Side Effects of dutasteride: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Dutasteride, a dual 5α-reductase inhibitor, is an effective treatment for benign prostatic hyperplasia (BPH). Unlike finasteride, dutasteride inhibits both isoenzymes of 5α-reductase, resulting in almost complete suppression of serum dihydrotestosterone (DHT). 6

Dutasteride has been shown to be effective in relieving BPH symptoms, improving quality of life, increasing peak urinary flow rate, and reducing the incidence of acute urinary retention and the need for surgery in 2-year randomized placebo-controlled trials. 6

Similar to finasteride, dutasteride reduces serum prostate-specific antigen (PSA) levels by about 50% at 6 months and total prostate volume by 25% after 2 years. 6

Dutasteride may have chemopreventive effects against prostate cancer, and its role is being confirmed in the ongoing REDUCE trial. 22

Reasons for Side Effects

Dutasteride significantly lowers DHT levels in the blood because it inhibits both isoenzymes of 5α-reductase. DHT plays an important role in male sexual function, especially libido and erectile function, so taking dutasteride can lead to sexual dysfunction. 6

Common Side Effects

Sexual Dysfunction

Common side effects of dutasteride include decreased libido, erectile dysfunction, and ejaculation disorders. 6 These side effects often appear within a few months of taking dutasteride and can worsen with long-term use. 1 Decreased libido has been reported in about 10% of patients taking dutasteride. 16 Erectile dysfunction has been reported in about 15% of patients taking dutasteride. 16 The incidence of sexual dysfunction does not seem to increase with use of dutasteride for over 4 years. 6

Gynecomastia

Taking dutasteride may cause gynecomastia. 6 Gynecomastia often appears within a few months of taking dutasteride and can worsen with long-term use. 1

Depression

Dutasteride may increase the risk of depression. 1 The exact mechanism by which dutasteride causes depression is unknown, but it may be related to changes in the hormone balance in the brain. 20

Hair Loss

Although dutasteride is a medication used to treat hair loss, it can paradoxically cause hair loss when administered through mesotherapy, which involves injections into the scalp. 12 Mesotherapy aims to suppress hair loss more effectively by directly injecting dutasteride into the scalp, but it can also cause side effects such as hair loss. 12

High-grade Prostate Cancer

Taking dutasteride may increase the risk of high-grade prostate cancer. 1 The exact mechanism by which dutasteride causes prostate cancer is unknown, but it may promote the growth of prostate cancer cells. 1 Dutasteride may reduce the incidence of prostate cancer but also suggests an increased risk of high-grade prostate cancer. 1 Compared to finasteride, dutasteride inhibits both types 1 and 2 of 5α-reductase, so it is thought to have a stronger effect on reducing the incidence of prostate cancer. 1 However, dutasteride is also suggested to have a higher risk of high-grade prostate cancer than finasteride. 1

Side Effect Countermeasures

Sexual Dysfunction

If sexual dysfunction occurs, you may need to stop taking dutasteride or reduce your dosage. 1 You can also take sexual function enhancers under the guidance of your doctor. 25 Combining 5α-reductase inhibitors and phosphodiesterase type 5 inhibitors (PDE5I) is expected to suppress the androgenic sexual side effects of 5α-reductase inhibitors and simultaneously achieve synergistic effects on LUTS. 25

Gynecomastia

If gynecomastia occurs, you should stop taking dutasteride. 1 You may also receive hormone therapy under the guidance of your doctor. 1

Depression

If depression occurs, you need to take antidepressants under the guidance of your doctor. 1 Counseling can also be helpful. 1

Hair Loss

If hair loss occurs due to mesotherapy, you should stop the mesotherapy treatment. 12 You also need to receive appropriate treatment under the guidance of your doctor. 12

High-grade Prostate Cancer

Because taking dutasteride may increase the risk of high-grade prostate cancer, you should get regular PSA tests. 1 PSA tests help detect prostate cancer early. 1

Comparison Across Studies

Commonalities Among Studies

Most studies have reported that taking dutasteride can cause sexual dysfunction, such as decreased libido, erectile dysfunction, and ejaculation disorders. 2 Some studies also suggest that taking dutasteride can cause side effects such as gynecomastia and depression. 1

