Effective treatment of esophagus disorders: A Synthesis of Findings from 76 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of esophagus disorders: A Synthesis of Findings from 76 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Esophageal cancer is a serious disease, and its treatment depends on the stage of the cancer, the patient's overall health, and other factors. Many studies have shown that combining chemotherapy, radiation therapy, and surgery can be effective in treating esophageal cancer. For example, 24 shows that neoadjuvant chemoradiotherapy before surgery improves survival rates compared to surgery alone. Additionally, 12 found that neoadjuvant chemotherapy improves survival for patients with advanced esophageal adenocarcinoma. However, 18 found no significant difference in early survival between chemoradiotherapy and surgery for esophageal squamous cell carcinoma.

Treatment Summary

Treatments used in the studies include: 24 (neoadjuvant chemoradiotherapy, surgery alone), 12 (neoadjuvant chemotherapy, surgery alone), 18 (chemoradiotherapy, surgery).

Benefits and Risks

Benefit Summary

Surgery, chemotherapy, radiation therapy, and immunotherapy are among the various methods used in treating esophageal cancer. These treatments are decided jointly by the doctor and the patient, considering the stage of the tumor, the patient's overall health, and other factors.

Surgery aims to completely remove the tumor. Surgery can control the progression of the tumor and increase the patient's survival rate.

Chemotherapy is a treatment that uses anticancer drugs to destroy tumor cells. Chemotherapy is used to kill any remaining cancer cells after surgery or to slow down the progression of the tumor.

Radiation therapy is a treatment that uses radiation to destroy tumor cells. Radiation therapy is used to shrink the tumor or slow down its progression.

Immunotherapy is a treatment that works by removing the brakes on immune cells, allowing them to attack cancer cells. Immunotherapy is used when other treatments are no longer effective.

Risk Summary

The risks of surgery include bleeding, infection, and organ damage.

The risks of chemotherapy include nausea, vomiting, hair loss, and low white blood cell count.

The risks of radiation therapy include skin inflammation, fatigue, and digestive problems.

The risks of immunotherapy include immune-related side effects such as pneumonia and hepatitis.

Comparison Between Studies

Similarities Among Studies

Many studies have shown that combining chemotherapy, radiation therapy, and surgery can be effective in treating esophageal cancer.

Differences Among Studies

The treatments, treatment combinations, patient groups, and study durations varied among the studies. Therefore, comparing the study results is difficult.

Consistency and Contradictions in Results

The research findings on esophageal cancer treatment show both consistency and contradictions. Therefore, more research is needed.

Important Considerations for Real-Life Application

Esophageal cancer treatment should be decided jointly by the doctor and the patient, considering the stage of the tumor, the patient's overall health, and other factors.

Limitations of Current Research

There is still not enough research on esophageal cancer treatment. Therefore, more research is needed.

Directions for Future Research

Esophageal cancer treatment research needs to focus on developing new treatments, improving treatment effectiveness, and reducing treatment side effects.

Conclusion

Esophageal cancer treatment is a complex process that should be decided jointly by the doctor and the patient, considering the stage of the tumor, the patient's overall health, and other factors.

There is still not enough research on esophageal cancer treatment. Therefore, more research is needed.

If you are diagnosed with esophageal cancer, it is important to follow your doctor's instructions and receive treatment.

Treatment Keywords

Surgery, chemotherapy, radiation therapy, immunotherapy, neoadjuvant therapy, adjuvant therapy, endoscopic treatment, chemoradiotherapy, stent insertion, hyperthermia

Keywords
Benefit Keywords
Improved survival
Preoperative irradiation
1
Esophageal cancer treatment
2
Improved survival
Tumor shrinkage
3
Chemoradiotherapy effective
Esophageal cancer treatment
4
Dysphagia relief
Oesophageal cancer treatment
Shorter hospitalization
5
Good tolerance
Longer survival period
6
Effective esophageal cancer treatment
Improved survival rates
7
Effective treatment
Improved prognosis
8
Esophageal cancer treatment
Improved survival rate
9
Improved survival
10
Esophageal cancer treatment
11
Improved survival
12
Esophageal cancer treatment
13
Improved survival
14
Improved cure rates
15
Improved local control
16
Esophageal cancer treatment
17
Similar survival
18
Improved esophageal cancer treatment
19
Improved esophageal cancer treatment
20
Survival prediction
21
Esophageal cancer treatment
22
Improved esophageal cancer
23
Improved prognosis
24
Improved Dysphagia
Reduced Re-intervention
25
Early esophageal cancer treatment
26
Esophageal cancer treatment
27
Esophageal cancer treatment
28
Dysphagia Palliation
29
Safer approach
Similar survival outcomes
30
Improved survival
Personalized treatment
31
Esophageal cancer treatment
32
Oesophageal cancer treatment
33
Esophageal cancer treatment
34
Esophageal cancer treatment
35
Esophageal cancer treatment
37
Improved survival rate
Reduced recurrence
38
Equivalent survival
Improved quality of life
40
2-year survival improvement
3-year survival improvement
Disease-free survival improvement
Esophageal cancer treatment
Median survival time improvement
41
Effective treatment
Improved survival
42
EC treatment
43
Esophageal/gastroesophageal cancer treatment
44
Early detection
Esophageal cancer treatment
45
Esophageal cancer treatment
S-1 CRT regimen
46
CRT
Esophageal cancer treatment
47
Endoscopic treatment
Esophageal cancer treatment
Neoadjuvant therapy
48
ESCC treatment
Preoperative treatment
49
Esophageal cancer treatment
50
Overall survival
51
Advanced esophageal or EGJ cancer treatment
Pembrolizumab
52
Exercise informatics for esophagectomy
53
Improved esophageal cancer treatment
54
Improved esophageal cancer treatment
55
Reduced complications
56
Stage-guided treatment
Staging accuracy
57
Radioresponse prediction
58
Esophageal cancer treatment
59
Improved ESCC treatment
60
Fewer adverse events
Prolonged OS (PD-L1 CPS ≥ 10)
61
CCRT for esophageal cancer
62
Stents for dysphagia
63
Compound Kushen Injection for esophageal cancer
64
OS improvement
PFS improvement
Tumor recurrence reduction
65
Improved treatment outcomes
66
Improved ORR
Improved PFS
Improved epCR
67
Improved survival
68
CRT for LAEC
69
Esophageal cancer treatment
Improved local control
70
EC treatment
71
Dysphagia relief
Survival improvement
72
Improved survival
Reduced blood loss
Reduced complications
Reduced hospital stay
Reduced operative time
73
Improved response rates
Increased survival
Reduced side effects
74
Better quality of life
Improved survival outcomes
75
Improved HRQoL
76
Risk Keywords
Gastrointestinal symptoms
3
Side effects
4
Advanced disease before symptoms
Extension to surrounding structures
Lymph node involvement
Submucosal spread
Unclear role of preoperative chemotherapy
10
Increased treatment mortality
14
Conflicting individual reports
15
Increased mortality
16
Chemotherapy risks
17
Operative mortality
Postoperative complications
18
Localized esophageal cancer
19
Esophageal cancer
20
Adverse events
23
Delayed Complications
Recurrent Dysphagia
25
Anastomotic leakage
Anastomotic stricture
27
Distant metastases
Higher risk of progression
30
Esophageal cancer
31
Increased acute toxic effects
38
Dysphagia
Higher mortality with radiotherapy
40
Adverse effects increase
41
Side effects
Toxicity
42
Recurrence
45
CRT toxicity
46
ESCC relapse
58
Controversial CCT benefit
62
Further research needed
67
Toxicity
70
Bleeding events
Pain events
Stent migration
72
Late toxicities
76
Literature analysis of 76 papers
Positive Content
73
Neutral Content
3
Negative Content
0
Article Type
30
30
32
22
72
1.

