Side Effects of flibanserin: A Synthesis of Findings from 8 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of flibanserin: A Synthesis of Findings from 8 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Main Research Findings

Flibanserin is an FDA-approved medication for the treatment of Hypoactive Sexual Desire Disorder (HSDD) in women. It primarily targets serotonin, dopamine, and norepinephrine neurotransmitters. 6 , 8 , 3 Despite showing statistically significant improvements in sexual desire, sexual distress, and satisfying sexual events, flibanserin also has noteworthy side effects. 8 It is completely contraindicated with alcohol consumption, as it can heighten the risks of dizziness, hypotension, and syncope. 6 , 1

Reasons for Side Effects

Flibanserin's side effects stem from its influence on serotonin, dopamine, and norepinephrine neurotransmitters. 8 Furthermore, its contraindication with alcohol is due to the potential for amplified risks of dizziness, hypotension, and syncope. 6

Common Side Effects

Sedation

A common side effect of flibanserin is sedation. 1 This effect is attributed to flibanserin's action on serotonin receptors, which can reduce brain activity. 8

Hypotension

Flibanserin can cause hypotension, or low blood pressure. 6 This effect is likely due to flibanserin's dilation of blood vessels. 8

Syncope

Flibanserin can trigger syncope, or fainting. 6 This is linked to the potential for flibanserin to cause hypotension. 8

Countermeasures for Side Effects

Sedation

To minimize sedation, it's recommended to take flibanserin before bedtime. 1

Hypotension

To help prevent hypotension, ensure you are well-hydrated before taking flibanserin. 6

Syncope

To reduce the risk of syncope, refrain from driving or operating machinery for at least 3 hours after taking flibanserin. 6

Comparison Between Studies

Similarities

Multiple studies have demonstrated that flibanserin effectively improves sexual desire, sexual distress, and sexually satisfying events in women. 8 However, they also highlight the potential for side effects. 6

Differences

Studies have shown varying degrees of effectiveness and side effects associated with flibanserin. 8 This variability can be attributed to differing study designs and participant characteristics. 3

Points to Note for Applying This to Real Life

Before taking flibanserin, consult with your doctor to ensure it is suitable for your individual body. 6 Additionally, abstain from alcohol while taking flibanserin. 6

Current Limits of Research

The long-term effects of flibanserin are still not fully understood. 8 Furthermore, more research is needed to understand potential drug interactions with flibanserin. 6

Future Research Directions

Further research is essential on the long-term effects of flibanserin and potential interactions with other medications. 8 Moreover, in-depth studies are needed on the specific effects of flibanserin on women. 3

Conclusion

Flibanserin is an FDA-approved medication for the treatment of Hypoactive Sexual Desire Disorder in women. 6 However, it can cause side effects such as sedation, hypotension, and syncope. 8 Always consult your doctor before taking flibanserin to ensure it's right for you. 6 Additionally, avoid alcohol while taking flibanserin. 6

Literature analysis of 8 papers
Positive Content
4
Neutral Content
2
Negative Content
2
Article Type
2
0
0
3
8
1.

Effects of Timing of Flibanserin Administration Relative to Alcohol Intake in Healthy Premenopausal Women: A Randomized, Double-Blind, Crossover Study.

Author: SimonJames A, ClaytonAnita H, KingsbergSheryl A, ParishSharon J, KimNoel N, MillheiserLeah

Treats sexual desire disorder
Hypotension risk
Sedation risk
Syncope risk

Flibanserin is approved for treating acquired, generalized, hypoactive sexual desire disorder in premenopausal women. Sedation is a common side effect, and while infrequent, hypotension and syncope are safety concerns due to potential interactions with alcohol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Flibanserin for hypoactive sexual desire disorder: place in therapy.

Author: GelmanFaina, AtrioJessica

Improved sexual function
Increased sexual desire
Contraindications
Side effects

This review provides an overview of current therapeutic modalities for hypoactive sexual desire disorder (HSDD) in women, including pharmacologic treatments like flibanserin and testosterone, as well as non-pharmacological interventions like cognitive behavioral therapy and pelvic floor therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Flibanserin for the treatment of hypoactive sexual desire disorder in premenopausal women.

Author: DhanukaIda, SimonJames A

HSDD treatment

Hypoactive sexual desire disorder (HSDD) is the most common form of female sexual dysfunction. Some theories suggest that HSDD has a neurobiological component linked to neurotransmitter imbalances. Flibanserin is the only FDA-approved treatment of HSDD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Effects of Timing of Flibanserin Administration Relative to Alcohol Intake in Healthy Premenopausal Women: A Randomized, Double-Blind, Crossover Study.

Author: SimonJames A, ClaytonAnita H, KingsbergSheryl A, ParishSharon J, KimNoel N, MillheiserLeah

Treats sexual desire disorder
Hypotension risk
Sedation risk
Syncope risk

Flibanserin is approved for treating acquired, generalized, hypoactive sexual desire disorder in premenopausal women. Sedation is a common side effect, and while infrequent, hypotension and syncope are safety concerns due to potential interactions with alcohol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Flibanserin toxicity in a toddler following ingestion.

Author: GranzellaNicholas, ChenBetty C, BairdGeoffrey S, ValentoMatthew

HSDD treatment

Flibanserin is a new medication approved by the FDA for women who experience a low sex drive. Although we know that other drugs which affect serotonin, norepinephrine, and dopamine can have side effects, we don’t know much about the side effects of flibanserin.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Flibanserin has anxiolytic effects without locomotor side effects in the infant rat ultrasonic vocalization model of anxiety.

Author: PodhornaJ, BrownR E

Anxiety treatment
Mood disturbance treatment

Flibanserin, a novel 5-HT(1A) agonist/5-HT(2A) antagonist, reduced separation-induced ultrasonic vocalizations (USVs) in rat pups as effectively as diazepam and imipramine, but with fewer motor side effects, suggesting potential for treating anxiety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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