Effects of cyclobenzaprine: A Synthesis of Findings from 16 Studies

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Original Abstract of the Article

Major Research Findings

Cyclobenzaprine is a muscle relaxant commonly used to relieve muscle tension and pain. 10 , 16 It is prescribed for conditions such as back pain, neck pain, and muscle spasms. 15 Studies have investigated the effects of cyclobenzaprine, finding that it can improve sleep quality and reduce pain. 5 , 2 Additionally, cyclobenzaprine has been shown to inhibit the activity of nerve cells in specific brain regions, leading to muscle relaxation. , Furthermore, some research suggests that cyclobenzaprine may have fewer negative cognitive effects compared to other muscle relaxants, making it potentially safe for elderly individuals. 4 However, cyclobenzaprine can also cause side effects such as nausea, drowsiness, and dry mouth. 1 , 8 Additionally, it can interact with other medications. 14 Therefore, it is crucial to follow your doctor's instructions when using cyclobenzaprine.

Benefits and Risks

Benefit Summary

Cyclobenzaprine may relieve muscle tension and pain. It may also improve sleep quality. Additionally, cyclobenzaprine may have fewer negative cognitive effects compared to other muscle relaxants, making it potentially safe for elderly individuals.

Risk Summary

Cyclobenzaprine can cause side effects such as nausea, drowsiness, and dry mouth. It can also interact with other medications. Furthermore, cyclobenzaprine may have stronger effects in elderly individuals and those with impaired liver function. Therefore, it is crucial to follow your doctor's instructions when using cyclobenzaprine.

Comparison Between Studies

Commonalities

Many studies indicate that cyclobenzaprine can relieve muscle tension and pain. Additionally, studies suggest that cyclobenzaprine can improve sleep quality. These studies produce consistent results showing that cyclobenzaprine can be effective in relieving muscle tension and pain.

Differences

Studies regarding the side effects of cyclobenzaprine show varying results. Some studies report side effects such as nausea and drowsiness, while others do not. These studies highlight inconsistencies regarding the reported side effects of cyclobenzaprine.

Consistency and Contradictions in Results

Research on cyclobenzaprine suggests its effectiveness in relieving muscle tension and pain, as well as improving sleep quality. However, studies on side effects show contradictions, with some reporting nausea, drowsiness, and other side effects, while others do not. This indicates consistency in its effectiveness but inconsistency regarding its side effects.

Points to Consider When Applying Results to Real Life

Cyclobenzaprine may be helpful in relieving muscle tension and pain. However, it can also cause side effects such as nausea and drowsiness. Additionally, it can interact with other medications. Therefore, it is crucial to follow your doctor's instructions when using cyclobenzaprine. It's particularly important to exercise caution in elderly individuals and those with impaired liver function, as cyclobenzaprine's effects may be stronger in these groups.

Limitations of Current Research

Research on cyclobenzaprine exhibits inconsistencies regarding side effects. Additionally, some studies have small sample sizes, potentially limiting the generalizability of their findings. Furthermore, there is a lack of research on the long-term effects of cyclobenzaprine.

Directions for Future Research

Further research on the side effects of cyclobenzaprine is needed. Research on the long-term effects of cyclobenzaprine is also important. Additionally, research aimed at enhancing the effectiveness of cyclobenzaprine is crucial.

Conclusion

Cyclobenzaprine may be effective in relieving muscle tension and pain. However, it can also cause side effects such as nausea and drowsiness. Therefore, it is crucial to follow your doctor's instructions when using cyclobenzaprine. Future research is expected to provide further clarity regarding the safety and effectiveness of cyclobenzaprine.

Literature analysis of 16 papers
Positive Content
6
Neutral Content
3
Negative Content
7
Article Type
4
0
0
1
15
1.

Neuropsychiatric side effects of cyclobenzaprine.

Author: ShprecherDavid, SloanColgan T, SederholmBenson

Serotonin syndrome

This case report describes a patient who experienced symptoms of delirium and hyperkinetic movement disorders after initiating treatment with cyclobenzaprine and oxycodone. These symptoms are consistent with serotonin syndrome, a potential side effect of cyclobenzaprine. The case reminds clinicians to monitor for serotonin syndrome when using cyclobenzaprine, especially when adding other medications that can affect serotonin levels.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study.

Author: MoldofskyHarvey, HarrisHerbert W, ArchambaultW Tad, KwongTerence, LedermanSeth

Cyclobenzaprine FM

Bedtime very low dose cyclobenzaprine (CBP) treatment improved core fibromyalgia (FM) symptoms, including pain, tenderness, fatigue, and mood. Nights with increased restorative sleep may provide a biomarker for assessing treatment effects on nonrestorative sleep.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Cyclobenzaprine pharmacokinetics, including the effects of age, gender, and hepatic insufficiency.

