Side Effects of duloxetine: A Synthesis of Findings from 21 Studies

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Original Abstract of the Article

Main Research Findings

Duloxetine is a medication commonly used to treat chronic pain conditions, such as diabetic neuropathy and fibromyalgia. 10 Many studies have shown that duloxetine can effectively reduce pain, but it is also known to cause various side effects. 10

Reasons for side effects

Duloxetine works by blocking the reabsorption of serotonin and norepinephrine, neurotransmitters that play a role in mood regulation and pain perception. This mechanism can lead to side effects, as it affects other areas of the body beyond pain relief. 7

Common side effects

Gastrointestinal System

Duloxetine can cause gastrointestinal side effects, with nausea, vomiting, constipation, and diarrhea being the most common. 11 14

Nervous System

Duloxetine can also affect the nervous system, causing dizziness, drowsiness, headaches, anxiety, and insomnia. 11

Metabolic System

Metabolic side effects of duloxetine include weight gain, appetite changes, and hypoglycemia (low blood sugar). 17

Other

Other potential side effects associated with duloxetine have been reported in research. 2 9

Side effects management

Gastrointestinal System

Dietary changes and lifestyle modifications can help alleviate gastrointestinal side effects. 11

Nervous System

Taking duloxetine as directed by your doctor and using sleep aids or sedatives if necessary can help manage nervous system side effects. 11

Metabolic System

Dietary adjustments and exercise can help control metabolic side effects. 17

Comparison of Studies

Commonalities

Many studies have demonstrated the effectiveness of duloxetine in reducing pain. 12 19 6

Differences

The effectiveness and side effects of duloxetine can vary depending on the specific disease, patient characteristics, and dosage. 21 2

Precautions for Real-Life Applications

It's essential to understand the potential risks associated with duloxetine before taking it. 4

Limitations of Current Research

Long-term effects of duloxetine are not yet fully understood. 10

Future Research Directions

Further research is needed to investigate the long-term consequences of duloxetine and explore the development of safer alternatives. 10

Conclusion

Duloxetine is a beneficial drug for pain management, but it is crucial to be aware of its potential side effects. 10

Always consult a doctor before starting duloxetine, and ensure you understand both the potential risks and benefits. 10

Literature analysis of 21 papers
Positive Content
19
Neutral Content
0
Negative Content
2
Article Type
1
2
2
9
21
1.

New frontiers in the pharmacological treatment of social anxiety disorder in adults: an up-to-date comprehensive overview.

Author: CaldiroliAlice, CapuzziEnrico, TagliabueIlaria, LeddaLuisa, ClericiMassimo, BuoliMassimiliano

SAD
Side effects

This review summarizes data on the efficacy of unlabeled molecules for treating social anxiety disorder (SAD).

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Comparison of efficacy and safety of gabapentin and duloxetine in painful diabetic peripheral neuropathy: A systematic review and meta-analysis of randomised controlled trials.

Author: KoYuan-Chun, LeeChe-Hsiung, WuChung-Sheng, HuangYu-Jui

Duloxetine efficacy
Gabapentin efficacy
PDPN treatment

This systematic review and meta-analysis compared the efficacy and safety of duloxetine with gabapentin in patients with painful diabetic peripheral neuropathy (PDPN), a common and debilitating complication of diabetes mellitus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

RgIA4 Prevention of Acute Oxaliplatin-Induced Cold Allodynia Requires &#945;9-Containing Nicotinic Acetylcholine Receptors and CD3<sup>+</sup> T-Cells.

Author: HuynhPeter N, ChristensenSean B, McIntoshJ Michael

Disease-modifying effects
Relieves cold allodynia

This study aimed to determine the necessity of the α9 nAChR subunit and potential T-cell mechanisms in RgIA4 efficacy against acute oxaliplatin-induced cold allodynia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

6.

Preoperative duloxetine on postoperative pain after laparoscopic gynecological surgeries: A systematic review and meta-analysis of randomized controlled trials.

Author: BaradwanSaeed, AlshahraniMajed Saeed, AlkhamisWaleed H, AllamHassan Saleh, AlSghanRayan, GhaziAhmed, RagabBassem, ElmazzalySaged Mohamed Metyli, AboshamaRehab Abdelhamid, IsmailReda A, DahshanShaimaa A, Al-TounyAiman A, DaghashNoha H, AbdelhakimAhmed Mohamed, AbbasAhmed M, FoudaAlbayoumi A, Ezzat AbdelfattahLaila

Improved postoperative pain
Reduced analgesic consumption

Preoperative administration of duloxetine was found to be safe and effective in improving postoperative pain and analgesia in women undergoing gynecologic laparoscopic surgeries. The meta-analysis of four RCTs showed significant reductions in pain scores and analgesic consumption in the duloxetine group compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

The Cardiovascular Effects of Newer Antidepressants in Older Adults and Those With or At High Risk for Cardiovascular Diseases.

