Effective treatment of fatty liver disease: A Synthesis of Findings from 66 Studies

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Original Abstract of the Article

Major research findings

Fatty liver disease is a condition where excess fat builds up in the liver, even if you don't drink too much alcohol. 65 , 27 It is closely related to metabolic diseases such as obesity and diabetes, which significantly affect human health outcomes. 65 , 21 , 11 , 35 , 43 , 24 , 37 , 34 , 2 , 44 , 18 , 10 , 9 , 4 , 46 , 51 , 50 , 49 , 47 , 14 , 35 , 19 , 23 , 26 , 36 , 58 , 41 , 31 , 25 , 57 , 66 , 17 , 48 , 21 , 38 , 64 , 63 , 61 , 30 , 29 These factors can cause other health problems such as heart disease and diabetes.

Treatment summary

Lifestyle changes are essential for the treatment of fatty liver disease. 17 , 58 , 35 , 41 , 9 In particular, weight loss, exercise, and diet are effective. 49 , 17 , 58 , 35 , 41 , 9 Some medications have also been shown to be effective. 30 , 64 , 63 For example, rosuvastatin has been reported to be effective in improving fatty liver. 30 , 27 Gut microbiota therapy is also attracting attention as a promising treatment. 65 , 25 Diabetes medications such as metformin may also be effective in improving fatty liver. 50 , 46 However, there is still no cure for fatty liver disease.

Benefits and risks

Benefit summary

Treatment of fatty liver disease can help suppress liver inflammation and fibrosis, reducing the risk of cirrhosis and liver cancer. 21 , 47 Weight loss and blood sugar improvement can also reduce the risk of metabolic diseases such as heart disease and diabetes. 18 , 49 , 65

Risk summary

Treatment of fatty liver disease has risks such as drug side effects and difficulty in improving lifestyle. 47 There is also a non-zero possibility that the liver condition will worsen due to treatment.

Comparison between studies

Commonalities of studies

Many studies have shown that fatty liver is closely related to metabolic diseases such as obesity and diabetes. 65 , 21 , 11 , 35 , 43 , 24 , 37 , 34 , 2 , 44 , 18 , 10 , 9 , 4 , 46 , 51 , 50 , 49 , 47 , 14 , 35 , 19 , 23 , 26 , 36 , 58 , 41 , 31 , 25 , 57 , 66 , 17 , 48 , 21 , 38 , 64 , 63 , 61 , 30 , 29 They also mention that weight loss, exercise, and diet are effective treatments. 17 , 58 , 35 , 41 , 9

Differences between studies

Different studies have different results about the treatment of fatty liver disease. 30 , 64 , 63 For example, some studies show that rosuvastatin is effective, while others show no effect. 30 , 27

Consistency and contradictions in the results

Effective treatment of fatty liver disease is still not established. 21 , 38 Many studies show that lifestyle changes are important, 17 , 58 , 35 , 41 , 9 but the effectiveness of medications is still unclear. 30 , 64 , 63 Therefore, further research is needed.

Notes on applying research to real life

Lifestyle changes are important for the prevention and treatment of fatty liver disease. 17 , 58 , 35 , 41 , 9 Specifically, it is necessary to focus on weight loss, exercise, and diet. 49 , 17 , 58 , 35 , 41 , 9 When taking medication, be sure to follow your doctor's instructions.

Current limitations of research

Not enough research has been done on fatty liver disease. 47 Therefore, there are still many unknowns about the effectiveness and safety of treatments.

Future research directions

The development of more effective treatments for fatty liver disease is needed. 38 Further research is also needed on the effectiveness and safety of medications.

Conclusion

Fatty liver disease is a disease that is increasing in recent years. 21 , 38 Lifestyle changes are important, 17 , 58 , 35 , 41 , 9 and you should focus on weight loss, exercise, and diet. 49 , 17 , 58 , 35 , 41 , 9 Early detection and treatment of fatty liver disease are also important.

Treatment list

Weight loss, exercise, diet, rosuvastatin, gut microbiota therapy, metformin, fenofibrate, pioglitazone, omega-3 fatty acids, ursodeoxycholic acid, N-acetylcysteine, taurine, curcumin, synbiotic supplementation, Gynostemma pentaphyllum, growth hormone, Mediterranean diet, medicinal and food homologous substances, diet and VSL#3

