Effects of clorazepate: A Synthesis of Findings from 20 Studies

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This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Major Research Findings

Clorazepate is a benzodiazepine drug used to treat anxiety disorders. Various studies have shown the efficacy and safety of clorazepate. For example, a study in 18 showed that it is effective for the treatment of alcohol withdrawal syndrome. In addition, a study in reported that clorazepate was as effective as clomethiazole, the standard treatment, in treating alcohol withdrawal syndrome, even in severe cases. Furthermore, a study in 17 revealed that clorazepate exhibited sustained anticonvulsant activity compared to diazepam.

Research in 12 and 7 revealed that clorazepate may cause side effects such as memory and attention impairments. A study in 19 reported that clorazepate can cause photosensitivity reactions.

Benefits and Risks

Benefits Summary

Clorazepate has been shown to be effective in treating anxiety disorders and alcohol withdrawal syndrome. Clorazepate has also been reported to show more sustained anticonvulsant effects than diazepam. Moreover, clorazepate is considered a relatively safe drug with fewer side effects such as memory and attention impairments compared to other benzodiazepines.

Risks Summary

Clorazepate may cause side effects such as memory and attention impairments and photosensitivity reactions. Clorazepate is also addictive and long-term use can lead to drug dependence. When taking clorazepate, follow your doctor's instructions and take it safely.

Comparison Across Studies

Commonalities

Many studies have shown that clorazepate is effective in treating anxiety disorders and alcohol withdrawal syndrome. Clorazepate has also been reported to show more sustained anticonvulsant effects than diazepam. These studies indicate that clorazepate is an effective drug for various applications.

Differences

There are differences in the results regarding the side effects of clorazepate between studies. For example, while a study in 12 showed that clorazepate may cause side effects such as memory and attention impairments, a study in 7 reported that clorazepate did not show drug effects on more complex cognitive function tests. These differences in research findings are thought to be due to differences in research methods and subjects.

Consistency and Contradictions in Findings

Research findings on the efficacy of clorazepate are generally consistent. However, there are contradictions in the research findings on side effects. These contradictions are thought to be due to differences in research methods and subjects. Further research to clarify the mechanism of side effects of clorazepate is expected to lead to the establishment of safer use.

Notes on Application to Real Life

While clorazepate is an effective drug for treating anxiety disorders and alcohol withdrawal syndrome, it is important to take it safely as there are risks of side effects. It is essential to follow your doctor's instructions. Also, clorazepate is addictive, so long-term use can lead to drug dependence. It is recommended to limit the use of clorazepate to the minimum necessary period as directed by your doctor.

Limitations of Current Research

There is still insufficient research on clorazepate. In particular, research on the side effects of clorazepate is limited. Further research is expected to clarify the safety of clorazepate.

Future Directions for Research

Research on the long-term effects of clorazepate is needed. Research on methods to reduce the side effects of clorazepate is also necessary. Further research is expected to establish a safe way to use clorazepate.

Conclusion

Clorazepate is an effective drug for treating anxiety disorders and alcohol withdrawal syndrome, but it is important to take it safely as there are risks of side effects. When taking clorazepate, consult your doctor thoroughly and find a treatment method that suits your situation.

Literature analysis of 20 papers
Positive Content
10
Neutral Content
3
Negative Content
6
Article Type
7
0
0
1
19
2.

Effects of clorazepate, diazepam, and oxazepam on a laboratory measurement of aggression in men.

Author: WeismanA M, BermanM E, TaylorS P

Tranquilization
Aggressive behavior

Diazepam, but not other benzodiazepines, increased aggressive behavior in healthy male volunteers. This finding highlights the need for caution when using benzodiazepines to manage potentially assaultive patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Effects of ethanol, caffeine, and clorazepate on hypertonic NaCl solution intake in rats.

Author: NadalR A, PallaresM A, FerreN S

Clorazepate and ethanol increase hypertonic saline intake in water-deprived rats, while caffeine decreases intake. These effects may reflect anxiolytic or anxiogenic properties.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

The effects of caffeine in the social interaction test and on exploration in rats: comparison with ethanol and clorazepate.

Author: NadalR.A., PallaresM.A., FerréN.S.

Enhanced social interaction

Caffeine enhances social interaction in rats, similar to standard anxiolytics. The effect is potentiated by repeated administration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

[Treatment of delirium tremens--a comparison between clomethiazole and clorazepate with reference to effectiveness and rate of side effects].

Author: CaspariD, WapplerM, BellaireW

Delirium tremens relief
Cardio-pulmonary complications

Clorazepate is an effective alternative to clomethiazol in treating delirium tremens. Both treatments were effective in decreasing symptoms, but clorazepate showed a significantly lower heart rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

7.

