Side Effects of eluxadoline: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Major findings

Eluxadoline has been suggested as a promising treatment option for diarrhea-predominant irritable bowel syndrome (IBS-D) based on recent studies. 5 describes eluxadoline as an orally active drug that acts on the enteric nervous system to alleviate diarrhea and pain associated with IBS-D. However, 4 reports a potential risk of pancreatitis associated with eluxadoline, highlighting the importance of considering this potential side effect when considering its use.

Reasons for side effects

Eluxadoline acts as a μ- and κ-opioid receptor agonist and a δ-opioid receptor antagonist, as described in 5 . This mechanism of action, while effective in targeting the enteric nervous system, could potentially affect the pancreas, which also contains opioid receptors. This may explain the risk of pancreatitis associated with eluxadoline. Furthermore, 4 points to a significant number of reports linking eluxadoline to pancreatitis, suggesting a potential causal relationship.

Common side effects

Pancreatitis

4 indicates that eluxadoline may increase the risk of pancreatitis, which is an inflammatory condition of the pancreas. Symptoms of pancreatitis include abdominal pain, nausea, and vomiting. In severe cases, it can be life-threatening.

Side effect management

Pancreatitis

If you experience any symptoms of pancreatitis while taking eluxadoline, it is crucial to seek immediate medical attention. Early symptoms can include abdominal pain, nausea, and vomiting. Promptly consulting a doctor allows for proper diagnosis and treatment of pancreatitis.

Comparison between studies

Commonalities

Eluxadoline has shown effectiveness in treating IBS-D.

Differences

5 provides limited details regarding the side effects of eluxadoline. On the other hand, 4 emphasizes the potential risk of pancreatitis associated with eluxadoline. These disparities suggest that the side effects of eluxadoline may vary depending on the study.

Considerations for real-life application

While eluxadoline is an effective medication for IBS-D, it is essential to be aware of the potential risk of pancreatitis. Closely monitor for any symptoms of pancreatitis and seek prompt medical attention if they occur.

Current research limitations

Research on the side effects of eluxadoline remains limited. Further investigations are needed, especially to understand the specific mechanisms by which eluxadoline may cause pancreatitis.

Future research directions

Comprehensive studies are required to thoroughly assess the safety and efficacy of eluxadoline. Elucidating the mechanisms behind pancreatitis induced by eluxadoline is crucial. Moreover, long-term effects of eluxadoline need to be further explored.

Conclusion

Eluxadoline is a promising treatment for IBS-D, but it carries the potential risk of pancreatitis. If taking eluxadoline, it is crucial to be vigilant for any signs of pancreatitis and seek immediate medical attention if necessary. More research is needed to fully understand the safety and efficacy of eluxadoline, particularly regarding the mechanisms of pancreatitis.

Literature analysis of 5 papers
Positive Content
2
Neutral Content
2
Negative Content
1
Article Type
1
0
2
3
5
1.

Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals.

Author: CliffordDavid B, EvansScott, YangYijun, AcostaEdward P, GoodkinKarl, TashimaKaren, SimpsonDavid, DorfmanDavid, RibaudoHeather, GulickRoy M

Improve neuropsychological performance
Neurological symptoms

Efavirenz is an antiretroviral drug that can cause neurologic side effects. A study found that these side effects were more common in the first week of treatment but resolved by week 4. Neuropsychological performance improved in both the efavirenz and the control groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

2.

Neuronal toxicity of efavirenz: a systematic review.

Author: DecloedtEric H, MaartensGary

Neurocognitive improvement
Cognitive impairment
Neuron damage
Neuropsychiatric side effects

Efavirenz may contribute to cognitive impairment by damaging nerve cells. Further research is needed to confirm this effect.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

A review of trials investigating efavirenz-induced neuropsychiatric side effects and the implications.

Author: GaidaRazia, TruterIlse, GroblerChristoffel, KotzeTheunis, GodmanBrian

Neuropsychiatric side effects

This review analyzed the neuropsychiatric side effects associated with efavirenz in HIV patients. Common side effects included sleep problems, depression, dizziness, and anxiety, which were generally mild and did not require discontinuation of the drug.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Clinical potential of eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome.

Author: Sobolewska-WłodarczykAleksandra, WłodarczykMarcin, StorrMartin, FichnaJakub

Improved IBS-D treatment

Eluxadoline, a μ- and κ-opioid receptor agonist and δ-opioid receptor antagonist, is a promising new treatment for diarrhea-predominant irritable bowel syndrome. It acts locally in the enteric nervous system and has no adverse effects in the central nervous system.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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