Side Effects of cefditoren: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Main Research Findings

Cefditoren pivoxil is an oral cephalosporin antibiotic effective for treating infections in children. 8 , 3 , 2 , 6 These studies showed that cefditoren pivoxil is effective against a wide range of bacteria and generally safe for children. 8 , 3 , 2 However, some patients have reported side effects. 9 , 5 , 4 , 3 , 6

Reason for Side Effects

Cefditoren pivoxil is a prodrug that contains pivalic acid. 9 Pivalic acid is metabolized in the body to pivaloylcarnitine. 9 This pivaloylcarnitine can affect carnitine metabolism and potentially cause side effects. 9

Common Side Effects

Diarrhea

Diarrhea has been reported in about 4% of children who took cefditoren pivoxil. 5 , 3 , 6

Gastrointestinal Symptoms

Some patients have reported gastrointestinal symptoms such as abdominal discomfort after taking cefditoren pivoxil. 7

Liver Function Abnormalities

Some patients have reported liver function abnormalities such as elevated GPT (GOT) after taking cefditoren pivoxil. 3 , 6

Increased Blood Cell Count

Some patients have reported increased blood cell counts such as elevated eosinophils and platelets after taking cefditoren pivoxil. 6

Side Effect Management

Diarrhea

If you experience diarrhea, drink plenty of fluids. If symptoms do not improve, consult your doctor. 5 , 3 , 6

Gastrointestinal Symptoms

If you experience gastrointestinal symptoms, consult your doctor. 7

Liver Function Abnormalities

If you experience liver function abnormalities, consult your doctor. 3 , 6

Increased Blood Cell Count

If you experience increased blood cell counts, consult your doctor. 6

Comparison Between Studies

Common Points of Studies

Cefditoren pivoxil is effective for treating infections in children and has been shown to be safe. 5 , 4 , 2 , 6 Side effects such as diarrhea have been reported. 5 , 4 , 3 , 6

Differences in Studies

There are differences in the types and incidence of side effects reported in different studies. 9 , 5 , 4 , 3 , 6 The results may also vary depending on the age of the patients and the type of infection studied. 8 , 3 , 2 , 6

Things to Keep in Mind When Applying It to Real Life

Cefditoren pivoxil is an effective medication for treating infections in children, but there are risks of side effects. 9 , 5 , 4 , 3 , 6 Always follow your doctor’s instructions for taking cefditoren pivoxil and consult your doctor immediately if you experience any side effects. 5 , 3 , 6

Limitations of Current Research

Research on cefditoren pivoxil is still insufficient. 9 , 5 , 4 , 3 , 6 In particular, research on long-term side effects is lacking. 7

Future Research Directions

More research on cefditoren pivoxil is needed. 9 , 5 , 4 , 3 , 6 In particular, it is necessary to investigate long-term side effects and the effects of cefditoren pivoxil on different age groups and types of infections. 7

Conclusion

Cefditoren pivoxil is an effective oral cephalosporin antibiotic for treating infections in children. 8 , 3 , 2 , 6 However, there is a risk of side effects. 9 , 5 , 4 , 3 , 6 Always follow your doctor’s instructions when taking cefditoren pivoxil and consult your doctor immediately if you experience any side effects. 5 , 3 , 6

Literature analysis of 10 papers
Positive Content
10
Neutral Content
0
Negative Content
0
Article Type
1
1
1
0
10
1.

Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis.

Author: LattanziSimona, BrigoFrancesco, TrinkaEugen, ZaccaraGaetano, CagnettiClaudia, Del GiovaneCinzia, SilvestriniMauro

Anti-seizure properties
Abuse liability

Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, shows promise as a new therapeutic option for epilepsy. CBD exhibits anti-seizure properties through multiple mechanisms, including modulation of ionic channels and neurotransmitter transporters.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

[Clinical studies of cefditoren pivoxil in pediatric field].

Author: NishimuraT, TabukiK, AokiS, TakagiM

Treats pediatric infections

Cefditoren pivoxil (CDTR-PI) in granules was effective in treating 12 out of 14 pediatric patients with various infections. No significant side effects were observed.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

4.

[A clinical study on cefditoren pivoxil in pediatrics].

Author: SatohY, IwataS, AkitaH, AoyamaT, TakeuchiY, YokotaT, SunakawaK

Safe
Treats pediatric infections
Diarrhea

Cefditoren pivoxil (CDTR-PI) in granules was effective in treating 94% of pediatric patients with infections, including tonsillitis, pneumonia, scarlet fever, impetigo, subcutaneous abscess and urinary tract infection. The eradication rate for bacteria presumed to be pathogens was 97%. Diarrhea was the most common side effect, occurring in 7.7% of patients.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

6.

[Pharmacokinetic and clinical studies of cefditoren pivoxil in the pediatric field. Pediatric Study Group of ME1207].

Author: FujiiR, YoshiokaH, OkunoA, FujitaK, MuronoK, MaruyamaS, SakataH, IsekiK, WagatsumaY, FukushimaN

Treats infections
Abnormal laboratory findings
Diarrhea

Cefditoren pivoxil, a new oral cephalosporin, is effective in treating various infections in children. It is well tolerated, with the most common side effect being diarrhea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : Japanese

7.

[Clinical long-term studies of the treatment of chronic complicated urinary tract infections. Utility and recurrence after 14-day treatment by cefditoren pivoxil].

Author: ArakawaS, TakagiS, KamidonoS, KataokaN, TomiokaO, HazamaM, HiroseT, YamazakiK, KumamotoY, HayashiK

Treats UTI
Abdominal discomfort
Abnormal laboratory findings

Cefditoren pivoxil (CDTR-PI) was effective in treating non-catheterized complicated urinary tract infections (UTI) in 72 patients. The efficacy rate was higher at day 14 than at day 7, with low rates of side effects and recurrence of infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : Japanese

8.

[Basic and clinical studies on cefditoren pivoxil in pediatric field].

Author: MotohiroT, HandaS, YamadaS, OkiS, YoshinagaY, SasakiH, AramakiM, OdaK, SakataY, KatoH

Antibacterial activity
Clinical efficacy
Safe for pediatric patients

Cefditoren pivoxil, a new oral cephem, showed excellent antibacterial activity against clinical isolates, with MICs comparable to or lower than conventional cephems. The drug was clinically effective in 53 pediatric patients with various infections, with no observed side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : Japanese

9.

[Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients].

Author: FujiiR, ChibaS, NumazakiK, MoriT, TerashimaI, MeguroH, MoriA, ToyonagaY, SunakawaK, SatohY

Cefditoren pivoxil effective
Infection treatment
Carnitine metabolism

Cefditoren pivoxil treatment increases urinary carnitine excretion and decreases free carnitine concentration in serum. In a study of 16 pediatric patients, cefditoren pivoxil treatment resulted in increased pivaloylcarnitine levels in urine and serum.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

10.

[Clinical evaluation of faropenem against infections in pediatric fields].

Author: SunakawaK, SatohY, IwataS, TerashimaI, MeguroH, KusumotoY, KatoT, AkitaH, GoshimaT, YokotaT, ToyonagaY, IshiharaT, KanemuraH, IwaiN, NakamuraH, NakashimaM

Antimicrobial activity
Effective treatment of respiratory infections
Diarrhea
Loose stool

Faropenem (FRPM) was found to be effective against penicillin-resistant Streptococcus pneumoniae in 40 pediatric patients. The combination of FRPM with a medicine for intestinal disorders (Enteronon-R) was found to be effective in reducing loose bowel movements.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Japanese

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