Effects of dihydroergotamine injection: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Main Research Findings

Research on the effects of dihydroergotamine injection has investigated various aspects of its effects. For instance, 5 shows that dihydroergotamine exhibits interactions with other medications. Specifically, it reports that concurrent use with calcium antagonists and antiarrhythmic drugs can lead to increased dihydroergotamine plasma concentrations, potentially impacting heart rate and electrical activity.

Additionally, 6 indicates that combining dihydroergotamine with quinidine can raise dihydroergotamine serum levels, increasing the risk of digoxin toxicity.

On the other hand, 13 compares dihydroergotamine with placebo and other medications, suggesting its potential effectiveness in treating atrial fibrillation and atrial flutter. However, this study only confirms dihydroergotamine's therapeutic effect on these conditions, lacking detailed information regarding specific benefits and risks.

4 demonstrates that dihydroergotamine influences the heart's electrical activity, causing changes in heart rate and electrical function. This is attributed to dihydroergotamine's effect on enhancing cardiac contractility.

12 suggests that dihydroergotamine could be effective in terminating pregnancy. However, this study is a pilot study requiring further validation.

11 investigated the impact of dihydroergotamine on electrocardiograms in patients experiencing acute atrial fibrillation. This study indicates that dihydroergotamine produces characteristic changes in electrocardiograms.

1 compared dihydroergotamine with digitoxin and found that both drugs enhance cardiac contractility. However, dihydroergotamine exhibited a greater tendency to suppress atrioventricular conduction compared to digitoxin.

10 indicates that dihydroergotamine is effective in treating chronic heart failure. The study found that dihydroergotamine improves cardiac output and heart rate, reducing symptoms associated with chronic heart failure. Additionally, it suggests that dihydroergotamine may lower the risk of death caused by heart failure.

9 shows that combination therapy involving dihydroergotamine and other medications is effective in treating chronic atrial fibrillation. This study confirmed that combining dihydroergotamine with diltiazem or betaxolol effectively controls the heart rate increase caused by atrial fibrillation.

3 shows that concurrent use of dihydroergotamine and bepridil results in increased dihydroergotamine serum concentrations. This study suggests that combining dihydroergotamine with bepridil could potentially affect cardiac contractility.

7 demonstrates that combining dihydroergotamine with quinidine raises dihydroergotamine serum levels and influences the heart's electrical activity.

8 is a study comparing the pharmacokinetics and pharmacodynamics of dihydroergotamine, digoxin, and beta-methyl digoxin. This study suggests that dihydroergotamine could potentially impact cardiac contractility.

2 indicates that discontinuing dihydroergotamine after prolonged use may lead to symptom worsening. However, the study found that only a small number of patients experienced worsening symptoms after stopping dihydroergotamine.

Benefits and Risks

Benefit Summary

Dihydroergotamine injection has shown potential effectiveness in treating atrial fibrillation and atrial flutter. It may also prove beneficial in managing chronic heart failure, improving cardiac output and heart rate. Furthermore, dihydroergotamine's ability to enhance cardiac contractility suggests its potential for reducing the risk of death caused by heart failure.

Risk Summary

Dihydroergotamine injection poses a risk of interacting with other medications, potentially leading to increased dihydroergotamine plasma concentrations and subsequent impacts on heart rate and electrical activity. It can also influence the heart's electrical activity, causing changes in heart rate and electrical function. Additionally, prolonged use of dihydroergotamine may result in symptom worsening upon discontinuation.

Comparison Across Studies

Commonalities Among Studies

Many studies indicate that dihydroergotamine affects cardiac contractility and electrical activity. A common finding is the potential for dihydroergotamine to interact with other medications.

Differences Among Studies

Variations exist among studies regarding the extent to which dihydroergotamine is effective in treating specific conditions like atrial fibrillation, atrial flutter, and chronic heart failure. The specific risks associated with dihydroergotamine interactions with other medications and the magnitude of those risks also vary across studies. Additionally, the effectiveness of dihydroergotamine in terminating pregnancy remains unclear.

Consistency and Contradictions in Findings

Numerous research findings suggest that dihydroergotamine injection could be effective in treating atrial fibrillation, atrial flutter, and chronic heart failure. However, comparing these studies directly is challenging due to differences in their scales and designs. Furthermore, research findings on the specific risks associated with dihydroergotamine interactions with other medications vary, making definitive conclusions difficult.

Considerations for Real-World Applications

It is crucial to use dihydroergotamine injection under the guidance of a physician. Dihydroergotamine has the potential to interact with other medications and affect the heart. Therefore, consulting with a physician before using dihydroergotamine and providing detailed information about your health condition and current medications is essential. If you experience any heart abnormalities while using dihydroergotamine, seek immediate medical attention.

Limitations of Current Research

Research on dihydroergotamine injection faces challenges in directly comparing findings due to differences in study scales and designs. Additionally, research regarding the effectiveness of dihydroergotamine in terminating pregnancy and the potential effects of long-term use is limited.

Future Research Directions

To gain a deeper understanding of the safety and efficacy of dihydroergotamine injection, large-scale studies with robust designs are needed. Further research is also required to determine the effectiveness of dihydroergotamine in terminating pregnancy and its potential effects from long-term use.

Conclusion

Research findings generally suggest that dihydroergotamine injection might be effective in treating atrial fibrillation, atrial flutter, and chronic heart failure. However, direct comparisons of study findings are challenging due to variations in scale and design. Additionally, research on the specific risks associated with dihydroergotamine interactions with other medications shows inconsistencies, making definitive conclusions difficult. When using dihydroergotamine, it is essential to adhere to physician instructions and provide comprehensive information about your health condition and current medications.

