Effective treatment of dengue: A Synthesis of Findings from 9 Studies

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Original Abstract of the Article

Major Research Findings

Research on dengue treatment has explored various medications and therapies, but definitive effective treatments remain elusive. 2 investigated celgosivir, a drug, for its potential in treating dengue. However, the study found no significant reduction in viral load or fever. 6 reported a case where riamilovir, an antiviral drug, appeared to be effective for dengue treatment. 7 suggested the potential of papaya leaf extract as a dengue treatment. 5 explored Chai-Shi-Jie-Du granules, a Traditional Chinese medicine (TCM), for its potential in dengue treatment. 3 suggested corticosteroids may be beneficial for dengue-related shock. 1 emphasized supportive care, including hydration and aggressive fluid management, as crucial for improving survival in children with hemorrhagic dengue.

Treatment Summary

2 explored celgosivir as a potential dengue treatment, but found no significant effect. 6 reported a case where riamilovir appeared to be effective for dengue treatment. 7 suggested the potential of papaya leaf extract as a dengue treatment. 5 explored Chai-Shi-Jie-Du granules, a TCM, for its potential in dengue treatment. 3 suggested corticosteroids may be beneficial for dengue-related shock. 1 emphasized supportive care, including hydration and aggressive fluid management, as crucial for improving survival in children with hemorrhagic dengue.

Benefits and Risks

Benefit Summary

Proper hydration and supportive care are considered critical for dengue treatment. 1 highlights the importance of supportive care, including hydration and aggressive fluid management, for children with hemorrhagic dengue. 3 suggests that corticosteroids may be beneficial for dengue-related shock. 7 suggests the potential of papaya leaf extract as a dengue treatment. 5 explored Chai-Shi-Jie-Du granules, a TCM, for its potential in dengue treatment. 6 reported a case where riamilovir appeared to be effective for dengue treatment. These findings indicate that alongside traditional supportive care, new medications and therapies are being explored for dengue treatment.

Risk Summary

Many dengue treatment options lack sufficient evidence, and potential side effects or risks should be considered. 2 found that celgosivir showed high safety but did not confirm its effectiveness for treating dengue. While 3 suggests that corticosteroids may be beneficial for dengue-related shock, their effectiveness and safety require further research.

Comparison Between Studies

Similarities in Studies

A common theme among multiple studies is the exploration of new medications and therapies for dengue treatment. 2 investigated celgosivir as a potential dengue treatment. 6 reported a case where riamilovir appeared to be effective for dengue treatment. 7 suggested the potential of papaya leaf extract as a dengue treatment. 5 explored Chai-Shi-Jie-Du granules, a TCM, for its potential in dengue treatment. These research efforts highlight the ongoing pursuit of advancements in dengue treatment.

Differences in Studies

Studies vary in their focus on specific medications or therapies, research methods, and participant groups, making direct comparisons difficult. 2 involved a clinical trial to assess the effectiveness of celgosivir. 6 presented a case report investigating the effectiveness of riamilovir. 7 utilized computer simulations to evaluate the potential of papaya leaf extract as a treatment. 5 conducted a clinical study on the effectiveness of Chai-Shi-Jie-Du granules, a TCM. These studies employed diverse approaches to explore dengue treatment options, yielding unique insights from each.

Consistency and Contradictions in Results

While several studies suggest promising potential for dengue treatment, conclusive findings remain elusive. 2 indicated that celgosivir may not be effective for dengue treatment. Conversely, 6 reported a case where riamilovir showed effectiveness in treating dengue. 7 suggests potential for papaya leaf extract as a dengue treatment. These inconsistencies highlight the need for further research to establish definitive conclusions.

Practical Implications and Cautions

While new medications and therapies for dengue treatment are under development, sufficient evidence remains limited, and potential side effects or risks should be considered. 2 confirmed the safety of celgosivir but did not confirm its effectiveness. 3 suggests corticosteroids may be beneficial for dengue-related shock, but their effectiveness and safety require further research. When considering treatment options for dengue, it is crucial to consult a physician and make informed decisions based on available research findings.

Current Research Limitations

Dengue treatment research faces several challenges. For example, 2 , a clinical trial evaluating the effectiveness of celgosivir, had a small number of participants, necessitating larger-scale studies. 6 presented a case report on the effectiveness of riamilovir; however, due to the limited number of cases, generalizability of these findings requires caution. 7 utilized computer simulations to evaluate the potential of papaya leaf extract as a treatment; real-world verification through clinical trials is necessary to confirm its effectiveness. Addressing these limitations and conducting further research are crucial for developing effective dengue treatments.

Future Research Directions

To advance dengue treatment, future research should prioritize the following areas: * Development and clinical trials of new medications and therapies. * Elucidating the pathogenesis of dengue and exploring novel therapeutic targets. * Development of preventive measures for dengue. * Research on dengue prevalence, patient impact, and related factors. Progress in these areas will contribute to the development of effective dengue treatments and preventive measures.

