Effects of epoetin alfa: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Major Research Findings

Epoetin alfa has been shown to be effective in treating anemia in a variety of patient populations, including those with chronic kidney disease (CKD), cancer, and HIV infection. 13 , 9 , 4 , 5 , 10 , 14 , 1 , 23 , 16 , 2 , 19 , 21 , 7 , 8 , 3 , 17 , 24 , 28 , 25 , 11 , 6 , 26 , 12 , 22 , 18 . Epoetin alfa has been shown to increase hemoglobin levels, reduce the need for blood transfusions, and improve quality of life. 13 , 9 , 4 , 5 , 10 , 14 , 1 , 23 , 16 , 2 , 19 , 21 , 7 , 8 , 3 , 17 , 24 , 28 , 25 , 11 , 6 , 26 , 12 , 22 , 18 . Epoetin alfa may also be effective in preventing anemia in cancer patients undergoing chemotherapy. 9 , 4 , 10 , 14 , 7 , 8 , 23 , 21 , 7 , 22 . In patients undergoing orthopedic surgery, epoetin alfa has been shown to reduce the need for blood transfusions. 1 , 2 , 25 .

Benefits and Risks

Benefit Summary

Epoetin alfa has been shown to have the following benefits in treating anemia: 13 , 9 , 4 , 5 , 10 , 14 , 1 , 23 , 16 , 2 , 19 , 21 , 7 , 8 , 3 , 17 , 24 , 28 , 25 , 11 , 6 , 26 , 12 , 22 , 18

  • Increased hemoglobin levels
  • Reduced need for blood transfusions
  • Improved quality of life

Risk Summary

Epoetin alfa has been shown to have the following risks: 10 , 8 , 11 , 17

  • Increased risk of blood clots
  • Increased risk of high blood pressure
  • Increased risk of heart disease
  • Increased risk of stroke
  • Increased risk of death

Comparison of Studies

Similarities between Studies

Many studies have shown that epoetin alfa is effective in treating anemia. 13 , 9 , 4 , 5 , 10 , 14 , 1 , 23 , 16 , 2 , 19 , 21 , 7 , 8 , 3 , 17 , 24 , 28 , 25 , 11 , 6 , 26 , 12 , 22 , 18 . Epoetin alfa has also been shown to be effective in preventing anemia in cancer patients undergoing chemotherapy. 9 , 4 , 10 , 14 , 7 , 8 , 23 , 21 , 7 , 22 . In patients undergoing orthopedic surgery, epoetin alfa has been shown to reduce the need for blood transfusions. 1 , 2 , 25 .

Differences between Studies

The dosage, route of administration, patient population, and outcome measures varied across studies, making direct comparisons difficult. Some studies have suggested that epoetin alfa may have an impact on survival, but this requires further investigation. 7 , 8 .

Consistency and Contradictions in Results

While many studies have demonstrated the effectiveness of epoetin alfa in treating anemia, some studies suggest a potential impact on survival. 7 , 8 . Further research is needed to clarify this potential link.

Important Considerations for Real-Life Applications

While epoetin alfa is an effective treatment for anemia, it is crucial to follow your doctor's instructions carefully due to the risks of blood clots and other complications. 10 , 8 , 11 , 17 . Remember that epoetin alfa is not a cure-all for all types of anemia and may not be effective for everyone. Consult your physician to determine the most appropriate treatment for your individual needs.

Limitations of Current Research

Direct comparison of research findings on epoetin alfa can be challenging due to varying patient populations, dosages, routes of administration, and outcome measures. Further research is needed to clarify the potential impact of epoetin alfa on survival. 7 , 8 .

Future Research Directions

Additional research is needed to explore the long-term effects and safety of epoetin alfa, especially its potential impact on survival. Larger clinical trials are needed to investigate this area. 7 , 8 . Further investigation into optimal dosing strategies and administration methods is also warranted.

Conclusion

Epoetin alfa is an effective treatment option for anemia, but it is crucial to follow your doctor's instructions closely due to potential side effects and risks. 10 , 8 , 11 , 17 . Consult your physician to discuss the most appropriate treatment plan for your individual needs.