Keywords
Benefit Keywords
ALT levels improvement
Steatosis reversal
1
Reduced ALP
Reduced AST
Reduced BMI
Reduced insulin
Reduced liver fat
2
NAFLD reduction
3
Improves insulin resistance
Improves liver function
4
Improved liver function
Well tolerated
5
Improved NAFLD treatment
6
Improved liver function
Nonalcoholic fatty liver disease treatment
7
NAFLD treatment
8
Improved NAFLD
9
NAFLD treatment
10
NAFLD treatment
11
NAFLD treatment
12
Improved ALT
Improved hepatocyte ballooning
Improved steatosis
13
NAFLD treatment
14
Combined treatment
Improved liver steatosis
15
NASH resolution
16
Reduced body mass index
Reduced body weight
17
Management of NAFLD
18
NAFLD treatment
19
Improved fibrosis
Improved liver function
Improved steatosis
20
NASH treatment
21
NAFLD treatment
22
TE accurate for fibrosis exclusion
23
NAFLD treatment
24
NAFLD treatment
25
NAFLD treatment
26
Ameliorate NASH
27
NAFLD can be reversed
28
Improved fatty liver
29
Lipid profile normalization
Metabolic syndrome resolution
NASH resolution
30
Beneficial metabolic effects
31
NAFLD treatment
32
Improved insulin-sensitivity
Improved lipid profile
Reduced hepatic steatosis
33
NAFLD treatment
34
Fenofibrate and pioglitazone therapy
36
Improved NAFLD treatment
37
NAFLD treatment
38
NAFLD treatment
39
NAFLD treatment
40
NAFLD improvement
41
Improved NAFLD treatment
42
Hyperferritinemia treatment
NAFLD management
43
Reduced liver disease activity
44
Reduced liver fat
45
NAFLD treatment
46
Improved NASH treatment
47
Improved insulin resistance
Reduced liver fat
48
Weight loss
49
Liver function improvement
NAFLD treatment
50
Improved liver function
51
Liver fibrosis reduction
Statin treatment
52
Hepatic steatosis treatment
53
NAFLD treatment
54
NAFLD treatment
56
Mediterranean lifestyle for NAFLD
57
Lifestyle interventions
NAFLD treatment
58
NAFLD and NASH treatment
59
High-protein diet
Liver steatosis reduction
Orlistat
60
ARLD treatment
61
Improved liver enzymes
62
Hepatic steatosis reduction (GH)
63
Liver enzyme reduction (statins)
64
Improved lipid profile
65
Glucose control
Lipid control
Liver function improvement
66
Risk Keywords
Increased fibrosis
1
Adverse effects
3
Non-alcoholic fatty liver disease
6
Limited data
7
Treatment effect unclear
15
ALT reduction
16
Alcohol abuse
27
NAFLD
36
Rare liver transplantation
40
limited data
41
Injection site issues
45
Liver fibrosis
49
MAFLD
Obesity
60
Lower extremity edema (GH)
63
Cardiovascular events
NAFLD
65
Literature analysis of 66 papers
Positive Content
62
Neutral Content
3
Negative Content
1
Article Type
29
25
32
19
64
1.

A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease.

Author: Zelber-SagiShira, KesslerAda, BrazowskyEli, WebbMuriel, LurieYoav, SantoMoshe, LeshnoMoshe, BlendisLaurence, HalpernZamir, OrenRan

ALT levels improvement
Steatosis reversal
Increased fibrosis

Orlistat improves serum ALT levels and steatosis on US in NAFLD patients, beyond its effect on weight reduction.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease.

Author: ChouShuo-Chi, ChenKwang-Wen, HwangJaw-Shan, LuWen-Tsoung, ChuYin-Yi, LinJen-Der, ChangHsiu-Jene, SeeLai-Chu

Reduced ALP
Reduced AST
Reduced BMI
Reduced insulin
Reduced liver fat

Gynostemma pentaphyllum (GP) is an effective adjunct treatment to diet therapy for patients with nonalcoholic fatty liver disease. In a randomized controlled trial, GP led to significant reductions in BMI, AST, ALP, insulin, and HOMA-IR compared to placebo after 6 months of combined treatment with diet therapy.

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomised study.

Author: AthyrosVasilios G, MikhailidisDimitri P, DidangelosTriandafillos P, GioulemeOlga I, LiberopoulosEvangelos N, KaragiannisAsterios, KakafikaAnna I, TziomalosKonstantinos, BurroughsAndrew K, ElisafMoses S

NAFLD reduction
Adverse effects

Multifactorial intervention, including lifestyle changes and medications, can effectively reduce surrogate markers of non-alcoholic fatty liver disease (NAFLD) in patients with the metabolic syndrome (MetS). A randomized study of 186 patients showed that atorvastatin and a combination of atorvastatin and fenofibrate led to a significantly higher percentage of patients no longer having biochemical and ultrasonographic evidence of NAFLD compared to fenofibrate alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Insulin sensitizers in treatment of nonalcoholic fatty liver disease: Systematic review.

Author: Chavez-TapiaNorberto-C, Barrientos-GutierrezTonatiuh, Tellez-AvilaFelix-I, Sanchez-AvilaFrancisco, Montano-ReyesMaria-Antonieta, UribeMisael

Improves insulin resistance
Improves liver function

Metformin and thiazolidinediones improved insulin resistance markers and liver function tests in patients with NAFLD.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Probiotics for non-alcoholic fatty liver disease and/or steatohepatitis.

Author: LirussiF, MastropasquaE, OrandoS, OrlandoR

Improved liver function
Well tolerated

This review evaluated the beneficial and harmful effects of probiotics for non-alcoholic fatty liver disease and/or steatohepatitis. The review found no randomized clinical trials evaluating probiotic treatment in any dose, duration, and route of administration versus no intervention, placebo, or other interventions in patients with non-alcoholic fatty liver disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Drugs improving insulin resistance for non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis.

Author: AngelicoF, BurattinM, AlessandriC, Del BenM, LirussiF

Improved NAFLD treatment
Non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a condition where fat builds up in the liver, which can progress to inflammation and scarring (cirrhosis). It is suspected in people with elevated liver enzymes and signs of insulin resistance. The exact cause of NAFLD is unclear, and there is no standard treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review.

Author: SochaPiotr, HorvathAndrea, VajroPietro, DziechciarzPiotr, DhawanAnil, SzajewskaHania

Improved liver function
Nonalcoholic fatty liver disease treatment
Limited data

Limited data do not allow one to draw firm conclusions on the efficacy of various treatments for NAFLD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease.

