Side Effects of cannabidiol: A Synthesis of Findings from 7 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of cannabidiol: A Synthesis of Findings from 7 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Main Research Findings

Cannabidiol (CBD) is a multi-target agent with anti-inflammatory and antioxidant properties. 7 . While CBD has gained popularity for its purported health benefits, the safety profile of unlicensed CBD is not fully understood. 7 . Some studies suggest that CBD is safe for humans and animals, with high doses up to 1,500 mg/day being well tolerated. 6 . However, further research is needed to clarify potential side effects. 6 .

Reasons for Side Effects

CBD's side effects may be caused by its interaction with various receptors and enzymes. 1 . CBD can potentially affect the release of neurotransmitters and the growth and differentiation of cells. Additionally, CBD is metabolized in the liver, potentially transforming into substances that can affect the body. These actions are believed to contribute to CBD's side effects.

Common Side Effects

Fatigue

CBD may cause fatigue. 5 . This could be due to CBD's potential influence on serotonin activity.

Diarrhea

CBD may lead to diarrhea. 5 . This might be related to CBD's potential impact on gastrointestinal motility.

Changes in Appetite

CBD may cause changes in appetite. 5 . This is possibly due to CBD's potential effects on the appetite control center.

Changes in Weight

CBD may result in changes in weight. 5 . This may be linked to CBD's potential influence on metabolism.

Liver Function Abnormalities

CBD may contribute to liver function abnormalities. 7 . This could be because CBD metabolism in the liver might put a strain on the organ.

Mental Disorders

CBD may cause mental disorders. 7 . This is potentially due to CBD's potential influence on dopamine.

Side Effect Management

Fatigue Management

Fatigue caused by CBD may be alleviated by getting enough rest. Adjusting the dosage of CBD can also help reduce fatigue in some cases.

Diarrhea Management

Diarrhea caused by CBD might be lessened by staying adequately hydrated. Additionally, taking antidiarrheal medications could help improve diarrhea.

Changes in Appetite Management

Changes in appetite caused by CBD can be addressed by adjusting the type and amount of food consumed. Adjusting the dosage of CBD can also help reduce appetite changes in some cases.

Changes in Weight Management

Changes in weight caused by CBD can be managed through diet and exercise. Adjusting the dosage of CBD can also help reduce weight changes in some cases.

Liver Function Abnormalities Management

Liver function abnormalities caused by CBD can be prevented by adjusting the dosage. Regularly monitoring liver function through tests can lead to early detection and treatment.

Mental Disorders Management

Mental disorders caused by CBD can be prevented by adjusting the dosage. Consult with a psychiatrist for proper treatment.

Comparison Across Studies

Research Similarities

Several studies suggest that CBD is generally safe, but also highlight the possibility of some side effects. These findings point to the need for further research on CBD's safety and effectiveness.

Research Differences

Some studies indicate that CBD could potentially cause liver function abnormalities and mental disorders. However, these studies have varied results depending on factors like CBD dosage and the study population. More research is needed to clarify these findings.

Practical Applications and Cautions

CBD is found in various products, including health foods and cosmetics. When using CBD, it's crucial to carefully review product information regarding ingredients and safety. Additionally, CBD can interact with other medications, so it's essential to consult with a doctor before using it.

Current Research Limitations

Research on CBD is still in its early stages, and there is not enough information about its safety and efficacy. Further research, particularly on the long-term effects of CBD use, is necessary.

Future Research Directions

More research on CBD's safety and effectiveness is needed. Specifically, detailed studies on the long-term effects of CBD use and its impact on various diseases are crucial.

Conclusion

While CBD offers potential health benefits, it also comes with potential side effects. When using CBD, carefully review product information and consult with a doctor before using it.

Literature analysis of 7 papers
Positive Content
4
Neutral Content
1
Negative Content
2
Article Type
0
1
1
2
7
1.

Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis.

Author: LattanziSimona, BrigoFrancesco, TrinkaEugen, ZaccaraGaetano, CagnettiClaudia, Del GiovaneCinzia, SilvestriniMauro

Anti-seizure properties
Abuse liability

Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, shows promise as a new therapeutic option for epilepsy. CBD exhibits anti-seizure properties through multiple mechanisms, including modulation of ionic channels and neurotransmitter transporters.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1-2 Phosphorylation.

Author: HudsonRoger, RenardJustine, NorrisChristopher, RushlowWalter J, LavioletteSteven R

THC side effect mitigation
Neuropsychiatric risks

This study demonstrates that THC increases dopamine neuronal activity in the ventral tegmental area, while CBD coadministration reverses this effect by downregulating pERK1-2 signaling. The findings suggest a mechanism by which CBD might counteract the psychotomimetic and psychotropic side effects of THC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.

Author: IfflandKerstin, GrotenhermenFranjo

CBD safety
Improved compliance
CBD interactions

This review summarizes the safety and side effects of cannabidiol (CBD). CBD is generally well tolerated, with the most common side effects being tiredness, diarrhea, and changes in appetite. Further research is needed to better understand CBD's interactions with other drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Safety and side effects of cannabidiol, a Cannabis sativa constituent.

Author: BergamaschiMateus Machado, QueirozRegina Helena Costa, ZuardiAntonio Waldo, CrippaJosé Alexandre S

Well tolerated
Altered cell viability
Inhibition of hepatic drug metabolism

Cannabidiol (CBD), a non-psychoactive component of Cannabis, has various benefits including anxiety relief, anti-psychotic, anti-emetic, and anti-inflammatory properties. While research indicates CBD is generally safe at doses up to 1,500 mg/day, some studies suggest potential side effects such as liver enzyme inhibition, reduced cell viability, and impaired fertilization. Further research is needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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