Keywords
Benefit Keywords
Facilitation of AB donation
Reduced allogeneic blood exposure
Well tolerated
1
Predonated autologous blood
Reduced allogeneic transfusion
Stimulated erythropoiesis
2
Anaemia treatment
Quality of life improvement
Transfusion reduction
3
Improved QOL
Reduced transfusion requirement
4
Improve QOL
5
Hemoglobin increase
Quality of life improvement
Transfusion reduction
6
Improved QOL
Increased Hb
Reduced transfusion requirements
Well tolerated
7
Alternative to blood transfusion
Improved survival
Pharmacoeconomic benefits
8
Cancer treatment
9
Improved quality of life
Increased hemoglobin levels
Reduced transfusion need
10
Improved hematologic response
Reduced transfusion risk
11
Increased Hb
Reduced transfusions
12
Equivalent Hb levels
Safe treatment
13
Improved Hb levels
Reduced transfusions
Well tolerated
14
Reduced RBC transfusions
Reduced stem cell collection attempts
15
Neuroprotection
17
Overcome erythropoietin hyporesponsiveness
Stable hemoglobin levels
18
Lower transfusion rate
No impact on hospitalization
19
Improved QOL
Increased Hb
Reduced transfusion requirements
Well tolerated
20
Improved cognitive function
Improved quality of life
Reduced fatigue
21
Improved QoL
22
Chemotherapy
Neuroprotection
23
Increased ejection fraction
Reduced LVMI
24
Hospitalization time reduction
Transfusion requirement reduction
25
Increased hemoglobin
Reduced transfusion requirements
26
Equivalent Hb levels
Safe treatment
27
Epoetin alfa for STEMI
28
Risk Keywords
Adverse events
3
Higher risk of thrombosis
8
Thromboembolic events
Uncertain survival impact
11
Infections
13
Adverse events
Thrombosis
17
Higher transfusion rate
Lower hemoglobin
19
Cognitive dysfunction
23
Infections
27
Cardiovascular morbidity and mortality
28
Literature analysis of 28 papers
Positive Content
25
Neutral Content
3
Negative Content
0
Article Type
21
3
3
6
28
1.

Epoetin alfa for autologous blood donation in patients with rheumatoid arthritis and concomitant anemia.

Author: MercurialiF

Facilitation of AB donation
Reduced allogeneic blood exposure
Well tolerated

This study investigated the efficacy and safety of epoetin alfa, a drug used to stimulate red blood cell production, for facilitating autologous blood donation in patients scheduled for major orthopedic surgery. Intravenous epoetin alfa (300 IU/kg twice weekly for 3 weeks) was effective in facilitating donation, but subcutaneous administration with a lower dosage (100 IU/kg twice weekly for 3 weeks with a single intravenous bolus of 200 IU/kg at the first subcutaneous dose) was equally effective. Both regimens reduced allogeneic blood exposure and were well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Improving the efficacy of preoperative autologous blood donation in patients with low hematocrit: a randomized, double-blind, controlled trial of recombinant human erythropoietin.

Author: PriceT H, GoodnoughL T, VoglerW R, SacherR A, HellmanR M, JohnstonM F, BolgianoD C, AbelsR I

Predonated autologous blood
Reduced allogeneic transfusion
Stimulated erythropoiesis

Epoetin alfa stimulated erythropoiesis, increased predonation of autologous blood, and reduced the risk of allogeneic transfusion in patients undergoing elective orthopedic surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Efficacy of epoetin alfa in the treatment of anaemia of multiple myeloma.

Author: DammaccoF, CastoldiG, RödjerS

Anaemia treatment
Quality of life improvement
Transfusion reduction
Adverse events

This placebo-controlled study evaluated the effects of epoetin alfa on transfusions, haemoglobin levels, and quality of life in patients with multiple myeloma and anemia. Epoetin alfa significantly decreased transfusion incidence, increased mean haemoglobin, and showed improvement in quality of life measures, suggesting its effectiveness and tolerability in treating anemia in this population.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized, double-blind, placebo-controlled trial.