Author: Vilar GomezE, Rodriguez De MirandaA, Gra OramasB, Arus SolerE, Llanio NavarroR, Calzadilla BertotL, Yasells GarciaA, Del Rosario Abreu VazquezM

NAFLD treatment

Nonalcoholic fatty liver disease (NAFLD) is a serious health concern without a standard treatment. Weight loss and antioxidant medications that improve insulin resistance and reduce fat buildup, inflammation, and scarring in the liver provide a rationale for clinical trials to test these approaches.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.

Author: LavineJoel E, SchwimmerJeffrey B, MollestonJean P, ScheimannAnn O, MurrayKaren F, AbramsStephanie H, RosenthalPhilip, SanyalArun J, RobuckPatricia R, BruntElizabeth M, UnalpAynur, TonasciaJames,

Improved NAFLD

The TONIC trial is testing whether treatment with metformin or vitamin E will lead to improvements in biochemical and histological features of nondiabetic children with biopsy-proven nonalcoholic fatty liver disease (NAFLD). The primary outcome measure is improvement in serum alanine aminotransferase (ALT) levels with treatment as compared to placebo.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Language : English

10.

Bariatric surgery for non-alcoholic steatohepatitis in obese patients.

Author: Chavez-TapiaNorberto C, Tellez-AvilaFelix I, Barrientos-GutierrezTonatiuh, Mendez-SanchezNahum, Lizardi-CerveraJavier, UribeMisael

NAFLD treatment

Nonalcoholic fatty liver disease (NAFLD) is becoming more common in overweight or obese people. While it resembles liver damage caused by alcohol, it occurs in people who don't drink excessively. NAFLD can range from simple fat buildup in the liver to more serious inflammation, scarring, and cirrhosis. The inflammatory stage is called non-alcoholic steatohepatitis (NASH). Recent studies suggest that weight loss surgery might help treat NASH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

[Use of Legalon in non-alcoholic fatty liver disease].

Author: ButurovaL I, TsybizovaT A, KalininA V

NAFLD treatment

This study examines nonalcoholic fatty liver disease (NAFLD), discussing its causes, different forms, risk factors, and progression. The study also looks at the effectiveness of Legalon, an herbal product, in treating NAFLD. The study found that a 2-month treatment with Legalon led to improvements in fatigue, right-sided abdominal pain and discomfort, and digestive problems. Blood tests showed a significant decrease in liver enzymes.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

12.

Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial.

Author: FosterTemitope, BudoffMatthew J, SaabSammy, AhmadiNaser, GordonCraig, GuerciAlan D

NAFLD treatment

Nonalcoholic fatty liver disease (NAFLD) can range from simple fat buildup in the liver to more serious inflammation and scarring. It affects up to 39% of people and can progress to liver disease in 15%. There is no proven treatment for NAFLD. This study investigates whether statin therapy might be effective for NAFLD and aims to identify factors that increase the risk of developing NAFLD.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

13.

Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis.

Author: RakoskiM O, SingalA G, RogersM A M, ConjeevaramH

Improved ALT
Improved hepatocyte ballooning
Improved steatosis

This meta-analysis assessed the efficacy of insulin-sensitizing agents for treating non-alcoholic steatohepatitis (NASH). Glitazones, but not metformin, were found to improve histological and biochemical outcomes, particularly in patients without diabetes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

14.

[Taurine in the treatment of non-alcoholic fatty liver disease].

Author: ZvenigorodskaiaL A, OvsiannikovaO N, NoskovaK K, NilovaT V, ElizarovaE P

NAFLD treatment

Nonalcoholic fatty liver disease (NAFLD) can progress from simple fat buildup in the liver to inflammation and scarring (cirrhosis). NAFLD is often linked to metabolic disorders and is associated with a high risk of heart disease, type 2 diabetes, and other conditions related to hardening of the arteries. NAFLD often progresses slowly without major changes, so treatment is usually only given to people at high risk of complications or those with significant changes in liver function tests. Preventing and treating these conditions early on can improve liver health.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

15.

Effect of atorvastatin, vitamin E and C on nonalcoholic fatty liver disease: is the combination required?

Author: ArendtBianca M, AllardJohane P

Combined treatment
Improved liver steatosis
Treatment effect unclear

While lifestyle modifications are the standard of care for nonalcoholic fatty liver disease, their effectiveness is limited. The benefits of pharmacological interventions are unclear, and further research is needed to evaluate the individual and combined effects of treatments like atorvastatin and antioxidants.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
EditorialAn article in which the editor or publisher expresses their opinion or perspective on a particular topic or issue. Its purpose is to convey a specific message or idea to the reader.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.

Language : English

16.

Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial.

Author: LavineJoel E, SchwimmerJeffrey B, Van NattaMark L, MollestonJean P, MurrayKaren F, RosenthalPhilip, AbramsStephanie H, ScheimannAnn O, SanyalArun J, ChalasaniNaga, TonasciaJames, ÜnalpAynur, ClarkJeanne M, BruntElizabeth M, KleinerDavid E, HoofnagleJay H, RobuckPatricia R,

NASH resolution
ALT reduction

Neither vitamin E nor metformin was superior to placebo in attaining the primary outcome of sustained reduction in ALT level in patients with pediatric NAFLD. The mean change in ALT level from baseline to 96 weeks was -35.2 U/L (95% CI, -56.9 to -13.5) with placebo vs -48.3 U/L (95% CI, -66.8 to -29.8) with vitamin E (P = .07) and -41.7 U/L (95% CI, -62.9 to -20.5) with metformin (P = .40).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Language : English

17.

