Effective treatment of dehydration: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Major Research Findings

Osmotic dehydration of olives prior to brining led to vigorous lactic acid processes as indicated by the obtained values of pH (3.7-4.1) and acidity (0.7-0.8%) regardless of the amount of MSG used. However, in non-osmotically dehydrated olives, the highest substitution level of MSG resulted in a final pH (4.5) that was beyond specification for this type of olives. 12

Oral rehydration therapy is used to treat dehydration caused by diarrhea. However, the rehydration solution does not reduce stool loss or length of illness. A solution able to do this may lessen the use of ineffective diarrhea treatments as well as improve morbidity and mortality related to diarrhea. 1

Excess fluid administration and dehydration treatment in a canine model of septic shock affected venous return.

Short-term treatment with empagliflozin resulted in dehydration and cardiac arrest in an elderly patient with specific complications. 4

The effects of osmotic dehydration (OD) treatment on volatile compound (myristicin) content and the antioxidant capacity of nutmeg (Myristica fragrans) were studied. Treatment of nutmeg with OD at 80% sugar concentration for 3 h is preferable, resulting in an acceptable level of myristicin and high antioxidants. 9

Vocal fold dehydration induced by dryness can reduce the stability of voice; such decreased voice stability can be improved by atomizing inhalation therapy; without proper treatment, voice stability caused by vocal fold dehydration cannot heal spontaneously; of three atomizing agents namely, IS, HS and SW, IS had the best treatment effect for decreased voice stability caused by vocal fold dehydration. 8

Oral rehydration therapy is cost-effective compared to intravenous rehydration for acute gastroenteritis without severe dehydration treatment. 7

The World Health Organization (WHO) rehydration management guidelines (Plan C) for children with acute gastroenteritis (AGE) and severe dehydration are widely practiced in resource-poor settings, yet have never been formally evaluated in a clinical trial. 10

Treatment Summary

Osmotic dehydration of olives prior to brining led to vigorous lactic acid processes as indicated by the obtained values of pH (3.7-4.1) and acidity (0.7-0.8%) regardless of the amount of MSG used. 12

Oral rehydration therapy is used to treat dehydration caused by diarrhea. 1 However, there is limited evidence to suggest that intravenous rehydration therapy is more effective than oral rehydration therapy in treating dehydration due to gastroenteritis. 2 The ORT group did have a higher risk of paralytic ileus, and the IVT group was exposed to risks of intravenous therapy. 2

In animal models of endolymphatic hydrops, dehydration treatment was effective in restoring hearing. 5

Careful assessment of dehydration and preventive water intake is recommended in elderly patients and those with neurological deficits, especially when receiving empagliflozin. 4

Benefits and Risks

Benefit Summary

Osmotic dehydration of olives prior to brining led to vigorous lactic acid processes as indicated by the obtained values of pH (3.7-4.1) and acidity (0.7-0.8%) regardless of the amount of MSG used. 12

Oral rehydration therapy is used to treat dehydration caused by diarrhea. 1 Oral rehydration therapy tended to have shorter hospital stays compared to intravenous rehydration therapy. 2

In animal models of endolymphatic hydrops, dehydration treatment was effective in restoring hearing. 5

Risk Summary

In non-osmotically dehydrated olives, the highest substitution level of MSG resulted in a final pH (4.5) that was beyond specification for this type of olives. 12

The ORT group did have a higher risk of paralytic ileus, and the IVT group was exposed to risks of intravenous therapy. 2

The effectiveness of dehydration treatment was limited in severe cases of endolymphatic hydrops. 5

Comparison of Studies

Commonalities of Studies

Several studies focus on the treatment of dehydration. 1 2 7 These studies emphasize that dehydration is a serious problem and requires effective treatment.

Differences of Studies

The subjects and methods vary, and each study differs in terms of the cause of dehydration, treatment methods, and assessment methods. For example, the study on osmotic dehydration of olives examined the effect on lactic acid production during fermentation. 12 On the other hand, studies on diarrhea-induced dehydration compared the effectiveness of oral rehydration therapy and intravenous rehydration therapy. 2 Furthermore, animal models of endolymphatic hydrops investigated the effects of dehydration treatment. 5

Consistency and Contradictions of Findings

Oral rehydration therapy has been shown to be effective in treating dehydration caused by diarrhea, but it does not reduce stool loss or shorten the duration of illness. 1 However, studies comparing the effectiveness of oral rehydration therapy and intravenous rehydration therapy may show inconsistent results. 2 This may be due to differences in study subjects and methods.

Application to Real Life

Dehydration, especially in children and older adults, can become serious, so it's crucial to address it promptly. If you experience symptoms of dehydration, consult a doctor. Also, it's vital to stay adequately hydrated and prevent dehydration in everyday life.

Limitations of Current Research

Research on dehydration treatment is still not comprehensive. In particular, studies on the optimal treatment methods under specific conditions are lacking. Moreover, studies on the long-term effects of dehydration and the cost-effectiveness of different treatment methods are also insufficient.

Future Research Directions

Further research on dehydration treatment methods is necessary. Studies on the optimal treatment methods under specific conditions, as well as the long-term effects of dehydration and the cost-effectiveness of different treatment methods are in demand. Research on dehydration prevention is also crucial.

Conclusion

Dehydration can cause serious health problems. By seeking appropriate treatment, you can prevent dehydration from becoming severe. If you experience symptoms of dehydration, consult a doctor. Additionally, staying adequately hydrated and preventing dehydration in everyday life is essential.