Literature analysis of 13 papers
Positive Content
8
Neutral Content
0
Negative Content
5
Article Type
12
1
0
1
13
1.

A comparison of the effects of digoxin and digitoxin on systolic time intervals and colour vision.

Author: JoubertP H, VenterC P, du PlooyW J

Inotropic effect

Digoxin and digitoxin, two cardiac glycosides, were found to produce similar inotropic effects and a trend towards digoxin having a greater effect on AV conduction. However, after administration of atropine or propranolol, the effect on AV conduction was similar for both drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Clinical, haemodynamic, and pharmacological effects of withdrawal and reintroduction of digoxin in patients with heart failure in sinus rhythm after long term treatment.

Author: PughS E, WhiteN J, AronsonJ K, Grahame-SmithD G, BloomfieldJ G

Clinical deterioration

Digoxin withdrawal was studied in 44 patients with stable heart failure. Only 25% of patients experienced clinical deterioration after withdrawal. Digoxin reintroduction was considered necessary in only 9% of cases. The occurrence of deterioration could not be predicted by clinical, haemodynamic, or pharmacological measurements.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Digoxin and bepridil: pharmacokinetic and pharmacodynamic interactions.

Author: BelzG G, WistubaS, MatthewsJ H

Digoxin inotropism
Heart rate reduction

Bepridil increased steady-state serum digoxin concentrations and counteracted its positive inotropic effect. This suggests that bepridil may interact with digoxin in a way that alters its effectiveness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

[Cardiac effects of a single daily dose of 0.15 mg and 0.20 mg of beta-methyldigoxin].

Author: BelzG G, WintrichR

Positive digitalis effect
Flattening of T wave
Shortening of STI

Beta-methyl digoxin was effective in lowering heart rate and reducing QTc intervals at a dose of 0.15mg once daily.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

5.

Interaction between digoxin and calcium antagonists and antiarrhythmic drugs.

Author: BelzG G, DoeringW, MunkesR, MatthewsJ

None reported
Increased digoxin effects

Calcium antagonists and antiarrhythmic drugs were investigated in 36 healthy men. The study found that the drugs interacted kinetically with digoxin. This increased plasma digoxin concentrations and increased glycoside effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Effects of quinidine and disopyramide on serum digoxin concentrations.

Author: ManolasE G, HuntD, SlomanG

Increased digoxin concentration

Quinidine significantly increased serum digoxin concentration in patients on maintenance digoxin therapy. Disopyramide may be a suitable alternative antiarrhythmic drug.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Quinidine-digoxin interaction: cardiac efficacy of elevated serum digoxin concentration.

Author: BelzG G, DoeringW, AustP E, HeinzM, MatthewsJ, SchneiderB

Prolonged STIs

Quinidine, an antiarrhythmic drug, significantly increased serum digoxin concentration and prolonged systolic time intervals, obscuring the effects of digoxin on cardiac activity. However, the true glycoside effect of the elevated digoxin concentration was comparable to the effect of a higher dose of digoxin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Comparative pharmacokinetics and pharmacodynamics of cardiac glycosides.

Author: KelmanA W, SumnerD J, LonsdaleM, LawrenceJ R, WhitingB

Effective heart failure treatment

Digoxin and beta-methyl digoxin, but not ouabain, shortened left ventricular ejection time (LVET) in normal volunteers. The shortening of LVET correlated linearly with the amounts of digoxin or beta-methyl digoxin present in the body tissues.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Comparative study of efficacy and safety of low-dose diltiazem or betaxolol in combination with digoxin to control ventricular rate in chronic atrial fibrillation: randomized crossover study.

Author: KohK K, SongJ H, KwonK S, ParkH B, BaikS H, ParkY S, InH H, MoonT H, ParkG S, ChoS K

Heart rate control
Reduced side effects

Combination therapy of low-dose diltiazem or bexatolol with digoxin can effectively control heart rate with minimal side effects. However, there is a need for further research to evaluate the long-term effects of this combination therapy in patients with impaired left ventricular function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Digoxin therapy in chronic heart failure.

Author: GheorghiadeM

Improved central hemodynamics
Increased cardiac output
Reduced hospitalization

Digoxin is beneficial for patients with chronic heart failure, improving cardiac output and reducing hospitalization rates. It is not associated with increased mortality but may be particularly helpful in patients with impaired cardiac function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Effects of digoxin on electrocardiogram in patients with acute atrial fibrillation--a randomized, placebo-controlled study. Digitalis in Acute Atrial Fibrillation (DAAF) Trial Group.

Author: HornestamB, HeldP, EdvardssonN

Treat atrial fibrillation

Further studies are needed to assess the effects of digoxin on the electrocardiogram in patients with atrial fibrillation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

A randomized pilot study on the effectiveness and side-effect profiles of two doses of digoxin as fetocide when administered intraamniotically or intrafetally prior to second-trimester surgical abortion.

Author: NucatolaDeborah, RothNitzan, GatterMary

Side effects

This pilot study investigated the use of digoxin to facilitate second-trimester surgical abortion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Digoxin versus placebo, no intervention, or other medical interventions for atrial fibrillation and atrial flutter: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis.

Author: SethiNaqash J, SafiSanam, FeinbergJoshua, NielsenEmil E, GluudChristian, JakobsenJanus C

Treats Atrial Fibrillation
Treats Atrial Flutter

This protocol describes a systematic review that aims to identify the beneficial and harmful effects of digoxin compared with placebo, no intervention, or with other medical interventions for atrial fibrillation and atrial flutter. Digoxin is a medication used to slow the heart rate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

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