Side Effects of carisoprodol: A Synthesis of Findings from 5 Studies

  1. Home
  2. Side Effects of carisoprodol
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of carisoprodol: A Synthesis of Findings from 5 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of carisoprodol: A Synthesis of Findings from 5 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Carisoprodol did not demonstrate significantly greater effect than placebo in a study on patients with myofascial pain-dysfunction syndrome. 3

Carisoprodol has been implicated in a fatal case of mixed drug toxicity, alongside other medications. 5

The metabolism of carisoprodol is affected by the CYP2C19 enzyme, and individuals with lower CYP2C19 activity may experience increased risk of side effects like drowsiness and low blood pressure due to higher carisoprodol levels. 1

Concerns have been raised about the potential for dependence and abuse of carisoprodol, along with its potential for toxicity. 4

Reasons for Side Effects

Side effects of carisoprodol are likely related to its central nervous system effects. While it works to relax muscles, it can also cause drowsiness and dizziness. Additionally, individual variations in CYP2C19 activity can influence carisoprodol metabolism and side effect risk. 1

Common Side Effects

Drowsiness

Drowsiness is a commonly reported side effect of carisoprodol. , 2

Dizziness

Dizziness is another common side effect. , 2

Dependence

There is a potential for carisoprodol to cause dependence. 4

Counteracting Side Effects

Drowsiness

Refrain from driving or operating heavy machinery while taking carisoprodol. , 2

Dizziness

Rise slowly to minimize dizziness. , 2

Dependence

Follow your doctor's instructions for carisoprodol use and do not alter the dosage or discontinue the medication without consulting them. 4

Comparison Between Studies

Commonalities

Several studies highlight drowsiness and dizziness as common side effects of carisoprodol. , 2

Differences

One study found no significant difference in the effectiveness of carisoprodol compared to placebo. 3

Real-Life Application Precautions

Avoid driving or operating heavy machinery while taking carisoprodol. Get up slowly to minimize dizziness. Always adhere to your doctor's instructions for carisoprodol use and avoid altering the dosage or discontinuing the medication without their advice. , 2 , 4

Limitations of Current Research

The existing research on the effects and side effects of carisoprodol is still limited. More research is necessary to fully understand the long-term implications of carisoprodol use.

Future Research Directions

Further research is needed to delve deeper into the effects and side effects of carisoprodol. Specific areas of focus include long-term effects and the risk of side effects in individuals with lower CYP2C19 activity.

Conclusion

Carisoprodol, while potentially effective for muscle relaxation, can cause side effects like drowsiness and dizziness. Concerns exist regarding dependence, abuse, and potential toxicity. Always follow your doctor's instructions for carisoprodol use and avoid altering the dosage or discontinuing the medication without their advice. 3 , , 2 , 4

Literature analysis of 5 papers
Positive Content
2
Neutral Content
1
Negative Content
2
Article Type
1
0
0
0
5
1.

Formation of meprobamate from carisoprodol is catalysed by CYP2C19.

Author: DalénP, AlvanG, WakelkampM, OlsenH

Analgesic
Muscle relaxant
Drowsiness
Hypotension

Poor metabolizers of mephenytoin have a lower capacity to metabolize carisoprodol and may have an increased risk of developing side effects such as drowsiness and hypotension if treated with ordinary doses.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Randomized, double-blind trial of carisoprodol 250 mg compared with placebo and carisoprodol 350 mg for the treatment of low back spasm.

Author: SerferGregory T, WheelerWilliam J, SacksHarry J

Musculoskeletal disorder treatment
Dizziness
Drowsiness

Carisoprodol, a muscle relaxant, was found to be effective at a lower dose (150 mg four times daily) with fewer side effects than a higher dose (350 mg four times daily).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Carisoprodol in the treatment of myofascial pain-dysfunction syndrome.

Author: GallardoF, MolgoJ, MiyazakiC, RossiE

No significant effect

Carisoprodol was not significantly more effective than placebo in treating patients with myofascial pain-dysfunction syndrome. Both carisoprodol and placebo had similar rates of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Multidrug toxicity involving sumatriptan.

Author: KnittelJessica L, VorceShawn P, LevineBarry, HughesRhome L, BosyThomas Z

Acute mixed drug toxicity
Multidrug fatality

This report describes a multidrug fatality involving sumatriptan, highlighting the potential risks associated with high doses of the medication.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.