Author: BehlkeLauren M, LenzeEric J, CarneyRobert M

Depression treatment
Cardiovascular side effects

Depression is a common mental health condition that can affect people of all ages, including older adults. While selective serotonin reuptake inhibitors (SSRIs) are often the first-line treatment for depression, many patients do not respond to these medications. This review summarizes what is known about the cardiovascular side effects of some of the newer antidepressants, including venlafaxine, desvenlafaxine, duloxetine, milnacipran, levomilnacipran, mirtazapine, bupropion, vilazodone, vortioxetine, agomelatine, moclobemide, and ketamine-esketamine. While some of these drugs may be safe and effective alternatives for older adults and patients with cardiovascular disease, more research is needed to fully understand their safety and efficacy in these patient populations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Diabetic peripheral neuropathy essentials: a narrative review.

Author: ChangMin Cheol, YangSeoyon

Painful DPN
Quality of Life Reduction

Painful diabetic peripheral neuropathy (DPN) is a common complication of diabetes affecting 6-34% of patients. DPN can significantly reduce quality of life. This article reviews the pathophysiology, diagnosis, and treatment of DPN.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

An Insight into Potential Pharmacotherapeutic Agents for Painful Diabetic Neuropathy.

Author: QureshiZunaira, AliMurtaza Najabat, KhalidMinahil

PDN pain management
Side effects

Painful diabetic neuropathy (PDN) is a debilitating complication of diabetes. This review explores the pathways involved in PDN and discusses FDA-approved and commercially available medications for its treatment, including duloxetine, pregabalin, tapentadol extended release, capsaicin, and spinal cord stimulation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Analgesic Medication in Fibromyalgia Patients: A Cross-Sectional Study.

Author: AsterH-C, EvdokimovD, BraunA, ÜçeylerN, SommerC

FMS treatment
Pain relief
Drug side effects
Fibromyalgia

Nonsteroidal anti-inflammatory drugs (NSAIDs) and metamizole were the most commonly used medications for fibromyalgia syndrome (FMS) pain. However, many patients used these medications "on demand" rather than daily, which is not in line with current guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Pregabalin-Tolperisone Combination to Treat Neuropathic Pain: Improved Analgesia and Reduced Side Effects in Rats.

Author: EssmatNariman, GalambosAnna Rita, LakatosPéter P, KarádiDávid Árpád, MohammadzadehAmir, AbboodSarah Kadhim, GedaOrsolya, LauferRudolf, KirályKornél, RibaPál, ZádoriZoltán S, SzökőÉva, TábiTamás, Al-KhrasaniMahmoud

Combination therapy
Pain relief
Gastrointestinal transit
Motor function

Combining tolperisone and pregabalin, targeting voltage-gated sodium and calcium channels respectively, provides a promising acute analgesic approach for neuropathic pain (NP). This combination demonstrates significant antiallodynic effects, restores elevated CSF glutamate content, and is well-tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Analgesic effects of medicinal plants and phytochemicals on chemotherapy-induced neuropathic pain through glial modulation.

Author: LeeJi Hwan, KimNari, ParkSangwon, KimSun Kwang

CIPN treatment

This review summarizes the analgesic efficacy of medicinal plants and their phytochemicals for chemotherapy-induced peripheral neuropathy (CIPN), focusing on glial modulation. Studies have shown that medicinal plants and their phytochemicals can effectively treat CIPN through glial modulation, offering an alternative therapeutic option with potential for reducing side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

A Brief Review on the Novel Therapies for Painful Diabetic Neuropathy.

Author: BasemJade I, BahFatoumata N, MehtaNeel D

PDN treatment options
PDN treatment side effects

Painful diabetic neuropathy (PDN) affects many people with diabetes. This article summarizes current and novel treatments for PDN, highlighting the challenges associated with existing options and the need for new therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review.

Author: HaddadHannah W, JumonvilleAllison C, StarkKatarina J, TempleShavonne N, DikeChukwudum C, CornettElyse M, KayeAlan D

Fibromyalgia treatment

Fibromyalgia (FM) is a chronic pain disorder. This narrative review examines the evidence regarding vitamin D for the treatment of FM.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Duloxetine-induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone in a Super-elderly Patient.

Author: HamadaToru, MatsukiKatsuyuki, KondouSeiji, FurukawaShinya, OnjiMorikazu

Depressive syndromes
Pain control
SIADH

This case report describes a super-elderly woman who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after receiving low-dose duloxetine. SIADH should be considered in elderly patients experiencing hyponatremia after duloxetine administration.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT.

Author: TesfayeSolomon, SloanGordon, PetrieJennifer, WhiteDavid, BradburnMike, YoungTracey, RajbhandariSatyan, SharmaSanjeev, RaymanGerry, GouniRavikanth, AlamUazman, JuliousSteven A, CooperCindy, LobanAmanda, SutherlandKatie, GloverRachel, WaterhouseSimon, TurtonEmily, HorspoolMichelle, GandhiRajiv, MaguireDeirdre, JudeEdward, AhmedSyed Haris, VasPrashanth, HarimanChristian, McDougallClaire, DeversMarion, TsatlidisVasileios, JohnsonMartin, BouhassiraDidier, BennettDavid L, SelvarajahDinesh

Improved quality of life
Pain relief
Predictable side effects

Three commonly used treatment pathways for diabetic peripheral neuropathic pain - amitriptyline supplemented with pregabalin, duloxetine supplemented with pregabalin, and pregabalin supplemented with amitriptyline - showed comparable patient outcomes at similar costs. The optimal treatment may depend on individual patient preference in terms of side effects.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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