Side Effects of desoximetasone topical: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Main Research Findings

A systematic review of randomized controlled trials comparing dexamethasone and prednisone for neuropsychological side effects in children with acute lymphoblastic leukemia showed no clinically significant differences in cognition, mood, or behavior. 1

Reasons for Side Effects

The specific reasons for neuropsychological side effects from dexamethasone and prednisone are not yet fully understood. Further research is needed to investigate the mechanisms underlying these effects.

Common Side Effects

Metabolic Side Effects

Dexamethasone is known to induce more metabolic side effects than prednisone. 1

Neuropsychological Side Effects

While both dexamethasone and prednisone can cause neuropsychological side effects, studies have not found clinically significant differences between the two drugs in terms of their impact on cognition, mood, or behavior. 1

Countermeasures for Side Effects

Countermeasures for Metabolic Side Effects

Managing metabolic side effects may involve dietary modifications, exercise, and other strategies. Consult with your doctor for personalized recommendations.

Countermeasures for Neuropsychological Side Effects

Cognitive behavioral therapy can be helpful for addressing neuropsychological side effects. Your doctor can guide you on appropriate interventions.

Comparison Across Studies

Commonalities Among Studies

Multiple studies consistently found no clinically significant difference in neuropsychological side effects between dexamethasone and prednisone.

Differences Among Studies

While most studies found no significant differences, some studies might have observed subtle variations in neuropsychological side effects. More research is needed to clarify these potential differences.

Precautions for Application to Real Life

When considering treatment options for acute lymphoblastic leukemia, it's crucial to weigh the potential benefits and risks of dexamethasone and prednisone. Discuss your child's individual needs and concerns with their doctor.

Limitations of Current Research

The research on neuropsychological side effects from dexamethasone and prednisone is still limited. Further studies are necessary to fully understand the long-term effects and individual variations in responses to these medications.

Future Research Directions

Future research should focus on understanding the mechanisms underlying neuropsychological side effects from these medications, exploring long-term effects, and investigating potential individual differences in response.

Conclusion

Available evidence suggests that dexamethasone and prednisone do not differ significantly in their impact on neuropsychological function in children with acute lymphoblastic leukemia. However, it's essential to be aware of potential side effects and work closely with your child's healthcare team to manage any concerns.

Keywords
Benefit Keywords
ALL treatment
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Risk Keywords
Neuropsychological side effects
1
Literature analysis of 1 papers
Positive Content
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Neutral Content
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Negative Content
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Article Type
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Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review.

Author: WarrisL T, van den Heuvel-EibrinkM M, den HoedM A H, AarsenF K, PietersR, van den AkkerE L T

ALL treatment
Neuropsychological side effects

Dexamethasone and prednisone are commonly used steroids for treating childhood acute lymphoblastic leukemia. This review found no clinically significant differences between the two drugs on cognitive, mood, or behavioral outcomes. This suggests that both drugs may be safe in terms of neuropsychological side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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