in a slightly greater decrease in blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Effects of blood pressure-lowering treatment in different subtypes of acute ischemic stroke.

Author: SandsetElse Charlotte, JusufovicMirza, SandsetPer Morten, BathPhilip M W, BergeEivind,

Improved functional outcome
Limited evidence

There was a trend toward a better effect of candesartan in patients with larger ischemic stroke infarcts (total anterior circulation or partial anterior circulation) than in patients with smaller infarcts (lacunar infarction). However, this finding needs to be confirmed in future trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

A Meta-analysis of antihypertensive effect of telmisartan versus candesartan in patients with essential hypertension.

Author: ZhaoDi, LiuHui, DongPingshuan

Telmisartan and candesartan, two angiotensin II receptor blockers, are both effective in lowering blood pressure. However, a meta-analysis revealed that there is no significant difference in antihypertensive effect between the two drugs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

11.

Stronger Effect of Azilsartan on Reduction of Proteinuria Compared to Candesartan in Patients with CKD: A Randomized Crossover Trial.

Author: SuehiroTakaichi, TsuruyaKazuhiko, YoshidaHisako, TsujikawaHiroaki, YamadaShunsuke, TanakaShigeru, TsuchimotoAkihiro, EriguchiMasahiro, FujisakiKiichiro, TorisuKumiko, NakanoToshiaki, KitazonoTakanari

CKD treatment

This open-label, randomized, crossover trial compared the antiproteinuric effect of azilsartan and candesartan in CKD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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