Effects of danazol: A Synthesis of Findings from 24 Studies

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Original Abstract of the Article

Major Research Findings

Danazol, a synthetic androgen derivative, has been studied for its effects on various physiological and pathological conditions. 11 found that danazol degrades in alkaline solutions through base-catalyzed proton abstraction, not an oxidative mechanism. Its stability was shown to be dependent on pH, buffer concentration, buffer species, and temperature. 22 investigated danazol's effects on mammary tumors in rats, revealing its suppressive effects on cell viability and DNA synthesis, likely due to dysfunction in the hypothalamic-pituitary-gonadal axis. Danazol has also been studied in relation to endometriosis. 24 compared danazol's efficacy to nafarelin acetate in treating endometriosis-related pain, demonstrating its effectiveness. Another study, 16 , suggested potential benefits of danazol in preventing endometriosis recurrence after surgery. Conversely, 14 indicated that danazol may prevent estrogen-related endometrial carcinogenesis in mice. Further research, 1 , showed that danazol has different effects on hematopoiesis compared to stanozolol in a murine model of immune-mediated bone marrow failure, with danazol showing faster platelet recovery and stanozolol demonstrating better erythrocyte recovery. 6 highlighted that danazol can negatively affect lipid profiles and coagulation parameters, potentially influencing the progression of atherosclerosis.

Benefits and Risks

Benefit Summary

Danazol has shown potential in treating conditions like endometriosis and immune-mediated bone marrow failure. It may also inhibit the growth and survival of mammary tumors. However, its effectiveness varies across individuals.

Risk Summary

Danazol can negatively affect lipid profiles, potentially increasing the risk of atherosclerosis progression. Other adverse effects may include liver abnormalities, cardiovascular issues, mental changes, and masculinization. Careful consideration of risks and benefits is crucial before using danazol, and consultation with a doctor is essential.

Comparison between Studies

Commonalities

These studies demonstrate the diverse effects of danazol on physiological and pathological conditions, highlighting its potential for treating conditions such as endometriosis, mammary tumors, and immune-mediated bone marrow failure. They also suggest that danazol can influence hormonal balance, especially affecting female hormone levels, due to its inhibitory effects on gonadal hormone secretion.

Differences

The studies present varying degrees of danazol's efficacy, mechanisms of action, and side effects. For instance, 11 reports danazol's instability in alkaline solutions, a detail not discussed in other research. The route of administration and dosage can also affect danazol's effectiveness and adverse effects. Individual genetic background and other factors further contribute to variation in responses. Therefore, tailored treatment plans and consultation with a doctor are crucial when considering danazol for individual patients.

Consistency and Contradictions in Results

The research findings on danazol's effects present both consistency and contradictions. While numerous studies indicate its effectiveness in treating endometriosis, 16 suggests its potential for preventing post-surgery recurrence but does not provide conclusive evidence. 1 demonstrates contrasting effects on hematopoiesis compared to stanozolol in a murine model, raising concerns about potential discrepancies between animal and human clinical trial findings. The effectiveness of danazol can vary significantly based on the route of administration, dosage, and patient condition. To accurately assess danazol's effects, further research is essential.

Considerations for Applying Results in Real-Life

While danazol is used for treating conditions like endometriosis and immune-mediated bone marrow failure, it carries various potential side effects such as liver abnormalities, cardiovascular issues, mental changes, and masculinization. Additionally, it can negatively impact lipid profiles and potentially accelerate atherosclerosis progression. Consultation with a doctor is essential before using danazol, and careful consideration of risks and benefits is crucial. Individuals with pre-existing liver issues, cardiovascular diseases, mental health conditions, pregnancy, or breastfeeding should consult their doctor before taking danazol.

Limitations of Current Research

Research on danazol still requires substantial development, particularly concerning its long-term effects and safety. The influence of individual genetic background and other factors on danazol's effectiveness remains a significant area for further exploration. To accurately assess danazol's effects, further research is essential.

Directions for Future Research

To gain a deeper understanding of danazol's effects, further research is needed in the following areas: 1. Long-term studies to evaluate danazol's efficacy and safety 2. Research examining the influence of genetic backgrounds and other factors on danazol's effectiveness 3. Studies exploring the combined effects of danazol and other treatment methods 4. Research focused on minimizing danazol's side effects

Conclusion

Danazol, a synthetic androgen derivative, has demonstrated effects on various physiological and pathological conditions. While potentially beneficial in treating conditions like endometriosis and immune-mediated bone marrow failure, it also presents certain risks, including negative impacts on lipid profiles and potential for adverse effects. Consultation with a doctor is essential before using danazol, and careful consideration of risks and benefits is vital. To gain a more comprehensive understanding of danazol's effects, further research is crucial.

Literature analysis of 24 papers
Positive Content
20
Neutral Content
3
Negative Content
1
Article Type
4
0
0
0
24
5.

[Comparison of the effects of sanjie zhentong capsule and danazol on the endometriosis rats].

Author: ZouJie, GuanZheng, ZhangWei-yi

Endometriosis treatment

Sanjie zhentong capsule (SZC) and danazol both effectively inhibited endometriosis growth in rats, but SZC showed significantly better effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

6.

Effects of short-term and long-term danazol treatment on lipoproteins, coagulation, and progression of atherosclerosis: two clinical trials in healthy volunteers and patients with hereditary angioedema.

