Effects of dorzolamide and timolol ophthalmic: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Major findings

Aripiprazole, an atypical antipsychotic, has shown promise in treating schizophrenia. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 It has been found to be effective in reducing psychotic symptoms and has a better safety profile compared to older typical antipsychotics. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 Aripiprazole has been shown to have less impact on weight gain, prolactin levels, and extrapyramidal symptoms compared to other atypical antipsychotics. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 Furthermore, studies suggest that higher doses of aripiprazole may be associated with greater efficacy. 8 However, it's crucial to consider that transitioning patients to aripiprazole should be done gradually to avoid symptom worsening. 5

Benefits and risks

Benefit Summary

Aripiprazole is a newer antipsychotic medication that shows promise in treating schizophrenia. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 It has been shown to be effective in reducing psychotic symptoms and has fewer side effects compared to older antipsychotics. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1

Risk Summary

While generally well-tolerated, aripiprazole can cause side effects. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 Common side effects include drowsiness, headache, insomnia, dizziness, restlessness, and nausea. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 In rare cases, more serious side effects like breathing difficulties or heart problems can occur. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1

Comparison of Studies

Commonalities of studies

Multiple studies show that aripiprazole is effective in reducing psychotic symptoms and has a favorable safety profile compared to older antipsychotics. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 The studies generally agree that aripiprazole causes less weight gain and has a lower risk of extrapyramidal symptoms compared to other atypical antipsychotics. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1

Differences in studies

Some studies show differences in side effect profiles, efficacy, and dosage recommendations. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 These variations may be attributed to factors such as participant demographics, severity of illness, and study design. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1

Consistency and contradictions in results

Overall, studies consistently show aripiprazole to be effective in reducing psychotic symptoms and has a favorable safety profile. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 However, discrepancies exist regarding the effectiveness of different dosage strategies, specific side effects, and the long-term effects of aripiprazole. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 Further research is needed to address these inconsistencies and provide clearer conclusions about the optimal use of aripiprazole. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1

Implications for daily life

Aripiprazole may be a viable treatment option for people with schizophrenia. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 However, it's important to remember that aripiprazole doesn't work for everyone. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 It's crucial to discuss treatment options with a doctor and work together to find the best approach for individual needs. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1

Limitations of Current Research

Current research on aripiprazole has limitations. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 Long-term studies are needed to assess the long-term effectiveness and safety of aripiprazole. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 The size of some studies is relatively small, and some studies have focused on specific subgroups, which may limit the generalizability of the findings. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1

Future Research Directions

Further research is necessary to address the limitations of current studies. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 Large-scale, long-term clinical trials are needed to assess the long-term effectiveness and safety of aripiprazole. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 Additional research should focus on different patient populations and subgroups to understand how aripiprazole works in a wider range of individuals. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1

Conclusion

Aripiprazole appears to be a promising treatment for schizophrenia. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1 It's important to discuss treatment options with a doctor to determine if aripiprazole is the right choice for your specific situation. 4 , 2 , 6 , 7 , 5 , 3 , 8 , 1

Literature analysis of 8 papers
Positive Content
7
Neutral Content
0
Negative Content
1
Article Type
3
3
4
3
7
1.

Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trials.

Author: MarderStephen R, McQuadeRobert D, StockElyse, KaplitaStephen, MarcusRonald, SaffermanAllan Z, SahaAnutosh, AliMirza, IwamotoTaro

Schizophrenia treatment
EPS
Prolactin elevation
QT(c) prolongation
Sedation
Weight gain

Aripiprazole, a novel antipsychotic, was well tolerated, with similar AE incidence rates to placebo, and lower rates than haloperidol for akathisia, extrapyramidal syndrome and somnolence. Objective EPS assessments demonstrated no significant differences between aripiprazole and placebo on Simpson-Angus Scale (SAS) scores, no dose-dependent effects on Barnes Akathisia scores, and significant reductions in Abnormal Involuntary Movement Scale (AIMS) scores from baseline vs. placebo (p</=0.01). Haloperidol showed increased SAS and Barnes Akathisia scores over placebo (p</=0.01). There was minimal mean weight change with aripiprazole (+0.71 kg) and haloperidol (+0.56 kg), and a lack of QT(c) prolongation. Serum prolactin increased with haloperidol, but not aripiprazole.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Aripiprazole, a novel atypical antipsychotic drug.

Author: ArgoTami R, CarnahanRyan M, PerryPaul J

Antipsychotic therapy
EPS reduction
Weight gain reduction

Aripiprazole is a new atypical antipsychotic drug that has been shown to be effective in treating psychosis. It has a low risk of weight gain and extrapyramidal side effects compared to other atypical antipsychotics.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Aripiprazole for schizophrenia.

Author: El-SayehH G, MorgantiC

Good antipsychotic effect
Minimal side effects

Aripiprazole is a newer atypical antipsychotic with good antipsychotic properties and a lower risk of adverse effects compared to older typical antipsychotics like haloperidol. It is used to treat schizophrenia and other psychoses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Aripiprazole for schizophrenia.

Author: El-SayehH G, MorgantiC

Good antipsychotic properties
Minimal adverse effects

Aripiprazole, an atypical antipsychotic, may offer good antipsychotic properties and minimal adverse effects compared to older typical antipsychotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Immediate versus gradual suspension of previous treatments during switch to aripiprazole: results of a randomized, open label study.

Author: PaeChi-Un, SerrettiAlessandro, ChiesaAlberto, MandelliLaura, LeeChanguk, LeeChul, KimJungjin, De RonchiDiana, PaikIn-Ho

Symptom reduction
Early symptom worsening

Switching patients to aripiprazole with a gradual tapering off strategy of the previous antipsychotic could be preferable to abrupt discontinuation to prevent early worsening of symptoms and premature discontinuation of treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Aripiprazole versus placebo for schizophrenia.

Author: BelgamwarRavindra B, El-SayehHany George G

Schizophrenia treatment
Adverse effects

This review examines the effects of aripiprazole, an atypical antipsychotic, compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Safety and cardiovascular effects of multiple-dose administration of aripiprazole and olanzapine in a randomised clinical trial.

Author: KollerDora, AlmenaraSusana, MejíaGina, Saiz-RodríguezMiriam, ZubiaurPablo, RománManuel, OchoaDolores, WojniczAneta, MartínSamuel, Romero-PalaciánDaniel, Navares-GómezMarcos, Abad-SantosFrancisco

ARI cardiovascular changes
OLA more ADRs
Polymorphisms influence effects

Aripiprazole and olanzapine, both antipsychotic medications, had different effects on cardiovascular parameters and adverse drug reactions (ADRs). Olanzapine induced more cardiovascular changes, while aripiprazole was associated with more ADRs. Genetic polymorphisms in several genes were associated with these effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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