Side Effects of clindamycin and benzoyl peroxide topical: A Synthesis of Findings from 19 Studies

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Original Abstract of the Article

Main Research Findings

Topical clindamycin and benzoyl peroxide are effective and widely used for the treatment of moderate to severe acne. 4 , 3 . These medications work by suppressing the growth of Propionibacterium acnes, the bacteria that cause acne, and reducing inflammation. 18 , 11 . However, some studies have shown that these drugs can cause side effects such as skin dryness, redness, and peeling. 6 , 2 . These side effects vary depending on the concentration and frequency of use of the drug, as well as the individual's skin type.

Reasons for Side Effects

Side effects of topical clindamycin and benzoyl peroxide are caused by the direct action of these drugs on the skin. Benzoyl peroxide uses oxidation to kill Propionibacterium acnes on the skin surface. This oxidizing action can cause side effects such as skin dryness, redness, and peeling. Clindamycin inhibits bacterial protein synthesis, suppressing the growth of Propionibacterium acnes. This action reduces skin inflammation, but it can also make the skin dry and sensitive.

Common Side Effects

Dryness

The most common side effect of topical clindamycin and benzoyl peroxide is skin dryness. 6 , 5 , 2 . These drugs remove oil from the skin surface, reducing the skin's ability to retain moisture, making the skin more prone to dryness. 7 . Dryness can range from mild to severe. Mild dryness may be felt as skin tightness or itching. Severe dryness can cause skin peeling and cracking.

Redness

Redness is also a common side effect of topical clindamycin and benzoyl peroxide. 6 , 5 . Benzoyl peroxide can cause skin inflammation, and redness is one of the symptoms of this inflammation. Clindamycin can increase skin sensitivity, which can also cause redness.

Peeling

Topical clindamycin and benzoyl peroxide can cause skin peeling. 6 , 5 . These drugs destroy cells on the skin surface, causing peeling. Peeling can range from mild to severe. Mild peeling may appear as small white flakes on the skin surface. Severe peeling can cause large areas of skin to peel off.

Itching

Topical clindamycin and benzoyl peroxide can cause skin itching. 6 . Itching can occur due to side effects such as dryness and redness. Itching can range from mild to severe. Mild itching may be felt as a slight irritation of the skin. Severe itching can cause a strong urge to scratch the skin.

Other

Other side effects of topical clindamycin and benzoyl peroxide include: 6 , 5 , 2 .

  • Burning sensation
  • Pain
  • Swelling
  • Roughness of the skin
  • Worsening acne

Countermeasures for Side Effects

Dryness

If your skin becomes dry from using topical clindamycin and benzoyl peroxide, it is important to use a moisturizer. 6 , 7 . Moisturizers help retain moisture in the skin and prevent dryness, itching, and peeling. Apply moisturizer several times a day if your skin is very dry. Also, apply moisturizer immediately after bathing or showering.

Redness

If your skin becomes red from using topical clindamycin and benzoyl peroxide, you can reduce the symptoms by cooling it down. 6 . Apply a cold towel or ice pack to the reddened area. Using sunscreen is also effective. Sunscreen blocks ultraviolet rays, reducing skin inflammation and redness.

Peeling

If your skin peels from using topical clindamycin and benzoyl peroxide, stop using the drug and consult a dermatologist. 6 . A dermatologist will prescribe appropriate treatment.

Itching

If your skin itches from using topical clindamycin and benzoyl peroxide, you can reduce the symptoms by taking antihistamines. 6 . Antihistamines inhibit the action of histamine, reducing itching. Applying an anti-itch cream is also effective. Anti-itch creams reduce skin inflammation and itching.

Comparison between Studies

Common Points of Studies

Many studies have shown that topical clindamycin and benzoyl peroxide are effective in treating acne. 3 , 6 . These drugs suppress the growth of bacteria that cause acne and reduce inflammation. 18 , 11 . Many studies also show that these drugs can cause side effects such as skin dryness, redness, and peeling. 6 , 2 . These side effects vary depending on the concentration and frequency of use of the drug, as well as the individual's skin type.