Author: LittlewoodT J, BajettaE, NortierJ W, VercammenE, RapoportB,

Improved QOL
Reduced transfusion requirement

Epoetin alfa, a recombinant erythropoietin, showed potential for reducing transfusion requirements, improving quality of life, and possibly enhancing survival in anemic cancer patients receiving nonplatinum chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Once-weekly epoetin alfa dosing is as effective as three times-weekly dosing in increasing hemoglobin levels and is associated with improved quality of life in anemic HIV-infected patients.

Author: GrossmanHoward A, GoonBetty, BowersPeter, LeitzGerhard,

Improve QOL

Once-weekly (QW) epoetin alfa was compared to three times weekly (TIW) epoetin alfa in anemic HIV-positive patients. Both regimens were effective in improving hematologic parameters and quality of life, but the QW regimen offered greater convenience.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Impact of epoetin alfa on clinical end points in patients with chronic renal failure: a meta-analysis.

Author: JonesMichael, IbelsLloyd, SchenkelBrad, ZagariMartin

Hemoglobin increase
Quality of life improvement
Transfusion reduction

This meta-analysis quantifies the effects of epoetin alfa on clinical efficacy, quality of life, hospitalizations, and transfusions in anemic patients with chronic renal failure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Effects of early intervention with epoetin alfa on transfusion requirement, hemoglobin level and survival during platinum-based chemotherapy: Results of a multicenter randomised controlled trial.

Author: SavonijeJ H, van GroeningenC J, van BochoveA, HonkoopA H, van FeliusC L, WormhoudtL W, GiacconeG

Improved QOL
Increased Hb
Reduced transfusion requirements
Well tolerated

Early intervention with epoetin alfa (EPO) significantly decreased transfusion requirements, increased hemoglobin levels, and improved quality of life in patients with mild anemia during platinum-based chemotherapy. However, no significant differences in survival were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Recombinant human erythropoietin in oncology: current status and further developments.

Author: EngertA

Alternative to blood transfusion
Improved survival
Pharmacoeconomic benefits
Higher risk of thrombosis

Erythropoietin is a drug that stimulates the production of red blood cells. It is used to treat anemia in cancer patients. While erythropoietin has been shown to improve quality of life and reduce transfusion requirements, its effect on survival in cancer patients is controversial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Early intervention with epoetin alfa during platinum-based chemotherapy: an analysis of the results of a multicenter, randomized, controlled trial based on initial hemoglobin level.

Author: SavonijeJorine H, van GroeningenCees J, WormhoudtLars W, GiacconeGuiseppe

Cancer treatment

This analysis of the results of a randomized, controlled trial evaluating the effects of epoetin alfa (EPO) therapy on transfusion requirements, hemoglobin (Hb), and quality of life (QOL) in patients with cancer receiving platinum-based chemotherapy was conducted to evaluate the effect of initial Hb level on study outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Epoetin alfa in platinum-treated ovarian cancer patients: results of a multinational, multicentre, randomised trial.

Author: WilkinsonP M, AntonopoulosM, LahousenM, LindM, KosmidisP,

Improved quality of life
Increased hemoglobin levels
Reduced transfusion need

This study investigated the effects of epoetin alfa on hematologic and quality of life (QOL) parameters in anemic ovarian cancer patients receiving platinum chemotherapy. Epoetin alfa, given 3 times weekly, increased hemoglobin levels and reduced transfusion requirements. Furthermore, epoetin alfa improved QOL scores compared to standard treatment alone.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Recombinant human erythropoietins and cancer patients: updated meta-analysis of 57 studies including 9353 patients.

Author: BohliusJulia, WilsonJayne, SeidenfeldJerome, PiperMargaret, SchwarzerGuido, SandercockJosie, TrelleSven, WeingartOlaf, BaylissSue, DjulbegovicBenjamin, BennettCharles L, LangensiepenSimon, HydeChris, EngertAndreas

Improved hematologic response
Reduced transfusion risk
Thromboembolic events
Uncertain survival impact

This systematic review of 57 trials and 9353 cancer patients found that epoetin and darbepoetin significantly reduced the risk of red blood cell transfusions and improved hematologic response. However, these drugs increased the risk of thromboembolic events. There is uncertainty about whether these drugs affect overall survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Double-blind, placebo-controlled study of quality of life, hematologic end points, and safety of weekly epoetin alfa in children with cancer receiving myelosuppressive chemotherapy.