Pre-operative radiotherapy prolongs survival in operable esophageal carcinoma: a randomized, multicenter study of pre-operative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancer.

Author: NygaardK, HagenS, HansenH S, HatlevollR, HultbornR, JakobsenA, MäntylaM, ModigH, Munck-WiklandE, RosengrenB

Improved survival
Preoperative irradiation

A study of 186 patients with squamous cell esophageal carcinoma found that pre-operative radiation therapy significantly improved 3-year survival rates compared to surgery alone, regardless of whether chemotherapy was also used. The study found no significant difference in survival between patients who received pre-operative chemotherapy and those who did not. Women had significantly better survival than men. The study concluded that pre-operative radiation is beneficial for improving survival in esophageal cancer, but the chemotherapy regimen used did not influence survival outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Preoperative therapy for esophageal cancer: a randomized comparison of chemotherapy versus radiation therapy.

Author: KelsenD P, MinskyB, SmithM, BeitlerJ, NiedzwieckiD, ChapmanD, BainsM, BurtM, HeelanR, HilarisB

Esophageal cancer treatment

A study of 96 patients with operable esophageal cancer compared the effectiveness of preoperative chemotherapy (CT) and radiation therapy (RT) before surgery. Both treatments showed similar tumor response rates, operability rates, resection rates, and mortality rates. However, CT allowed for higher doses when given as initial therapy. The median survival for all patients was 11 months, with 20% surviving without disease after 34 months. The study suggests that CT may be as effective as RT for local tumor control but offers the potential benefit of treating systemic disease. Further research is needed to develop more effective chemotherapy regimens for esophageal cancer. Outside of clinical trials, surgery alone or radiation alone remain the standard treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

[Preoperative chemotherapy of esophageal cancer].

Author: WangZ Y

Improved survival
Tumor shrinkage
Gastrointestinal symptoms

This study investigated the effects of pre-operative chemotherapy followed by surgery in 25 patients with advanced esophageal cancer. While pre-operative chemotherapy had minimal side effects and did not hinder surgery, it led to noticeable improvements in tumor size and symptoms in 5 out of 25 patients. The study also found significant differences in tumor tissue after surgery, with increased keratinization and cell death in the chemotherapy group. The study suggests that further research is needed to explore the potential benefits of this combined approach to treating esophageal cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

4.

Combination of bleomycin and adriamycin with and without radiation on the treatment of inoperable esophageal cancer. A randomized study.

Author: KolarićK, MaricićZ, RothA, DujmovićI

Chemoradiotherapy effective
Esophageal cancer treatment
Side effects

A study of 31 patients with inoperable esophageal cancer compared chemotherapy (bleomycin and adriamycin) alone to chemotherapy plus radiation therapy. The combination of chemotherapy and radiation resulted in a significantly higher response rate (60%) compared to chemotherapy alone (19%). While both treatments were associated with side effects, the combined treatment showed longer durations of remission and greater effectiveness in controlling the disease. These findings suggest that combined chemoradiotherapy may be a beneficial treatment approach for inoperable esophageal cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

[Palliative radiation schedules with and without chemotherapy in advanced carcinoma of the esophagus].

Author: AlbertsA S, AndersonJ D, GoedhalsL, CronjeJ D, DomanM J

Dysphagia relief
Oesophageal cancer treatment
Shorter hospitalization

A study of 272 patients with advanced esophageal cancer compared different combinations of radiation and chemotherapy. While 67% of patients experienced relief from difficulty swallowing, the median survival was only 3 months and the 1-year survival was 7%. There was no significant difference in survival between the different treatment groups. The study concluded that while chemotherapy alone did not improve outcomes, the shorter radiation schedule with larger doses was as effective as the traditional schedule. A feeding tube was found to be useful for patients with esophageal cancer. The study emphasizes the need for a multi-modality approach, including chemotherapy, for improving outcomes in this aggressive disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Afrikaans

6.