Weight reduction for non-alcoholic fatty liver disease.

Author: PengLijun, WangJiyao, LiFeng

Reduced body mass index
Reduced body weight

This review examined the benefits and harms of weight reduction for patients with NAFLD. While seven trials were included, the sparse data and high risk of bias preclude drawing any definite conclusions on lifestyle programs or orlistat for treating NAFLD. Further trials are needed to determine the benefits and harms of weight reduction in NAFLD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials.

Author: MussoG, CassaderM, RosinaF, GambinoR

Management of NAFLD

Nonalcoholic fatty liver disease (NAFLD) ranges from simple fat buildup in the liver to more severe forms that cause liver inflammation. NAFLD increases the risk of heart disease, diabetes, and liver complications. The effects of current treatment recommendations on these conditions are unknown, and this study reviews the evidence for managing liver disease and cardio-metabolic risks associated with NAFLD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial.

Author: JanczykWojciech, SochaPiotr, LebensztejnDariusz, WierzbickaAldona, MazurArtur, Neuhoff-MurawskaJoanna, MatusikPawel

NAFLD treatment

Non-alcoholic fatty liver disease (NAFLD) is a liver condition linked to obesity and insulin resistance. It increases the risk of heart disease. Finding safe and effective treatments for NAFLD is urgent. Research suggests that omega-3 fatty acids, which are found in fatty fish, may be helpful for conditions related to metabolic syndrome and can reduce the risk of heart disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

The role of ursodeoxycholic acid in non-alcoholic steatohepatitis: a systematic review.

Author: XiangZun, ChenYi-peng, MaKui-fen, YeYue-fang, ZhengLin, YangYi-da, LiYou-ming, JinXi

Improved fibrosis
Improved liver function
Improved steatosis

Ursodeoxycholic acid (UDCA) therapy is effective in non-alcoholic steatohepatitis (NASH), especially when combined with other drugs. However, the low quality of the studies and the heterogeneity of the results precluded further meta-analysis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Systematic review with meta-analysis: non-alcoholic steatohepatitis - a case for personalised treatment based on pathogenic targets.

Author: YounossiZ M, ReyesM J, MishraA, MehtaR, HenryL

NASH treatment

Non-alcoholic fatty liver disease (NAFLD) includes simple fatty liver and non-alcoholic steatohepatitis (NASH), both linked to metabolic syndrome. NASH is associated with higher death rates. While many treatments for NASH have been studied, there is limited evidence to support the effectiveness of most.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Weight reduction improves markers of hepatic function and insulin resistance in type-2 diabetic patients with non-alcoholic fatty liver.

Author: Al-JiffriO, Al-SharifF M, Abd El-KaderS M, AshmawyE M

NAFLD treatment

Non-alcoholic fatty liver disease (NAFLD) is increasing rapidly, affecting up to 30% of people globally. While there are limited treatment options, medication hasn't been very effective. The most promising approach for managing NAFLD involves lifestyle changes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease--the role of transient elastography and plasma cytokeratin-18 fragments.

Author: KwokR, TseY-K, WongG L-H, HaY, LeeA U, NguM C, ChanH L-Y, WongV W-S

TE accurate for fibrosis exclusion

This review examined the use of non-invasive tests to assess the severity of non-alcoholic fatty liver disease (NAFLD). The review found that current non-invasive tests are accurate in excluding advanced fibrosis in NAFLD patients, and may be used for initial assessment. Further development and evaluation of NASH biomarkers are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.

Author: EslamiLayli, MeratShahin, MalekzadehReza, Nasseri-MoghaddamSiavosh, AraminHermineh

NAFLD treatment

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common liver conditions that can lead to liver damage and death. While there's no effective treatment yet, some reports suggest that statins (medications used to lower cholesterol) may help normalize elevated liver enzymes. However, more research is needed to confirm this effect and to see if statins improve overall health outcomes beyond just normalizing liver enzymes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study.

Author: EslamparastTannaz, PoustchiHossein, ZamaniFarhad, SharafkhahMaryam, MalekzadehReza, HekmatdoostAzita

NAFLD treatment

This pilot study found that synbiotic supplementation in addition to lifestyle modification was superior to lifestyle modification alone for the treatment of nonalcoholic fatty liver disease (NAFLD), at least partially through attenuation of inflammatory markers in the body.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Design and rationale of the WELCOME trial: A randomised, placebo controlled study to test the efficacy of purified long chainomega-3 fatty acid treatment in non-alcoholic fatty liver disease [corrected].

Author: ScorlettiE, BhatiaL, McCormickK G, CloughG F, NashK, CalderP C, ByrneC D,

NAFLD treatment

Non-alcoholic fatty liver disease (NAFLD) affects a large portion of the population, with up to 70% of people with type 2 diabetes having NAFLD. NAFLD can range from simple fatty liver to advanced liver disease requiring a transplant. It is not only a risk factor for liver failure and liver cancer, but also for type 2 diabetes and heart disease. Effective treatments for NAFLD are urgently needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Effect of rosuvastatin on non-alcoholic steatohepatitis in patients with metabolic syndrome and hypercholesterolaemia: a preliminary report.