Effects of clorazepate dipotassium and placebo on psychomotor skills.

Author: MoodleyP, GolombokS, LaderM

Impaired attention
Impaired reaction time

Clorazepate dipotassium impaired attention and simple reaction time in healthy subjects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Lack of amnestic effects of clorazepate on geriatric recall.

Author: ScharfM B, HirschowitzJ, WoodsM, ScharfS

No memory impairment

Clorazepate did not impair memory in geriatric subjects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Effects of clorazepate on breathlessness and exercise tolerance in patients with chronic airflow obstruction.

Author: EimerM, CableT, GalP, RothenbergerL A, McCueJ D

Not tolerated at higher doses

Clorazepate did not benefit nonanxious patients with chronic lung disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Plasma concentrations and clinical effects after single oral doses of prazepam, clorazepate, and diazepam.

Author: ShaderR I, ParyR J, HarmatzJ S, AllisonS, LocniskarA, GreenblattD J

Anxiolytic effect
Fatigue
Feeling spacey

The absorption rate of benzodiazepines affects the intensity of their effects. Clorazepate and diazepam have faster absorption rates than prazepam, resulting in stronger effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

Effects of clorazepate, diazepam, lorazepam, and placebo on human memory.

Author: HealeyM, PickensR, MeischR, McKennaT

Impaired memory

Lorazepam significantly impaired word recall memory in healthy adults, while diazepam and clorazepate did not. Higher doses of lorazepam had a greater effect on memory.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Steady-state plasma desmethyldiazepam during long-term clorazepate use: effects of antacids.

Author: ShaderR I, CirauloD A, GreenblattD J, HarmatzJ S

Antacids did not alter steady-state plasma desmethyldiazepam concentrations in patients receiving clorazepate dipotassium.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Physiological and psychological effects of clorazepate in man.

Author: LaderM H, CurryS, BakerW J

None

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Pharmacopsychological investigations concerning the combined effects of dipotassium clorazepate and ethanol.

Author: StaakM, RaffG, NusserW

Impaired performance

Dipotassium clorazepate (DPC), a benzodiazepine, was found to slightly impair psychomotor performance when administered alone. When combined with ethanol, DPC significantly exacerbated the impairment in performance compared to ethanol alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Individual variations in the effects of flurazepam, clorazepate, L-dopa and thyrotropin-releasing hormone on REM sleep in man.

Author: NakazawaY, KotoriiT, HorikawaS, KotoriiM, OhshimaM, HasuzawaH

REM sleep suppression

The effects of flurazepam, clorazepate, L-dopa, and thyrotropin-releasing hormone (TRH) on REM sleep were investigated. Flurazepam significantly decreased REM sleep time, while clorazepate, L-dopa, and TRH had no significant effects. A negative correlation was observed between the decrease in REM sleep time during flurazepam and the increase in REM sleep time after REM sleep deprivation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Comparison of anticonvulsant effects of clorazepate dipotassium and diazepam. Four week anticonvulsant study in Rhesus monkeys.

Author: PlotnikoffN P, O'BrienG S

Anticonvulsant activity
Clorazepate efficacy
Limited data
Side effects

This study compared the anticonvulsant activity of clorazepate dipotassium and diazepam in Rhesus monkeys. Clorazepate exhibited sustained anticonvulsant activity over a longer period compared to diazepam, suggesting that clorazepate may be a more effective long-term anticonvulsant agent.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Benzodiazepine-induced photosensitivity reactions: A compilation of cases from literature review with Naranjo causality assessment.

Author: MominNoorulain, PhanPhuong, AliAshmal A, I AliHamed, SeegerChristina M, JosephMerlyn

None reported
Photosensitivity

Five benzodiazepines were identified as potential inducers of photosensitivity reactions, with five cases showing a definite association. Reporting to pharmacovigilance databases is crucial to identify other culprits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Vasorelaxant effects of benzodiazepines, non-benzodiazepine sedative-hypnotics, and tandospirone on isolated rat arteries.

Author: KagotaSatomi, MorikawaKana, IshidaHirotake, ChimotoJunko, Maruyama-FumotoKana, YamadaShizuo, ShinozukaKazumasa

Vasorelaxation

This study investigated the direct effects of benzodiazepines (BDZs) and non-BDZ sedative-hypnotics on blood vessels. It found that many of these drugs, including zolpidem and tandospirone, directly relax blood vessels, potentially contributing to their side effects such as low blood pressure.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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