Effects of dexamethasone injection: A Synthesis of Findings from 29 Studies

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Original Abstract of the Article

Major Research Findings

Dexamethasone injection has been found to have various effects in different medical situations. For example, a study 14 showed that it can improve hoarseness caused by vocal fold scarring. Another study 4 demonstrated its effectiveness in treating ulcerative colitis. Furthermore, a study 20 indicated that spinal dexamethasone injection is effective as a premedication in rabbit anesthesia. However, dexamethasone injection can also cause side effects, such as increased blood sugar levels 29 and neurotoxicity 25 . The severity of these side effects can vary depending on the dosage and method of administration.

Benefits and Risks

Benefits Summary

Dexamethasone injection has been shown to alleviate various symptoms. For instance, it can improve hoarseness caused by vocal fold scarring 14 , treat ulcerative colitis 4 , provide pre-anesthesia pain relief 20 , and reduce post-operative pain 27 .

Risks Summary

Dexamethasone injection can have several side effects, including increased blood sugar levels 29 , neurotoxicity 25 , and bone loss 15 . These side effects can vary in severity depending on the dosage and method of administration.

Comparison between Studies

Commonalities between Studies

These studies suggest that dexamethasone injection has the potential to have various effects in different medical situations. They indicate that dexamethasone injection has the ability to suppress pain and inflammation, as well as suppress the immune system. Dexamethasone injection can also affect various tissues and organs.

Differences between Studies

These studies differ in terms of their target diseases, methods of administration, and evaluation methods. Therefore, it is challenging to directly compare the research findings. Additionally, some studies report side effects of dexamethasone injection. The safety and effectiveness of dexamethasone injection can vary based on individual patients and diseases. Thus, it is crucial to use it appropriately under the guidance of a doctor.

Consistency and Contradictions in Findings

Although these studies suggest that dexamethasone injection can have a range of effects, the effects can vary significantly depending on the dosage, method of administration, and target disease. It has also been shown that dexamethasone injection can cause several side effects. By evaluating these research findings together, we can conclude that while dexamethasone injection shows promise, the risk of side effects should also be taken into account.

Cautions for Real-Life Application

Dexamethasone injection should be used with proper dosage and methods under the guidance of a doctor. Self-administering dexamethasone injection can increase the risk of side effects. It is important to note that dexamethasone injection is not effective for all symptoms. If your symptoms do not improve, consult your doctor.

Limitations of Current Research

These studies are all relatively small in scale and further research may be necessary. Additionally, these studies have not thoroughly investigated the long-term effects of dexamethasone injection. Further research on the long-term effects of dexamethasone injection is needed.

Directions for Future Research

To investigate the safety and effectiveness of dexamethasone injection in greater detail, conducting large-scale clinical trials is essential. Further research is required on the long-term effects and methods for reducing side effects of dexamethasone injection. Furthermore, research should be conducted to determine the optimal administration methods to maximize the effects and minimize the risks of dexamethasone injection.

Conclusion

Dexamethasone injection has been demonstrated to have a positive effect on alleviating various symptoms. However, it is important to note that dexamethasone injection can also cause side effects. It is crucial to use dexamethasone injection with the proper dosage and methods under the guidance of a doctor. If your symptoms do not improve, consult your doctor.

Literature analysis of 29 papers
Positive Content
25
Neutral Content
0
Negative Content
4
Article Type
3
0
0
1
29
1.

Immunohistochemical and Electron Microscopic Study of the Inhibitory Effects of Olive Oil Polyphenol on Dexamethasone-Induced Apoptosis.

Author: KhalatbaryAli Reza, MohammadnegadBehrooz, GoudarziGhazaleh, Fazlollahpour BalefAli

Reduced apoptosis

Oleuropein, a polyphenol present in olive oil, was found to reduce dexamethasone-induced apoptosis in mouse thymocytes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Short-Term Curcumin Gavage Sensitizes Insulin Signaling in Dexamethasone-Treated C57BL/6 Mice.

Author: TianLili, ZengKejing, ShaoWeijuan, YangBurton B, FantusI George, WengJianping, JinTianru

Glucose reduction
Insulin sensitization

This study suggests that short-term curcumin treatment can improve insulin sensitivity in a rapid dexamethasone-induced insulin resistance mouse model, suggesting that curcumin's beneficial effects are not solely due to chronic anti-inflammatory and antioxidative functions. The study found that curcumin increased FGF21 expression, a known insulin sensitizer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Dexamethasone injection into the pterygomandibular space in lower third molar surgery.

