Side Effects of diclofenac transdermal patch: A Synthesis of Findings from 2 Studies

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Original Abstract of the Article

Main Research Findings

Two studies have shown that diclofenac is an effective drug for reducing pain after surgery. 1 found that the combination of diclofenac and paracetamol reduced the need for morphine compared to paracetamol alone after a Cesarean section. 2 showed that diclofenac was effective in reducing pain after endoscopic urological surgery.

Reasons for Side Effects

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are chemicals that cause pain and inflammation. Prostaglandins are also present in tissues such as the gastrointestinal tract, kidneys, and heart, so side effects of diclofenac can affect these tissues.

Common Side Effects

Gastrointestinal

Diclofenac can cause gastrointestinal side effects such as stomach pain, indigestion, nausea, and vomiting. 1 did not report any gastrointestinal side effects in patients who received diclofenac. 2 did not mention gastrointestinal side effects.

Kidneys

Diclofenac can impair kidney function and may lead to kidney failure. 1 did not report any kidney side effects in patients who received diclofenac. 2 did not mention kidney side effects.

Heart

Diclofenac can increase the risk of heart attack and stroke. 1 did not report any heart side effects in patients who received diclofenac. 2 did not mention heart side effects.

Side Effect Management

Gastrointestinal

To reduce gastrointestinal side effects, it is recommended to take diclofenac with food or to take antacids.

Kidneys

To reduce kidney side effects, it is important to take diclofenac as directed by a doctor and avoid taking it if you have impaired kidney function.

Heart

To reduce heart side effects, it is important to take diclofenac as directed by a doctor and avoid taking it if you have a history of heart disease.

Comparison Between Studies

Similarities

Both studies found that diclofenac is an effective drug for reducing pain after surgery. Both studies concluded that diclofenac is a safe drug.

Differences

The two studies differed in the type of surgery that was being studied. 1 focused on pain after Cesarean section, while 2 focused on pain after endoscopic urological surgery. 1 studied the combination of diclofenac and paracetamol, while 2 studied diclofenac alone.

Real-Life Application Considerations

Diclofenac can be a helpful drug for reducing pain after surgery, but it is important to remember that there is a risk of side effects. If you are considering taking diclofenac, consult with your doctor to make sure it is the right medication for you.

Limitations of Current Studies

Both studies were relatively small in size and had a limited number of participants. Therefore, further research is needed to generalize these findings.

Future Research Directions

Larger studies are needed to evaluate the long-term safety and efficacy of diclofenac. Further research is also needed to identify ways to reduce the side effects of diclofenac.

Conclusion

Diclofenac is an effective drug for reducing pain after surgery, but it is important to remember that there is a risk of side effects. If you are considering taking diclofenac, consult with your doctor to make sure it is the right medication for you.

Keywords
Benefit Keywords
Pain relief
1
Pain relief
2
Risk Keywords
Endoscopic urological surgery
2
Literature analysis of 2 papers
Positive Content
2
Neutral Content
0
Negative Content
0
Article Type
2
0
0
0
2
1.

A double-blind randomised controlled trial of paracetamol, diclofenac or the combination for pain relief after caesarean section.

Author: MunishankarB, FettesP, MooreC, McLeodG A

Pain relief

A combination of diclofenac and paracetamol was found to be more effective in reducing morphine use after elective caesarean section than paracetamol alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effects of Pipemidic Acid, Phenazopyridine HCL and Sodium Diclofenac on Pain Perception Following Endoscopic Urological Surgery: Double-blinded Randomized-Controlled Trial.

Author: YuriPrahara, AliZulfikar, RasyidNur, BirowoPonco

Pain relief
Endoscopic urological surgery

Oral analgesics, including pipemidic acid, phenazopyridine, and sodium diclofenac, were effective in reducing pain after endoscopic urological surgery in 80 patients. Pipemidic acid demonstrated a superior analgesic effect compared to the other two drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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