[Multidisciplinary treatment of esophageal cancer].

Author: KuwanoH, SadanagaN, WatanabeM, IkebeM, MoriM, SugimachiK

Good tolerance
Longer survival period

This study of 21 patients with squamous cell carcinoma of the thoracic esophagus found that hyperthermo-chemotherapy was more effective than chemotherapy alone in achieving complete or partial response.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Japanese

7.

A prospective study of combined therapy in esophageal cancer.

Author: ApinopC, PuttisakP, PreechaN

Effective esophageal cancer treatment
Improved survival rates

This study of 69 patients with squamous esophageal cancer found that combined treatment with chemotherapy (cisplatinum and 5-fluorouracil) and radiation followed by resection was associated with slightly better survival rates at one and five years compared to resection alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

[Multidisciplinary preoperative treatment of esophageal cancer].

Author: IkebeM, KuwanoH, MaekawaS, SugimachiK

Effective treatment
Improved prognosis

Preoperative hyperthermia combined with radiation and chemotherapy (HCR) was more effective than chemotherapy and radiotherapy (CR) alone in treating esophageal cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Japanese

9.

[A clinical analysis of combination treatment with brachytherapy and external radiation, plus chemotherapy for the treatment of esophageal cancer].

Author: ZhongX, YuanD, YangL

Esophageal cancer treatment
Improved survival rate

Combined treatment with external radiation, brachytherapy, and chemotherapy improved local tumor control and survival rate in patients with esophageal cancer. A study involving 120 patients with esophageal cancer found that combination therapy was significantly more effective than external radiation alone in improving survival rates and reducing cancer recurrence and progression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

11.

A meta-analysis of randomized controlled trials that compared neoadjuvant chemotherapy and surgery to surgery alone for resectable esophageal cancer.

Author: UrschelJohn D, VasanHari, BlewettChris J

Esophageal cancer treatment

A meta-analysis of randomized controlled trials (RCTs) examined the effectiveness of neoadjuvant chemotherapy combined with surgery compared to surgery alone in treating esophageal cancer.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Neoadjuvant treatment of advanced stage esophageal adenocarcinoma increases survival.

Author: WalshT N, GrennellM, MansoorS, KellyA

Improved survival

A study found that multimodal therapy, including chemotherapy and surgery, increased survival for patients with esophageal cancer compared to surgery alone. The median survival for patients with minimal residual disease was 27 months for multimodal therapy and 14 months for surgery alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer.

Author: UrschelJohn D, VasanHari

Esophageal cancer treatment

This study reviewed multiple clinical trials that compared the effectiveness of surgery alone versus surgery combined with chemotherapy and radiation (neoadjuvant chemoradiation) for treating esophageal cancer. The study aimed to determine if neoadjuvant chemoradiation, despite potential side effects, improved survival rates for patients with esophageal cancer.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Neoadjuvant treatment for resectable cancer of the esophagus and the gastroesophageal junction: a meta-analysis of randomized clinical trials.

Author: KaklamanosIoannis G, WalkerGail R, FerryKristian, FranceschiDido, LivingstoneAlan S

Improved survival
Increased treatment mortality

Neoadjuvant chemotherapy followed by surgery seems to have a modest survival advantage over surgery alone. However, there is an apparent increase in treatment-related mortality, especially for patients who receive neoadjuvant chemoradiotherapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

15.

Preoperative chemotherapy for resectable thoracic esophageal cancer.

Author: MalthanerR, FenlonD

Improved cure rates
Conflicting individual reports

Surgery has been the standard treatment for localized esophageal cancer. Studies investigating whether giving chemotherapy before surgery (preoperative chemotherapy) improves cure rates have yielded conflicting results. This review aims to provide an updated analysis of the role of preoperative chemotherapy in treating resectable esophageal cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus.

Author: StahlMichael, StuschkeMartin, LehmannNils, MeyerHans-Joachim, WalzMartin K, SeeberSiegfried, KlumpBodo, BudachWilfried, TeichmannReinhard, SchmittMarcus, SchmittGerd, FrankeClaus, WilkeHansjochen

Improved local control
Increased mortality

Adding surgery to chemoradiotherapy improves local tumor control but does not increase survival of patients with locally advanced esophageal SCC. Tumor response to induction chemotherapy identifies a favorable prognostic group within these high-risk patients, regardless of the treatment group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial.

Author: BurmeisterBryan H, SmithersB Mark, GebskiVal, FitzgeraldLara, SimesR John, DevittPeter, AcklandStephen, GotleyDavid C, JosephDavid, MillarJeremy, NorthJohn, WalpoleEuan T, DenhamJames W,

Esophageal cancer treatment
Chemotherapy risks

This study investigates whether a short preoperative chemoradiotherapy regimen improves outcomes for patients with resectable esophageal cancer, aiming to address local recurrence and distant metastasis after surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Multicenter prospective randomized trial comparing standard esophagectomy with chemoradiotherapy for treatment of squamous esophageal cancer: early results from the Chinese University Research Group for Esophageal Cancer (CURE).

Author: ChiuPhilip W Y, ChanAngus C W, LeungS F, LeongH T, KwongK H, LiMicheal K W, Au-YeungAlex C M, ChungSydney C S, NgEnders K W

Similar survival
Operative mortality
Postoperative complications

This randomized trial compared esophagectomy to chemoradiation as curative treatments for squamous cell carcinoma of the esophagus, finding that both treatments offered similar early clinical outcomes and survival.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Preoperative chemotherapy for resectable thoracic esophageal cancer.

