Side Effects of esomeprazole injection: A Synthesis of Findings from 3 Studies

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Original Abstract of the Article

Major Research Findings

Antidepressant side effects are common and can affect how well treatment works for people with major depressive disorder (MDD). 2 One study found that the severity of side effects changed over time and was related to how well treatment worked. 1 Another study looked at how side effects of a specific type of antidepressant (SSRI) were related to differences in people's genes, specifically those involved in how the brain uses serotonin.

Reasons for Side Effects

Antidepressant side effects are thought to be caused by changes in the levels of chemicals in the brain, such as serotonin, dopamine, and norepinephrine. 2 , 1

Common Side Effects

Nausea and Vomiting

A common side effect of antidepressants is feeling sick to your stomach or throwing up. 2

Headache

Another common side effect is having headaches. 2

Drowsiness

Feeling sleepy is another common side effect. 2

Gastrointestinal symptoms

Antidepressants can also cause problems with your digestive system. 1

Sexual side effects

Some people taking antidepressants experience changes in their sexual function. 1

Side Effect Management

Nausea and Vomiting

Eating small meals more often can help reduce nausea and vomiting. Drinking plenty of fluids is also important. 2

Headache

Over-the-counter pain relievers can help reduce headaches. 2

Drowsiness

Taking medication at bedtime may help reduce drowsiness. 2

Gastrointestinal symptoms

Changes in diet and lifestyle may help manage digestive problems. 1

Sexual side effects

Reducing the dosage of the medication may help lessen sexual side effects. 1

Comparison between Studies

Similarities between Studies

Both studies suggest that antidepressant side effects can affect how well depression treatment works. 2 , 1

Differences between Studies

The 2 study looked at how the severity of side effects changed over the course of treatment. The 1 study investigated the association between antidepressant side effects and genetic variation in the serotonin system in anxious, older adults participating in a randomized, placebo-controlled trial of the selective serotonin reuptake inhibitor (SSRI) escitalopram.

Notes on Applying to Real Life

Side effects of antidepressants can vary from person to person. 2 , 1

If you are concerned about side effects, talk to your doctor.

Limitations of Current Research

There is still a lot we don't know about antidepressant side effects. 2 , 1

Future Research Directions

More research is needed on antidepressant side effects. 2 , 1

Conclusion

Antidepressant side effects can impact how well depression treatment works. 2 , 1

If you are concerned about side effects, talk to your doctor.

Literature analysis of 3 papers
Positive Content
2
Neutral Content
0
Negative Content
1
Article Type
2
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3
1.

Common selective serotonin reuptake inhibitor side effects in older adults associated with genetic polymorphisms in the serotonin transporter and receptors: data from a randomized controlled trial.

Author: GarfieldLauren D, DixonDavid, NowotnyPetra, LotrichFrancis E, PollockBruce G, KristjanssonSean D, DoréPeter M, LenzeEric J

Antidepressant side effects

This study investigated the relationship between antidepressant side effects and genetic variations in the serotonin system in older adults experiencing anxiety. The research aimed to understand the impact of genetic variations on the effectiveness and tolerability of escitalopram, a selective serotonin reuptake inhibitor, in this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

2.

Antidepressant side effects and their impact on treatment outcome in people with major depressive disorder: an iSPOT-D report.

Author: BraundTaylor A, TillmanGabriel, PalmerDonna M, GordonEvian, RushA John, HarrisAnthony W F

Depression treatment
Side effects
Treatment outcome

This study looks at the frequency, intensity, and burden of side effects associated with antidepressant medications in people with major depressive disorder (MDD). The study found that the burden of side effects was associated with poorer treatment outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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