Effective treatment of floods: A Synthesis of Findings from 33 Studies

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Original Abstract of the Article

Major Research Findings

Chronic fatigue syndrome (CFS) is characterized by persistent, medically unexplained fatigue, as well as symptoms such as musculoskeletal pain, sleep disturbance, headaches, and impaired concentration and short-term memory. 16 , 20 , 22 , 18 , 23 CFS is a common, debilitating, and serious health problem.

Fatigue is a common and distressing symptom that can last for months or years in up to one-third of cancer survivors. 21 Despite its prevalence, the nature and mechanisms of cancer-related fatigue are poorly understood, and the available treatments may not provide sufficient relief. Fatigue has been identified as a significant contributor to decreased quality of life, making it an important target for intervention.

In healthy individuals, fatigue is a protective response to physical or mental stress, often relieved by rest. By contrast, in palliative care patients, fatigue can be severely debilitating, thereby impacting daily activity and quality of life, often with rest not counteracting fatigue. 9 Fatigue frequently occurs in patients with advanced disease, and modalities treating cancer often contribute or cause fatigue. Further complicating issues are its multidimensionality, subjective nature, and lack of a consensus definition of fatigue. Pathophysiology is not fully understood, and evidence-based treatment approaches are needed.

Exercise therapy has been shown to reduce fatigue and improve physical functioning in CFS. 4

Bright light therapy has been shown to improve cancer-related fatigue in cancer survivors. 24

Cognitive behavioral therapy (CBT) has been shown to be effective in reducing severe fatigue during cancer treatment. 28

Melatonin has been shown to reduce fatigue associated with breast cancer and its adjuvant treatments. 30

Treatment Summary

Exercise therapy for CFS has been investigated in 4 , 20 , 22 , 18 , 23 and has been shown to be beneficial in reducing fatigue and improving physical functioning.

Bright light therapy for cancer-related fatigue has been investigated in 21 , 24 and has been shown to have a positive impact on fatigue, mood, and quality of life in cancer survivors.

Pharmacological treatments for fatigue in palliative care patients have been investigated in 9 , 17 . However, the pathophysiology of fatigue is not fully understood, and evidence-based treatment approaches are needed.

CBT for severe fatigue during cancer treatment has been investigated in 28 and has been shown to be effective in reducing fatigue.

Melatonin for fatigue associated with breast cancer and its adjuvant treatments has been investigated in 30 and has been shown to reduce fatigue.

Benefits and Risks

Benefits Summary

Exercise therapy may improve fatigue and physical functioning in CFS. 4

Bright light therapy may improve cancer-related fatigue, mood, and quality of life. 24

CBT may reduce severe fatigue during cancer treatment. 28

Melatonin may reduce fatigue associated with breast cancer and its adjuvant treatments. 30

Risks Summary

Exercise therapy may be less acceptable to patients than other management approaches, such as rest or pacing. 4

Comparison of Studies

Commonalities of Studies

Many studies suggest that exercise therapy, light therapy, CBT, and pharmacological treatments have the potential to reduce fatigue symptoms.

Differences in Studies

Studies vary in various aspects, including the type of fatigue, target population, interventions used, and methods of measuring outcomes.

Consistency and Contradictions of Results

While there is consistency among study results, some contradictions also exist. For instance, the effectiveness of exercise therapy varies across studies, with 4 showing benefits while 28 demonstrates no effect.

Practical Applications and Considerations

When choosing a treatment for fatigue, it is essential to consider the patient's specific circumstances, the cause of fatigue, and the potential risks and benefits of treatment.

Limitations of Current Research

Many studies have small sample sizes and limited target populations, making it challenging to generalize findings.

Future Research Directions

Larger and longer-term studies are needed to investigate the long-term effects of various treatments for different types of fatigue. Research is also needed to explore the optimal combination of different treatments to reduce fatigue.

Conclusions

Exercise therapy, light therapy, CBT, and pharmacological treatments have the potential to reduce fatigue symptoms. However, study results show consistency while also revealing some contradictions. When choosing a treatment for fatigue, it is crucial to consider the patient's specific circumstances, the cause of fatigue, and the potential risks and benefits of treatment.

Individuals experiencing fatigue should consult with a healthcare professional to determine the most appropriate treatment approach for their individual needs.

Treatment List

Exercise therapy, Light therapy, Cognitive behavioral therapy (CBT), Pharmacological treatments

Literature analysis of 33 papers
Positive Content
27
Neutral Content
3
Negative Content
3
Article Type
16
12
15
14
33
1.

Fatigue patterns observed in patients receiving chemotherapy and radiotherapy.