Author: KargiotisKonstantinos, KatsikiNiki, AthyrosVasilios G, GioulemeOlga, PatsiaouraKalliopi, KatsikiEvangelia, MikhailidisDimitri P, KaragiannisAsterios

Ameliorate NASH
Alcohol abuse

A preliminary study of 6 patients with metabolic syndrome (MetS), NASH on liver biopsy and dyslipidaemia found that rosuvastatin (10 mg/day) for 1 year could ameliorate NASH within a year of treatment. Five of the 6 patients showed complete resolution of NASH on liver biopsy, while serum ALT and AST activities were reduced by 76 and 61%, respectively. Fasting plasma glucose and glycated haemoglobin (HbA1c) were also significantly reduced. Lipid values were totally normalized.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Non-alcoholic fatty liver disease: epidemiology, clinical course, investigation, and treatment.

Author: WeißJohannes, RauMonika, GeierAndreas

NAFLD can be reversed

The review discusses the global obesity epidemic and its impact on fatty liver disease, specifically non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steato-hepatitis (NASH). The review highlights the progression of NAFLD and NASH, diagnostic methods, and the importance of lifestyle and nutritional changes in managing the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

29.

Urinary (1)H-NMR-based metabolic profiling of children with NAFLD undergoing VSL#3 treatment.

Author: MiccheliA, CapuaniG, MariniF, TomassiniA, PraticòG, CeccarelliS, GnaniD, BavieraG, AlisiA, PutignaniL, NobiliV

Improved fatty liver

VSL#3 treatment induced changes in non-alcoholic fatty liver disease (NAFLD) urinary metabolic phenotype in children, which may be considered as non-invasive effective biomarkers to evaluate the response to treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome.

Author: KargiotisKonstantinos, AthyrosVasilios G, GioulemeOlga, KatsikiNiki, KatsikiEvangelia, AnagnostisPanagiotis, BoutariChrysoula, DoumasMichael, KaragiannisAsterios, MikhailidisDimitri P

Lipid profile normalization
Metabolic syndrome resolution
NASH resolution

Rosuvastatin monotherapy could ameliorate biopsy-proven NASH and resolve metabolic syndrome within 12 months. It also reduced fasting plasma glucose and SUA levels, potentially reducing the risk of vascular and liver morbidity and mortality in NASH patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial.

Author: PanahiYunes, KianpourParisa, MohtashamiReza, JafariRamezan, Simental-MendíaLuis E, SahebkarAmirhossein

Beneficial metabolic effects

Curcumin, a natural product found in turmeric, is being explored for its potential benefits in treating nonalcoholic fatty liver disease (NAFLD), a common liver disease associated with dyslipidemia, hyperuricemia, and insulin resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Outcome of phlebotomy for treating nonalcoholic fatty liver disease: A systematic review and meta-analysis.

Author: JaruvongvanichVeeravich, RiangwiwatTanawan, SanguankeoAnawin, UpalaSikarin

NAFLD treatment

There are currently no medications approved to treat nonalcoholic fatty liver disease (NAFLD). Lifestyle changes are the primary approach. NAFLD is often associated with high levels of ferritin (a protein involved in iron storage), which may contribute to liver damage and insulin resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Docosahexanoic Acid Plus Vitamin D Treatment Improves Features of NAFLD in Children with Serum Vitamin D Deficiency: Results from a Single Centre Trial.

Author: Della CorteClaudia, CarpinoGuido, De VitoRita, De StefanisCristiano, AlisiAnna, CianfaraniStefano, OveriDiletta, MoscaAntonella, StronatiLaura, CucchiaraSalvatore, RaponiMassimiliano, GaudioEugenio, ByrneChristopher D, NobiliValerio

Improved insulin-sensitivity
Improved lipid profile
Reduced hepatic steatosis

There are no approved treatments for non-alcoholic fatty liver disease (NAFLD) in adults or children. Studies have shown that omega-3 fatty acids may improve blood fats, insulin sensitivity, and liver fat buildup. Vitamin D has also been suggested to potentially reduce scarring in the liver.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Pharmacological interventions for non-alcohol related fatty liver disease (NAFLD): an attempted network meta-analysis.

Author: LombardiRosa, OnaliSimona, ThorburnDouglas, DavidsonBrian R, GurusamyKurinchi Selvan, TsochatzisEmmanuel

NAFLD treatment

Non-alcoholic fatty liver disease (NAFLD) is a condition where fat builds up in the liver, not due to alcohol use or other liver problems. It ranges from simple fatty liver to a more serious form called non-alcoholic steatohepatitis (NASH), which can lead to scarring (cirrhosis). There's no proven medication for NAFLD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Systematic Review: Nutrition and Physical Activity in the Management of Paediatric Nonalcoholic Fatty Liver Disease.

Author: GibsonPhilippa S, LangSarah, DhawanAnil, FitzpatrickEmer, BlumfieldMichelle L, TrubyHelen, HartKathryn H, MooreJ Bernadette

This research examines the role of nutrition and physical activity interventions in managing pediatric nonalcoholic fatty liver disease (NAFLD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Comparison of fenofibrate and pioglitazone effects on patients with nonalcoholic fatty liver disease.

Author: YaghoubiMalek, JafariSattar, SajediBehnam, GohariSepehr, AkbariehSamira, HeydariAmir H, JameshooraniMaryam

Fenofibrate and pioglitazone therapy
NAFLD

This study aimed to compare the therapeutic effects of fenofibrate and pioglitazone on nonalcoholic fatty liver disease (NAFLD), highlighting the lack of a proven treatment for this condition.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis.

