Side Effects of clarithromycin: A Synthesis of Findings from 24 Studies

  1. Home
  2. Side Effects of clarithromycin
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of clarithromycin: A Synthesis of Findings from 24 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of clarithromycin: A Synthesis of Findings from 24 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Clarithromycin is used to treat a variety of diseases, including Helicobacter pylori infection, atypical mycobacterial infections, and respiratory infections. However, multiple studies have shown that clarithromycin also carries the risk of side effects.

For example, a study in 16 reported that the incidence of side effects was higher in the treatment of Helicobacter pylori infection with clarithromycin compared to placebo.

In a study in 11 , it was reported that clarithromycin and amoxicillin-clavulanate may cause manic episodes when used together.

A study in 18 reported that clarithromycin and tacrolimus may cause increased drug levels and acute kidney injury when used together.

A study in 14 reported that the addition of clarithromycin to lenalidomide and dexamethasone may increase the risk of death.

A study in 6 reported that the risk of liver failure and death is increased when clarithromycin is used with colchicine.

Reasons for Side Effects

Clarithromycin can inhibit the metabolism of other drugs by inhibiting CYP3A4 enzymes, potentially leading to increased blood concentrations. This can make interactions with other drugs more likely and increase the risk of side effects.

Common Side Effects

Gastrointestinal System

Clarithromycin can cause side effects in the gastrointestinal system. Common side effects include nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. 16 , 12 , 14 , 3 , 23 , 20

Nervous System

Clarithromycin can cause side effects in the nervous system. Common side effects include headache, dizziness, drowsiness, confusion, and hallucinations. 11 ,

Liver

Clarithromycin can cause side effects in the liver. Common side effects include liver dysfunction and jaundice. 6

Kidney

Clarithromycin can cause side effects in the kidneys. Common side effects include acute kidney injury. 18

Blood

Clarithromycin can cause side effects in the blood. Common side effects include leukopenia, thrombocytopenia. 6

Allergy

Clarithromycin can cause allergic reactions. Common side effects include rash, itching, hives, and anaphylactic shock. 2

Mental

Clarithromycin can cause mental side effects. Common side effects include manic episodes. 11 , 5

Side Effect Management

Gastrointestinal System

Diet and medication may be used to reduce gastrointestinal side effects. Dietary changes include eating easily digestible foods, eating smaller meals, and chewing thoroughly. Medications such as antiemetics and laxatives may be prescribed.

Nervous System

Appropriate medication may be used to reduce nervous system side effects, depending on the symptoms. For example, analgesics may be prescribed for headache, antihistamines for dizziness or drowsiness.

Liver

Liver function tests should be performed to reduce liver side effects, and medication may be discontinued or the dosage reduced if necessary.

Kidney

Kidney function tests should be performed to reduce kidney side effects, and medication may be discontinued or the dosage reduced if necessary.

Blood

Blood tests should be performed to reduce blood side effects, and blood transfusions or medication may be given if necessary.

Allergy

If an allergic reaction occurs, you should see a doctor immediately. If anaphylactic shock occurs, emergency treatment is required.

Mental

If mental side effects occur, you should see a psychiatrist. If your mental state becomes unstable, such as manic episodes, hospitalization may be necessary.

Comparison Between Studies

Commonalities

Multiple studies have shown that clarithromycin carries the risk of various side effects. In particular, it has been reported that side effects are more likely to occur in the gastrointestinal system, nervous system, liver, kidneys, blood, allergies, and mental health.

Differences

The types, severity, and frequency of side effects caused by clarithromycin vary depending on the study. This is likely due to differences in the disease, age, and medications being studied.

Precautions for Applying Research to Real Life

It is important to understand the risks of side effects when taking clarithromycin. Be especially careful of drug interactions and consult your doctor before taking any medication. If side effects occur, report them to your doctor immediately.

Limitations of Current Research

Research on the side effects of clarithromycin is still not sufficient. In particular, further research is needed on the effects of long-term use and the incidence of side effects in specific patient populations.

Directions for Future Research

To better understand the side effects of clarithromycin, further research is needed on the effects of long-term use and the incidence of side effects in specific patient populations. Development of methods to prevent and treat side effects is also expected.

Conclusion

Clarithromycin is an effective drug, but it has been shown to carry the risk of various side effects. When taking clarithromycin, it is important to understand the risks of side effects and follow your doctor's instructions.

Literature analysis of 24 papers
Positive Content
18
Neutral Content
0
Negative Content
6
Article Type
3
0
1
1
21
1.

Analysis of adverse drug events in pulmonary Mycobacterium avium complex disease using spontaneous reporting system.