Author: SchwartzA L, NailL M, ChenS, MeekP, BarsevickA M, KingM E, JonesL S

Cancer-related fatigue management

This study analyzed the patterns of cancer-related fatigue (CRF) and vigor in patients receiving chemotherapy or radiation therapy. The study found different patterns of CRF for the two types of treatment, with chemotherapy-related fatigue peaking in the days after treatment and radiation therapy-related fatigue gradually accumulating over time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

2.

A randomized, double-blind, placebo-controlled trial of psychostimulants for the treatment of fatigue in ambulatory patients with human immunodeficiency virus disease.

Author: BreitbartW, RosenfeldB, KaimM, Funesti-EschJ

Reduced fatigue

Fatigue is a common symptom of HIV disease and can significantly impact mental health, daily functioning, and quality of life. Preliminary studies suggest that psychostimulants, which are medications used to treat fatigue in other conditions like cancer and multiple sclerosis, may be effective in reducing fatigue in people with HIV.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Is graded exercise better than cognitive behaviour therapy for fatigue? A UK randomized trial in primary care.

Author: RidsdaleL, DarbishireL, SeedP T

Fatigue treatment

The study aimed to test cognitive behaviour therapy (CBT) and graded exercise therapy (GET) for patients presenting to their family doctor with fatigue, and describe the outcome for a cohort of patients who received standard care plus a booklet.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Exercise therapy for chronic fatigue syndrome.

Author: EdmondsM, McGuireH, PriceJ

Improved physical functioning
Reduced fatigue
Treatment dropout

This review assessed the relative effectiveness of exercise therapy for chronic fatigue syndrome (CFS). The review found that exercise therapy was associated with reduced fatigue and improved physical functioning, but that there was a higher dropout rate in the exercise therapy group. The authors recommend that exercise therapy be offered to patients with CFS, but that their progress be monitored carefully.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Predictors of outcome following treatment for chronic fatigue.

Author: DarbishireLucy, SeedPaul, RidsdaleLeone

Cognitive-behavioural therapy
Graded exercise
Chronic fatigue syndrome

Patients with chronic fatigue syndrome were found to have a higher likelihood of poor outcomes following graded exercise or cognitive-behavioural therapy, especially those with greater functional impairment or perceived negative consequences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Exercise for the management of cancer-related fatigue in adults.

Author: CrampF, DanielJ

Reduced cancer-related fatigue

Exercise was statistically more effective than control intervention in reducing cancer-related fatigue during and post cancer therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Psychosocial interventions for reducing fatigue during cancer treatment in adults.

Author: GoedendorpMartine Margaretha, GielissenMarieke F M, VerhagenConstantijn A H H V M, BleijenbergGijs

This study notes the common occurrence of fatigue in cancer patients undergoing treatment and the lack of comprehensive research on psychological interventions for fatigue during cancer treatment, particularly for those with early-stage cancer or those receiving chemotherapy. The study highlights the need for more research in this area.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Physical Activity during Cancer Treatment (PACT) Study: design of a randomised clinical trial.

Author: VelthuisMiranda J, MayAnne M, Koppejan-RensenbrinkRia Ag, GijsenBrigitte C M, van BredaEric, de WitG Ardine, SchröderCarin D, MonninkhofEvelyn M, LindemanEline, van der WallElsken, PeetersPetra H M

Improved quality of life
Reduced fatigue
Reduced healthcare costs

This study aimed to assess the effect of exercise during cancer treatment on reducing fatigue and healthcare utilization.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Pharmacological treatments for fatigue associated with palliative care.

Author: PeuckmannVera, ElsnerFrank, KrummNorbert, TrottenbergPeter, RadbruchLukas

Palliative care fatigue

While fatigue is a normal response to stress that is usually relieved by rest, in people receiving palliative care, fatigue can be severe and disabling, significantly affecting daily life and quality of life. Cancer treatments often contribute to fatigue, and the complex nature of fatigue makes it difficult to define and treat. Further research is needed to understand the causes and develop effective treatments for fatigue in this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

[Chronic fatigue in cancer patients].

Author: ReifKarl, de VriesUlrike, PetermannFranz, GörresStefan

Cancer-related fatigue treatment

Cancer survivors experience fatigue at a high rate (17% to 56%), but current treatments don't fully address the complex causes of this symptom.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

11.

Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial.

Author: WhiteP D, GoldsmithK A, JohnsonA L, PottsL, WalwynR, DeCesareJ C, BaberH L, BurgessM, ClarkL V, CoxD L, BavintonJ, AngusB J, MurphyG, MurphyM, O'DowdH, WilksD, McCroneP, ChalderT, SharpeM,

CBT for CFS
GET for CFS
Treatment effectiveness unclear

Cognitive behavior therapy (CBT) and graded exercise therapy (GET) are effective treatments for chronic fatigue syndrome, but concerns remain about potential harm. The study assesses the effectiveness and safety of all four treatment approaches.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Frequency and natural history of fatigue after stroke: a systematic review of longitudinal studies.