Author: LeeHyo Young, JunDae Won, KimHyun Jung, OhHyunwoo, SaeedWaqar Khalid, AhnHyeongsik, CheungRamsey C, NguyenMindie H

Improved NAFLD treatment

The effects of cholesterol-lowering agents on hepatic steatosis and NAFLD activity score (NAS) in patients with nonalcoholic fatty liver disease (NAFLD) require further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

38.

Systematic review and meta-analysis of controlled intervention studies on the effectiveness of long-chain omega-3 fatty acids in patients with nonalcoholic fatty liver disease.

Author: Musa-VelosoKathy, VendittiCarolina, LeeHan Youl, DarchMaryse, FloydSeth, WestSpencer, SimonRyan

NAFLD treatment

Omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) were found to significantly improve metabolic risk factors, liver enzyme levels, liver fat content, and steatosis scores in patients with nonalcoholic fatty liver disease (NAFLD). However, n-3 LC-PUFAs did not affect histological outcomes in patients with nonalcoholic steatohepatitis (NASH).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Prebiotic and probiotic treatment of nonalcoholic fatty liver disease: a systematic review and meta-analysis.

Author: LomanBrett R, Hernández-SaavedraDiego, AnRuopeng, RectorR Scott

NAFLD treatment

A review of the evidence for alternative treatments aimed at modulating intestinal microbiota for nonalcoholic fatty liver disease (NAFLD) found that scarce evidence regarding their effectiveness in clinical populations exists.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

NAFLD and Liver Transplantation in Children-Working Group Report From the ILTS Single Topic Conference on NAFLD.

Author: CananziMara, VajroPietro, RelaMohamed, DhawanAnil

NAFLD treatment
Rare liver transplantation

Nonalcoholic fatty liver disease (NAFLD) is becoming increasingly common in children. While liver transplantation is rare for children with NAFLD, it's important to rule out other possible causes of fatty liver, particularly genetic conditions affecting metabolism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys: A Randomized Clinical Trial.

Author: SchwimmerJeffrey B, Ugalde-NicaloPatricia, WelshJean A, AngelesJorge E, CorderoMaria, HarlowKathryn E, AlazrakiAdina, DurelleJanis, Knight-ScottJack, NewtonKimberly P, CleetonRebecca, KnottCynthia, KonomiJuna, MiddletonMichael S, TraversCurtis, SirlinClaude B, HernandezAlbert, SekkarieAhlia, McCrackenCourtney, VosMiriam B

NAFLD improvement
limited data

This randomized clinical trial of 40 adolescent boys with nonalcoholic fatty liver disease (NAFLD) evaluated the effects of a diet low in free sugars. The intervention diet group showed significant improvement in hepatic steatosis and alanine aminotransferase levels compared to the usual diet group after 8 weeks. While promising, these findings are preliminary, and further research is needed to assess long-term outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

42.

Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial.

Author: AnushiravaniAmir, HaddadiNiloufar, PourfarmanbarMaedeh, MohammadkarimiVahid

Improved NAFLD treatment

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease globally and a leading reason for liver transplants. Heart disease is a major cause of death for these patients. There are no FDA-approved medications for NAFLD. This study aims to provide more evidence on the use of readily available and affordable medications, including metformin, silymarin, pioglitazone, and vitamin E, for treating NAFLD.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

43.

Hyperferritinemia in Nonalcoholic Fatty Liver Disease: Iron Accumulation or Inflammation?

Author: MorisWenke, VerhaeghPauline, JonkersDaisy, DeursenCees van, KoekGer

Hyperferritinemia treatment
NAFLD management

Hyperferritinemia in nonalcoholic fatty liver disease (NAFLD) is often due to inflammation without hepatic iron overload, not iron overload alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

N-ACETYLCYSTEINE AND/OR URSODEOXYCHOLIC ACID ASSOCIATED WITH METFORMIN IN NON-ALCOHOLIC STEATOHEPATITIS: AN OPEN-LABEL MULTICENTER RANDOMIZED CONTROLLED TRIAL.

Author: OliveiraClaudia P, CotrimHelma P, StefanoJose Tadeu, SiqueiraAna Cristina G, SalgadoAna Lucia Azevedo, PariseEdison Roberto

Reduced liver disease activity

The combination of N-acetylcysteine (NAC) and metformin (MTF) may reduce liver disease activity in patients with non-alcoholic steatohepatitis (NASH). The combination resulted in significant improvements in steatosis degree, ballooning, and NAFLD Activity Score (NAS) scores. However, no significant changes in liver fibrosis were observed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

45.

Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial.

Author: StanleyTakara L, FourmanLindsay T, FeldpauschMeghan N, PurdyJulia, ZhengIsabel, PanChelsea S, AepfelbacherJulia, BucklessColleen, TsaoAndrew, KelloggAnela, BranchKaren, LeeHang, LiuChia-Ying, CoreyKathleen E, ChungRaymond T, TorrianiMartin, KleinerDavid E, HadiganColleen M, GrinspoonSteven K

Reduced liver fat
Injection site issues

Tesamorelin might be beneficial in people with HIV and non-alcoholic fatty liver disease (NAFLD), with a greater reduction of hepatic fat fraction (HFF) than placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Language : English

46.

Diabetes drugs for nonalcoholic fatty liver disease: a systematic review.

Author: BlazinaIan, SelphShelley

NAFLD treatment

This study investigated whether medications approved to treat diabetes could also be helpful in reducing weight and improving fatty liver disease in people with NAFLD, a condition linked to obesity and other metabolic problems. Since there are currently no specific medications for NAFLD, the study aims to identify potential treatments from existing diabetes drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Systematic Literature Review and Critical Appraisal of Health Economic Models Used in Cost-Effectiveness Analyses in Non-Alcoholic Steatohepatitis: Potential for Improvements.