Author: MalthanerR A, CollinS, FenlonD

Improved esophageal cancer treatment
Localized esophageal cancer

Surgery has been the main treatment for early-stage esophageal cancer. Studies examining whether giving chemotherapy before surgery (preoperative chemotherapy) improves cure rates have produced mixed results. This review provides an updated analysis of the role of preoperative chemotherapy in treating resectable esophageal cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Factors predicting survival in patients with advanced oesophageal cancer: a prospective multicentre evaluation.

Author: BergquistH, JohnssonA, HammerlidE, WengerU, LundellL, RuthM

Survival prediction

Health-related quality of life questionnaires can provide prognostic information in addition to M-stage for patients with advanced cancer of the oesophagus or gastro-oesophageal junction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781.

Author: TepperJoel, KrasnaMark J, NiedzwieckiDonna, HollisDonna, ReedCarolyn E, GoldbergRichard, KielKrystyna, WillettChristopher, SugarbakerDavid, MayerRobert

Esophageal cancer treatment

Survival, response, and patterns of failure of trimodality therapy were compared to esophagectomy alone in patients with nonmetastatic esophageal cancer.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

[Phase II clinical trial of concurrent chemoradiotherapy (cisplatin plus 5-fluorouracil) for esophageal cancer].

Author: LinQiang, GaoXian-Shu, QiaoXue-Ying, ChenKun, WangYa-Di, ZhouZhi-Guo

Improved esophageal cancer
Adverse events

This study evaluated the efficacy of concurrent chemoradiotherapy with cisplatin plus 5-fluorouracil (PF) regimen on esophageal cancer in China.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

24.

Neoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the esophagus (CROSS).

Author: van HeijlM, van LanschotJ J B, KoppertL B, van Berge HenegouwenM I, MullerK, SteyerbergE W, van DekkenH, WijnhovenB P L, TilanusH W, RichelD J, BuschO R C, BartelsmanJ F, KoningC C E, OfferhausG J, van der GaastA

Improved prognosis

A randomized phase III trial is needed to prove that neoadjuvant chemoradiotherapy improves overall survival in patients with esophageal cancer.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Interventions for dysphagia in oesophageal cancer.

Author: SreedharanAravamuthan, HarrisKeith, CrellinAdrian, FormanDavid, EverettSimon M

Improved Dysphagia
Reduced Re-intervention
Delayed Complications
Recurrent Dysphagia

Self-expanding metal stent insertion is safe, effective and quicker in palliating dysphagia compared to other modalities in patients with inoperable or unresectable primary oesophageal cancer. High-dose intraluminal brachytherapy is a suitable alternative and might provide additional survival benefit with a better quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

The safety and effectiveness of endoscopic and non-endoscopic approaches to the management of early esophageal cancer: a systematic review.

Author: McCannPaul, StafinskiTania, WongClarence, MenonDevidas

Early esophageal cancer treatment

Traditional treatment for early-stage esophageal cancer involved surgery, sometimes with chemotherapy and/or radiation. To improve outcomes and reduce side effects, less invasive, endoscopic procedures have been developed to remove cancer while preserving healthy tissue. This review compares the safety and effectiveness of these endoscopic procedures to traditional treatments for early esophageal cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Literature analysis of radiotherapy for esophageal cancer in China.

Author: ZhouZhi-Guo, GaoXian-Shu, QiaoXue-Ying, ZhangPing

Esophageal cancer treatment

This study reviews research on radiation therapy for esophageal cancer in China over the past 15 years. The study analyzes the effectiveness of radiation therapy, looking at survival rates, how well the cancer is controlled locally, and potential side effects. The study aims to provide insight into the best approaches to treating esophageal cancer using radiation therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

29.

WITHDRAWN: Interventions for dysphagia in oesophageal cancer.

Author: SreedharanAravamuthan, HarrisKeith, CrellinAdrian, FormanDavid, EverettSimon M

Dysphagia Palliation

Self-expanding metal stent insertion was found to be safe, effective and quicker in palliating dysphagia compared to other modalities in patients with inoperable or unresectable primary oesophageal cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Radiotherapy versus surgery within multimodality protocols for esophageal cancer--a meta-analysis of the randomized trials.

Author: PöttgenChristoph, StuschkeMartin

Safer approach
Similar survival outcomes
Distant metastases
Higher risk of progression

This review compared definitive (chemo-)radiotherapy with surgery for potentially resectable esophageal cancer. The results suggest that radiotherapy is a reasonable alternative to surgery, particularly in patients with comorbidities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

31.

Systematic review and meta-analysis of tumor biomarkers in predicting prognosis in esophageal cancer.

Author: ChenMeilan, HuangJizheng, ZhuZhenli, ZhangJun, LiKe

Improved survival
Personalized treatment
Esophageal cancer

This study aims to assess the prognostic value of biomarkers in predicting overall survival in esophageal cancer (EC). The goal is to guide personalized cancer treatment for improved remission chances.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

The current evidence in support of multimodal treatment of locally advanced, potentially resectable esophageal cancer.

Author: ZacherlJohannes

Esophageal cancer treatment

Treating advanced esophageal cancer that can be surgically removed is complex. Improvements in surgical techniques, chemotherapy, and radiation therapy have significantly advanced treatment options over the past few decades. Diagnosis and treatment plans are now guided by sophisticated imaging technology, and specialists work together in multidisciplinary teams to determine the best course of action based on the latest evidence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

34.

The clinical research of the endoscopic sequential treatment for patients with intermediate-advanced esophageal cancer: a randomized clinical trial.

Author: WenLiming, QuanHonglin, LiLinyan, HuangChun, ChenXiaohui, YangYaling, WangLiming, HeXiguo, ZhangXudong

Esophageal cancer treatment

This study investigated different treatment approaches for advanced esophageal cancer. The study found that combining chemotherapy with either iodine-125 particle stents or traditional metal stents led to better survival rates, quality of life, and fewer complications compared to other treatment methods. While both iodine-125 and metal stents were effective, iodine-125 stents were associated with higher quality of life and fewer complications. The study suggests that combining chemotherapy with iodine-125 particle stents could be a promising treatment for this type of cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Multimodality approaches for the curative treatment of esophageal cancer.