Author: DuncanFiona, WuSimiao, MeadGillian E

None identified
Fatigue after stroke

Fatigue is present soon after stroke onset and remains common in the longer term. Further research is needed to investigate the temporal relationship between fatigue and mood.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Systematic monitoring and treatment of physical symptoms to alleviate fatigue in patients with advanced cancer: a randomized controlled trial.

Author: de RaafPleun J, de KlerkCora, TimmanReinier, BusschbachJan J V, OldenmengerWendy H, van der RijtCarin C D

Reduced fatigue

Guidelines for managing cancer-related fatigue recommend addressing other symptoms, but evidence from well-designed studies is lacking. This study investigated whether closely monitoring and treating physical symptoms would improve fatigue in cancer patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

The effects of cognitive behavioral therapy for postcancer fatigue on perceived cognitive disabilities and neuropsychological test performance.

Author: GoedendorpMartine M, KnoopHans, GielissenMarieke F M, VerhagenConstans A H H V M, BleijenbergGijs

Fatigue treatment

Fatigue and cognitive problems are common side effects of cancer treatment. This study will investigate the effectiveness of cognitive behavioral therapy (CBT) in treating fatigue and cognitive problems after cancer treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Exercise therapy for chronic fatigue syndrome.

Author: LarunLillebeth, BrurbergKjetil G, Odgaard-JensenJan, PriceJonathan R

Treat chronic fatigue syndrome

Chronic fatigue syndrome (CFS) is a debilitating and common condition characterized by persistent fatigue and other symptoms. This review examines the use of exercise therapy for CFS, updating a previous review from 2004.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Pharmacological treatments for fatigue associated with palliative care.

Author: MückeMartin, , CuhlsHenning, Peuckmann-PostVera, MintonOllie, StonePatrick, RadbruchLukas

Improved quality of life

Fatigue is a common and debilitating symptom in patients receiving palliative care, especially those with advanced cancer. While the underlying causes of fatigue are complex, there is a need for evidence-based treatments to manage this symptom.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Exercise therapy for chronic fatigue syndrome.

Author: LarunLillebeth, BrurbergKjetil G, Odgaard-JensenJan, PriceJonathan R

Exercise therapy
Debilitating health problem

This review updates the evidence for exercise therapy in the treatment of chronic fatigue syndrome (CFS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Protocol for a pilot randomised controlled trial of an online intervention for post-treatment cancer survivors with persistent fatigue.

Author: CorbettTeresa, WalshJane C, GroarkeAnnMarie, Moss-MorrisRona, McGuireBrian E

Persistent fatigue

This study focused on understanding the psychological factors influencing fatigue in post-treatment cancer survivors, exploring theoretical models and coping behaviors related to cancer-related fatigue (CrF).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Exercise therapy for chronic fatigue syndrome.

Author: LarunLillebeth, BrurbergKjetil G, Odgaard-JensenJan, PriceJonathan R

Treatment for chronic fatigue syndrome

This review discusses the treatment of chronic fatigue syndrome (CFS), focusing on exercise therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

The LITE study: Rationale and protocol for a randomized controlled trial of light therapy for cancer-related fatigue in cancer survivors.

Author: JohnsonJillian A, GarlandSheila N, CarlsonLinda E, SavardJosée, SimpsonJ Steven A, Ancoli-IsraelSonia, CampbellTavis S

Inexpensive treatment
Safe treatment

Fatigue is a common and distressing problem for many cancer survivors, lasting for months or years. While the causes and effective treatments for this fatigue are not fully understood, bright light therapy is being explored as a safe and affordable option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Exercise therapy for chronic fatigue syndrome.

Author: LarunLillebeth, BrurbergKjetil G, Odgaard-JensenJan, PriceJonathan R

CFS treatment
CFS symptom severity

This review discussed the treatment of chronic fatigue syndrome (CFS), focusing on exercise therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Exercise therapy for chronic fatigue syndrome.

Author: LarunLillebeth, BrurbergKjetil G, Odgaard-JensenJan, PriceJonathan R

Reduced fatigue
Chronic fatigue syndrome

This review discussed the treatment of chronic fatigue syndrome (CFS), focusing on exercise therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Bright light therapy improves cancer-related fatigue in cancer survivors: a randomized controlled trial.

Author: JohnsonJillian A, GarlandSheila N, CarlsonLinda E, SavardJosée, SimpsonJ Steven A, Ancoli-IsraelSonia, CampbellTavis S

Bright light therapy
Cancer-related fatigue

This study investigates the impact of a 1-month bright light therapy intervention on fatigue, mood, and quality of life in cancer survivors with fatigue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

The effect of a 12-week home-based walking program on reducing fatigue in women with breast cancer undergoing chemotherapy: A randomized controlled study.

