Side Effects of diphenhydramine injection: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Major Research Findings

This research examined whether prophylactic administration of diphenhydramine could prevent adverse effects associated with neuroleptics. After analyzing data from nine studies, the research suggested that diphenhydramine significantly reduced the incidence of extrapyramidal side effects compared to placebo. 1

Reasons for Side Effects

Diphenhydramine is thought to have an effect on the nervous system, potentially mitigating adverse effects caused by neuroleptics. This research indicates that diphenhydramine might be effective in preventing side effects associated with neuroleptics. 1

Common Side Effects

Extrapyramidal Symptoms

Extrapyramidal symptoms are a common side effect of neuroleptics. Diphenhydramine is believed to be effective in preventing extrapyramidal symptoms. 1

Akathisia

Akathisia is a side effect of neuroleptics characterized by restlessness and an inability to stay still. This research suggested that diphenhydramine may be effective in preventing akathisia. 1

Side Effect Management

Extrapyramidal Symptoms

Anticholinergic drugs such as diphenhydramine are sometimes used to prevent extrapyramidal symptoms. 1

Akathisia

Treatment for akathisia may involve the use of anti-anxiety medications or beta-blockers. 1

Comparison Between Studies

Commonalities Among Studies

All nine studies investigated the potential of diphenhydramine to prevent side effects from neuroleptics. 1

Differences Between Studies

The nine studies differed in their research designs and target patient groups. 1

Important Notes Regarding Real-World Application

This research focused on the effectiveness of diphenhydramine in preventing side effects from neuroleptics. However, diphenhydramine can interact with other medications beyond neuroleptics. Therefore, consulting with a doctor before taking diphenhydramine is crucial. 1

Limitations of Current Research

This research involved the analysis of data from nine studies. Consequently, variations in research design and target patients require caution when interpreting the results. 1

Future Directions for Research

To further clarify the effectiveness of diphenhydramine in preventing neuroleptic side effects, larger-scale studies are necessary. 1

Conclusion

This research suggests that diphenhydramine can be effective in preventing neuroleptic side effects. However, variations in research designs and target patients require caution in interpreting the results. Larger-scale studies are warranted. 1

Keywords
Benefit Keywords
Reduced extrapyramidal effects
1
Risk Keywords
None reported
1
Literature analysis of 1 papers
Positive Content
1
Neutral Content
0
Negative Content
0
Article Type
0
1
1
0
1
1.

Prophylactic Administration of Diphenhydramine to Reduce Neuroleptic Side Effects in the Acute Care Setting: A Systematic Review and Meta-Analysis.

Author: MokhtariAkram, YipOlivia, AlainJudith, BerthelotSimon

Reduced extrapyramidal effects
None reported

Diphenhydramine, when compared to placebo, was associated with a significant reduction in extrapyramidal adverse effects in patients receiving neuroleptic medications. However, the overall quality of evidence is low, and further research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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