Author: JohansenPierre, HowardDaniel, BishopRyan, MorenoSøren Ilsøe, BuchholtzKristine

Improved NASH treatment

Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD) with an unmet need for effective treatments. This review highlights the lack of approved pharmacologic agents for NASH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Effects of a carbohydrate-restricted diet on hepatic lipid content in adolescents with non-alcoholic fatty liver disease: A pilot, randomized trial.

Author: GossAmy M, DowlaShima, PendergrassMay, AshrafAmbika, BoldingMark, MorrisonShannon, AmersonAlesha, SoleymaniTaraneh, GowerBarbara

Improved insulin resistance
Reduced liver fat

A moderately CHO-restricted diet may result in decreased hepatic lipid, as well as improvements in body composition and insulin resistance in adolescents with NAFLD even in the absence of intentional caloric restriction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

The Effect of Moderate Weight Loss on a Non-Invasive Biomarker of Liver Fibrosis: A Randomised Controlled Trial.

Author: KoutoukidisDimitrios A, JebbSusan A, AveyardPaul, AstburyNerys M

Weight loss
Liver fibrosis

This randomized controlled trial examined whether the Enhanced Liver Fibrosis (ELF) score changes with weight loss in patients with non-alcoholic fatty liver disease (NAFLD). The study found no evidence that a community weight loss program reduced the ELF score, despite greater weight loss compared to usual care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

The effects of metformin administration on liver enzymes and body composition in non-diabetic patients with non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis: An up-to date systematic review and meta-analysis of randomized controlled trials.

Author: JalaliMohammad, RahimlouMehran, MahmoodiMarzieh, MoosavianSeyedeh Parisa, SymondsMichael E, JalaliRonak, ZareMorteza, ImaniehMohammad Hadi, StasiCristina

Liver function improvement
NAFLD treatment

A meta-analysis of 6 RCTs found that metformin significantly reduced BMI, liver enzymes, and improved liver function in non-diabetic patients with NAFLD. These findings suggest the potential benefit of metformin in treating non-diabetic NAFLD, although further large-scale studies are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Antidiabetic drugs and non-alcoholic fatty liver disease: A systematic review, meta-analysis and evidence map.

Author: KumarJai, MemonRoha Saeed, ShahidIzza, RizwanTehlil, ZamanMaryam, MenezesRitesh G, KumarSarwan, SiddiqiTariq Jamal, UsmanMuhammad Shariq

Improved liver function

Pioglitazone significantly improved liver enzymes and liver histology in both diabetic and non-diabetic patients with NAFLD. Early evidence suggests that new antidiabetic drugs may improve liver enzymes and hepatic steatosis in patients with diabetic NAFLD. Further research is needed to determine the efficacy of these drugs for NAFLD treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Prevalence, Diagnosis, and Treatment with 3 Different Statins of Non-alcoholic Fatty Liver Disease/Non-alcoholic Steatohepatitis in Military Personnel. Do Genetics Play a Role?

Author: SfikasGeorgios, PsallasMichael, KoumarasCharalambos, ImprialosKonstantinos, PerdikakisEvangelos, DoumasMichael, GioulemeOlga, KaragiannisAsterios, AthyrosVasilios G

Liver fibrosis reduction
Statin treatment

Atorvastatin, rosuvastatin, and pitavastatin have a beneficial and safe effect in non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Dipeptidyl Peptidase IV Inhibitors for Nonalcoholic Fatty Liver Disease - Systematic Review and Metanalysis.

Author: Dos SantosLucas Ribeiro, DuarteMarcio Luis, PeccinMaria Stella, GagliardiAntônio Ricardo de Toledo, MelnikTamara

Hepatic steatosis treatment

Fatty liver disease (hepatic steatosis) is common, especially in people who are overweight and have insulin resistance. It's usually diagnosed with imaging tests. While it's common and can lead to complications, there's no specific treatment approved for it, although many medications have been studied.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Effect of dietary carbohydrate and lipid modification on clinical and anthropometric parameters in nonalcoholic fatty liver disease: a systematic review and meta-analysis.

Author: GarcêzLais S, AvelarCamila R, FonsecaNedja S S, CostaPriscila R F, LyraAndré C, CunhaCarla M, JesusRosangela P, OliveiraLucivalda P M

NAFLD treatment

Nonalcoholic fatty liver disease (NAFLD) is a common liver condition that affects about 25% of adults worldwide. While it's a major public health concern, there's no agreement on the best dietary approach to treat it.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

The efficacy of novel metabolic targeted agents and natural plant drugs for nonalcoholic fatty liver disease treatment: A PRISMA-compliant network meta-analysis of randomized controlled trials.

Author: ZhouJingwen, ChenYidi, YuJun, LiTianci, LuZiyu, ChenYan, ZhangXiaolong, YeFang

There is no approved drug for the treatment of nonalcoholic fatty liver disease, but some agents, including metabolic target agents and natural plant drugs, have shown promising results.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

Efficacy of statins in treatment and development of non-alcoholic fatty liver disease and steatohepatitis: A systematic review and meta-analysis.

