Side Effects of diethylpropion: A Synthesis of Findings from 18 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of diethylpropion: A Synthesis of Findings from 18 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Major Findings

Several studies have shown that diethylpropion is more effective in weight loss than placebo. 15 , 9 , 18 , 13 However, some studies have found that diethylpropion is less effective in weight loss compared to fenfluramine or mazindol. 11 , 18 These studies indicate that diethylpropion is beneficial for short-term weight loss, but its long-term safety remains uncertain. 3 Therefore, careful consideration is required for long-term use of diethylpropion.

Reasons for Side Effects

Diethylpropion is a medication that suppresses appetite and stimulates the sympathetic nervous system. 17 This action can lead to various side effects.

Common Side Effects

Nervous System

As diethylpropion affects the central nervous system, side effects related to the nervous system such as anxiety, insomnia, dizziness, headache, and decreased concentration have been reported. 13 , 17 In rare cases, psychological symptoms like depression, hallucinations, and delusions may occur. 7

Cardiovascular System

Because diethylpropion stimulates the sympathetic nervous system, side effects on the cardiovascular system like palpitations, tachycardia, and increased blood pressure have been reported. 9 , 17 However, these side effects may improve with weight loss. 9

Digestive System

Diethylpropion can also cause digestive system side effects such as constipation, diarrhea, dry mouth, and loss of appetite. 17 Stomach pain and nausea may also occur.

Other

Other side effects such as sweating, fatigue, and rash have been reported. 17

Countermeasures for Side Effects

Nervous System

If you experience side effects on the nervous system, discontinue taking diethylpropion or consult your doctor. 17 Ensure adequate sleep and rest, and try to avoid mental stress.

Cardiovascular System

If you experience cardiovascular side effects, stop taking diethylpropion and consult your doctor. 17 Regularly monitor your blood pressure and heart rate and report any abnormalities to your doctor.

Digestive System

If you experience side effects on the digestive system, make adjustments to your diet, drink plenty of fluids, and review your lifestyle habits. 17 Consult your doctor if symptoms persist.

Comparison Among Studies

Commonalities in Studies

Many studies have shown that diethylpropion is more effective in weight loss than placebo. 15 , 9 , 18 , 13 It is also common across studies that diethylpropion can cause side effects involving the nervous system, cardiovascular system, and digestive system. 17

Differences in Studies

The weight loss effect of diethylpropion varies depending on the study. 11 , 18 The frequency and types of side effects also differ between studies. 17

Cautions Regarding Application to Real Life

Diethylpropion is an effective drug for short-term weight loss, but its long-term safety remains unconfirmed. 3 Therefore, if taking diethylpropion, follow your doctor's instructions and avoid stopping or modifying the dosage without their guidance.

Limitations of Current Research

Research on the long-term safety of diethylpropion is insufficient. 3 Further research is needed on the mechanisms by which diethylpropion causes side effects and on effective methods for reducing side effects.

Future Research Directions

Further research is required on the long-term safety of diethylpropion, elucidating the mechanisms by which side effects occur, and effective methods for minimizing side effects.

Conclusion

Diethylpropion is an effective drug for short-term weight loss, but its long-term safety remains unconfirmed. 3 If taking diethylpropion, adhere to your doctor's instructions and consult them immediately if you experience any side effects.

Literature analysis of 18 papers
Positive Content
16
Neutral Content
0
Negative Content
2
Article Type
5
0
0
4
18
1.

A double-blind randomised controlled trial of paracetamol, diclofenac or the combination for pain relief after caesarean section.

Author: MunishankarB, FettesP, MooreC, McLeodG A

Pain relief

A combination of diclofenac and paracetamol was found to be more effective in reducing morphine use after elective caesarean section than paracetamol alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effects of Pipemidic Acid, Phenazopyridine HCL and Sodium Diclofenac on Pain Perception Following Endoscopic Urological Surgery: Double-blinded Randomized-Controlled Trial.

Author: YuriPrahara, AliZulfikar, RasyidNur, BirowoPonco

Pain relief
Endoscopic urological surgery

Oral analgesics, including pipemidic acid, phenazopyridine, and sodium diclofenac, were effective in reducing pain after endoscopic urological surgery in 80 patients. Pipemidic acid demonstrated a superior analgesic effect compared to the other two drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Update on pharmacology of obesity: benefits and risks.

Author: Cabrerizo GarcíaLucio, Ramos-LevíAna, Moreno LoperaCarmen, Rubio HerreraMiguel A

Obesity treatment
Weight loss
Side effects

This review examines the current landscape of medications for obesity treatment, highlighting the challenges and opportunities in this field. While orlistat is the only available drug in Europe, the US has recently approved lorcaserin and the combination phentermine/topiramate, both with varying levels of effectiveness and potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Pharmacological and neurotoxicological actions mediated by bupropion and diethylpropion.

