Effects of edaravone injection: A Synthesis of Findings from 16 Studies

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Original Abstract of the Article

Main Research Findings

Edaravone is a powerful free radical scavenger that has shown promising results in treating various neurological conditions such as Alzheimer's disease, stroke, vascular dementia, and others. 7 , 4 , 5 , 3 , 12 , 10 , 6 , 9 , 11 , 15 , 13 , 8 , 14 , 2 . Studies have indicated that edaravone can improve cognitive function in rats with Alzheimer's disease, enhance neurological function after brain hemorrhage, alleviate colitis, protect pregnant mice and their developing fetuses from placental ischemia, treat acute large-area cerebral infarction, prevent hearing loss caused by tobramycin, slow down motor decline in ALS model mice, improve learning and memory in rats with vascular dementia, prevent noise-induced hearing loss, protect against ischemic spinal cord injury, safeguard neonatal rats from hypoxic-ischemic brain injury, prevent ischemia-induced facial palsy, inhibit the formation and progression of abdominal aortic aneurysm, and prevent anthracycline-induced myocardial cell death.

Benefits and Risks

Benefit Summary

Edaravone holds promise as a treatment option for various neurological conditions. These diseases often stem from brain cell damage and depletion of neurotransmitters. Edaravone's ability to capture free radicals could potentially prevent brain cell damage and curb neurotransmitter decline. Additionally, edaravone is believed to possess anti-inflammatory properties.

Risk Summary

Edaravone is generally considered a safe medication. However, some individuals have reported side effects such as nausea, vomiting, rash, and indigestion. It's crucial to consult with a doctor before using edaravone.

Comparison Across Studies

Similarities in Studies

Multiple studies have demonstrated the effectiveness of edaravone in treating various neurological conditions by capturing free radicals. Notably, its neuroprotective and anti-inflammatory effects have garnered significant attention.

Differences in Studies

The diseases and mechanisms through which edaravone exerts its effects vary across studies. For example, in Alzheimer's disease, neuroprotective effects are paramount, while in stroke, blood flow improvement plays a crucial role.

Consistency and Contradictions in Results

Numerous studies have indicated edaravone's efficacy in treating neurological conditions. However, some studies have reported potential side effects. Therefore, consulting a doctor is vital before using edaravone.

Considerations for Real-World Application

While edaravone shows promise in treating neurological disorders, it's not yet a universal cure for all conditions. Moreover, there's a possibility of side effects. Therefore, consulting a physician for appropriate treatment is paramount when considering edaravone use.

Limitations of Current Research

Research on edaravone is still in its early stages. Consequently, further investigation is necessary to thoroughly understand its effects and side effects. Additionally, the specific neurological conditions it effectively treats and the extent of its efficacy are still under exploration. As research progresses, edaravone may become more widely utilized as a therapeutic agent for neurological diseases.

Future Directions for Research

Edaravone holds considerable promise as a treatment for numerous neurological disorders. Future research should delve deeper into its effectiveness and efficacy for specific conditions. Moreover, a more comprehensive understanding of its potential side effects is crucial. Through these advancements, edaravone can be employed more safely and effectively as a treatment for neurological diseases.

Conclusion

Edaravone, a potent free radical scavenger, shows promise in treating various neurological conditions such as Alzheimer's disease, stroke, and vascular dementia. Its neuroprotective and anti-inflammatory properties are particularly noteworthy. It's essential to consult a doctor before using edaravone to ensure appropriate treatment and manage any potential side effects. Research on edaravone is still ongoing, and further studies are needed to fully understand its benefits and risks. As research progresses, edaravone may become a more widely utilized and effective treatment option for neurological disorders.

Literature analysis of 16 papers
Positive Content
16
Neutral Content
0
Negative Content
0
Article Type
1
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0
0
16
1.

A Single-Center Clinical Study to Evaluate Shenxiong Glucose Injection Combined with Edaravone in the Treatment of Acute Large-Area Cerebral Infarction.

Author: LiZongqin, RongXiaoxia, LuoJun, ZengTao, HuangPan, XuXuejie

Inflammation reduction
Nerve function recovery
Platelet aggregation improvement

Shenxiong glucose injection combined with edaravone improved platelet aggregation and reduced inflammation in patients with acute large-area cerebral infarction, leading to better neurological function recovery.

Clinical StudyResearch involving human participants to assess the safety, efficacy, and effects of an intervention/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Edaravone Dexborneol Versus Edaravone Alone for the Treatment of Acute Ischemic Stroke: A Phase III, Randomized, Double-Blind, Comparative Trial.