Author: BirjmohunRakesh S, Kees HovinghG, StroesErik S G, HofstraJorit J, Dallinga-ThieGeesje M, MeijersJoost C M, KasteleinJohn J P, LeviMarcel

Adverse coagulation
Decreases HDL-C

Danazol, a synthetic androgen, is used for prophylaxis in patients with hereditary angioedema. However, it can decrease HDL-C levels and negatively affect coagulation parameters, potentially increasing the risk of atherothrombosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Effects of danazol on endothelial cell function and angiogenesis.

Author: ThomasGregory W, RaelLeonard T, ShimonkevitzRick, CurtisC Gerald, Bar-OrRaphael, Bar-OrDavid

Angiogenesis inhibition

Danazol, an androgen-like synthetic steroid, interfered with endothelial cell proliferation and tube formation, but not invasion, in vitro. These findings may help elucidate the mode of action for danazol in vivo.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedema.

Author: SzéplakiGábor, VargaLilian, ValentinSzilvia, KleiberMónika, KarádiIstván, RomicsLászló, FüstGeorge, FarkasHenriette

HAE treatment

Danazol, an attenuated androgen, is used for long-term prophylaxis of hereditary angioedema (HAE).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Comparison of the effects of leuprorelin acetate and danazol treatments on serum CA-125 levels in women with endometriosis.

Author: MatalliotakisIoannis M, AriciAydin, GoumenouAnastasia G, KatassosTheodoros, KarkavitsasNicolas, KoumantakisEvgenios E

Endometriosis treatment

Both danazol and leuprorelin acetate are effective in treating endometriosis. Danazol has a longer-lasting effect on CA-125 levels compared to leuprorelin acetate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Synergistic effects of danazol and mifepristone on the cytotoxicity of UCN-01 in hormone-responsive breast cancer cells.

Author: YokoyamaY, ShinoharaA, TakahashiY, WanX, TakahashiS, NiwaK, TamayaT

Antitumor activity

UCN-01 is an antitumor agent that inhibits protein kinases. This study suggests that sex steroid agonists/antagonists may modulate the cytotoxicity of UCN-01 by interacting with PKC signaling.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Preventive effects of danazol on endometrial carcinogenesis in mice.

Author: NiwaK, HashimotoM, MorishitaS, YokoyamaY, LianZ, TagamiK, MoriH, TamayaT

Prevent estrogen-related endometrial carcinogenesis

Danazol was found to be effective in reducing the incidence of endometrial hyperplasia in mice, which is a precancerous condition. This effect was attributed to the suppression of estrogen-induced c-fos/jun expression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Danazol effects on human endometrial cells in vitro.

Author: TanakaT, UmesakiN, ChenH, MizunoK, OgitaS

Endometriosis treatment

Danazol, a drug used for endometriosis, may not directly inhibit endometrial cell growth but rather regulate it.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Effects of 3 month therapy with danazol after laparoscopic surgery for stage III/IV endometriosis: a randomized study.

Author: BianchiS, BusaccaM, AgnoliB, CandianiM, CaliaC, VignaliM

Danazol, a synthetic androgen, was compared to expectant management after laparoscopic conservative surgery for stage III-IV endometriosis. This study found no significant advantage of danazol therapy over expectant management.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

The effects of danazol after endometrial resection--results of a randomized, placebo-controlled, double-blind study.

Author: ErianM M, ThomasI L, BuckR J, LewinM W, CoglanM, BattistuttaD

Amenorrhea
Endometrial resection

Danazol treatment after hysteroscopic endometrial resection significantly increased the rate of amenorrhea in patients receiving high-dose (600 mg daily) treatment. A similar trend was observed with low-dose (200 mg daily) treatment. This finding suggests that danazol may be a useful treatment option for menorrhagia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Acquired hypoprothrombinemia: effects of danazol treatment.

Author: WilliamsS, LinardicC, WilsonO, CompP, GralnickH R

Acquired factor II deficiency treatment
Bleeding treatment
Hemorrhagic diathesis

Danazol was effective in treating acquired factor II deficiency associated with lupus anticoagulant in a patient with discoid lupus erythematosis. Danazol did not affect the binding of immunoglobulin to factor II but increased factor II levels by increasing its synthesis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164,384, danazol, and promegestone (R-5020).

Author: NguyenB L, ChetriteG, PasqualiniJ R

Breast cancer treatment

The interconversion of estrone (E1) and estradiol (E2) is different in hormone-dependent and -independent breast cancer cells. Hormone-dependent cells tend to convert E1 to E2, while hormone-independent cells convert E2 to E1.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Effects of danazol on proliferation and viability of 7,12-dimethylbenz(a)anthracene-induced mammary tumours in rats.

Author: YoshimuraS, SakamotoS, KudoH, SuzukiS, SassaS, MatsubaraM, NagasawaH

Cancer treatment

Danazol, a synthetic steroid, suppressed cellular viability and DNA synthesis in mammary tumors in rats, possibly due to its effects on the hypothalamo-hypophysial-gonadal axis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Effects of danazol on thrombopoiesis in rats.

Author: SuzukiS, KudoH, NakayamaT, KuwaK, SugiuraY, LiuL, SakamotoS

Does not induce thrombosis

Danazol, a synthetic analog of ethinyltestosterone, does not increase megakaryocyte or thrombocyte counts in normal rats. This suggests that Danazol is unlikely to induce thrombosis with thrombocytosis in humans and animals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Pain of endometriosis: effects of nafarelin and danazol therapy.

Author: AdamsonG D, KweiL, EdgrenR A

Danazol endometriosis efficacy
Nafarelin endometriosis efficacy

Nafarelin acetate and danazol both significantly relieved dysmenorrhea, dyspareunia, and pelvic pain in women with endometriosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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