Author: HuangHsiang-Ping, WenFur-Hsing, YangTsui-Yun, LinYung-Chang, TsaiJen-Chen, ShunShiow-Ching, JaneSui-Whi, ChenMei-Ling

Cancer fatigue treatment
Exercise

Fatigue is a common and debilitating symptom for cancer patients, both during and after treatment. While exercise is known to reduce fatigue after cancer treatment, its effect during treatment is not consistent.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Yoga intervention and reminder e-mails for reducing cancer-related fatigue - a study protocol of a randomized controlled trial.

Author: ZetzlTeresa, SchulerMichael, RennerAgnes, JentschkeElisabeth, van OorschotBirgitt

Reduced fatigue

This study examined the short-term and long-term effects of yoga on fatigue in cancer patients. The study also investigated the effect of weekly reminder e-mails on exercise frequency and fatigue symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

The effectiveness of psychological interventions for fatigue in cancer survivors: systematic review of randomised controlled trials.

Author: CorbettT K, GroarkeA, DevaneD, CarrE, WalshJ C, McGuireB E

Reduced fatigue

This systematic review of 33 psychological interventions found that some psychological interventions may be effective in reducing fatigue in cancer survivors after treatment. However, as the RCTs were heterogeneous in nature and the number of high-quality studies was limited, definitive conclusions are not yet possible.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Cognitive behavioral therapy or graded exercise therapy compared with usual care for severe fatigue in patients with advanced cancer during treatment: a randomized controlled trial.

Author: PoortH, PetersM E W J, van der GraafW T A, NieuwkerkP T, van de WouwA J, Nijhuis-van der SandenM W G, BleijenbergG, VerhagenC A H H V M, KnoopH

CBT
GET

This study assessed the effects of cognitive behavioral therapy (CBT) and graded exercise therapy (GET) on fatigue in patients with advanced cancer during palliative treatment, providing insights into potential interventions for this debilitating symptom.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Prevalence and risk factors of cancer-related fatigue: A systematic review and meta-analysis.

Author: MaYuxia, HeBo, JiangMengyao, YangYanlin, WangChenxia, HuangCan, HanLin

Reduced cancer-related fatigue

The pooled prevalence of cancer-related fatigue was 52% across 84 studies. Risk factors for fatigue included poor performance status, chemoradiotherapy, female sex, insomnia, neuroticism, pain, and depression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

A Randomized, Controlled, Parallel-Group, Trial on the Effects of Melatonin on Fatigue Associated with Breast Cancer and Its Adjuvant Treatments.

Author: Sedighi PashakiAbdolazim, MohammadianKamal, AfsharSaeid, GholamiMohammad Hadi, MoradiAbbas, JavadiniaSeyed Alireza, Keshtpour AmlashiZahra

Fatigue reduction

Coadministration of melatonin during adjuvant chemotherapy and radiotherapy in women with breast cancer significantly reduced fatigue levels compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

[An updated synthesis of the international recommendations about the use of non-pharmacological interventions in the treatment of fatigue].

Author: CharlesCécile, Vaz LuisInes, ChiesaSéverine, BoironClaude, BourgierCéline, CavalcantiAndréa, DauchySarah, FavréEstelle, FerrandezJean-Claude, Gueroult-AccolasLaure, KarsentiLucille, MateusChristine, VansteeneDamien, AllaFrançois, MontagniIlaria, CambonLinda

Improved fatigue management

Fatigue is a common and distressing symptom in cancer patients. This study reviewed non-pharmacological interventions for fatigue, which are often overlooked but can be helpful for managing this symptom.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : French

32.

Condition or cognition? Mechanism of change in fatigue in a randomized controlled trial of graded exercise therapy or cognitive behavior therapy for severe fatigue in patients with advanced cancer.

Author: PoortHanneke, MüllerFabiola, BleijenbergGijs, VerhagenStans A H H V M, VerdamMathilde G E, NieuwkerkPythia T, KnoopHans

CBT effectiveness
Cancer fatigue treatment

Cognitive behavioral therapy (CBT) has been shown to significantly reduce fatigue in patients with advanced cancer, while graded exercise therapy (GET) has not shown to be beneficial. This study aims to understand the mechanisms by which CBT and GET impact fatigue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Corticosteroids for the management of cancer-related fatigue in adults with advanced cancer.

Author: SandfordAmy, HaywoodAlison, RickettKirsty, GoodPhillip, KhanSohil, FosterKaryn, HardyJanet R

Cancer-related fatigue treatment
Adverse effects

This study focuses on cancer-related fatigue (CRF), a common and debilitating symptom that significantly impacts quality of life (QoL) in patients with advanced cancer. While corticosteroids are often used to manage CRF, their effectiveness and long-term effects require further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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