Author: FatimaKaneez, MoeedAbdul, WaqarEisha, AtifAbdul Raafe, KamranAlishba, RizviHura, SuriNoor Fatima, HaiderHoorain, ShujaSyed Hasan, KhalidMariam, MinhasAbdul Mannan Khan

NAFLD treatment

Non-alcoholic fatty liver disease (NAFLD) is a major health problem globally. While there is no standard treatment, some studies suggest that statins, which lower cholesterol, might help reduce liver enzyme levels and improve liver health. However, we need more research to determine how well they work for NAFLD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Association between Non-Alcoholic Fatty Liver Disease and Mediterranean Lifestyle: A Systematic Review.

Author: MascaróCatalina M, BouzasCristina, TurJosep A

Mediterranean lifestyle for NAFLD

This systematic review assessed the evidence for the Mediterranean lifestyle in preventing and reversing non-alcoholic fatty liver disease (NAFLD). NAFLD is linked to metabolic syndrome and lacks effective pharmacological treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

Lifestyle changes in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis.

Author: FernándezTiziana, ViñuelaMacarena, VidalCatalina, BarreraFrancisco

Lifestyle interventions
NAFLD treatment

Non-alcoholic fatty liver disease (NAFLD) is a growing problem worldwide and could become the leading cause of serious liver damage in the next few years. There's no proven medication for NAFLD. Losing 7-10% of body weight is the primary treatment and can improve liver health. This study will assess the effectiveness of diet, exercise, or both, compared to standard care in people with NAFLD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Statins for the Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis.

Author: DaiWeiwei, XuBaohong, LiPeng, WengJunhua

NAFLD and NASH treatment

This meta-analysis evaluated the efficacy of statins for treating nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Statins were found to significantly lower serum levels of liver enzymes, triglycerides, and cholesterol. The authors recommend further research, including larger randomized controlled trials, to confirm these findings.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

60.

Treatment of obesity and metabolic-associated fatty liver disease with a diet or orlistat: A randomized controlled trial.

Author: FengXiongcai, LinYansong, ZhuoShuyu, DongZhi, ShaoCongxiang, YeJunzhao, ZhongBihui

High-protein diet
Liver steatosis reduction
Orlistat
MAFLD
Obesity

This study compared the effects of orlistat and an experimental high-protein/lower-carbohydrate diet with a control diet in Asian patients with obesity and metabolic-associated fatty liver disease (MAFLD). Both orlistat and the experimental diet group showed significant reductions in liver steatosis compared to the control group. The study concluded that both orlistat and the experimental diet are effective in reducing liver steatosis in patients with obesity and MAFLD.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

Comparison of sodium-glucose cotransporter-2 inhibitors and thiazolidinediones for management of non-alcoholic fatty liver disease: A systematic review and meta-analysis.

Author: HameedIshaque, HayatJaveria, MarsiaShayan, SamadSyed Abdus, KhanRafay, SiddiquiOmer Mustafa, KhanMohammad Omer, MalikShanza, FatimaKaneez, FudimMarat, KrasuskiRichard A

Improved liver enzymes

SGLT2 inhibitors and TZDs had similar effects on liver enzymes, steatosis, and fibrosis in patients with NAFLD. However, SGLT2 inhibitors significantly decreased visceral fat area and body weight. Further research is needed to determine the utility of SGLT2 inhibitors for treating NAFLD.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

63.

Growth Hormone Administration Improves Nonalcoholic Fatty Liver Disease in Overweight/Obesity: A Randomized Trial.

Author: DichtelLaura E, CoreyKathleen E, HainesMelanie S, ChicoteMark L, LeeHang, KimballAllison, CollingCaitlin, SimonTracey G, LongMichelle T, HusseiniJad, BredellaMiriam A, MillerKaren K

Hepatic steatosis reduction (GH)
Lower extremity edema (GH)

A randomized, double-blind, placebo-controlled trial of low-dose growth hormone (GH) administration in adults with overweight/obesity and nonalcoholic fatty liver disease (NAFLD) found that GH administration reduced hepatic steatosis without worsening glycemic measures.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

64.

Statins on nonalcoholic fatty liver disease: A systematic review and meta-analysis of 14 RCTs.

Author: ZhouHaiyan, ToshiyoshiMaeda, ZhaoWenli, ZhaoYe, ZhaoYan

Liver enzyme reduction (statins)

Statins were found to significantly reduce liver biochemical indicators in patients with nonalcoholic fatty liver disease (NAFLD).

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

65.

Effects of gut microbial therapy on lipid profile in individuals with non-alcoholic fatty liver disease: an umbrella meta-analysis study.

Author: NaghipourAmirhossein, Amini-SalehiEhsan, Orang GorabzarmakhiMahdi, ShahdkarMilad, FouladiBahman, AlipourfardIraj, SanatZahra Momayez

Improved lipid profile
Cardiovascular events
NAFLD

This study summarizes meta-analysis results investigating the impact of gut microbial therapy (probiotics, synbiotics, and prebiotics) on the lipid profile of individuals with non-alcoholic fatty liver disease (NAFLD).

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

66.

The effects of medicinal and food homologous substances on blood lipid and blood glucose levels and liver function in patients with nonalcoholic fatty liver disease: a systematic review of randomized controlled trials.

Author: ZhangQian, JiaYatian, ZhangYuexing, WangYan, LiXinru, TianXiaoying, HanShifan

Glucose control
Lipid control
Liver function improvement

Nonalcoholic fatty liver disease (NAFLD) is a common liver problem. Previous studies have shown that using natural substances, like certain medications and foods, can improve blood fat levels, blood sugar, and liver function in people with NAFLD.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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