Differences Among Studies

Some studies suggest that taking dutasteride may increase the risk of high-grade prostate cancer, while other studies have not observed such a trend. 1 There are also several reports that taking dutasteride can cause hair loss, but this side effect is relatively rare. 12

Things to Note Regarding Application to Real Life

Dutasteride is an effective medication for treating BPH, but it can cause side effects such as sexual dysfunction, gynecomastia, and depression. 2 It is important to consult with your doctor before taking dutasteride and understand the risks of side effects. 2 You should also undergo regular checkups with your doctor while taking dutasteride. 2 Especially, if you experience symptoms such as sexual dysfunction or gynecomastia, consult your doctor immediately. 2

Limitations of Current Research

Research on the side effects of dutasteride is still insufficient. 2 In particular, there are many unknowns about the side effects of dutasteride with long-term use. 2 Also, many studies on the side effects of dutasteride are small, and it is important to be cautious about generalizing their results. 2

Future Research Directions

More detailed research is needed on the side effects of dutasteride with long-term use. 2 Furthermore, research on the side effects of dutasteride needs to be conducted on a larger scale. 2

Conclusion

Dutasteride is an effective medication for treating BPH, but it can cause side effects such as sexual dysfunction, gynecomastia, and depression. 2 It is important to consult with your doctor before taking dutasteride and understand the risks of side effects. 2 You should also undergo regular checkups with your doctor while taking dutasteride. 2

Keywords
Benefit Keywords
BPH treatment
1
Hair growth
2
Improved LUTS
Improved sexual function
4
BPH treatment
5
Benign prostatic hyperplasia treatment
Reduced prostate volume
Reduced prostatic specific antigen
6
BPH treatment
7
Treat LUTS/BPO
9
Hair loss treatment
10
Treats androgenic alopecia
Treats prostate disease
11
Hair loss treatment
12
BPH treatment
Cancer prevention
Prostate volume reduction
13
Hair regrowth
14
ED management
15
Benign prostatic hyperplasia treatment
16
Improved urinary tract symptoms
18
Enhanced permeation
Reduced side effects
19
BPH treatment
Prostate cancer prevention
22
Effective
Well tolerated
23
Hair growth
24
Improved LUTS
Reduced clinical progression
Reduced prostate growth
25
Improved hair growth
26
Alopecia treatment
27
Risk Keywords
Depression
Prostate cancer
Sexual dysfunction
1
Cancer
Gynecomastia
Infertility
Mood disorders
Sexual dysfunction
2
Reduced quality of life
3
Sexual dysfunction
4
Sexual side effects
5
Decreased libido
Ejaculation disorders
Erectile dysfunction
Gynaecomastia
6
Decreased libido
Erectile dysfunction
Psychological effects
7
Sexual dysfunction
Somatic symptoms
8
Erectile dysfunction
Libido alterations
9
Negative affect balance
Post-finasteride syndrome
Sexual disorders
11
Patchy alopecia
Skin atrophy
12
Sexual side effects
13
Side effects
14
ED adverse effects
15
Erectile dysfunction
Hypoactive sexual desire
16
Metabolic effects
17
Depression
Gynecomastia
Sexual dysfunction
18
Depression
Neuropsychiatric adverse effects
20
PFS
Sexual dysfunction
21
Erectile dysfunction
Gynecomastia
22
Dyspepsia
Ejaculation disorder
Fatigue
Gynecomastia
Impotence
Libido decreased
Sexual function abnormality
23
Androgenic side effects
25
Angioedema
Frontal edema
Scalp abscesses
Subcutaneous necrosis
26
Literature analysis of 27 papers
Positive Content
18
Neutral Content
3
Negative Content
6
Article Type
2
2
2
16
26
1.

The dark side of 5α-reductase inhibitors' therapy: sexual dysfunction, high Gleason grade prostate cancer and depression.

Author: TraishAbdulmaged M, MulgaonkarAshwini, GiordanoNicholas

BPH treatment
Depression
Prostate cancer
Sexual dysfunction

Finasteride and dutasteride, 5α-reductase inhibitors (5α-RIs), are effective in reducing urinary retention and minimizing surgical intervention in patients with BPH symptoms. However, they have been shown to have adverse side effects on sexual function, high-grade prostate cancer incidence, central nervous system function, and depression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Side Effects of 5-Alpha Reductase Inhibitors: A Comprehensive Review.