Author: JangRaymond, DarlingGail, WongRebecca K S

Esophageal cancer treatment

While esophageal cancer that hasn't spread is potentially curable, the cure rate is low. Combining different treatments has been shown to improve survival rates by 10-15% compared to using a single treatment. This review examines the timing of chemotherapy and radiation, whether it's best before or after surgery, and whether surgery can be avoided in some cases. It also incorporates recommendations from treatment guidelines from Ontario, NCCN, and Belgium.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Prognostic Factors in Patients Receiving Neoadjuvant 5-Fluorouracil plus Cisplatin for Advanced Esophageal Cancer (JCOG9907).

Author: YokotaTomoya, AndoNobutoshi, IgakiHiroyasu, ShinodaMasayuki, KatoKen, MizusawaJunki, KatayamaHiroshi, NakamuraKenichi, FukudaHaruhiko, KitagawaYuko

Neoadjuvant chemotherapy with 5-fluorouracil plus cisplatin is a standard treatment for clinical stage II/III squamous cell carcinoma (SCC) of the esophagus. This study investigates prognostic factors for patients who received neoadjuvant chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

Preoperative chemotherapy for resectable thoracic esophageal cancer.

Author: KidaneBiniam, CoughlinShaun, VogtKelly, MalthanerRichard

Esophageal cancer treatment

Surgery is the standard treatment for localized esophageal cancer. While some studies suggest that giving chemotherapy before surgery may improve cure rates, the results are mixed. This review aims to provide an updated assessment of the benefits of preoperative chemotherapy for patients with resectable esophageal cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

A Meta-Analysis of Concurrent Chemoradiotherapy for Advanced Esophageal Cancer.

Author: ZhuLi-Li, YuanLing, WangHui, YeLin, YaoGui-Ying, LiuCui, SunNiu-Niu, LiXiao-Jing, ZhaiShi-Cong, NiuLing-Juan, ZhangJun-Bo, JiHong-Long, LiXiu-Min

Improved survival rate
Reduced recurrence
Increased acute toxic effects

Concurrent chemoradiotherapy significantly improved overall survival rate and reduced the risk of persistence and recurrence in patients with local advanced esophageal cancer. However, it had little effect on the primary tumor response and increased the occurrence of acute toxic effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Simultaneous Comparison of Efficacy and Adverse Events of Interventions for Patients with Esophageal Cancer: Protocol for a Systematic Review and Bayesian Network Meta-analysis.

Author: Doosti-IraniAmin, MansourniaMohammad Ali, Rahimi-ForoushaniAbbas, CheraghiZahra, Holakouie-NaieniKourosh

This review compares the efficacy and adverse events of different treatment interventions for esophageal cancer using a network meta-analysis. The study aims to identify treatment options that offer better overall survival with fewer side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

40.

Non-surgical versus surgical treatment for oesophageal cancer.

Author: BestLawrence M J, MughalMuntzer, GurusamyKurinchi Selvan

Equivalent survival
Improved quality of life
Dysphagia
Higher mortality with radiotherapy

Chemoradiotherapy appears to be at least equivalent to surgery in terms of short-term and long-term survival in people with oesophageal cancer who are fit for surgery and are responsive to induction chemoradiotherapy. However, there is uncertainty in the comparison of definitive chemoradiotherapy versus surgery for oesophageal cancer (adenocarcinoma type) and we cannot rule out significant benefits or harms of definitive chemoradiotherapy versus surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Risks and Benefits of Multimodal Esophageal Cancer Treatments: A Meta-Analysis.

Author: SunLei, ZhaoFen, ZengYan, YiCheng

2-year survival improvement
3-year survival improvement
Disease-free survival improvement
Esophageal cancer treatment
Median survival time improvement
Adverse effects increase

This meta-analysis investigated the efficacy and safety of different treatment strategies for esophageal cancer, comparing the outcomes of adding therapies to radiotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

42.

Overview of different available chemotherapy regimens combined with radiotherapy for the neoadjuvant and definitive treatment of esophageal cancer.

Author: TomaselloGianluca, GhidiniMichele, BarniSandro, PassalacquaRodolfo, PetrelliFausto

Effective treatment
Improved survival
Side effects
Toxicity

This systematic review examined the activity and toxicity of various neoadjuvant chemoradiotherapy (CTRT) regimens for esophageal cancer, highlighting the effectiveness of radiotherapy combined with carboplatin plus paclitaxel chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Comparison of IMRT versus 3D-CRT in the treatment of esophagus cancer: A systematic review and meta-analysis.

Author: XuDandan, LiGuowen, LiHongfei, JiaFei

EC treatment

This meta-analysis compared the effectiveness of intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) in treating esophageal cancer (EC). Although IMRT is believed to be superior, the meta-analysis did not find significant differences in survival, toxicity, or dose-volume histograms between the two techniques.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer.

Author: JanmaatVincent T, SteyerbergEwout W, van der GaastAte, MathijssenRon Hj, BrunoMarco J, PeppelenboschMaikel P, KuipersErnst J, SpaanderManon Cw

Esophageal/gastroesophageal cancer treatment

About half of people diagnosed with esophageal or gastroesophageal junction cancer have cancer that has spread. While chemotherapy and targeted therapies are increasingly used to slow the disease and improve quality of life, there is limited evidence for the effectiveness of these treatments, except for ramucirumab.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

The role of surgical treatment in isolated organ recurrence of esophageal cancer-a systematic review of the literature.

