Effective treatment of fever: A Synthesis of Findings from 5 Studies

  1. Home
  2. Effective treatment of fever
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of fever: A Synthesis of Findings from 5 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of fever: A Synthesis of Findings from 5 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major research findings

Research on fever treatment in critically ill patients explores effective treatment methods for fever. 2 compared the effects of acetaminophen and physical cooling on core body temperature and cardiovascular responses in critically ill patients. This study found that mean body temperature slightly increased in the acetaminophen-only group, while it decreased slightly in the physical cooling-only group and the group that combined acetaminophen with physical cooling. 4 investigated the feasibility of conducting a definitive randomized controlled trial (RCT) to evaluate the clinical effectiveness and cost-effectiveness of different temperature thresholds for antipyretic management in critically ill children with fever due to infection. This study randomly assigned patients to two groups: one group received antipyretics at a permissive temperature threshold (39.5°C), and the other group received antipyretics at a restrictive temperature threshold (37.5°C). The results showed that the temperature in the permissive group was slightly higher compared to the restrictive group. 1 examined the effects of physical treatment on induced fever in humans. This study suggests that physical cooling might be counterproductive because decreasing skin temperature increases the thermoregulatory core target temperature. 3 compared the effects of ibuprofen and paracetamol for adjunctive treatment of uncomplicated typhoid fever in Vietnamese children. This study demonstrated that ibuprofen had a superior antipyretic effect compared to paracetamol, especially in children with prolonged fever. These studies suggest that various approaches, such as antipyretics and physical cooling, can be utilized in treating fever. However, the effectiveness and safety of these approaches can vary depending on the patient.

treatment summary

Fever treatment in critically ill patients utilizes various treatment methods, including acetaminophen and physical cooling. 2 compared the effects of acetaminophen and physical cooling in critically ill patients with fever, observing a slight decrease in temperature in the physical cooling-only group and the combined acetaminophen and physical cooling group, while the acetaminophen-only group showed a slight increase in temperature. 4 randomly assigned critically ill children with infection-related fever to receive antipyretics at permissive (39.5°C) or restrictive (37.5°C) temperature thresholds. 3 compared the effectiveness of ibuprofen and paracetamol as adjunctive treatment for uncomplicated typhoid fever, concluding that ibuprofen exhibited superior antipyretic effects, particularly in patients with prolonged fever.

Benefits and risks

Benefit summary

Treatment methods like antipyretics and physical cooling can help alleviate discomfort and symptoms associated with fever. 2 found a slight decrease in temperature in the group that combined acetaminophen and physical cooling. 3 demonstrated that ibuprofen had a superior antipyretic effect compared to paracetamol, especially in children with prolonged fever.

Risk summary

Antipyretics and physical cooling come with potential side effects. 1 suggests that physical cooling might be counterproductive due to the increase in thermoregulatory core target temperature caused by decreasing skin temperature. Antipyretics could also trigger gastrointestinal issues or allergic reactions.

Comparison between studies

Commonalities

These studies highlight the use of various approaches for managing fever.

Differences

These research studies utilize diverse patient populations, treatments, and evaluation criteria, making direct comparison of results challenging.

Consistency and contradictions in findings

These studies present varying results regarding the effectiveness and safety of fever treatment methods. For instance, 2 indicates that acetaminophen might not be effective for fever in critically ill patients, while 3 demonstrates the efficacy of ibuprofen in patients with typhoid fever. These contradictions suggest that fever treatment approaches can vary depending on individual patients.

Considerations for real-world application

Fever treatment necessitates a personalized approach for each patient. Factors to consider include the cause of fever, its severity, the patient's age, and overall health status. Consulting a healthcare professional for guidance on fever management is crucial.

Limitations of current research

These research studies are limited by small sample sizes and their lack of implementation across diverse patient populations, hindering the generalization of their findings. Additionally, these studies do not comprehensively assess the effects of various treatment methods.

Directions for future research

Further research on fever treatment methods is warranted. Focusing on the long-term effectiveness and safety of various treatment methods, as well as identifying optimal temperature thresholds, is crucial.

Conclusion

These studies indicate the use of various approaches in treating fever. However, the effectiveness and safety of these approaches can differ among patients. Seeking guidance from a healthcare professional is essential for managing fever.

treatment list

・Acetaminophen ・Physical cooling ・Ibuprofen ・Paracetamol ・Antibiotics (for specific causes like typhoid fever)

Literature analysis of 5 papers
Positive Content
4
Neutral Content
1
Negative Content
0
Article Type
5
0
0
0
5
1.

The effects of physical treatment on induced fever in humans.

Author: LenhardtR, NegishiC, SesslerD I, VuongK, BastanmehrH, KimJ S, BjorkstenA R

Autonomic stress
Metabolic stress
Thermal discomfort

While initial fever treatment focuses on addressing the underlying cause and using antipyretic medications, active cooling is sometimes used for patients who don't respond. However, cooling can have negative effects. Lowering skin temperature may actually raise the body's internal temperature set point, leading to further fever. Cooling can also cause metabolic and autonomic stress and discomfort.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

2.

Comparison of fever treatments in the critically ill: a pilot study.

Author: HenkerR, RogersS, KramerD J, KelsoL, KerrM, SereikaS

Reduced body temperature
Increased vascular resistance

Physical cooling was more effective than acetaminophen in reducing core body temperature in febrile critically ill patients. Acetaminophen alone resulted in a slight increase in body temperature.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Double blind comparison of ibuprofen and paracetamol for adjunctive treatment of uncomplicated typhoid fever.

Author: VinhHa, ParryChristopher M, HanhVo Thi Ngoc, ChinhMai Thu, HouseDeborah, ThamCao Thi, ThaoNguyen Thi Thu, DiepTo Song, WainJohn, DayNicholas P J, WhiteNicholas J, FarrarJeremy J

Superior antipyretic effect

Ibuprofen was more effective than paracetamol in reducing fever in children with typhoid fever, particularly in those with prolonged fever. Both drugs were safe.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Different temperature thresholds for antipyretic intervention in critically ill children with fever due to infection: the FEVER feasibility RCT.

Author: PetersMark J, KhanImran, WoolfallKerry, DejaElizabeth, MounceyPaul R, WulffJerome, MasonAlexina, AgbekoRachel, DraperElizabeth S, FennBlaise, GouldDoug W, KoelewynAbby, KleinNigel, MackernessChristine, MartinSian, O'NeillLauran, RamnarayanPadmanabhan, TibbyShane, TumeLyvonne, WatkinsJason, ThorburnKent, WellmanPaul, HarrisonDavid A, RowanKathryn M

High metabolic cost

A feasibility study was conducted to determine whether a definitive randomized controlled trial (RCT) of different temperature thresholds for antipyretic management in critically ill children is feasible. The study found that parents and clinicians found the study acceptable, but there were concerns about the use of a permissive temperature threshold. A definitive RCT using a modified protocol should be conducted, but further work is required to agree on important outcome measures for clinical trials among critically ill children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infection Model.

Author: JinCelina, GibaniMalick M, PenningtonShaun H, LiuXinxue, ArdreyAlison, AljayyoussiGhaith, MooreMaria, AngusBrian, ParryChristopher M, BiaginiGiancarlo A, FeaseyNicholas A, PollardAndrew J

Azithromycin
Antimicrobial resistance

This article highlights the challenges posed by antimicrobial resistance in enteric fever treatment, suggesting that azithromycin may not be optimal for all patients and emphasizing the need for fluoroquinolones in some cases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.