Conclusion

Dengue poses a global health challenge, demanding the development of effective treatments. While promising new medications and therapies have emerged, definitive conclusions remain elusive. Further research is crucial for establishing effective dengue treatments. Preventing dengue through mosquito bite avoidance is paramount.

Treatment List

Celgosivir, riamilovir, papaya leaf extract, Chai-Shi-Jie-Du granules, corticosteroids

Literature analysis of 9 papers
Positive Content
7
Neutral Content
1
Negative Content
1
Article Type
1
1
2
2
9
1.

[Treatment of hemorrhagic dengue in the pediatric population: a systematic review].

Author: Gutiérrez-AlvarezAngela María, Medina SilvaNicolas, Vargas BazurtoMaría Catalina, Montoya OsorioSindy

Improved survival

This review of eight clinical studies found that supportive care and aggressive fluid management are crucial for improving survival in patients with hemorrhagic dengue. While various treatments, including corticosteroids and activated factor VII, were explored, none were proven to reduce mortality. Currently, no vaccine or effective antiviral treatment exists for hemorrhagic dengue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

2.

Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial.

Author: LowJenny G, SungCynthia, WijayaLimin, WeiYuan, RathoreAbhay P S, WatanabeSatoru, TanBoon Hian, TohLiying, ChuaLian Tee, HouYan'an, ChowAngelia, HoweShiqin, ChanWing Ki, TanKah Hin, ChungJasmine S, CherngBenjamin P, LyeDavid C, TambayahPaul A, NgLee Ching, ConnollyJohn, HibberdMartin L, LeoYee Sin, CheungYin Bun, OoiEng Eong, VasudevanSubhash G

Safe and tolerated

Celgosivir does not seem to reduce viral load or fever burden in patients with dengue.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Corticosteroids for dengue infection.

Author: ZhangFan, KramerChristine V

Dengue treatment

Dengue is a common and serious mosquito-borne viral infection that is a major health concern in many developing countries. Severe dengue can be fatal, especially for children. While there's no specific treatment for dengue, some studies suggest that corticosteroids may help in cases of severe dengue with shock. Some believe that corticosteroids given early in the illness might prevent it from becoming severe.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Pediatric Profound Dengue Shock Syndrome and Use of Point-of-Care Ultrasound During Mechanical Ventilation to Guide Treatment: Single-Center Retrospective Study, 2013-2021.

Author: VoLuan Thanh, NguyenDat Tat, TranThinh Ngoc, TranHang Hoang-Thanh, ĐoanTrang Thi-Hoai, PhamTram Ngoc, MaiThanh Thi-Hoai, NguyenQuynh Xuan-Thuy, NguyenThuan Khac, NguyenThuong Thi-Kim, BurzaSakib, NguyenThanh Tat

High fatality rate

This article discusses the challenges of managing profound dengue shock syndrome (DSS) complicated by severe respiratory failure requiring mechanical ventilation (MV), highlighting the difficulty in assessing intravascular volume due to severe plasma leakage and MV.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Real-World Study on Chai-Shi-Jie-Du Granules for the Treatment of Dengue Fever and the Possible Mechanisms Based on Network Pharmacology.

Author: YangHuiqin, MaDehong, LiQin, ZhouWen, ChenHongyi, ShanXiyun, ZhengHaipeng, LuoChun, OuZhiyue, XuJielan, WangChangtai, ZhaoLingzhai, SuRui, ChenYuehong, LiuQingquan, TanXinghua, LinLuping, JiangTao, ZhangFuchun

Dengue fever treatment
TCM efficacy
Dengue fever
TCM prescription

This real-world study investigates the effects of Chai-Shi-Jie-Du (CSJD) granules in the treatment of dengue fever, a widely used traditional Chinese medicine (TCM) method in China. The study aims to evaluate the effects of CSJD granules on dengue fever symptoms and explore the underlying mechanisms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

[The experience in treatment of dengue fever using antiviral drug riamilovir in the Republic of Guinea (case report)].

Author: MaltsevO V, KasyanenkoK V, ZhdanovK V, MalyshevN A, KolomoetsE V, KonomouV K

Dengue fever treatment

Dengue fever is a widespread viral disease with no proven etiotropic drugs. This study highlights the potential of the nucleoside analog riamilovir in treating dengue fever, focusing on the key role of NS5 protein inhibition in viral replication.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

9.

Simple clinical and laboratory predictors to improve empirical treatment strategies in areas of high scrub typhus and dengue endemicity, central Vietnam.

Author: TranHanh Thi Duc, SchindlerChristian, PhamThuy Thi Thanh, VienMai Quang, DoHung Manh, NgoQuyet Thi, NguyenTrieu Bao, HoangHang Thi Hai, VuLan Thi Hoang, SchellingEsther, ParisDaniel H

Dengue fever management
Scrub typhus management
Diagnostic limitations
Treatment limitations

This study examines the clinical management of dengue fever and scrub typhus, two common febrile illnesses in Vietnam. It highlights the need for accurate diagnostics and appropriate treatment strategies for both conditions, emphasizing the importance of addressing these underappreciated diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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