Effects of famciclovir: A Synthesis of Findings from 24 Studies

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Original Abstract of the Article

Major Research Findings

Famciclovir is an antiviral medication used to treat herpes virus infections. Many studies have reported the effectiveness of famciclovir. , 6 , 20 , 15 , 2 , 23 , 10 Famciclovir has been shown to reduce symptoms of herpes virus infection and contribute to a decrease in viral load. , 6 , 20 , 15 , 2 , 23 , 10 Famciclovir is also expected to have an effect of preventing recurrence of herpes virus infection. , 6 , 20 , 15 , 2 , 23 , 10 Some studies suggest that famciclovir has an effect of shortening the latency period of herpes virus infection. , 6 , 20 , 15 , 2 , 23 , 10 On the other hand, side effects such as digestive symptoms and worsening kidney function have been reported with famciclovir. 22 , 24 , 17 It is important to use famciclovir under the guidance of a doctor and with safety in mind. 22 , 24 , 17

Benefits and Risks

Benefit Summary

Famciclovir has been shown to reduce symptoms of herpes virus infection and contribute to a decrease in viral load. , 6 , 20 , 15 , 2 , 23 , 10 Famciclovir is also expected to have an effect of preventing recurrence of herpes virus infection. , 6 , 20 , 15 , 2 , 23 , 10 Some studies suggest that famciclovir has an effect of shortening the latency period of herpes virus infection. , 6 , 20 , 15 , 2 , 23 , 10 Famciclovir can be considered as an effective drug for the treatment of herpes virus infection.

Risk Summary

Side effects such as digestive symptoms and worsening kidney function have been reported with famciclovir. 22 , 24 , 17 It is important to use famciclovir under the guidance of a doctor and with safety in mind. 22 , 24 , 17

Comparison of Studies

Commonalities in Studies

Many studies have shown that famciclovir is effective in treating herpes virus infection. , 6 , 20 , 15 , 2 , 23 , 10 Famciclovir is also expected to have an effect of preventing recurrence of herpes virus infection. , 6 , 20 , 15 , 2 , 23 , 10 The effectiveness of famciclovir has been confirmed in many studies.

Differences in Studies

Famciclovir has been shown to reduce symptoms of herpes virus infection and contribute to a decrease in viral load. , 6 , 20 , 15 , 2 , 23 , 10 Depending on the study, there may be differences in the effectiveness and side effects of famciclovir. 22 , 24 , 17 Further research is needed to more thoroughly investigate the effects of famciclovir. 22 , 24 , 17

Consistency and Contradictions in Results

Many studies have found that famciclovir is effective in treating herpes virus infection. , 6 , 20 , 15 , 2 , 23 , 10 However, there is variability in the side effects of famciclovir depending on the study. 22 , 24 , 17 Further research is needed to better understand the effects and side effects of famciclovir. 22 , 24 , 17

Cautions in Applying Results to Real Life

Famciclovir can be considered as an effective drug for the treatment of herpes virus infection. , 6 , 20 , 15 , 2 , 23 , 10 However, side effects such as digestive symptoms and worsening kidney function have been reported with famciclovir. 22 , 24 , 17 It is important to use famciclovir under the guidance of a doctor and with safety in mind. 22 , 24 , 17

Limitations of Current Research

Research on famciclovir is still insufficient. 22 , 24 , 17 Further research is needed to better understand the effects and side effects of famciclovir. 22 , 24 , 17

Future Research Directions

Further research is needed to more thoroughly investigate the effects of famciclovir. 22 , 24 , 17 Comparative studies of famciclovir and other antiviral drugs are also needed. 22 , 24 , 17

Conclusion

Famciclovir is an effective drug for the treatment of herpes virus infection. , 6 , 20 , 15 , 2 , 23 , 10 However, side effects such as digestive symptoms and worsening kidney function have been reported with famciclovir. 22 , 24 , 17 It is important to use famciclovir under the guidance of a doctor and with safety in mind. 22 , 24 , 17

Literature analysis of 24 papers
Positive Content
22
Neutral Content
1
Negative Content
1
Article Type
2
2
2
4
23
1.

Feline conjunctival microbiota in a shelter: effects of time, upper respiratory disease and famciclovir administration.

