Side Effects of ceftibuten: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Main Research Findings

Ceftibuten has been shown to be as effective as amoxicillin-clavulanate in the treatment of acute exacerbations of chronic bronchitis (AECB). 1 Furthermore, ceftibuten was associated with fewer gastrointestinal side effects compared to amoxicillin-clavulanate. 1

Ceftibuten has also been shown to be as effective as trimethoprim-sulfamethoxazole (TMP-SMX) in the treatment of dysentery caused by Shigella and enteroinvasive Escherichia coli in children. 8 However, ceftibuten was more effective than TMP-SMX against TMP-SMX-resistant strains. 8

Ceftibuten has also been shown to be as effective as cefaclor in the treatment of acute lower respiratory tract infections. 7 Ceftibuten was administered twice daily, while cefaclor was administered three times daily, but both drugs showed comparable clinical and bacteriological efficacy. 7

Ceftibuten has been shown to be as effective as intravenous ceftriaxone followed by oral ceftibuten in the treatment of acute pyelonephritis in children. 3 This study showed that the ceftibuten group had a significantly lower renal scarring rate compared to the intravenous/oral ceftriaxone group. 3

Ceftibuten has been shown to have significantly better patient compliance compared to other antibiotics. 6 This is thought to be due to the fact that ceftibuten is administered once daily, making it less likely for patients to forget to take their medication. 6

Reasons for side effects

Ceftibuten is a type of cephalosporin antibiotic that exerts antibacterial effects by inhibiting bacterial cell wall synthesis. 5 Ceftibuten has been shown to have fewer gastrointestinal side effects compared to other antibiotics. 2 This is thought to be because ceftibuten has a minimal impact on the gut flora, making it less likely to disrupt the balance of the gut flora. 5 However, ceftibuten, like other antibiotics, can still cause side effects. 5

Common Side Effects

Gastrointestinal

The most common side effect of ceftibuten is gastrointestinal symptoms. 2 According to studies, 15% of patients in the ceftibuten group and 24% of patients in the amoxicillin-clavulanate group experienced gastrointestinal disorders. 1 Specific symptoms include diarrhea, abdominal pain, nausea, and vomiting. 4

Other

Allergic reactions such as rash, hives, and itching have also been reported as side effects of ceftibuten. 1 Blood tests may also show abnormal values. 4

Side Effects Management

Gastrointestinal

If you experience gastrointestinal side effects from ceftibuten, you may need to consider dietary or drug therapy. 4 Dietary therapy includes eating easily digestible foods and consuming a diet rich in fiber. 4 Drug therapy may involve the use of antiemetics and laxatives. 4 You may also consider discontinuing ceftibuten as directed by your doctor. 1

Other

If you experience an allergic reaction to ceftibuten, consult your doctor immediately. 1 If blood tests show abnormal values, you may need to stop taking ceftibuten or switch to a different medication as directed by your doctor. 4

Comparison of Studies

Commonalities in Research

Many studies have shown that ceftibuten is clinically equivalent to other antibiotics. 1 Additionally, ceftibuten has been associated with fewer gastrointestinal side effects compared to other antibiotics. 2

Differences in Research

The administration methods and dosages of ceftibuten vary across studies. 1 Also, the types of infections for which ceftibuten is considered effective vary across studies. 8

Practical Application Considerations

Ceftibuten should be taken as prescribed by your doctor. 8 Self-treating with ceftibuten or taking it in a manner that deviates from your doctor's instructions can increase the risk of side effects. 4 Ceftibuten is not effective against all infections. 7 It is important to consult your doctor before taking ceftibuten. 3

Current Research Limitations

There is still a lack of sufficient research on ceftibuten. 4 Further research is needed, particularly on the safety and efficacy of long-term ceftibuten use. 6

Future Research Directions

Research is needed to evaluate the safety and efficacy of long-term use of ceftibuten. 6 Additionally, research is required to identify the range of infections for which ceftibuten is effective. 7

Conclusion

Ceftibuten is an effective antibiotic for certain infections. 3 Ceftibuten has been associated with fewer gastrointestinal side effects compared to other antibiotics. 2 However, ceftibuten can still cause side effects. 4 If you are taking ceftibuten, follow your doctor's instructions. 1

Literature analysis of 8 papers
Positive Content
7
Neutral Content
0
Negative Content
1
Article Type
6
0
0
0
8
1.

Comparison of ceftibuten once daily and amoxicillin-clavulanate three times daily in the treatment of acute exacerbations of chronic bronchitis.

Author: McAdooM A, RiceK, GordonG R, SahnS A

Clinical success
Microbiologic eradication
Gastrointestinal disturbances

Ceftibuten once daily had a similar clinical success rate to amoxicillin-clavulanate three times daily in the treatment of patients with acute exacerbations of chronic bronchitis (AECB). Ceftibuten had a trend toward fewer gastrointestinal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Comparison of ceftibuten versus amoxicillin/clavulanate in the treatment of acute exacerbations of chronic bronchitis.

Author: AubierM A

Clinical efficacy
Tolerability
Gastrointestinal side effects

Ceftibuten, administered once or twice daily, was found to be equally effective as amoxicillin/clavulanate in treating acute exacerbations of chronic bronchitis. Ceftibuten was better tolerated, with fewer gastrointestinal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Randomised trial of oral versus sequential intravenous/oral cephalosporins in children with pyelonephritis.

Author: NeuhausThomas J, BergerChristoph, BuechnerKatja, ParvexPaloma, BischoffGian, GoetschelPhilippe, HusarikDaniela, WilliUlrich, MolinariLuciano, RudinChristoph, GervaixAlain, HunzikerUrs, StockerSergio, GirardinEric, NadalDavid

pyelonephritis treatment

Oral ceftibuten for 14 days was as effective as intravenous ceftriaxone followed by oral ceftibuten in children with acute pyelonephritis and scintigraphy-documented lesions. The oral therapy allowed for outpatient management in the majority of cases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

The relationship between an increase in beta-lactamase activity after oral administration of three new cephalosporins and protection against intestinal ecological disturbances.

Author: EdlundC, StarkC, NordC E

Colonization with resistant bacteria
Ecological effects on microflora

Oral cephalosporins were found to increase beta-lactamase activity and cause ecological disturbances in the intestinal microflora, with amoxycillin showing less significant effects compared to other cephalosporins.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

[Patient adherence in respiratory tract infections: ceftibuten versus other antibiotics (PARTICULAR study)].

Author: KardasP, Ratajczyk-PakalskaE

Respiratory infection treatment

This study evaluated patient compliance to antibiotic therapy in respiratory tract infections. Once-daily antibiotic dosing was found to lead to the best possible compliance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Polish

7.

Randomized comparative study of ceftibuten versus cefaclor in the treatment of acute lower respiratory tract infections.

Author: KammerR B, RessR

Lower respiratory tract infection treatment
Gastrointestinal side effects

Ceftibuten was as effective as cefaclor in treating acute lower respiratory tract infections, with similar adverse experiences reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Ceftibuten and trimethoprim-sulfamethoxazole for treatment of Shigella and enteroinvasive Escherichia coli disease.

Author: PradoD, LópezE, LiuH, DevotoS, WolojM, ContriniM, MurrayB E, GómezH, ClearyT G

Effective for dysentery
Safe for children

Ceftibuten was as effective as trimethoprim-sulfamethoxazole in treating dysentery in 22 children. Ceftibuten was more effective in patients with TMP-SMX-resistant organisms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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