Side Effects of demeclocycline: A Synthesis of Findings from 17 Studies

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Original Abstract of the Article

Major research findings

Demeclocycline is a medication used to treat the syndrome of inappropriate antidiuretic hormone secretion (SIADH), a condition where the body retains too much water, leading to low sodium levels in the blood. 13 、 17 、 3 、 16

Demeclocycline works by blocking the action of antidiuretic hormone (ADH), which helps the body retain water. By blocking ADH, demeclocycline increases the excretion of water, helping to restore normal sodium levels. 13 、 3 、 16

Reasons for side effects

Demeclocycline can cause side effects due to its effect on the kidneys. It inhibits the reabsorption of water in the kidneys, leading to increased water excretion. This can disrupt the body's electrolyte balance and potentially cause problems. 9 、 8

Common side effects

Renal dysfunction

Demeclocycline can affect the kidneys and cause renal dysfunction. This is a potential side effect that needs to be monitored closely. 9 、 8

Photosensitivity

Demeclocycline can make your skin more sensitive to sunlight, leading to sunburn or other skin reactions. It's crucial to protect your skin from the sun while taking this medication. 12

Gastrointestinal symptoms

Demeclocycline can cause gastrointestinal symptoms such as nausea, vomiting, or diarrhea. These symptoms are usually mild and may resolve on their own, but if they persist or worsen, it's important to consult a doctor. 13

Other side effects

Demeclocycline can also potentially affect the heart, thyroid, and central nervous system. If you experience any unusual symptoms, it's essential to seek medical attention. 13

Countermeasures for side effects

Renal dysfunction

To reduce the risk of renal dysfunction, regular kidney function tests are recommended, and the dosage may need to be adjusted based on the results. 9 、 8

Photosensitivity

To prevent photosensitivity, it's essential to protect your skin from the sun. Wear sunscreen, a hat, and protective clothing when outdoors, particularly during peak sun hours. 12

Gastrointestinal symptoms

If you experience gastrointestinal symptoms, it's important to consult with your doctor. They can help determine the cause and provide appropriate treatment, if necessary. 13

Other side effects

If you experience any other side effects, consult your doctor immediately. They can assess the situation and recommend the appropriate course of action. 13

Comparison between studies

Common points in studies

Multiple studies have consistently shown that demeclocycline is an effective treatment for SIADH. 13 、 17 、 3 、 16

Additionally, numerous studies have indicated that demeclocycline can potentially cause side effects such as renal dysfunction. 9 、 8

Differences in studies

The incidence and severity of demeclocycline's side effects may vary between different studies. 9 、 10 、 1

Precautions for real-life application

It's crucial to take demeclocycline only as prescribed by your doctor. Never adjust the dosage or stop taking the medication without consulting your healthcare provider. Also, remember to protect your skin from sunlight while taking this medication. 12

Limitations of current research

Research on the side effects of demeclocycline is still ongoing, and more information is needed. Long-term studies are particularly lacking. 13

Future research directions

More research is required to further understand the side effects of demeclocycline. Long-term studies are needed to assess potential long-term effects, and research focused on minimizing the risk of side effects is crucial. 13

Conclusion

Demeclocycline is a valuable medication for treating SIADH. However, it's important to be aware of the potential side effects, such as renal dysfunction and photosensitivity. If you're prescribed demeclocycline, follow your doctor's instructions carefully, protect your skin from the sun, and consult with your healthcare provider if you experience any side effects. 13 、 17 、 3 、 16

Literature analysis of 17 papers
Positive Content
13
Neutral Content
2
Negative Content
2
Article Type
2
1
1
7
17
1.

Demeclocycline treatment in the syndrome of inappropriate antidiuretic hormone secretion.

Author: CherrillD A, StoteR M, BirgeJ R, SingerI

ADH inhibition
Diabetes insipidus treatment
Few side effects

Demeclocycline partially inhibited the action of ADH in a patient with inappropriate ADH secretion, producing a reversible nephrogenic diabetes insipidus.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Management of the syndrome of inappropriate secretion of antidiuretic hormone.