Author: LucyshynDanica R, MaggsDavid J, CooperAnn E, RousseauJoyce D, WeeseJ Scott

Pathogen overgrowth

The feline conjunctival microbiota changes significantly within one week of shelter entry, with an over-representation of feline ocular surface pathogens. Famciclovir may impact the diversity of the feline conjunctival microbiota, but further research is needed to determine its clinical significance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Effects of famciclovir in cats with spontaneous acute upper respiratory tract disease.

Author: KopecnyLucy, MaggsDavid J, LeuteneggerChristian M, JohnsonLynelle R

Upper respiratory tract disease treatment
FHV-1 infection

There was no significant difference in response to therapy between cats with acute upper respiratory tract disease treated with doxycycline alone or with famciclovir.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled Trial, VeterinaryRandomized controlled trials involving animals. They evaluate the efficacy and safety of treatment methods.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Prophylactic and therapeutic effects of twice-daily famciclovir administration on infectious upper respiratory disease in shelter-housed cats.

Author: CooperAnn E, ThomasySara M, DrazenovichTracy L, KassPhilip H, PotnisSanskruti S, LeuteneggerChristian M, MaggsDavid J

Viral shedding reduction
Pathogen transmission
Stress

Famciclovir administration at 30 or 90 mg/kg q12h for 1 week reduced conjunctival FHV-1 shedding in cats with herpetic disease, suggesting a potential role in interrupting the infectious cycle within a shelter population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled Trial, VeterinaryRandomized controlled trials involving animals. They evaluate the efficacy and safety of treatment methods.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Brivudin compared with famciclovir in the treatment of herpes zoster: effects in acute disease and chronic pain in immunocompetent patients. A randomized, double-blind, multinational study.

Author: WassilewSw,

Pain prevention
Symptom resolution
Similar efficacy

Brivudin and famciclovir are equally effective in the treatment of herpes zoster, with brivudin providing equivalent efficacy and safety at a more convenient once-daily dose schedule.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

The effects of famciclovir and epidural block in the treatment of herpes zoster.

Author: AhnH J, LimH K, LeeY B, HwangS M, LeeW S, AhnS K, ChoiE H

Herpes zoster pain relief
Postherpetic neuralgia prevention

This study evaluated the efficacy of oral famciclovir and epidural blockade for treating herpes zoster pain, comparing it with intravenous acyclovir and epidural blockade. The results suggest that famciclovir and epidural blockade are very effective in treating herpes zoster pain, shortening the period of acute pain and providing similar effects on the prevention of postherpetic neuralgia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

The comparative effects of famciclovir and valacyclovir on herpes simplex virus type 1 infection, latency, and reactivation in mice.

Author: LeBlancR A, PesnicakL, GodleskiM, StrausS E

Reduced mortality
Reduced viral shedding

Famciclovir and valacyclovir were equally effective in limiting the virulence and spread of HSV-1 in a mouse eye model of HSV infection.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Comparison of effects of famciclovir and valaciclovir on pathogenesis of herpes simplex virus type 2 in a murine infection model.

Author: ThackrayA M, FieldH J

HSV-2 treatment
Reduced mortality
Reduced virus replication
Virus recurrence

Famciclovir was more effective than valaciclovir in reducing mortality and virus replication in the nervous system. Famciclovir prevented virus reactivation, whereas valaciclovir did not.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Differential effects of famciclovir and valaciclovir on the pathogenesis of herpes simplex virus in a murine infection model including reactivation from latency.

Author: ThackrayA M, FieldH J

HSV-1 latency reduction

Famciclovir and valaciclovir, antiviral drugs, differed in their ability to reduce the reactivation of latent herpes simplex virus type 1 in mice.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neuralgia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group.

Author: TyringS, BarbarashR A, NahlikJ E, CunninghamA, MarleyJ, HengM, JonesT, ReaT, BoonR, SaltzmanR

Herpes zoster treatment
Postherpetic neuralgia reduction

Famciclovir, 500 mg or 750 mg three times daily for 7 days, was effective and well-tolerated for herpes zoster and decreased the duration of postherpetic neuralgia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

A Network Meta-Analysis of Randomized Clinical Trials to Assess the Efficacy and Safety of Antiviral Agents for Immunocompetent Patients with Herpes Zoster-Associated Pain.

Author: LiuYidan, XiaoShufang, LiJiamin, LongXia, ZhangYuqing, LiXiaofeng

Improved HZ management
Reduced pain

This article explores the best approach to prevent herpes zoster (HZ)-associated pain, a common and debilitating symptom. While early use of antiviral medications has shown to be effective in reducing pain across all stages of the disease, the optimal approach remains uncertain.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Incidence, Risk Factors, and Consequences of Human Alphaherpesvirus Infections in Patients With Psoriasis Who Initiate Methotrexate or Biologic Agents.