Author: XuJie, WangAnxin, MengXia, YalkunGulbahram, XuAnding, GaoZhiqiang, ChenHuisheng, JiYong, XuJun, GengDeqin, ZhuRunxiu, LiuBo, DongAiqin, MuHua, LuZhihong, LiShuya, ZhengHuaguang, ChenXia, WangYilong, ZhaoXingquan, WangYongjun,

AIS treatment

Edaravone dexborneol, a novel neuroprotective agent with synergistic antioxidant and anti-inflammatory effects, was compared to edaravone in a clinical trial involving patients with acute ischemic stroke. The study aimed to evaluate the effects of both treatments on 90-day functional outcome.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Edaravone injection ameliorates cognitive deficits in rat model of Alzheimer's disease.

Author: YangRui, WangQingjun, LiFang, LiJian, LiuXuewen

Cholinergic system improvement
Neuroprotection

Edaravone is a free radical scavenger that has antioxidant effects. This study investigated the neuroprotective effects of edaravone in a rat model of Alzheimer's disease. Edaravone was found to ameliorate spatial learning and memory deficits and reduce 4-hydroxynonenal levels in the hippocampus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

[Edaravone protects hearing from acute acoustic trauma in guinea pigs].

Author: GaoGang, SunJian-Jun, GongShu-Sheng, LiuYa, JiangPing

Hearing loss protection

This study found that intratympanic edaravone injection significantly inhibited the production of free radicals and reduced hearing loss induced by noise exposure in guinea pigs. Intravenous edaravone injection did not have a similar effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

10.

Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice.

Author: ItoHidefumi, WateReika, ZhangJianhua, OhnishiShizuo, KanekoSatoshi, ItoHisashi, NakanoSatoshi, KusakaHirofumi

Preserves motor neurons
Reduces SOD1 deposition
Reduces nitrotyrosine
Slows motor decline

Edaravone, a free radical scavenger, has been shown to slow motor decline and preserve motor neurons in mice with Amyotrophic Lateral Sclerosis (ALS).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Low-dose edaravone injection into the clamped aorta prevents ischemic spinal cord injury.

Author: HamaishiMakoto, OrihashiKazumasa, IsakaMitsuhiro, KumagaiHajime, TakahashiShinya, OkadaKenji, OhtakiMegu, SuedaTaijiro

Spinal cord protection

This study investigates the protective effects of low-dose edaravone injected directly into the clamped segment of the aorta against ischemic spinal cord injury in rabbits. Low-dose edaravone effectively prevented both immediate and delayed neuronal injury.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Protective effect of edaravone against tobramycin-induced ototoxicity.

Author: AsplundMonika Stenkvist, LidianAdnan, LinderBirgitta, TakumidaMasaya, AnnikoMatti

Protected hearing
Hearing loss

Simultaneous treatment with the radical scavenger edaravone protected rats from hearing loss caused by tobramycin ototoxicity. Even when edaravone treatment was delayed by 7 days, it still prevented hearing loss, but a 14-day delay did not protect from ototoxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Protective effects of edaravone against ischemia-induced facial palsy.

Author: TakedaTaizo, TakedaSetsuko, TakumidaMasaya, OkadaTeruhiko, KakigiAkinobu, NakataniHiroaki, HamadaMasashi, YamakawaKazuhiro

Facial palsy protection

Edaravone, an inhibitor of reactive oxygen species (ROS), was found to have a protective effect against the development of ischemia-induced facial palsy in guinea pigs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Edaravone, a potent free radical scavenger, prevents anthracycline-induced myocardial cell death.

Author: IkegamiEi, FukazawaRyuji, KanbeMasaru, WatanabeMiki, AbeMasanori, WatanabeMakoto, KamisagoMitsuhiro, HajikanoMiharu, KatsubeYasuhiro, OgawaShunichi

Cardiotoxicity protection

This study found that edaravone protects cardiomyocytes from anthracycline-induced cardiotoxicity via an anti-necrotic rather than an anti-apoptotic effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Neuroprotection of edaravone on hypoxic-ischemic brain injury in neonatal rats.

Author: YasuokaNoriko, NakajimaWako, IshidaAkira, TakadaGoro

Neuroprotection

This study investigates edaravone, a drug known to protect brain cells from damage. It shows that edaravone is effective in protecting the brains of young animals from hypoxic-ischemic injury, a type of damage caused by lack of oxygen. This suggests that edaravone might be a promising treatment for brain injuries in infants.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Protective effect of edaravone against tobramycin-induced ototoxicity.

Author: AsplundMonika Stenkvist, LidianAdnan, LinderBirgitta, TakumidaMasaya, AnnikoMatti

Protected hearing
Hearing loss

Simultaneous treatment with the radical scavenger edaravone protected rats from hearing loss caused by tobramycin ototoxicity. Even when edaravone treatment was delayed by 7 days, it still prevented hearing loss, but a 14-day delay did not protect from ototoxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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