Author: TrostLandon, SaitzTheodore R, HellstromWayne J G

Hair growth
Cancer
Gynecomastia
Infertility
Mood disorders
Sexual dysfunction

This review summarizes the findings from published literature detailing adverse effects (AEs) associated with 5α-reductase inhibitor (5ARI) use. 5ARIs are associated with slightly increased rates over placebo for decreased libido (1.5%), erectile dysfunction (ED) (1.6%), ejaculatory dysfunction (EjD) (3.4%), and gynecomastia (1.3%).

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Comorbid LUTS and erectile dysfunction: optimizing their management.

Author: KaminetskyJed

Reduced quality of life

This article discusses the relationship between lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH) and erectile dysfunction (ED). It explores the diagnostic workup, treatment options, and potential effects of treatments on this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Sexual dysfunction and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).

Author: RosenRaymond C, GiulianoFrancois, CarsonCulley C

Improved LUTS
Improved sexual function
Sexual dysfunction

Benign prostatic hyperplasia (BPH) is a common condition that can affect sexual function in older men. This article discusses the relationship between BPH and sexual dysfunction, including erectile dysfunction and ejaculatory dysfunction. It also explores the impact of various treatments for BPH on sexual function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Dutasteride: a novel dual inhibitor of 5alpha-reductase for benign prostatic hyperplasia.

Author: DjavanBob, MilaniShirin, FongYan Kit

Benign prostatic hyperplasia treatment
Reduced prostate volume
Reduced prostatic specific antigen
Decreased libido
Ejaculation disorders
Erectile dysfunction
Gynaecomastia

Dutasteride is a new dual 5alpha-reductase inhibitor for the treatment of benign prostatic hyperplasia. It has been shown to be effective in symptomatic relief, improvements in quality of life and peak urinary flow rate, and reduction of acute urinary retention events and the need for surgery.

Duplicate PublicationPublishing the same research/results in multiple journals/publications without proper disclosure/permission.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation.

Author: GurSerap, KadowitzPhilip J, HellstromWayne Jg

BPH treatment
Decreased libido
Erectile dysfunction
Psychological effects

5-alpha reductase inhibitors (5ARIs) are commonly used for benign prostatic hyperplasia (BPH). 5-9% of patients experience de novo erectile dysfunction. Decreased circulating dihydrotestosterone (DHT) associated with 5ARI use can lead to diminished sexual desire and/or orgasm.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Impact of combination therapy 5-alpha reductase inhibitors (5-ARI) plus alpha-blockers (AB) on erectile dysfunction and decrease of libido in patients with LUTS/BPH: a systematic review with meta-analysis.

Author: FavillaVincenzo, RussoGiorgio Ivan, PriviteraSalvatore, CastelliTommaso, GiardinaRaimondo, CalogeroAldo E, CondorelliRosita A, La VigneraSandro, CiminoSebastiano, MorgiaGiuseppe

Treat LUTS/BPO
Erectile dysfunction
Libido alterations

This systematic review and meta-analysis (n=6131) evaluated the impact of combination therapy with alpha-blockers (AB) and 5-alpha reductase inhibitors (5-ARI) on the risk of erectile dysfunction (ED) and libido alterations (LA) in men with lower urinary tract symptoms (LUTS) secondary to benign prostatic obstruction (BPO). Combination therapy significantly increased the risk of ED (OR 1.81) and LA (OR 1.58) compared to AB monotherapy. Combination therapy also increased the risk of ED compared to 5-ARI monotherapy (OR 1.25), but not LA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Effect of dutasteride 0.5 mg/d in men with androgenetic alopecia recalcitrant to finasteride.

Author: JungJae Yoon, YeonJe Ho, ChoiJee Woong, KwonSoon Hyo, KimBeom Joon, YounSang Woong, ParkKyoung Chan, HuhChang Hun

Hair loss treatment

Dutasteride, a dual inhibitor of type I and type II 5 alpha-reductase, may be more effective than finasteride in treating androgenetic alopecia (AGA), as finasteride shows limited improvement in 30-50% of patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Post-finasteride syndrome - does it really exist?