Author: BoonsirisethK, LattM M, KiattavorncharoenS, PairuchvejV, WongsirichatN

Mouth opening improvement
Pain relief
Postoperative swelling reduction

An injection of 8mg dexamethasone into the pterygomandibular space was effective in reducing postoperative swelling, limited mouth opening, and pain following impacted lower third molar extraction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

4.

Therapeutic effects of triptolide via the inhibition of IL-1β expression in a mouse model of ulcerative colitis.

Author: ZhangHaifeng, GongChen, QuLishuai, DingXiaoling, CaoWei, ChenHaiqin, ZhangBin, ZhouGuoxiong

UC treatment

This study investigated the effect of triptolide (TL) on ulcerative colitis (UC) in a mouse model and found that TL inhibited IL-1β expression, suggesting its potential as a new therapeutic target for UC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Effects of high CO2 level during early incubation and late incubation in ovo dexamethasone injection on perinatal embryonic parameters and post-hatch growth of broilers.

Author: WillemsenH, TonaK, BruggemanV, OnagbesanO, DecuypereE

Increased body weight
Reduced embryo mortality
Decreased hatchability

High CO(2) levels during early incubation and dexamethasone injection at d 18 of incubation can decrease embryo mortality, but combining both treatments can increase mortality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

The effects of round window membrane injury and the use of a model electrode application on hearing in rats.

Author: KocMurat, DalgicAbdullah, OzuerMehmet Ziya

Hearing loss

This animal study investigated the effects of mechanical trauma to the round window during cochlear implant surgery and the potential benefits of topical steroids in preventing hearing loss.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Effects of dexamethasone on foetal Doppler flow velocimetry.

Author: NofalAhmed M, SayyedTarek M, MahmoudHesham S, AtiaTamer Y

newborn outcomes

Dexamethasone administration before preterm birth improves fetal respiratory outcome.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

8.

The influence of dexamethasone on postoperative swelling and neurosensory disturbances after orthognathic surgery: a randomized controlled clinical trial.

Author: Semper-HoggW, FuessingerM A, DirlewangerT W, CorneliusC P, MetzgerM C

Reduce neurosensory disturbances
Reduce swelling

A randomized controlled trial evaluated the effects of a preoperative intravenous dexamethasone injection on postoperative swelling and neurosensory disturbances after orthognathic surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Effects of combined ovariectomy with dexamethasone on rat lumbar vertebrae.

Author: RenHui, LiangDe, ShenGengyang, YaoZhensong, JiangXiaobing, TangJingjing, CuiJianchao, LinShunxin

Osteoporosis

Combined ovariectomy with dexamethasone treatment induced more serious osteoporosis in rat lumbar vertebrae than either ovariectomy or dexamethasone alone. The combined effect may be due to suppressed bone formation and increased bone resorption.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effect of dexamethasone gargle, intravenous dexamethasone, and their combination on postoperative sore throat: a randomized controlled trial.

Author: KiSeunghee, MyoungInwook, CheongSoonho, LimSehun, ChoKwangrae, KimMyoung-Hun, HanYongjae, OhMinkyung, ParkYohan, KimKwanghee, LeeJeonghan

POST reduction

This study investigates the effects of gargling with dexamethasone, intravenous dexamethasone injection, and a combination of both on the incidence and severity of postoperative sore throat.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Intracameral dexamethasone injection in the treatment of cataract surgery induced inflammation: design, development, and place in therapy.

Author: ShahTirth J, ConwayMandi D, PeymanGholam A

Cataract surgery
Intraocular pressure

This review explores various drug delivery approaches for managing intraocular inflammation after cataract surgery, including intracameral dexamethasone (DXM). Intracameral DXM shows promise in reducing postoperative inflammation and may be preferred by patients over topical steroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Voice Outcomes following a Single Office-Based Steroid Injection for Vocal Fold Scar.

Author: YoungWilliam G, HoffmanMatthew R, KoszewskiIan J, WhitedChad W, RuelBrienne N, DaileySeth H

Improved voice
Low risk

A single office-based steroid injection combined with voice therapy improved patient-reported and functional voice measures in patients with mild to moderate vocal fold scar. This approach may offer a safe and effective treatment option for vocal fold scar.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Effect of glucocorticoid withdrawal on glucocorticoid inducing bone impairment.