Differences between Studies

The effects and side effects of topical clindamycin and benzoyl peroxide vary depending on the study. 3 , 6 , 5 , 2 . This is because the concentration and frequency of use of the drug, the skin type of the study participants, and the design of the study are different. Some studies may also have a more detailed investigation of the effects and side effects of these drugs.

Precautions for Application to Real Life

Topical clindamycin and benzoyl peroxide are effective medications for acne treatment, but they also carry the risk of side effects. 6 , 2 . When using these medications, it is important to consult a dermatologist and understand the proper usage. 7 . If you experience any side effects, stop using the drug immediately and consult a dermatologist.

Limitations of Current Research

There is still not enough research on topical clindamycin and benzoyl peroxide. 3 , 6 , 5 , 2 . In particular, research on long-term effects and side effects is insufficient. Further research is needed that considers the skin type and lifestyle of the study participants.

Directions for Future Research

The following points need to be considered in future research on topical clindamycin and benzoyl peroxide. 3 , 6 , 5 , 2 .

  • Research on long-term effects and side effects
  • Research on people with different skin types and lifestyles
  • Research to optimize the concentration and frequency of use of the drug

Conclusion

Topical clindamycin and benzoyl peroxide are effective medications for acne treatment, but they also carry the risk of side effects. 6 , 2 . When using these medications, it is important to consult a dermatologist and understand the proper usage. 7 . If you experience any side effects, stop using the drug immediately and consult a dermatologist.

Literature analysis of 19 papers
Positive Content
17
Neutral Content
2
Negative Content
0
Article Type
4
1
2
8
19
3.

Management of Severe Acne Vulgaris With Topical Therapy.

Author: Stein GoldLinda, BaldwinHilary E, LinTina

Severe acne treatment

This study reviewed the available clinical evidence for the use of fixed combination topical therapies to treat severe acne.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Optimizing topical combination therapy for the treatment of acne vulgaris.

Author: ZeichnerJoshua A

Acne treatment
Faster results
Reduced inflammation
Burning
Erythema
Peeling
Skin irritation

This review discusses the use of combination therapy for acne. Topical retinoids and antimicrobials are commonly employed in combination to address multiple pathogenic factors and achieve quicker and more efficacious treatment outcomes than monotherapy. The review presents the latest data on two topical acne products that have demonstrated excellent efficacy and tolerability profiles and suggests the potential for their combination use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris.

Author: AkarsuSevgi, FetilEmel, YücelFiliz, GülEylem, GüneşAli T

Acne treatment efficacy
Faster treatment
Dryness

A combination of salicylic acid and clindamycin phosphate and benzoyl peroxide showed significantly better and faster results in reducing acne lesion counts compared to clindamycin phosphate and benzoyl peroxide alone, but it was associated with a higher frequency of mild to moderate dryness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

How patients experience and manage dryness and irritation from acne treatment.

Author: FeldmanSteven R, ChenDiana M

Improved adherence
Dryness
Skin irritation

Irritation to clindamycin-5% BPO is a common problem that reduces patients' use of the medication. Strategies to improve treatment include communication with patients on possible side effects, providing written instruction on how to manage irritation and dryness and consideration of alternative topical treatments and treatment regimens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

[Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid].

Author: WorretWolf-Ingo, FluhrJoachim W

Cost-effective
Treatment of acne
Bleaching
Drug-resistant bacteria
Irritation

Benzoyl peroxide (BPO) is a standard topical treatment for acne. It reduces anaerobic bacteria and is safe for use during pregnancy and lactation. Topical antibiotics such as erythromycin, clindamycin, and tetracycline are also effective for acne, but can lead to drug-resistant bacteria. Azelaic acid, with antibacterial and comedolytic effects, is a safe option for pregnant and lactating women.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

9.

[Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies].

Author: GollnickHarald P M, GraupeKlaus, ZaumseilRolf-Peter

Acne treatment

A new non-alcoholic hydrogel formulation containing 15% azelaic acid was clinically tested against two standard drugs--5% benzoyl peroxide (BPO) and 1% clindamycin.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

10.