Author: MaksymRadosław B, KajdyAnna, RabijewskiMichał

Treats androgenic alopecia
Treats prostate disease
Negative affect balance
Post-finasteride syndrome
Sexual disorders

This abstract discusses the potential long-term adverse effects of 5α-steroid reductase inhibitors, particularly the post-finasteride syndrome (PFS), and its implications for treatment decisions and patient education.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Two Cases of Paradoxical Nonscarring Alopecia after Mesotherapy with Dutasteride.

Author: Reguero Del CuraLeandra, De Quintana SanchoAdrian, Rubio LombrañaMarta, López SundhAna Elisabet, González LópezMarcos Antonio

Hair loss treatment
Patchy alopecia
Skin atrophy

Two cases of patchy alopecia after mesotherapy with dutasteride are presented. Mesotherapy with dutasteride is a novel treatment for hair loss, but these cases highlight the possible paradoxical side effects of mesotherapy.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

13.

Dutasteride: a review of current data on a novel dual inhibitor of 5alpha reductase.

Author: MarihartSibylle, HarikMike, DjavanBob

BPH treatment
Cancer prevention
Prostate volume reduction
Sexual side effects

This article reviews the use of dutasteride, a 5alpha-reductase inhibitor, for treating benign prostatic hyperplasia (BPH). Dutasteride effectively reduces prostate size and improves symptoms of BPH, including urinary flow rate and frequency. The article discusses the side effects of dutasteride and its potential for preventing prostate cancer.

Duplicate PublicationPublishing the same research/results in multiple journals/publications without proper disclosure/permission.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Safety concerns when using novel medications to treat alopecia.

Author: AlmohannaHind M, PerperMarina, TostiAntonella

Hair regrowth
Side effects

Alopecia, or hair loss, can be distressing for patients. This review summarizes the safety concerns associated with various emerging treatments for alopecia, including JAK inhibitors, hair transplantation, mesotherapy, oral minoxidil, platelet-rich plasma, microneedling, and 5α-reductase inhibitors. The review emphasizes the importance of considering both potential benefits and risks when choosing treatment options for hair loss.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Medications Most Commonly Associated With Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database.

Author: Kaplan-MaransElie, SandoziArshia, MartinezMariela, LeeJeffrey, SchulmanAriel, KhurginJacob

ED management
ED adverse effects

5-α reductase inhibitors (5-ARIs) and neuropsychiatric medications were most frequently associated with reports of ED. Finasteride and dutasteride had the highest PRRs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Sexual dysfunction in subjects treated with inhibitors of 5α-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis.

Author: CoronaG, TirabassiG, SantiD, MaseroliE, GacciM, DicuioM, SforzaA, MannucciE, MaggiM

Benign prostatic hyperplasia treatment
Erectile dysfunction
Hypoactive sexual desire

This study reviewed and meta-analyzed randomized clinical trials evaluating the rate of sexual side effects in men treated with 5α-reductase inhibitors (5ARIs). The results show that 5ARIs significantly increase the risk of erectile dysfunction and hypoactive sexual desire in subjects with benign prostatic hyperplasia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Co-administration of 5α-reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids.

Author: OthonosNantia, MarjotThomas, WoodsConor, HazlehurstJonathan M, NikolaouNikolaos, PofiRiccardo, WhiteSarah, BonaventuraIlaria, WebsterCraig, DuffyJoanne, CornfieldThomas, MoollaAhmad, IsidoriAndrea M, HodsonLeanne, TomlinsonJeremy W

Metabolic effects

5α-reductase inhibitors (5α-RIs) exacerbate the adverse effects of prednisolone by increasing circulating prednisolone levels. This led to increased glucose production and decreased glucose utilization and oxidation. 5α-RIs also impaired insulin-mediated suppression of nonesterified fatty acids (NEFA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients.

