This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of fatty liver disease: A Synthesis of Findings from 66 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of fatty liver disease: A Synthesis of Findings from 66 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to Dataset
Please check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major research findings

Fatty liver disease is a condition where excess fat builds up in the liver, even if you don't drink too much alcohol. 65 , 27 It is closely related to metabolic diseases such as obesity and diabetes, which significantly affect human health outcomes. 65 , 21 , 11 , 35 , 43 , 24 , 37 , 34 , 2 , 44 , 18 , 10 , 9 , 4 , 46 , 51 , 50 , 49 , 47 , 14 , 35 , 19 , 23 , 26 , 36 , 58 , 41 , 31 , 25 , 57 , 66 , 17 , 48 , 21 , 38 , 64 , 63 , 61 , 30 , 29 These factors can cause other health problems such as heart disease and diabetes.

Treatment summary

Lifestyle changes are essential for the treatment of fatty liver disease. 17 , 58 , 35 , 41 , 9 In particular, weight loss, exercise, and diet are effective. 49 , 17 , 58 , 35 , 41 , 9 Some medications have also been shown to be effective. 30 , 64 , 63 For example, rosuvastatin has been reported to be effective in improving fatty liver. 30 , 27 Gut microbiota therapy is also attracting attention as a promising treatment. 65 , 25 Diabetes medications such as metformin may also be effective in improving fatty liver. 50 , 46 However, there is still no cure for fatty liver disease.

Benefits and risks

Benefit summary

Treatment of fatty liver disease can help suppress liver inflammation and fibrosis, reducing the risk of cirrhosis and liver cancer. 21 , 47 Weight loss and blood sugar improvement can also reduce the risk of metabolic diseases such as heart disease and diabetes. 18 , 49 , 65

Risk summary

Treatment of fatty liver disease has risks such as drug side effects and difficulty in improving lifestyle. 47 There is also a non-zero possibility that the liver condition will worsen due to treatment.

Comparison between studies

Commonalities of studies

Many studies have shown that fatty liver is closely related to metabolic diseases such as obesity and diabetes. 65 , 21 , 11 , 35 , 43 , 24 , 37 , 34 , 2 , 44 , 18 , 10 , 9 , 4 , 46 , 51 , 50 , 49 , 47 , 14 , 35 , 19 , 23 , 26 , 36 , 58 , 41 , 31 , 25 , 57 , 66 , 17 , 48 , 21 , 38 , 64 , 63 , 61 , 30 , 29 They also mention that weight loss, exercise, and diet are effective treatments. 17 , 58 , 35 , 41 , 9

Differences between studies

Different studies have different results about the treatment of fatty liver disease. 30 , 64 , 63 For example, some studies show that rosuvastatin is effective, while others show no effect. 30 , 27

Consistency and contradictions in the results

Effective treatment of fatty liver disease is still not established. 21 , 38 Many studies show that lifestyle changes are important, 17 , 58 , 35 , 41 , 9 but the effectiveness of medications is still unclear. 30 , 64 , 63 Therefore, further research is needed.

Notes on applying research to real life

Lifestyle changes are important for the prevention and treatment of fatty liver disease. 17 , 58 , 35 , 41 , 9 Specifically, it is necessary to focus on weight loss, exercise, and diet. 49 , 17 , 58 , 35 , 41 , 9 When taking medication, be sure to follow your doctor's instructions.

Current limitations of research

Not enough research has been done on fatty liver disease. 47 Therefore, there are still many unknowns about the effectiveness and safety of treatments.

Future research directions

The development of more effective treatments for fatty liver disease is needed. 38 Further research is also needed on the effectiveness and safety of medications.

Conclusion

Fatty liver disease is a disease that is increasing in recent years. 21 , 38 Lifestyle changes are important, 17 , 58 , 35 , 41 , 9 and you should focus on weight loss, exercise, and diet. 49 , 17 , 58 , 35 , 41 , 9 Early detection and treatment of fatty liver disease are also important.

Treatment list

Weight loss, exercise, diet, rosuvastatin, gut microbiota therapy, metformin, fenofibrate, pioglitazone, omega-3 fatty acids, ursodeoxycholic acid, N-acetylcysteine, taurine, curcumin, synbiotic supplementation, Gynostemma pentaphyllum, growth hormone, Mediterranean diet, medicinal and food homologous substances, diet and VSL#3


Keywords
Benefit Keywords
Risk Keywords
Literature analysis of 66 papers
Positive Content
62
Neutral Content
3
Negative Content
1
Article Type
29
25
32
19
64

Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : Russian


Language : English


Language : English


Language : Russian


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Language : English


Author: StanleyTakara L, FourmanLindsay T, FeldpauschMeghan N, PurdyJulia, ZhengIsabel, PanChelsea S, AepfelbacherJulia, BucklessColleen, TsaoAndrew, KelloggAnela, BranchKaren, LeeHang, LiuChia-Ying, CoreyKathleen E, ChungRaymond T, TorrianiMartin, KleinerDavid E, HadiganColleen M, GrinspoonSteven K


Language : English


Language : English