Author: KinzieB J

Hyponatremia treatment
Coma
Death
Seizures

SIADH, a common cause of hyponatremia, is characterized by excessive ADH secretion, leading to fluid retention and hyponatremia. Treatment focuses on eliminating underlying causes and fluid restriction. Demeclocycline can be used for long-term therapy if other measures are ineffective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

A clinical comparison of pivmecillinam plus pivampicillin (Miraxid) and a triple tetracycline combination (Deteclo) in respiratory infections treated in general practice.

Author: BeatsonJ M, MarshB T, TalbotD J

Fewer side effects
Treat respiratory tract infections
Side effects

Pivmecillinam plus pivampicillin is as effective as a combination of tetracycline, chlortetracycline and demeclocycline in treating respiratory tract infections and causes fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Minocycline therapy in acne vulgaris.

Author: CullenS I, CohanR H

Acne treatment
Minocycline efficacy
No vestibular side effects

Minocycline, at a lower dose, was as effective as tetracycline in treating acne vulgaris, without vestibular side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Hyponatremia and heart failure--treatment considerations.

Author: SicaDomenic A

Hyponatremia treatment
Cardiovascular side effects
Renal side effects

This study examined the treatment of hyponatremia in heart failure patients. Vasopressin receptor antagonists are a new treatment that may improve free water excretion without the adverse consequences of other therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Renal function during treatment of inappropriate secretion of antidiuretic hormone with demeclocycline.

Author: DanovitchG M, Le RoithD, GlickS

Corrects hypo-osmolality
Corrects hyponatremia
Deterioration in glomerular filtration rate
Fluid volume contraction
Inappropriate natriuresis

Demeclocycline was effective in treating patients with inappropriate ADH secretion, but it can have potentially dangerous side effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

[Treatment of inappropriate ADH secretion syndrome with demethylchlortetracycline].

Author: AppianiA C, EdefontiA, PorziaR, PrimiD

Resolved ADH secretion

Demethylchlortetracycline was effective in treating a 16-month-old girl with inappropriate ADH secretion. The disorder resolved completely on a dose of 20 mg/kg/day, and maintenance dose of 15 mg/kg/day was effective with no side effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

11.

Interventions for chronic non-hypovolaemic hypotonic hyponatraemia.

Author: NaglerEvi V, HallerMaria C, Van BiesenWim, VanholderRaymond, CraigJonathan C, WebsterAngela C

Hyponatraemia treatment

Chronic hyponatremia is common, can be caused by various factors, and is linked to shorter survival and longer hospital stays. Treatments, such as fluid restriction or vasopressin receptor antagonists, can improve hyponatremia but their impact on patient outcomes is uncertain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Drug-Induced Photosensitivity - a Continuing Diagnostic Challenge.

Author: Lugović-MihićLiborija, DuvančićTomislav, FerčekIva, VukovićPetra, JapundžićIva, ĆesićDiana

Drug photosensitivity

This review discusses the potential for drug-induced photosensitivity reactions on the skin, emphasizing the importance of patient education and photoprotection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

The pharmacologic management of the syndrome of inappropriate secretion of antidiuretic hormone.

Author: MiyagawaC I

SIADH Treatment
Demeclocycline Side Effects
Lithium Side Effects

Demeclocycline is effective in all types of SIADH and is considered the regimen of choice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Systemic and local applications of steroids in endodontics: an update review.

Author: MohammadiZahed

Reduced pain
Side effects

This article reviews the use of glucocorticoid steroids to manage post-treatment endodontic pain. Steroids can reduce pain by reducing inflammation and the activity of inflammatory mediators.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

[Non-antibiotic effects of antibiotics: from side effects to therapeutic uses].

Author: RoblotP, Becq-GiraudonB

New drug indications
Drug side effects

Antibiotics are often prescribed for non-infectious pathologies due to their side effects, which can have therapeutic benefits in some cases. Examples of these indications include immunosuppressive or antiinflammatory, small bowel prokinetic action, endocrine effects, enzymatic effects, sclerotherapy, pro- or anti-tumoral effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

17.

The clinical challenge of SIADH-three cases.

Author: van der LubbeNils, ThompsonChristopher J, ZietseRobert, HoornEwout J

SIADH treatment
Drug-induced SIADH

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is difficult to treat. Traditional treatment options have limitations, and new therapies, such as vasopressin-receptor antagonists, are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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