Author: OzawaTakuya, NamkoongHo, TakayaRisako, TakahashiYusuke, FukunagaKoichi, EnokiYuki, TaguchiKazuaki, KizuJunko, MatsumotoKazuaki, HasegawaNaoki

MAC-LD treatment
Adverse events

This study investigated adverse events associated with clarithromycin, ethambutol, and rifampicin using the Japanese Adverse Drug Event Report (JADER) database. The study aimed to identify potential adverse events using spontaneous reporting systems, providing valuable data for drug safety monitoring.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

[Mycobacterium abscessus infection management: Macrolide and quinolone desensitization].

Author: AksuKurtuluş, Çuhadar ErçelebiDilek, ÖzkaraŞeref, TürkyılmazSüleyman, Koca Kalkanİlkay, DedeoğluÖzlem, Başa AkdoğanBuket, AteşHale, Köycü BuhariGözde

Successful desensitization
Anaphylaxis
Antibiotic hypersensitivity

This study describes a case of successful desensitization to clarithromycin and moxifloxacin in a patient with Mycobacterium abscessus lung disease who developed anaphylaxis after treatment initiation. This case highlights the challenges of treating Mycobacterium abscessus infections, particularly when hypersensitivity reactions occur. Desensitization can be a viable option in situations where alternative treatment options are limited.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Turkish

4.

Interdigital Pedal Erythrasma treated with one-time dose of oral clarithromycin 1 g: Two case reports.

Author: KhanMohammad Junayed

Erythrasma treatment
Lower treatment costs
Reduced side effects

This case report describes two successful treatments of Interdigital Pedal Erythrasma with a one-time dose of oral clarithromycin 1 g. This approach is ideal for patients who failed topical therapy or have other restrictions.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

5.

The First Case of Ceftazidime-Induced Antibiomania: A Case Report and Literature Review.

Author: PalletiSujith K, WadhwaAnuradha, RasheedAbdul H

Antibiomania
Manic symptoms

Antibiomania is a rare condition where antibiotics trigger manic symptoms. This is the first case report of antibiomania in a peritoneal dialysis patient caused by ceftazidime, a cephalosporin antibiotic.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

7.

Tailored eradication strategy <i>vs</i> concomitant therapy for <i>Helicobacter pylori</i> eradication treatment in Korean patients.

Author: ChoiYoun I, ChungJun-Won, KimKyoung Oh, KwonKwang An, KimYoon Jae, KimJung Ho, SeoJa Young, ParkDong Kyun

<i>H. pylori</i> infection treatment
Antibiotic resistance

This review discusses the emergence of antibiotic resistance to Helicobacter pylori infection and the potential of tailored therapy to overcome this challenge.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea.

Author: MartinsAna M, MartoJoana M, JohnsonJodi L, GraberEmmy M

Anti-inflammatory properties
Topical treatment option
Drug-induced lupus
Hypersensitivity syndrome

This review discusses the increasing resistance of Cutibacterium acnes to topical antibiotics used for treating acne. The review highlights the potential of topical minocycline formulations as a treatment option, offering fewer adverse effects and less drug interaction compared to oral minocycline.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Pharmacovigilance network as an additional tool for the surveillance of antimicrobial resistance.

Author: HabarugiraJean Marie Vianney, FiguerasAlbert

Surveillance of AMR

Antimicrobial resistance (AMR) is a significant public health concern. This study explored the potential role of Pharmacovigilance databases in monitoring AMR. The study found that Pharmacovigilance databases can play a valuable role in AMR surveillance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Antibiomania: a case report of clarithromycin and amoxicillin-clavulanic acid induced manic episodes separately.

Author: MeszarosEdith Paula, StancuCatheline, CostanzaAlessandra, BessonMarie, SarasinFrançois, BondolfiGuido, AmbrosettiJulia

Antibiomania

A brief manic episode was suspected to be induced by clarithromycin and amoxicillin-clavulanic acid in a patient with no psychiatric history. Early recognition and intervention are crucial for managing psychiatric side effects related to antibiotics.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Painful Purulent Nodules Caused by Mycobacterium at Site of Lipodissolve Injections.

Author: KaurHarsimran, Reyes-BarronCynthia, SipprellWilliam H, CameronAndrew, LouieTed, TsaiPeihsuan R, ScottGlynis

Injection site infection

A case report describes an unusual infection with Mycobacterium abscessus after cosmetic injections of 'Lipodissolve', highlighting the potential risks associated with this non-FDA-approved procedure.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates.

Author: ViazisNikos, ArgyriouKonstantinos, KotzampassiKaterina, ChristodoulouDimitrios K, ApostolopoulosPeriklis, GeorgopoulosSotirios D, LiatsosChristos, GioulemeOlga, KoustenisKanellos, VeretanosChristos, StogiannouDimitris, MoutzoukisMiltiadis, PoutakidisCharalambos, MylonasIoannis Ioardanis, TsetiIoulia, MantzarisGerassimos J

H. pylori eradication
Reduced side effects

This study found that adding probiotics to a standard Helicobacter pylori eradication regimen increased the eradication rate by 5.2% and significantly reduced the incidence of side effects by 33.7%.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Lenalidomide and dexamethasone with or without clarithromycin in patients with multiple myeloma ineligible for autologous transplant: a randomized trial.

