Side Effects of crofelemer: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Main Research Findings

Crofelemer has shown to be effective in the treatment of secretory diarrhea in several studies. 4 Crofelemer is a novel antidiarrheal agent that works by targeting two channels in the gut that are responsible for fluid and chloride secretion. 4 Colchicine has been shown to be associated with different levels of myelosuppression. 2 Despite its expanded use in cardiovascular and inflammatory conditions, clinicians are concerned about its potential for myelosuppression. 2 SP-303 has shown to be safe and effective when taken orally for the symptomatic treatment of diarrhea in patients with AIDS. 5

Reasons for Side Effects

The side effects of crofelemer are thought to be due to its mechanism of action, which is to inhibit chloride and fluid secretion in the GI tract. 4 Studies have shown that colchicine may cause myelosuppression. 2

Common Side Effects

Gastrointestinal

Crofelemer was generally well tolerated with minimal GI adverse effects when given orally. 4 Colchicine can cause gastrointestinal side effects, especially diarrhea, nausea, and abdominal pain. 1

Hematologic

Colchicine can cause myelosuppression. 2

Side Effect Management

Gastrointestinal

GI side effects with crofelemer were usually mild and did not require treatment discontinuation. 4 There are several strategies to reduce GI side effects from colchicine, including dietary changes and medications. 1

Hematologic

Regular blood tests should be performed to minimize the risk of myelosuppression with colchicine. 2

Comparison Between Studies

Similarities

These studies suggest that crofelemer and colchicine may be effective in the treatment of diarrhea in a variety of settings. However, they also indicate that these drugs can cause side effects, such as GI side effects and myelosuppression. 4 2 5 3 1

Differences

These studies show that the frequency and severity of side effects with crofelemer and colchicine can vary between studies. 4 2 5 3 1

Considerations for Real-World Application

Crofelemer and colchicine are effective drugs for the treatment of diarrhea, but it is important to be aware of the risk of side effects. 4 2 5 3 1 When using these drugs, it is important to discuss the risks and benefits with your doctor. 4 2 5 3 1

Limitations of Current Research

Research on the side effects of crofelemer and colchicine is still limited. 4 2 5 3 1 Future research needs to evaluate the long-term safety and efficacy of these drugs. 4 2 5 3 1

Future Research Directions

Future research should aim to elucidate the mechanisms of side effects with crofelemer and colchicine and develop new methods to reduce these side effects. 4 2 5 3 1

Conclusion

Crofelemer and colchicine are effective drugs for the treatment of diarrhea, but it is important to remember that they have the potential to cause side effects. 4 2 5 3 1 When using these drugs, it is important to discuss the risks and benefits with your doctor. 4 2 5 3 1

Literature analysis of 5 papers
Positive Content
5
Neutral Content
0
Negative Content
0
Article Type
1
1
1
2
5
2.

Examining the Characteristics of Colchicine-Induced Myelosuppression in Clinical Cases: A Systematic Review.

Author: SimBernice L, SimBeatrice Z, TunbridgeMatthew, LiewDavid F L, RobinsonPhilip C

Cardiovascular treatment
Inflammation treatment
Myelosuppression

Colchicine, a drug used for various conditions, can cause myelosuppression, necessitating careful monitoring of blood cell counts in patients receiving colchicine.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Crofelemer for the symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on anti-retroviral therapy.

Author: CastroJose G, Chin-BeckfordNafeesa

Diarrhea relief

Chronic diarrhea is a common concern in patients with HIV, even with antiretroviral therapy. This review discusses crofelemer, a newly approved medication for the symptomatic relief of non-infectious diarrhea in adults with HIV. Crofelemer has a novel mechanism of action and can improve quality of life and adherence to antiretroviral therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Crofelemer for the treatment of secretory diarrhea.

Author: CottreauJessica, TuckerAnne, CrutchleyRustin, GareyKevin W

Secretory diarrhea treatment
Gastrointestinal effects

Crofelemer is a new antidiarrheal agent that targets two distinct channels in the GI tract. It is effective in secretory diarrhea, such as cholera, travelers' diarrhea and acute infectious diarrhea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

A double blind, randomized, placebo-controlled phase II study to assess the safety and efficacy of orally administered SP-303 for the symptomatic treatment of diarrhea in patients with AIDS.

Author: HolodniyM, KochJ, MistalM, SchmidtJ M, KhandwalaA, PenningtonJ E, PorterS B

Reduces stool weight and frequency
Safe
Well-tolerated

SP-303 is safe and well tolerated in patients with AIDS and diarrhea, showing a potential for reducing stool weight and frequency.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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