Side Effects of feverfew: A Synthesis of Findings from 9 Studies

  1. Home
  2. Side Effects of feverfew
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of feverfew: A Synthesis of Findings from 9 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of feverfew: A Synthesis of Findings from 9 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Feverfew has shown potential benefits in preventing migraine headaches. found that people taking feverfew experienced significantly fewer and less severe migraine attacks compared to those taking a placebo. Additionally, suggested that feverfew is effective in preventing migraines and that side effects are mild and temporary.

Feverfew may also help alleviate pain associated with diabetic neuropathy. indicated that feverfew was as effective in relieving neuropathic pain as clinically used antihyperalgesic drugs like carbamazepine, lamotrigine, and L-acetyl-L-carnitine.

Feverfew might also contribute to treating Parkinson's disease. 2 demonstrated that parthenolide, a component of feverfew, significantly reduced motor dysfunction and dopaminergic neurodegeneration in mice with Parkinson's disease when combined with L-DOPA.

Reasons for Side Effects

Side effects of feverfew are believed to stem from sesquiterpene lactones such as parthenolide. found that extracts from fresh feverfew leaves, which are rich in parthenolide, strongly inhibited vascular smooth muscle. Conversely, extracts from dried feverfew leaves, lacking parthenolide, caused smooth muscle contraction.

Common Side Effects

Digestive System

reported digestive symptoms (maldigestion, abdominal pain, diarrhea, nausea) as side effects of feverfew.

Skin

1 reported skin symptoms (aphthous ulcers, lip and tongue irritation, swelling) as side effects of feverfew.

Oral

1 reported oral symptoms (gingival bleeding, tongue numbness) as side effects of feverfew.

Other

reported vomiting as a side effect of feverfew.

Countermeasures for Side Effects

Digestive Side Effects

To mitigate digestive side effects, start with a small amount of feverfew and gradually increase the dosage. Taking it with meals might also lessen side effects.

Skin Side Effects

If skin side effects occur, discontinue the use of feverfew and consult a doctor.

Oral Side Effects

If oral side effects occur, discontinue the use of feverfew and consult a dentist.

Comparison of Studies

Commonalities

Multiple studies have indicated that feverfew may be effective in preventing migraine headaches. Furthermore, side effects of feverfew are generally considered mild and temporary.

Differences

There is variability in the results of studies regarding the efficacy and side effects of feverfew. This may be attributed to differences in the quality and manufacturing methods of feverfew, as well as variations in research designs.

Points to Note in Real-Life Applications

While feverfew might be beneficial in preventing migraine headaches, it is not guaranteed to work for everyone. Additionally, there is a possibility of side effects. It is recommended to consult a doctor before taking feverfew.

Current Limitations of Research

Research on feverfew is still inadequate. Particularly, data on long-term safety is lacking. Therefore, caution is advised when using feverfew long-term.

Future Directions for Research

More research is needed to evaluate the long-term safety and efficacy of feverfew. It is also crucial to clarify the components and mechanisms of action of feverfew.

Conclusion

Feverfew is a herb that might be effective in preventing migraine headaches. However, there is a potential for side effects. It is advisable to consult a doctor before taking feverfew. Research on feverfew is still insufficient. More research is necessary in the future.

Literature analysis of 9 papers
Positive Content
7
Neutral Content
0
Negative Content
2
Article Type
0
0
0
8
9
1.

An overview of herbal supplement utilization with particular emphasis on possible interactions with dental drugs and oral manifestations.

Author: AbebeWorku

Drug interactions
Oral manifestations

Herbal medication is popular in the US, but its regulation is limited. This paper discusses the potential interactions of herbal supplements with oral health drugs and oral manifestations. Dental hygienists should be aware of these potential interactions to provide appropriate oral health care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.

Author: LiuQianqian, ZhangShaozhi, ZhuDashuai, TangXinyu, CheYongzhe, FengXizeng

Astrocyte activation
IL-1β production
Neurodegeneration
Reduced motor dysfunction
α-synuclein overexpression

This study investigated the potential of ACT001, a derivative of parthenolide, to synergize with l-DOPA in treating Parkinson's disease. ACT001 significantly reduced motor dysfunction, dopaminergic neurodegeneration, and α-synuclein overexpression in MPTP-treated mice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Evidenced-based use of botanicals, minerals, and vitamins in the prophylactic treatment of migraines.

Author: RiosJuanita, PasseMegan M

Migraine prophylaxis
Limited research

This study reviewed evidence-based information about alternative prophylactic migraine treatments, such as feverfew, butterbur, magnesium, and riboflavin. The study found that current clinical data support the use of these treatments for migraine prophylaxis, but that more research is needed to confirm their safety and efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?

Author: KaurKavaljeet, HernandezVernicia, Al HajajSari W, EbrahimAhmed M, RazackMirash, ElShariefMohamed W, DragasDavid

Migraine frequency reduction
Natural treatment
Mixed severity & duration results

Herbal supplements and nutraceuticals, such as coenzyme Q10, riboflavin, feverfew, and magnesium, may help reduce the frequency of migraine headaches. Mixed results were observed regarding severity and duration of headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Non-Pharmacological Approaches to Headaches: Non-Invasive Neuromodulation, Nutraceuticals, and Behavioral Approaches.

Author: GrazziLicia, ToppoClaudia, D'AmicoDomenico, LeonardiMatilde, MartellettiPaolo, RaggiAlberto, GuastafierroErika

Headache relief

This paper presents the main approaches reported in the literature for managing headache disorders, specifically focusing on non-invasive neuromodulation, nutraceuticals, and behavioral therapies. The review highlights the increasing use of these approaches as valid treatment options, especially for patients with medication overuse or contraindications to drug treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Complementary and Integrative Medicines as Prophylactic Agents for Pediatric Migraine: A Narrative Literature Review.

Author: YamanakaGaku, KanouKanako, TakamatsuTomoko, TakeshitaMika, MorichiShinichiro, SuzukiShinji, IshidaYu, WatanabeYusuke, GoSoken, OanaShingo, KawashimaHisashi

Migraine prevention

This review summarizes the evidence for the efficacy and safety of eight complementary and integrative medicines (CIMs) used for pediatric migraine prevention. Riboflavin showed relatively high evidence of efficacy, while evidence for other CIMs, including melatonin, coenzyme Q10, magnesium, and polyunsaturated fatty acids, was insufficient.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Complementary and Integrative Medicine for Episodic Migraine: an Update of Evidence from the Last 3 Years.

Author: WellsRebecca Erwin, BeuthinJustin, GranetzkeLaura

This review evaluates evidence from the past three years on complementary and integrative medicine treatments for episodic migraine, focusing on mind/body therapies, supplements, and manual therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

The impact of herbal medicines on dermatologic surgery.

Author: ChangL K, WhitakerD C

Epinephrine potentiation
Increased bleeding

Herbal medicines like Ginkgo biloba, garlic, ginger, ginseng, feverfew, and vitamin E may increase the risk of bleeding, and ephedra may potentiate the effects of epinephrine. These should be discontinued prior to dermatologic surgery to minimize surgical complications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Usefulness of nutraceuticals in migraine prophylaxis.

Author: D'OnofrioFlorindo, RaimoSimona, SpitaleriDaniele, CasucciGerardo, BussoneGennaro

Migraine prevention
Nutraceutical side effects

This overview summarizes randomized controlled trials investigating the efficacy and side effects of commonly used nutraceutical treatments for migraine, including magnesium, coenzyme Q10, riboflavin, petasites, and feverfew. These alternative therapies are often sought by individuals dissatisfied with conventional medical treatments for migraine prophylaxis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.