Author: ShenGengyang, RenHui, QiuTing, LiangDe, WeiQiushi, TangJingjing, ZhangZhida, YaoZhensong, ZhaoWenhua, JiangXiaobing

Bone impairment

Glucocorticoid withdrawal after short-term use can lead to insufficient bone recovery in glucocorticoid-induced osteoporosis (GIOP) rats. This study suggests that anti-osteoporosis therapy may still be necessary even after glucocorticoid withdrawal, emphasizing the importance of monitoring bone health in these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

High-dose dexamethasone injection disordered metabolism and multiple protein kinases expression in the mouse kidney.

Author: ZhangZaikuan, RanYingchun, XuLei, PanZheng, XieYajun

anti-inflammatory effect
anti-shock effect
immunosuppressive effect
immune dysregulation
metabolic effects

This study profiled the gene expression of kidney from mice with high-dose dexamethasone (DEX) treatment and found that DEGs were strongly associated with immune-response and cell adhesion gene sets.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) ameliorated dexamethasone induced hepatic gluconeogenesis through activation of Akt/FoxO1 pathway.

Author: ShiYanan, QiaoJiayun, MuBiao, ZuoBingfeng, YuanJihong

Diabetes treatment

K145 is a new drug that is being developed to treat diabetes. This study looked at how K145 works to improve glucose intolerance in mice. The study found that K145 improved glucose intolerance by inhibiting gluconeogenesis, the process by which the liver produces glucose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Piezo-surgery technique and intramuscular dexamethasone injection to reduce postoperative pain after impacted mandibular third molar surgery: a randomized clinical trial.

Author: NehmeWissam, FaresYoussef, Abou-AbbasLinda

Reduced pain

This study aims to evaluate the effectiveness of piezo-surgery and dexamethasone injection in reducing postoperative pain and other sequelae after surgical extraction of impacted mandibular third molars. The findings will provide insights into the benefits of these techniques compared to conventional methods, potentially improving patient outcomes and recovery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Intratympanic mixture gentamicin and dexamethasone versus dexamethasone for unilateral Meniere's disease.

Author: ÖztürkKayhan, AtaNurdoğan

Meniere's disease treatment

Intratympanic (IT) injection of a mixture of gentamicin and dexamethasone was more effective than IT dexamethasone alone in controlling vertigo and protecting hearing in Meniere's disease patients with persistent vertigo despite medical treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Intratympanic injection in delayed endolymphatic hydrops.

Author: LiuBo, ZhangSulin, LengYangming, ZhouRenhong, LiuJingjing, KongWeijia

DEH treatment

Intratympanic dexamethasone injection is effective for treating contralateral and ipsilateral delayed endolymphatic hydrops. Intratympanic gentamicin injection is a simple alternative for controlling vertigo in patients with ipsilateral DEH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Adrenergic receptors blockade alleviates dexamethasone-induced neurotoxicity in adult male Wistar rats: Distinct effects on β-arrestin2 expression and molecular markers of neural injury.

Author: MohamedRasha M S M, Ahmad AhmadEnssaf, AminDalia M, AbdoSamar Ahmed, IbrahimIslam A A E-H, MahmoudMona F, AbdelaalShimaa

Neurotoxicity prevention
Dexamethasone neurotoxicity

Blocking α- and/or β-adrenergic receptors alleviated dexamethasone-induced neurotoxicity in rats, despite their distinct effects on β-arrestin2 levels in the cerebral cortex.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

Intravenous Dexamethasone Injection Reduces Pain From 12 to 21 Hours After Total Knee Arthroplasty: A Double-Blind, Randomized, Placebo-Controlled Trial.

Author: TammachoteNattapol, KanitnateSupakit

Reduced nausea
Reduced pain

Intravenous dexamethasone (DEX) relieves postoperative pain between 12 to 21 hours after total knee arthroplasty (TKA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Risk Factors of Hyperglycemia After Nerve Blockade with Dexamethasone in Non-Diabetes Mellitus Patients: A Cohort Study.

Author: TanabeKumiko, IshiharaTakuma, NakamuraYoshimi, YoshimuraNoritaka, YamaguchiShinobu, SuetsuguReiko, IidaHiroki

Pain inhibition
Side effects

While single-dose glucocorticoid injections are generally considered safe, this study examines the amount of systemic absorption and potential side effects following local injections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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