Author: SchizasDimitrios, LazaridisIoannis I, MorisDemetrios, MastorakiAikaterini, LazaridisLazaros-Dimitrios, TsilimigrasDiamantis I, CharalampakisNikolaos, LiakakosTheodore

Early detection
Esophageal cancer treatment
Recurrence

While early detection and treatment of esophageal cancer have improved, over half of patients develop the disease again within three years. These patients have a poor prognosis. Treatment after recurrence varies, and there's no single best approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Role of adjuvant chemoradiotherapy after endoscopic treatment of early-stage esophageal cancer: a systematic review.

Author: GoenseLucas, MezianiJihane, BorggreveAlicia S, van RossumPeter S, MeijerGert J, RuurdaJelle P, van HillegersbergRichard, WeustenBas L

CRT
Esophageal cancer treatment

Surgery is typically recommended for early-stage esophageal cancer with a high risk of spread, but some patients are not healthy enough for surgery. This review examines the safety and effectiveness of combining endoscopic treatment with chemotherapy and radiation therapy (CRT) as an alternative approach for these high-risk patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Neoadjuvant therapy or upfront surgery? A systematic review and meta-analysis of T2N0 esophageal cancer treatment options.

Author: MotaF C, CecconelloI, TakedaF R, TustumiF, SallumR A A, BernardoW M

Endoscopic treatment
Esophageal cancer treatment
Neoadjuvant therapy

Esophageal cancer has a poor long-term survival rate, even with surgery. Giving treatments before surgery (neoadjuvant therapy) is becoming more common to shrink the tumor, potentially increasing the chance of a complete removal. While endoscopic treatments are used for early-stage cancers and surgery is the preferred option for larger tumors, there is no clear consensus on the best approach for those with intermediate stage esophageal cancer.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Efficacy of postoperative adjuvant chemotherapy for esophageal squamous cell carcinoma: A meta-analysis.

Author: ZhaoPeiliang, YanWanpu, FuHao, LinYao, ChenKe-Neng

ESCC treatment
Preoperative treatment

Esophageal squamous cell carcinoma (ESCC) is a common type of esophageal cancer. While the benefits of treatment before surgery are well-understood, the role of chemotherapy after surgery is still debated. This review updates previous research to examine the effectiveness of chemotherapy after surgery for ESCC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

18F FDG-PET/CT evaluation of histological response after neoadjuvant treatment in patients with cancer of the esophagus or gastroesophageal junction.

Author: GabrielsonStefan, Sanchez-CrespoAlejandro, KlevebroFredrik, AxelssonRimma, Albert TsaiJon, JohanssonOve, NilssonMagnus

Esophageal cancer treatment

18F-FDG positron emission tomography/computed tomography (PET/CT) is currently used for preoperative disease staging in esophageal cancer, but is not well established in the evaluation of neoadjuvant treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

51.

The role of definitive chemoradiotherapy versus surgery as initial treatments for potentially resectable esophageal carcinoma.

Author: MaMing-Wei, GaoXian-Shu, GuXiao-Bin, XieMu, CuiMing, ZhangMin, LiuLing, YinHuan, ChenLong-Qi

Overall survival

Definitive chemoradiotherapy (dCRT) and esophagectomy are equally effective as initial treatments for potentially resectable esophageal cancer. In a meta-analysis of 2071 patients, there were no significant differences in 2-year or 5-year overall survival rates. Western patients who received dCRT had poorer prognoses than patients who underwent surgery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

52.

KEYNOTE-590: Phase III study of first-line chemotherapy with or without pembrolizumab for advanced esophageal cancer.

Author: KatoKen, ShahManish A, EnzingerPeter, BennounaJaafar, ShenLin, AdenisAntoine, SunJong-Mu, ChoByoung Chul, ÖzgüroğluMustafa, KojimaTakashi, KostorovVladimir, HierroCinta, ZhuYing, McLeanLee Anne, ShahSukrut, DoiToshihiko

Advanced esophageal or EGJ cancer treatment
Pembrolizumab

Treatment options for advanced esophageal or esophagogastric junction (EGJ) cancer are limited. Standard treatments for this advanced cancer often include platinum-based chemotherapy. Pembrolizumab, a type of immunotherapy, has shown promise in treating advanced esophageal and EGJ cancer in patients who have already received other treatments.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

The effectiveness of a nurse-led exercise and health education informatics program on exercise capacity and quality of life among cancer survivors after esophagectomy: A randomized controlled trial.

Author: ChangYu-Ling, TsaiYun-Fang, HsuChien-Lung, ChaoYin-Kai, HsuChih-Chin, LinKuan-Chia

Exercise informatics for esophagectomy

This randomized controlled trial found that an exercise and nursing education health informatics program significantly improved quality of life, exercise capacity, and nutrition in patients following esophagectomy for esophageal cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

54.

A phase-II/III randomized controlled trial of adjuvant radiotherapy or concurrent chemoradiotherapy after surgery versus surgery alone in patients with stage-IIB/III esophageal squamous cell carcinoma.

Author: NiWenjie, YuShufei, ZhangWencheng, XiaoZefen, ZhouZongmei, ChenDongfu, FengQinfu, LiangJun, LvJima, GaoShugeng, MaoYousheng, XueQi, SunKelin, LiuXiangyang, FangDekang, LiJian, WangDali

Improved esophageal cancer treatment

While chemotherapy and radiation before surgery are the standard for many esophageal cancers, some patients have surgery first. This study proposes a clinical trial to compare surgery alone with adding radiation after surgery (PORT) or both chemotherapy and radiation after surgery (POCRT) for patients with more advanced esophageal cancer. This is because adding treatment after surgery may improve survival rates for these patients, who often have a poor prognosis. The trial will help determine the best approach for improving outcomes for this group of patients.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

Treatment-related complications in patients with esophageal cancer: A systematic review and network meta-analysis.