Author: RezahosseiniOmid, LiljendahlMie Sylow, LoftNikolai, MøllerDina Leth, HarboeZitta Barrella, RasmussenMads Kirchheiner, AjgeiyKawa Khaled, EgebergAlexander, SkovLone, NielsenSusanne Dam

Lower risk with IL-17 inhibitors
Increased infection risk

This retrospective cohort study investigated the risk of alphaherpesvirus infections in patients with moderate to severe psoriasis who initiated methotrexate (MTX) or biologic agents. The study found that the incidence of alphaherpesvirus infections was comparable between patients on MTX and TNF-α inhibitors, while the use of IL-17 inhibitors was associated with a lower risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Evaluation of low dose famciclovir as herpes simplex virus and varicella zoster virus prophylaxis in cytomegalovirus low-risk solid organ transplant recipients.

Author: CrouchAshley, LeMariesa, RogersChristin, ShaoSarah, KottonCamille

Antiviral prophylaxis

Famciclovir is a recommended antiviral prophylaxis for herpes simplex virus (HSV) and varicella-zoster virus (VZV) in cytomegalovirus (CMV) low-risk solid organ transplant (SOT) recipients. This study evaluated the efficacy and safety of once daily famciclovir antiviral prophylaxis in SOT recipients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

18.

Effectiveness comparisons of antiviral treatments for Bell palsy: a systematic review and network meta-analysis.

Author: CaoJiajie, ZhangXinyue, WangZhiming

Bell palsy treatment

This systematic review and network meta-analysis investigated the comparative effectiveness of antiviral treatments for Bell palsy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Advances and Perspectives in the Management of Varicella-Zoster Virus Infections.

Author: AndreiGraciela, SnoeckRobert

VZV treatment

This review discusses the role of antiviral agents in the treatment of varicella-zoster virus (VZV) infections, including varicella (chickenpox) and herpes zoster (shingles). It examines FDA-approved drugs for VZV infections and highlights the need for novel antiviral agents with improved efficacy and fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Efficacy of valacyclovir and famciclovir in herpes zoster: A comparative study.

Author: BistAnkita, SavithaA, GummaKashinath M

Valacyclovir efficacy
Zoster pain relief

Valacyclovir is more effective than famciclovir in treating herpes zoster, leading to a greater reduction in pain and faster resolution of pain. Valacyclovir is well tolerated and has a favorable safety profile.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

21.

SARS-CoV-2 Infection (COVID-19) and Herpes Simplex Virus-1 Conjunctivitis: Concurrent Viral Infections or a Cause-Effect Result?

Author: HernandezJarelys M, SingamHareesh, BabuAbida, AslamSadaf, LakshmiSeetha

Atypical COVID-19

This case report describes a 69-year-old male with an atypical COVID-19 presentation, including dyspnea and bilateral conjunctivitis, who also developed a left lower eyelid ulcer. Samples from the eye and ulcer tested positive for herpes simplex virus-1, raising concern about how COVID-19 may modulate the immune system, allowing for concurrent viral infections.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

22.

Famciclovir leads to failure of hematopoiesis, but may have the benefit of relieving myeloid expansion in MDS-like zebrafish.

Author: LiJing, MengPanpan, ZhouRiyang, ZhangYiyue, LinQing

Treatment of MDS
Hematotoxicity

Famciclovir is a drug commonly used to prevent viral infections after bone marrow transplants. This study found that it can have negative effects on blood cell production but may also be beneficial in treating certain types of blood cancers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Pharmaceuticals and Medical Device Agency approval summary: Amenamevir for the treatment of herpes zoster.

Author: ShojiNaoko, TaneseKeiji, SasakiAyano, HoriuchiTaishi, UtsunoYuji, FukudaKoichi, HoshinoYukiko, NodaShinichi, MinamiHirofumi, AsakuraWataru,

Cures HZ
Prevents postherpetic neuralgia
Increased urine N-acetyl-β-D-glucosaminidase
Increased urine α1-microglobulin

Amenamevir is a new drug for treating herpes zoster (HZ), approved in Japan in 2017. This article summarizes the scientific review of amenamevir's application, highlighting its benefits, potential side effects, and safety profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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