List of Treatments

  • Oral rehydration therapy
  • Intravenous rehydration therapy
  • Osmotic dehydration
Literature analysis of 13 papers
Positive Content
10
Neutral Content
2
Negative Content
1
Article Type
1
1
3
4
11
1.

Rice-based oral rehydration solution for treating diarrhoea.

Author: FontaineO, GoreS M, PierceN F

While oral rehydration therapy helps replace lost fluids during diarrhea, it doesn't reduce the amount of stool or the duration of illness. A solution that could achieve these effects could decrease the use of ineffective treatments and improve health outcomes associated with diarrhea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Oral versus intravenous rehydration for treating dehydration due to gastroenteritis in children.

Author: HartlingL, BellemareS, WiebeN, RussellK, KlassenT P, CraigW

Shorter hospital stays
Paralytic ileus
Treatment failure

Oral rehydration therapy (ORT) was associated with a higher risk of paralytic ileus compared to intravenous rehydration therapy (IVT). However, IVT is associated with risks of intravenous therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

WITHDRAWN: Rice-based oral rehydration solution for treating diarrhoea.

Author: FontaineO, GoreS M, PierceN F

While oral rehydration therapy helps replace lost fluids during diarrhea, it doesn't reduce the amount of stool or the duration of illness. A solution that could achieve these effects could decrease the use of ineffective treatments and improve health outcomes associated with diarrhea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Short-Term Treatment with Empagliflozin Resulted in Dehydration and Cardiac Arrest in an Elderly Patient with Specific Complications: A Case Report and Literature Review.

Author: SupakulSopak, NishikawaYurika, TeramuraMasanori, TakaseTetsuro

Dehydration
Empagliflozin

This case study describes a patient with diabetes mellitus and heart failure who experienced severe dehydration and cardiac arrest after initiating empagliflozin treatment. The case highlights the importance of careful monitoring for dehydration, particularly in elderly patients and those with neurological deficits, especially when receiving empagliflozin.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs.

Author: WangShu-Qi, LiChen-Long, XuJing-Qi, ChenLi-Li, XieYou-Zhou, DaiPei-Dong, RenLiu-Jie, YaoWen-Juan, ZhangTian-Yu

Hearing restoration
Limited dehydration efficacy
SNHL

Endolymphatic hydrops (EH) caused hearing loss by increasing cochlear impedance, and mannitol dehydration restored hearing in early-stage EH models. However, sensorineural hearing loss (SNHL) occurred in severe EH models, limiting the effectiveness of dehydration therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Comparison of electrical impedance tomography and intracranial pressure during dehydration treatment of cerebral edema.

Author: YangBin, LiBing, XuCanhua, HuShijie, DaiMeng, XiaJunying, LuoPeng, ShiXuetao, ZhaoZhanqi, DongXiuzhen, FeiZhou, FuFeng

Cerebral edema monitoring

Cerebral edema after brain injury can be life-threatening if not detected and treated promptly. This study investigates the potential of electrical impedance tomography (EIT) as a non-invasive imaging tool for monitoring cerebral edema development. The findings indicate that EIT correlates well with intracranial pressure (ICP) measurements, suggesting that EIT could provide a valuable real-time tool for early identification of cerebral edema.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Cost-effectiveness analysis of oral rehydration therapy compared to intravenous rehydration for acute gastroenteritis without severe dehydration treatment.

Author: MoseguiGabriela G, ViannaCid M, RodriguesMarcus S, VallePaula M, SilvaFrances V

Cost-effective diarrhea treatment

This study aimed to assess the cost-effectiveness of different treatment options for diarrhea in children with acute gastroenteritis and non-severe dehydration. Diarrhea is a major health problem, particularly in children under 5 years of age.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Impact of Vocal Fold Dehydration on Vocal Function and Its Treatment.

Author: ZouZhe-Fei, ChenWei, LiWei, YuanKun

Improved voice stability

Vocal fold dehydration due to dryness can significantly decrease voice stability. This study found that atomizing inhalation therapy, particularly with 0.9% normal saline, effectively improves voice stability in patients with vocal fold dehydration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

A Novel Practical Equation for Treatment of Emergent Hypernatremia and Dehydration Phase in Infants.

Author: GhaffarySaba, MoghaddasAzadeh, DianatkhahMehrnoush

Adjustable rehydration rate
Severe cerebral damages

This study suggests a practical equation to determine the amount of fluid that should be administered to neonates and infants with hypernatremia. The equation considers changes in serum Na, total body water, and infusate Na.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

13.

Identifying early dehydration risk with home-based sensors during radiation treatment: a feasibility study on patients with head and neck cancer.

Author: PetersonSusan K, ShinnEileen H, Basen-EngquistKaren, Demark-WahnefriedWendy, ProkhorovAlexander V, BaruChaitanya, KruegerIngolf H, FarcasEmilia, RiosPhilip, GardenAdam S, BeadleBeth M, LinKai, YanYan, MartchStephanie L, PatrickKevin

Early dehydration detection

Remote monitoring systems can enhance cancer care by allowing for early identification of health issues outside the clinic setting. This study evaluates the feasibility of using CYCORE, a software-based cyberinfrastructure, for early at-home identification of dehydration risk in head and neck cancer patients undergoing radiation therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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