Author: RazzoukBassem I, HordJeffrey D, HockenberryMarilyn, HindsPamela S, FeusnerJames, WilliamsDenise, RackoffWayne R

Increased Hb
Reduced transfusions

Once-weekly epoetin alfa (EPO) was well tolerated and had hematologic benefits in children with cancer. No significant difference in health-related quality of life (HRQOL) was detected between treatment groups, but a significant positive correlation was observed between Hb changes and HRQOL changes in the EPO group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Comparison of the therapeutic effects of epoetin zeta to epoetin alfa in the maintenance phase of renal anaemia treatment.

Author: WizemannVolker, RutkowskiBoleslaw, BaldamusConrad, ScigallaPaul, KoytchevRossen,

Equivalent Hb levels
Safe treatment
Infections

Epoetin zeta is therapeutically equivalent to epoetin alfa in maintaining target haemoglobin levels in patients with renal anaemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Prevention of anaemia by early intervention with once weekly epoetin alfa during chemotherapy.

Author: SchouwinkJ H, CodringtonH, SleeboomH P, KerkhofsL G M, WormhoudtL W

Improved Hb levels
Reduced transfusions
Well tolerated

Early intervention with epoetin alfa, a medication for anemia, in cancer patients receiving chemotherapy, was found to be more effective in improving hemoglobin (Hb) levels than standard therapy. Early intervention also resulted in a lower amount of blood transfused, despite a similar percentage of patients receiving transfusions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Effects of exercise in combination with epoetin alfa during high-dose chemotherapy and autologous peripheral blood stem cell transplantation for multiple myeloma.

Author: ColemanElizabeth A, CoonSharon K, KennedyRobert L, LockhartKimberly D, StewartCarol B, AnaissieElias J, BarlogieBart

Reduced RBC transfusions
Reduced stem cell collection attempts

Exercise with prophylactic epoetin alfa therapy reduces the number of red blood cell transfusions and attempts at stem cell collection for patients receiving intensive treatment for multiple myeloma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Population pharmacokinetic modeling of epoetin delta in pediatric patients with chronic kidney disease.

Author: KnebelWilliam, PalmenMary, DowellJames A, GastonguayMarc

This analysis quantified the population pharmacokinetics of subcutaneous and intravenous epoetin delta in pediatric patients with chronic kidney disease. The results suggest that epoetin delta pharmacokinetic parameters are similar in children and adults when scaled by weight.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Systematic Review of Erythropoietin (EPO) for Neuroprotection in Human Studies.

Author: HemaniSalman, LaneOlabisi, AgarwalSunil, YuShan Ping, WoodburyAnna

Neuroprotection
Adverse events
Thrombosis

This systematic review examined the application and risks of erythropoietin (EPO) as a neuroprotective treatment in normonemic adults. It found that EPO has potential benefits but also a risk of thrombosis and adverse events, particularly when co-administered with tPA. Future trials should evaluate EPO's role in post-operative pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Comparative Effects of Pegylated Erythropoietin and Darbepoetin Alfa on Erythropoietin Hyporesponsive Anemia of Patients with Chronic Kidney Disease on Maintenance Hemodialysis.

Author: NandNitya, NandanRaghu, JainDeepak

Overcome erythropoietin hyporesponsiveness
Stable hemoglobin levels

Pegylated erythropoietin was more effective than darbepoetin alfa in overcoming erythropoietin hyporesponsiveness and maintaining stable hemoglobin levels in chronic kidney disease (CKD) patients on maintenance hemodialysis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Effects of early intervention with epoetin alfa on transfusion requirement, hemoglobin level and survival during platinum-based chemotherapy: Results of a multicenter randomised controlled trial.

Author: SavonijeJ H, van GroeningenC J, van BochoveA, HonkoopA H, van FeliusC L, WormhoudtL W, GiacconeG

Improved QOL
Increased Hb
Reduced transfusion requirements
Well tolerated

Early intervention with epoetin alfa (EPO) significantly decreased transfusion requirements, increased hemoglobin levels, and improved quality of life in patients with mild anemia during platinum-based chemotherapy. However, no significant differences in survival were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Feasibility of quantifying the effects of epoetin alfa therapy on cognitive function in women with breast cancer undergoing adjuvant or neoadjuvant chemotherapy.

