Key Research Findings

Diazepam nasal spray has been shown to be effective in the emergency treatment of seizure clusters in long-term clinical trials. 2 Intranasal benzodiazepines have been shown to provide ease of use and patient and caregiver satisfaction in pediatric and adult patients. 2 Adverse events attributed to acute rescue treatments have been characterized as mild to moderate, and no reports of respiratory depression have been attributed to treatment in long-term safety studies. 2

The pharmacokinetics of oral diazepam are affected by food, but food-effect studies have not been conducted for diazepam nasal spray because it is believed that most absorption occurs via the nasal mucosa. 1 However, gastrointestinal side effects reported with nasal diazepam suggest that at least a portion of the drug may be absorbed enterally and thus subject to food effects. 1 The objective of this study was to evaluate the possible effects of food on the pharmacokinetics of diazepam nasal spray in healthy adults. 1

Reasons for Side Effects

Side effects of diazepam nasal spray may be due to absorption from the gastrointestinal tract. 1 Food may affect the absorption of diazepam from the gastrointestinal tract. 1

Common Side Effects

Gastrointestinal Side Effects

Gastrointestinal side effects of diazepam nasal spray may be affected by food. 1

Side Effect Management

Gastrointestinal Side Effect Management

To reduce gastrointestinal side effects of diazepam nasal spray, you can try diet therapy or lifestyle changes. 1

Comparison of Studies

Similarities of Studies

Both studies aimed to evaluate the effectiveness and safety of diazepam nasal spray. 2 1

Differences of Studies

The first study evaluated the effectiveness and safety of diazepam nasal spray in a long-term clinical trial. 2 The second study used a randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults. 1

Practical Implications

Diazepam nasal spray has been shown to be effective in the emergency treatment of seizure clusters. 2 However, food can affect the pharmacokinetics of diazepam, so caution is needed. 1

Limitations of Current Research

There is limited research on the food effect of diazepam nasal spray. 1 Further research is needed.

Future Research Directions

Further research is needed on the food effect of diazepam nasal spray. 1 This is important information for the safe and effective use of diazepam nasal spray.

Conclusion

Diazepam nasal spray has been shown to be effective in the emergency treatment of seizure clusters. 2 However, food can affect the pharmacokinetics of diazepam, so caution is needed. 1 Further research is needed on the food effect of diazepam nasal spray. 1