Author: TraishAbdulmaged M, HassaniJohn, GuayAndre T, ZitzmannMichael, HansenMichael L

Improved urinary tract symptoms
Depression
Gynecomastia
Sexual dysfunction

This study reviewed the clinical efficacy and potential adverse effects of 5α-reductase inhibitors, finasteride and dutasteride, used for treating lower urinary tract symptoms and hair loss. While these agents have been shown to be effective, the magnitude of adverse effects on sexual function, gynecomastia, depression, and quality of life requires further investigation.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

The connection of 5-alpha reductase inhibitors to the development of depression.

Author: SaengmearnuparpThiraphat, LojanapiwatBannakij, ChattipakornNipon, ChattipakornSiriporn

Depression
Neuropsychiatric adverse effects

This review summarizes the association between 5-alpha reductase inhibitors (5-ARIs) and depression, including the condition known as 'post finasteride syndrome (PFS)'. Several clinical studies have linked 5-ARIs to a higher incidence of depressive symptoms and neuropsychiatric side effects. Potential mechanisms, such as alteration in neuroactive steroids, dopaminergic dysfunction, and neuroinflammation, are discussed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

Post-finasteride syndrome: a surmountable challenge for clinicians.

Author: TraishAbdulmaged M

PFS
Sexual dysfunction

This study reviews the scientific and clinical evidence for post-finasteride syndrome (PFS), a constellation of persistent adverse effects reported by some men after discontinuing finasteride treatment. The author argues that finasteride and dutasteride can induce persistent sexual, neurological, and physical side effects in predisposed individuals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

The REDUCE trial: chemoprevention in prostate cancer using a dual 5alpha-reductase inhibitor, dutasteride.

Author: MusqueraMireia, FleshnerNeil E, FinelliAntonio, ZlottaAlexandre R

BPH treatment
Prostate cancer prevention
Erectile dysfunction
Gynecomastia

Dutasteride, a dual 5alpha-reductase inhibitor, is used to treat benign prostatic hyperplasia (BPH). It reduces serum prostate-specific antigen levels and prostate volume, demonstrating efficacy in symptomatic relief and improved quality of life. Side effects include decreased libido, erectile dysfunction, ejaculation disorders, and gynecomastia. While preliminary data suggests a decrease in prostate cancer detection in dutasteride-treated patients, further investigation is ongoing in the REDUCE trial to assess its potential for prostate cancer prevention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Dutasteride in Androgenetic Alopecia: An Update.

Author: ArifTasleem, DorjayKonchok, AdilMohammad, SamiMarwa

Hair growth

Dutasteride, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type-1 and type-2 isoenzymes of 5-α-reductase. Dutasteride has been demonstrated to be effective in several randomized, double-blind, placebo controlled trials in androgenetic alopecia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

5-Alpha-Reductase Inhibitors and Combination Therapy.

Author: FüllhaseClaudius, SchneiderMarc P

Improved LUTS
Reduced clinical progression
Reduced prostate growth
Androgenic side effects

5-Alpha reductase inhibitors (5ARIs) can reduce prostate size and improve symptoms of benign prostatic hyperplasia (BPH). The combination therapy of 5ARIs with alpha-blockers (ABs) is effective for the treatment of BPH, and combining Phosphodieseterase type 5 inhibitors (PDE5Is) with 5ARIs can counteract the sexual side effects of 5ARIs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

26.

Frontal edema due to mesotherapy for androgenetic alopecia: A case series.

Author: MeloDaniel Fernandes, Saceda-CorraloDavid, TostiAntonella, WeffortFlavia, Carla JorgeMachado, de BarrosClaudia Carreira, de Melo CarvalhoRaquel, StaraceMichela

Improved hair growth
Angioedema
Frontal edema
Scalp abscesses
Subcutaneous necrosis

This study reports on 14 patients who developed swelling on their forehead after receiving mesotherapy for hair loss. The swelling was temporary and resolved on its own. The researchers warn that dermatologists should be aware of this potential side effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

27.

Novel drug delivery approaches for the management of hair loss.

Author: AlsalhiWaleed, AlalolaAmmar, RandolphMichael, GwillimEran, TostiAntonella

Alopecia treatment

This review article summarizes novel drug delivery approaches for the management of alopecia, including microneedling, laser-assisted, radio-frequency, sonophoresis, iontophoresis, and nanoparticles.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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