Author: WinchellGregory A, KingJoyce D, Chavez-EngCynthia M, ConstanzerMarvin L, KornScott H

Muscle relaxant

This study examines the pharmacokinetics and bioavailability of cyclobenzaprine, a muscle relaxant, exploring the effects of age, gender, and hepatic insufficiency on drug levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Lack of sedative and cognitive effects of diphenhydramine and cyclobenzaprine in elderly volunteers.

Author: LinesC, TraubM, RaskinS, MantT, ReinesS

Cognitive impairment
Drowsiness

This study found that diphenhydramine and cyclobenzaprine did not cause drowsiness or affect cognitive function in elderly volunteers. This suggests that elderly individuals may be less sensitive to the central nervous system effects of these drugs than younger people.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia.

Author: ReynoldsW J, MoldofskyH, SaskinP, LueF A

Increased sleep time
Reduced fatigue

Cyclobenzaprine, a muscle relaxant, decreased evening fatigue and increased total sleep time in 9 patients with fibromyalgia. However, it did not significantly affect pain, mood, or sleep physiology.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Cyclobenzaprine effects on locus coeruleus cells in tissue slice.

Author: LangI M, BarnesC D

Reduced locus coeruleus firing
None reported

Cyclobenzaprine had different effects on the firing rate of locus coeruleus neurons depending on the initial discharge rate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Baclofen and the risk of fall and fracture in older adults: A real-world cohort study.

Author: HwangY Joseph, ChangAlex R, BrotmanDaniel J, InkerLesley A, GramsMorgan E, ShinJung-Im

Fall risk
Fracture risk

This study aimed to assess the risk of falls and fractures associated with oral baclofen compared to other muscle relaxants (tizanidine or cyclobenzaprine) in older adults.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Serotonin syndrome from combination hydrocodone and cyclobenzaprine in a patient with cerebral palsy.

Author: BansalVishal, ArankeMayank, VuPeter, JavedSaba

Serotonin syndrome

A 58-year-old female with cerebral palsy, metastatic malignancy, and mood disorder presented with acute-on-chronic pain and signs of serotonin syndrome (SS). It was suspected that additional doses of hydrocodone and cyclobenzaprine contributed to moderate SS. This case highlights the importance of considering comorbidities and unusual pain medications that may predispose patients to SS.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Baclofen and the Risk of Encephalopathy: A Real-World, Active-Comparator Cohort Study.

Author: HwangY Joseph, ChangAlex R, BrotmanDaniel J, InkerLesley A, GramsMorgan E, ShinJung-Im

Encephalopathy

This study compared the risk of encephalopathy associated with oral baclofen to tizanidine and cyclobenzaprine. The study found that baclofen was associated with a significantly higher risk of encephalopathy compared to both tizanidine and cyclobenzaprine, as early as 30 days and persisting through the first year of treatment. These findings suggest that healthcare providers should carefully consider the risks and benefits of baclofen when prescribing it for muscle relaxation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Postoperative Use of the Muscle Relaxants Baclofen and/or Cyclobenzaprine Associated With an Increased Risk of Delirium Following Lumbar Fusion.

Author: PerezEli A, RayEmanuel, GoldColin J, ParkBrian J, PiscopoAnthony, CarnahanRyan M, BanksMatthew, SandersRobert D, OlingerCatherine R, MuellerRashmi N, WoodroffeRoyce W

Delirium

Postoperative use of muscle relaxants in older adults undergoing lumbar fusion surgery was associated with an increased risk of delirium. The incidence of delirium was 17.6% in patients who received muscle relaxants compared to 7.9% in those who did not. Multivariate analysis confirmed a 2.00 times higher risk of delirium in the muscle relaxant group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Acute Dystonia With Rhabdomyolysis Induced by Paliperidone Palmitate: A Rare Adverse Effect.

Author: AllenaNishant, DoppalapudiSai, KhanalSneha, TankSteven, NasrRabih

Extrapyramidal side effects
Rhabdomyolysis

This report describes a case of rhabdomyolysis following a long-acting injectable (LAI) paliperidone palmitate injection, highlighting the importance of early diagnosis and treatment of extrapyramidal side effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

14.

Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants.

Author: KhanNazleen F, BykovKatsiaryna, BarnettMichael L, GlynnRobert J, VineSeanna M, GagneJoshua J

Opioid overdose risk

This study compared the risk of opioid overdose in patients on long-term opioid therapy who concurrently initiate skeletal muscle relaxants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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