Author: Holakouie-NaieniKourosh, MansourniaMohammad Ali, Doosti-IraniAmin, Rahimi-ForoushaniAbbas, HaddadPeiman

Reduced complications

This network meta-analysis compared the available treatments of esophageal squamous cell carcinoma (SCC) in terms of treatment-related complications. The study found that video-assisted thoracoscopy + laparoscopy (VATS) was associated with a lower risk of pulmonary complications and anastomotic leakage, while surgery + cisplatin + fluorouracil (SCF) was associated with a lower risk of cardiovascular complications, and 3-dimensional conformal radiotherapy + docetaxel + cisplatin (3DCRTDC) was associated with a lower risk of esophagitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Predicting lymph node metastases with endoscopic resection in cT2N0M0 oesophageal cancer: A systematic review and meta-analysis.

Author: Al-KaabiAli, van der PostRachel S, HuisingJonathan, RosmanCamiel, NagtegaalIris D, SiersemaPeter D

Stage-guided treatment
Staging accuracy

This study explores the suboptimal staging of clinically staged T2N0M0 (cT2N0M0) oesophageal cancer, often leading to overtreatment. The study proposes that endoscopic resection, the first-line therapy for early localized tumors, could be used to improve staging and identify predictors of nodal upstaging, enabling more stage-guided treatment decisions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

Identification of Radioresponsive Genes in Esophageal Cancer from Longitudinal and Single Cell Exome Sequencing.

Author: YangLing, ZhangXiaoyan, MacKayMatthew, FooxJonathan, HouQiang, ZhengXiaoli, ZhouRongjing, HuangMing, JingZhao, MasonChristopher E, WuShixiu

Radioresponse prediction
ESCC relapse

Longitudinal whole-exome sequencing of 42 esophageal squamous cell carcinoma (ESCC) tumor samples revealed allelic shifts underlying radioresponse. Several radioresponsive genes were identified, including NOTCH1, MAML3, CDKN2A, NFE2L2, GAS2L2, OBSCN, and TP53. These findings offer new therapeutic target genes and loci for ESCC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

60.

A meta-analysis on surgery with or without postoperative radiotherapy to treat squamous cell esophageal carcinoma.

Author: LinHao-Nan, ChenLong-Qi, ShangQi-Xin, YuanYong, YangYu-Shang

Improved ESCC treatment

This meta-analysis examines the benefits and harms of postoperative radiotherapy (PORT) versus surgery alone for patients with esophageal squamous cell carcinoma (ESCC) after curative resection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

61.

Randomized Phase III KEYNOTE-181 Study of Pembrolizumab Versus Chemotherapy in Advanced Esophageal Cancer.

Author: KojimaTakashi, ShahManish A, MuroKei, FrancoisEric, AdenisAntoine, HsuChih-Hung, DoiToshihiko, MoriwakiToshikazu, KimSung-Bae, LeeSe-Hoon, BennounaJaafar, KatoKen, ShenLin, EnzingerPeter, QinShu-Kui, FerreiraPaula, ChenJia, GirottoGustavo, de la FouchardiereChristelle, SenellartHelene, Al-RajabiRaed, LordickFlorian, WangRuixue, SuryawanshiShailaja, BhagiaPooja, KangS Peter, MetgesJean-Philippe,

Fewer adverse events
Prolonged OS (PD-L1 CPS ≥ 10)

Pembrolizumab, a type of immunotherapy, prolonged overall survival compared to chemotherapy as second-line treatment for patients with advanced esophageal cancer who had a PD-L1 combined positive score (CPS) of ≥10. Pembrolizumab was also associated with fewer treatment-related adverse events.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

63.

Palliative radiotherapy combined with stent insertion to reduce recurrent dysphagia in oesophageal cancer patients: the ROCS RCT.

Author: AdamsonDouglas, BlazebyJane, PorterCatharine, HurtChristopher, GriffithsGareth, NelsonAnnmarie, SewellBernadette, JonesMari, SvobodovaMartina, FitzsimmonsDeborah, NixonLisette, FitzgibbonJim, ThomasStephen, MillinAnthony, CrosbyTom, StaffurthJohn, ByrneAnthony

Stents for dysphagia

For patients with advanced oesophageal cancer, the mean survival is 3-5 months. Treatment emphasis is on effective palliation, and most patients require intervention for dysphagia. Insertion of a self-expanding metal stent provides rapid relief, but dysphagia may recur within 3 months owing to tumour progression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

64.

Investigation on the clinical efficacy and mechanism of compound kushen injection in treating esophageal cancer based on multi-dimensional network meta-analysis and in vitro experiment.

Author: ZhouWei, HuangZhihong, WuChao, LuShan, FuChanggeng, YePeizhi, TanYingying, WuZhishan, FanXiaotian, ZhangJingyuan, GuoSiyu, JiaShanshan, StalinAntony, WangHaojia, ZhangXiaomeng, WangMiaomiao, WuJiarui

Compound Kushen Injection for esophageal cancer

Compound Kushen Injection, a Chinese herbal injection, showed a significant clinical advantage in treating esophageal cancer when combined with chemotherapy. A network meta-analysis revealed that Compound Kushen Injection was superior to other anti-tumor Chinese herbal injections in improving overall clinical efficiency, quality of life, and reducing nausea and vomiting. In vitro studies showed that Compound Kushen Injection inhibited esophageal cancer cell proliferation by downregulating the expression of EGFR and AURKA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

65.

Esophagectomy versus definitive chemoradiotherapy as initial treatment for clinical stage I esophageal cancer: a systematic review and meta-analysis.

Author: MeiLi-Xiang, MoJun-Xian, ChenYong, DaiLei, WangYong-Yong, ChenMing-Wu

OS improvement
PFS improvement
Tumor recurrence reduction

Esophagectomy shows superior survival benefits compared to definitive chemoradiotherapy as the initial treatment for clinical stage I esophageal cancer (EC). However, future high-quality randomized controlled trials are needed to validate this conclusion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Esophageal microbiota composition and outcome of esophageal cancer treatment: a systematic review.