Author: O'ShaughnessyJoyce A, VukeljaSvetislava J, HolmesFrankie Ann, SavinMichael, JonesMonte, RoyallDonald, GeorgeMartine, Von HoffDaniel

Improved cognitive function
Improved quality of life
Reduced fatigue

This pilot trial investigated the effects of epoetin alfa on cognitive function, mood, fatigue, and quality of life (QOL) in patients with breast cancer receiving anthracycline-based chemotherapy. Epoetin alfa showed a potential benefit in attenuating cognitive impairment and fatigue during chemotherapy, with no significant differences in mood or QOL. The study also demonstrated the feasibility of quantifying the effects of epoetin alfa on cognitive function and mood.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Meta-analysis of the effects of epoetin alfa treatment on quality of life in anaemic cancer patients.

Author:

Improved QoL

Epoetin alfa is a drug used to treat anemia in cancer patients. Meta-analysis of studies shows that epoetin alfa improves quality of life in patients with anemia receiving chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Effects of epoetin alfa on cognitive function, mood, asthenia, and quality of life in women with breast cancer undergoing adjuvant chemotherapy.

Author: O'ShaughnessyJoyce A

Chemotherapy
Neuroprotection
Cognitive dysfunction

This pilot study explores the feasibility of administering standardized neurocognitive assessment tests in oncology settings and assesses whether epoetin alfa can mitigate cognitive dysfunction associated with chemotherapy in breast cancer patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

Epoetin alfa and darbepoetin alfa: effects on ventricular hypertrophy in patients with chronic kidney disease.

Author: ChenH-H, TarngD-C, LeeK-F, WuC Y, ChenY-C

Increased ejection fraction
Reduced LVMI

Epoetin alfa and darbepoetin alfa, when given to patients with chronic kidney disease (CKD) in doses aimed at standard anemia correction, were associated with a similar degree of left ventricular mass index (LVMI) reduction without enhancing CKD progression.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Effects of epoetin alfa on blood transfusions and postoperative recovery in orthopaedic surgery: the European Epoetin Alfa Surgery Trial (EEST).

Author: WeberE W G, SlappendelR, HémonY, MählerS, DalénT, RouwetE, van OsJ, VosmaerA, van der ArkP

Hospitalization time reduction
Transfusion requirement reduction

This study examined the impact of preoperative epoetin alfa administration on postoperative recovery and infection rate. The study found that preoperative epoetin alfa administration decreased transfusion requirements but did not significantly reduce postoperative recovery time or infection rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

The effects of epoetin alfa on transfusion requirements in head and neck cancer patients: a prospective, randomized, placebo-controlled study.

Author: ScottShaun N, BoeveThomas J, McCullochTimothy M, FitzpatrickKari A, KarnellLucy H

Increased hemoglobin
Reduced transfusion requirements

Epoetin alfa demonstrated a significant improvement in hematopoietic parameters and a trend toward decreased transfusion requirements in patients undergoing major head and neck cancer surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Comparison of the therapeutic effects of epoetin zeta to epoetin alfa in the maintenance phase of renal anaemia treatment.

Author: WizemannVolker, RutkowskiBoleslaw, BaldamusConrad, ScigallaPaul, KoytchevRossen,

Equivalent Hb levels
Safe treatment
Infections

Epoetin zeta is therapeutically equivalent to epoetin alfa in maintaining target haemoglobin levels in patients with renal anaemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Long term effects of epoetin alfa in patients with ST- elevation myocardial infarction.

Author: FokkemaMarieke L, KleijnLennaert, van der MeerPeter, BelonjeAnne M, AchterhofSandra K, HillegeHans L, van 't HofArnoud, JukemaJ Wouter, PeelsHans O, HenriquesJosé P, ten BergJurriën M, VosJeroen, van GilstWiek H, van VeldhuisenDirk J, VoorsAdriaan A

Epoetin alfa for STEMI
Cardiovascular morbidity and mortality

This study evaluated clinical events at 1 year after PCI in patients with a first ST-elevation myocardial infarction (STEMI) who received epoetin alfa.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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