Author: AriasHugo R, SantamaríaAbel, AliSyed F

Antidepressant effects
Antismoking aid
Oxidative damage
Psychomotor alterations

Bupropion (BP) is an antidepressant and antismoking aid that is also being investigated as a potential antiaddictive compound. BP is a noncompetitive antagonist of several nicotinic acetylcholine receptors (AChRs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

[Pharmacotherapy of obesity].

Author: SchusdziarraV, ErdmannJ

Appetite control
Weight loss
Decreasing benefit
Side effects

Sibutramine and orlistat are effective in the long-term treatment of obesity, but their effectiveness decreases after one year of use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

7.

Diethylpropion pharmacotherapeutic adjuvant therapy for inpatient treatment of cocaine dependence: a test of the cocaine-agonist hypothesis.

Author: AlimT N, RosseR B, VocciF J, LindquistT, DeutschS I

Cocaine craving
Side effects

Diethylpropion was not found to be more effective than placebo in attenuating cocaine cue-induced craving in cocaine-dependent patients. This study confirmed earlier reports that craving for cocaine diminishes during inpatient hospitalization. Although diethylpropion was not effective, the study demonstrates that the cocaine cue-induced craving paradigm is effective in stimulating craving for cocaine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

8.

The current status of antiobesity drugs.

Author: GallowayS M, FarquharD L, MunroJ F

Weight loss
Dependence
Withdrawal depression

Antiobesity drugs can produce a modest weight loss, but the effects are temporary. Drug choice depends on factors like cost and side effects. Intermittent use of phentermine and diethylpropion is recommended. Fenfluramine is best used continuously. Weight regain is common after stopping medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

A comparative study of phentermine and diethylpropion in the treatment of obese patients in general practice.

Author: Vallé-JonesJ C, BrodieN H, O'HaraH, O'HaraJ, McGhieR L

Reduced blood pressure
Reduced heart rate
Weight loss
Minor side effects

Phentermine and diethylpropion were compared in 99 obese patients. Phentermine was more effective in helping patients lose weight. Side effects were generally minor and comparable in both groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Formula diet in the treatment of moderate obesity.

Author: AndersenT, HyldstrupL, QuaadeF

Improved compliance
Weight loss

Formula diets were effective in promoting weight loss, but the weight loss was not significantly different between groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Three controlled trials of weight loss with phenylpropanolamine.

Author: AltschulerS, ConteA, SebokM, MarlinR L, WinickC

Few side effects
Weight loss
Side effects

Phenylpropanolamine-caffeine combination proved as effective as mazindol and diethylpropion in achieving weight loss and was significantly more effective than placebo. It also had fewer side effects compared to the other drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Ephedrine as an anorectic: the story of the 'Elsinore pill'.

Author: Malchow-MøllerA, LarsenS, HeyH, StokholmK H, JuhlE, QuaadeF

Weight loss
Exaltation
Insomnia
Tremor

This study compared the effects of diethylpropion, 'Elsinore pills' (ephedrine and caffeine), and placebo on weight loss in obese patients. Both diethylpropion and 'Elsinore pills' were significantly more effective than placebo in reducing weight after 12 weeks, with median weight losses of 8.4 kg and 8.1 kg, respectively. However, 4 patients in each treatment group experienced side effects like exaltation, tremor, and insomnia. Tremor was more frequent in the 'Elsinore pill' group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

A double-blind controlled study of the use of diethylpropion hydrochloride (Tenuate) in obese patients in a rural practice.

Author: ElliottB J

Weight loss
Side effects

Long-acting diethylpropion hydrochloride (TD) was more effective in producing weight loss than placebo, with no significant increase in side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Treatment of obesity: cost-benefit assessment of behavioral therapy, placebo, and two anorectic drugs.

Author: DahmsW T, MolitchM E, BrayG A, GreenwayF L, AtkinsonR L, HamiltonK

Weight reduction
Anorectic drug side effects

Behavioral therapy was found to be as effective as mazindol, diethylpropion, and placebo in producing weight reduction in obese patients. Behavioral therapy also had advantages in terms of cost and side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

17.

Anorectic drugs: use in general practice.

Author: CraddockD

Effective for obesity
Addiction risk
Depression
Drowsiness
Euphoria
Gastrointestinal irritation
Insomnia
Irritability
Nervousness
Restlessness
Sympathetic stimulation

Anorectic drugs were found to be effective in the treatment of obesity, with diethylpropion emerging as the drug of first choice due to a lower risk of addiction and fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

A comparison of mazindol (Teronac) with diethylpropion in the treatment of exogenous obesity.

Author: MurphyJ E, DonaldJ F, MollaA L, CrowderD

Mazindol efficacy
Weight loss
Central stimulant side effects
Diethylpropion tolerance

Mazindol produced greater weight loss than diethylpropion in obese patients. Mazindol was associated with fewer side effects and did not lead to tolerance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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