Author: PuigNoemi, HernándezMiguel T, RosiñolLaura, GonzálezEsther, de ArribaFelipe, OriolAlbert, González-CalleVerónica, EscalanteFernando, de la RubiaJavier, GironellaMercedes, RíosRafael, García-SánchezRicarda, ArguiñanoJosé M, AlegreAdrián, MartínJesús, GutiérrezNorma C, CalasanzMaría J, MartínMaría L, CoutoMaría Del Carmen, CasanovaMaría, ArnaoMario, Pérez-PersonaErnesto, GarzónSebastián, GonzálezMarta S, Martín-SánchezGuillermo, OcioEnrique M, ColemanMorton, EncinasCristina, ValeAna M, TeruelAna I, Cortés-RodríguezMaría, PaivaBruno, CedenaM Teresa, San-MiguelJesús F, LahuertaJuan J, BladéJoan, NiesvizkyRuben, MateosMaría-Victoria

Complete response
Toxic death

Adding clarithromycin to lenalidomide and dexamethasone (Rd) for multiple myeloma (MM) patients ineligible for stem cell transplant did not improve progression-free survival (PFS) despite increasing complete response rates. This phase III trial found higher toxic deaths in the clarithromycin group.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Comparing the Efficacy of Sequential and Standard Quadruple Therapy for Eradication of H. Pylori Infection.

Author: RazavizadehMohsen, ArjAbbas, MadaniMaryam, GilassiHamidreza

H. pylori eradication

Sequential therapy for H. pylori eradication was found to be more effective than standard quadruple therapy, with higher eradication rates and fewer complications. However, more research is needed to confirm these findings.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Lactobacillus ruteri compared with placebo as an adjuvant in quadruple therapy for Helicobacter pylori eradication: A randomized, double-blind, controlled trial.

Author: MohtashamMahsa, JoukarFarahnaz, MaroufizadehSaman, MojtahediKourosh, AsgharnezhadMehrnaz, Mansour-GhanaeiFariborz

Reduced side effects

This randomized, double-blind, controlled trial evaluated the efficacy of adding Lactobacillus ruteri probiotic to quadruple therapy for H. pylori eradication. The probiotic did not significantly improve eradication rates, but it reduced the frequency of drug-associated side effects, such as headache and gastrointestinal adverse events.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

A misdiagnosed case of blastic plasmacytoid dendritic cell neoplasm experiencing multiple recurrences who underwent allogeneic stem cell transplantation: a case report.

Author: SalemiFateme, MortazavizadehSeyed Mohammad Reza, MirmoeeniSeyyedmohammadsadeq, Azari JafariAmirhossein, KosariFarid, Naghibi IrvaniSeyed Sina

Hematologic malignancy

Blastic plasmacytoid dendritic cell neoplasm is a rare blood cancer that often causes skin lesions. It commonly affects older men and involves lymph nodes, blood, and bone marrow, leading to an aggressive course and poor prognosis. The cancer cells are similar to myeloid lineage cells, requiring immunohistochemistry staining for diagnosis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Efficacy of different antibiotics in treatment of children with respiratory mycoplasma infection.

Author: ZhangMei-Ying, ZhaoYan, LiuJin-Feng, LiuGuo-Ping, ZhangRui-Yun, WangLi-Min

<i>Mycoplasma pneumoniae</i> infection treatment

This article discusses the widespread clinical attention on treatment strategies for *Mycoplasma pneumoniae* infection in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Efficacy and safety of low-dose rifabutin-based 7-day triple therapy as a third- or later-line Helicobacter pylori eradication regimen.

Author: InokuchiKazumi, MoriHideki, MatsuzakiJuntaro, HirataKenro, HaradaYosuke, SaitoYoshimasa, SuzukiHidekazu, KanaiTakanori, MasaokaTatsuhiro

H. pylori eradication

This study evaluated the efficacy and safety of a 7-day rifabutin, amoxicillin, and vonoprazan triple therapy for treating refractory Helicobacter pylori infection. The study found the regimen to be effective and safe, suggesting it may be a valuable option for third- or later-line treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Non-steroidal anti-inflammatory drugs in management of COVID-19; A systematic review on current evidence.

Author: YousefifardMahmoud, ZaliAlireza, ZarghiAfshin, Madani NeishabooriArian, HosseiniMostafa, SafariSaeed

Viral respiratory infection treatment

This study aims to evaluate the efficacy and safety of various NSAIDs in viral respiratory infections, including COVID-19, to provide evidence-based recommendations for their use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.