Main Research Findings

Crisaborole topical ointment is a non-steroidal phosphodiesterase 4 (PDE4) inhibitor used to treat mild to moderate atopic dermatitis. 3 Seven clinical trials have been completed for atopic dermatitis, with the 2% strength appearing to be the most effective. 3 Itching was significantly reduced within a week. 3 Objective efficacy assessments in patients treated with crisaborole topical ointment were statistically significant compared to vehicle. 3

Colchicine is used for cardiovascular and inflammatory conditions, but it has been linked to varying degrees of myelosuppression. 2 A systematic review was conducted to explore the reported myelosuppressive events of colchicine. 2

Colchicine is an emerging treatment for cardiovascular diseases, however, concerns about side effects, particularly gastrointestinal, limit its use. 1 A meta-analysis of 21 randomized controlled trials involving 14,188 patients evaluated the reported side effects of colchicine for cardiovascular indications. 1

Reasons for Side Effects

Crisaborole topical ointment works by inhibiting PDE4, an enzyme that regulates cyclic AMP (cAMP) levels. 3 This action is less immunosuppressive than other pathways and doesn't thin the skin. 3 Inhibiting PDE4 disrupts the itch sensation (pruritus) which can break the itch-scratch cycle, a major issue for atopic dermatitis patients. 3

Common Side Effects

Crisaborole Topical Ointment

The most common side effects of crisaborole topical ointment are skin redness and rash. 3 These side effects are usually mild and resolve within a few days. 3

Colchicine

Colchicine can cause gastrointestinal side effects, including nausea, vomiting, abdominal pain, and diarrhea. 1 Colchicine can also cause myelosuppression. 2

Countermeasures for Side Effects

Crisaborole Topical Ointment

If you experience any side effects from crisaborole topical ointment, consult your doctor. 3 They may adjust your treatment plan or prescribe medication to help manage the side effects. 3

Colchicine

To reduce the risk of colchicine side effects, take it as prescribed by your doctor. 2 If you experience gastrointestinal side effects, talk to your doctor. 1 Before starting colchicine, discuss the risk of myelosuppression with your doctor. 2

Comparison of Studies

Commonalities of Studies

Both crisaborole topical ointment and colchicine are medications with anti-inflammatory properties. 3 2 However, both drugs carry different risks of side effects. 3 2

Differences in Studies

Crisaborole topical ointment has been shown to have fewer skin-thinning side effects. 3 Colchicine, on the other hand, has been reported to have a higher risk of myelosuppression. 2 Colchicine has also been reported to have a high risk of gastrointestinal side effects when used for cardiovascular conditions. 1

Cautions for Application in Real Life

Crisaborole topical ointment has been shown to be effective in treating mild to moderate atopic dermatitis. 3 However, it can cause side effects such as skin redness and rash. 3 It's crucial to follow your doctor's instructions and monitor for side effects closely when using crisaborole topical ointment. 3

Limitations of Current Research

More research is needed on the side effects of crisaborole topical ointment and colchicine. 3 2 1 There's still a lot we don't know about the long-term side effects and safety of these medications. 3 2 1

Future Research Directions

More research is required on the side effects of crisaborole topical ointment and colchicine. 3 2 1 Specifically, more research on the long-term side effects and safety of these drugs is needed. 3 2 1

Conclusion

Crisaborole topical ointment and colchicine are both medications with anti-inflammatory effects but have different side effect risks. 3 2 1 It's vital to follow your doctor's instructions and carefully monitor for side effects when using these medications. 3 2 1 More research on the long-term side effects and safety of these drugs is necessary. 3 2 1