Author: PlatVictor D, van RossenTessel M, DaamsFreek, de BoerNanne K, de MeijTim G J, BuddingAndries E, Vandenbroucke-GraulsChristina M J E, van der PeetDonald L

Improved treatment outcomes

Esophageal microbiota may play a role in the outcome of esophageal cancer treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

Survival rates and safety associated with chemoradiotherapy followed by surgery and chemoradiotherapy alone for patients with T4 esophageal cancer: a systematic review and meta-analysis.

Author: LeeChia Ching, SoonYu Yang, VellayappanBalamurugan, HoFrancis, TeyJeremy C S

Improved survival

This meta-analysis compared the survival rates and safety of chemoradiotherapy followed by surgery (CRT-S) and chemoradiotherapy alone (CRT) for T4 N<sub>any</sub> M0 esophageal cancer. The study aimed to determine the optimal treatment approach for this type of esophageal cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Comparative analyses of paclitaxel/carboplatin with cisplatin/5-fluorouracil-based chemoradiation in locally advanced inoperable upper and middle third esophageal cancer: A randomized prospective pilot study.

Author: KumarDivyesh, DeyTreshita, KhoslaDivya, GedelaSandeep, OinamArun S, KapoorRakesh

CRT for LAEC

This pilot study compared the outcomes of two different chemoradiation therapy (CRT) regimens for inoperable locally advanced esophageal cancer (LAEC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

70.

Dose escalation based on <sup>18</sup>F-FDG PET/CT response in definitive chemoradiotherapy of locally advanced esophageal squamous cell carcinoma: a phase III, open-label, randomized, controlled trial (ESO-Shanghai 12).

Author: ZhuHongcheng, LiuQiufang, XuHao, MoMiao, WangZezhou, LuKui, ZhouJialiang, ChenJunqiang, ZhengXiangpeng, YeJinjun, GeXiaolin, LuoHonglei, LiuQi, DengJiaying, AiDashan, HaoShengnan, ZhangJunhua, TsengI Hsuan, SongShaoli, ChenYun, ZhaoKuaile

Esophageal cancer treatment
Improved local control
Toxicity

Definitive chemoradiotherapy (CRT) is the standard treatment for locally advanced esophageal cancer. The standard dose of 50-50.4 Gy has been established, but recent studies have investigated the potential benefits of dose escalation. PET-based dose escalation using <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography/computed tomography (PET/CT) may be a promising approach to tailor therapy for patients not responding to CRT.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

72.

Palliative radiotherapy combined with stent insertion to relieve dysphagia in advanced esophageal carcinoma patients: A systematic review and meta-analysis.

Author: XuZhiyuan, LiuHaonan, LiShengli, HanZhengxiang, ChenJingjing, LiuXiangting, LiQiang, MuHong, YuanJiaqi, LuHailong, JinPeisheng, YanXianliang

Dysphagia relief
Survival improvement
Bleeding events
Pain events
Stent migration

This meta-analysis of 9 studies with a total of 851 patients found that palliative radiotherapy after esophageal cancer stenting (ROCS) could significantly improve dysphagia scores and median overall survival compared to stenting alone.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

Efficacy of Aidi injection combined with chemotherapy, radiotherapy or chemoradiotherapy for unresectable esophageal cancer treatment: A meta-analysis and systematic review of 29 randomized controlled trials based on Asian populations (China).

Author: HuangJinsheng, FanTeng, RongYuming, LiXujia, JiangQi, KanJun, QiuHuijuan, QuanQi, ZhangBei, GuoGuifang

Improved response rates
Increased survival
Reduced side effects

This meta-analysis evaluated the efficacy of Aidi combined with standard treatment for unresectable esophageal cancer. The study found that Aidi-based combination therapy resulted in higher objective response rates, disease control rates, and one-year overall survival, while also reducing the incidence of adverse events. The study concluded that Aidi-based combination therapy is a promising treatment option for unresectable esophageal cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Effectiveness of S-1-Based Chemoradiotherapy in Patients 70 Years and Older With Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial.

Author: WangXin, HanWeiming, ZhangWencheng, WangXiaomin, GeXiaolin, LinYu, ZhouHaiwen, HuMiaomiao, WangWei, LiuKe, LuJianchao, QieShuai, ZhangJihong, DengWei, WangLan, HanChun, LiMinghe, ZhangKaixian, LiLing, WangQifeng, ShiHongyun, YuZhilong, ZhaoYidian, SunXinchen, ShiYonggang, PangQingsong, ZhouZongmei, LiangJun, ChenDongfu, FengQinfu, BiNan, ZhangTao, DengLei, WangWenqing, LiuWenyang, WangJianyang, ZhaiYirui, WangJunjie, ChenWanqing, ChenJunqiang, XiaoZefen,

Better quality of life
Improved survival outcomes

Double-agent intravenous chemotherapy concurrent with radiotherapy is the standard of care for patients with inoperable esophageal cancer. However, patients tend to tolerate intravenous chemotherapy less well with age and comorbidities. This study aims to find a better treatment modality that improves survival outcomes without reducing quality of life.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

76.

Late Toxicity and Health-Related Quality of Life Following Definitive Chemoradiotherapy for Esophageal Cancer: A Systematic Review and Meta-analysis.

Author: PapeMarieke, VeenLinde M, SmitThom M, KuijperSteven C, VissersPauline A J, GeijsenElisabeth D, van RossumPeter S N, SprangersMirjam A G, DerksSarah, VerhoevenRob H A, van LaarhovenHanneke W M

Improved HRQoL
Late toxicities

This study investigates the effect of definitive chemoradiotherapy (dCRT) on late toxicities and health-related quality of life (HRQoL) in patients with esophageal cancer. A meta-analysis of the literature is performed to assess the long-term consequences of dCRT treatment.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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