Double-blind, randomized, vehicle-controlled clinical trial of once-daily benzoyl peroxide/clindamycin topical gel in the treatment of patients with moderate to severe rosacea.

Author: BrenemanDebra, SavinRonald, VandePolChristine, VamvakiasGeorge, LevySharon, LeydenJames

Rosacea treatment
Well tolerated

Topical application of a combination of 5% benzoyl peroxide and 1% clindamycin was effective and well tolerated in patients with moderate to severe rosacea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Topical antibiotic therapy: current status and future prospects.

Author: EadyE A, CoveJ H

Effective for infections
Reduced systemic side effects
Antibiotic resistance

Topical antibiotics are becoming increasingly popular for treating a variety of dermatoses. They offer advantages like reduced risk of systemic side effects and lower drug usage, but can contribute to antibiotic resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

[1 percent clindamycin phosphate solution versus 5 percent benzoyl peroxide gel in papulopustular acne].

Author: SchmidtJ B, NeumannR, FantaD, RaabW

Effective treatment for acne
Less side effects

Clindamycin phosphate and benzoyl peroxide were compared for their effectiveness in treating papulopustular acne. Both treatments showed comparable efficacy, but clindamycin phosphate was associated with significantly fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

13.

Comparison of topical clindamycin phosphate, benzoyl peroxide, and a combination of the two for the treatment of acne vulgaris.

Author: TuckerS B, TausendR, CochranR, FlanniganS A

Effective combination therapy
Improved acne
Improved acne symptoms
Reduced acne lesions
Cutaneous side effects
Itching (benzoyl peroxide)
Redness (benzoyl peroxide)
Scaling (benzoyl peroxide)
Skin irritation (benzoyl peroxide)

A study comparing topical clindamycin phosphate, benzoyl peroxide, and a combination of both for treating acne vulgaris found that the combination therapy was most effective in decreasing all types of acne lesions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

A systematic review and network meta-analysis of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris.

Author: MavranezouliIfigeneia, DalyCaitlin H, WeltonNicky J, DeshpandeShalmali, BergLaura, BromhamNathan, ArnoldStephanie, PhillippoDavid M, WilcockJane, XuJingyuan, RavenscroftJane C, WoodDamian, RafiqMohammed, FouLinyun, DworzynskiKatharina, HealyEugene

Improved acne
Reduced lesions
Side effects
Treatment discontinuation

Topical pharmacological treatment combinations, chemical peels, and photochemical therapy were most effective for mild-to-moderate acne. For moderate-to-severe acne, topical pharmacological treatment combinations, oral antibiotics combined with topical treatments, oral isotretinoin, and photodynamic therapy were most effective.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Light therapies for acne.

Author: BarbaricJelena, AbbottRachel, PosadzkiPawel, CarMate, GunnLaura H, LaytonAlison M, MajeedAzeem, CarJosip

Acne treatment

This abstract discusses the use of light therapies for acne vulgaris, a common skin problem. It highlights the potential benefits of light therapies as an alternative to oral and topical treatments, which can be limited due to ineffectiveness, inconvenience, or side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Novel vesicular and particulate drug delivery systems for topical treatment of acne.

Author: CastroGisele A, FerreiraLucas Am

Reduced acne side effects
Cutaneous irritation

Topical acne medications are effective but can cause skin irritation. This article discusses the use of novel drug delivery systems, such as vesicles and nanoparticles, to reduce the side effects of topical acne medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Systemic antibiotic therapy of acne vulgaris.

Author: OchsendorfFalk

Acne treatment

This article provides an overview of the use of systemic antibiotics for treating inflammatory acne vulgaris. The rationale for antibiotic use in acne is based on their effects on Propionibacterium acnes and their intrinsic anti-inflammatory properties. The article summarizes existing research on the efficacy and side effects of different antibiotics used for acne treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

An open study of Triphasil and Diane 50 in the treatment of acne.

Author: WishartJ M

Acne treatment
Hormonal changes

Both Triphasil, containing levonorgestrel, and Diane, containing cyproterone acetate, effectively reduced acne counts in 20 patients with similar acne severity. Diane produced more marked hormonal changes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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