Side Effects of flunisolide nasal spray: A Synthesis of Findings from 15 Studies

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Original Abstract of the Article

Main Research Findings

Flunisolide nasal spray has been shown to be effective in preventing nasal polyp recurrence, treating seasonal allergic rhinitis, and treating perennial allergic rhinitis in several studies. 8 , 4 , 2 , 1 , 3 , 5 , 9 , 6 , 7 , 10 , 12 These studies have shown that flunisolide is significantly more effective than placebo. Flunisolide has also been shown to alleviate nasal symptoms and improve quality of life. 2 , 3

Reasons for Side Effects

The side effects of flunisolide nasal spray are thought to be due to irritation of the nasal mucosa or, rarely, systemic effects. 4 Irritation of the nasal mucosa is caused by flunisolide being a steroid drug, one of its mechanisms of action being to suppress inflammation, so it acts directly on the nasal mucosa. Systemic effects, though rare, include adrenal suppression. 2 This could occur because flunisolide is absorbed from the nasal mucosa, travels through the bloodstream, and reaches the whole body.

Common Side Effects

Nasal Irritation

The most common side effect of flunisolide nasal spray is nasal irritation. 4 , 6 , 7 , 10 , 12 , 3 This is due to irritation of the nasal mucosa, and may manifest as nasal burning, stinging, or pain. 6

Nosebleeds

Nosebleeds may occur with the use of flunisolide nasal spray. 8 This may be caused by flunisolide drying out the nasal mucosa.

Nasal Congestion

Nasal congestion may occur with the use of flunisolide nasal spray. 8 This may be caused by flunisolide suppressing swelling of the nasal mucosa.

Adrenal Suppression

Long-term use of flunisolide nasal spray may suppress the adrenal cortex. 2 This could occur because flunisolide is absorbed from the nasal mucosa, travels through the bloodstream, and reaches the whole body. The adrenal cortex is involved in the production of cortisol, a stress hormone, and suppression of its function can lead to poor health and weakened immunity.

Side Effects Management

Nasal Irritation

If you experience nasal irritation, you may be able to reduce it by washing your nasal passages before using the nasal spray, or by reducing the amount of nasal spray you use. 4

Nosebleeds

If you experience nosebleeds, gently pinch your nose to stop the bleeding. If the bleeding does not stop, consult your doctor.

Nasal Congestion

If you experience nasal congestion, washing your nasal passages may help alleviate it.

Comparison Between Studies

Commonalities

Multiple studies have shown that flunisolide nasal spray is effective in reducing nasal symptoms. 8 , 4 , 2 , 1 , 3 , 5 , 9 , 6 , 7 , 10 , 12

Differences

The effectiveness and severity of side effects of flunisolide nasal spray may vary between studies. 8 , 4 , 2 , 1 , 3 , 5 , 9 , 6 , 7 , 10 , 12 This is thought to be due to differences in the study participants and methodologies.

Points to Note Regarding Application in Real Life

It is important to use flunisolide nasal spray as directed by your doctor. 8 , 4 , 2 , 1 , 3 , 5 , 9 , 6 , 7 , 10 , 12 In particular, be careful not to change the dosage or duration of use without consulting a doctor. Also, pregnant women and breastfeeding women should consult a doctor before use.

Limitations of Current Research

There has not been enough research on the long-term effects of flunisolide nasal spray. 8 , 4 , 2 , 1 , 3 , 5 , 9 , 6 , 7 , 10 , 12 Therefore, further research is needed on the possibility of side effects from long-term use.

Future Research Directions

Research is needed to evaluate the long-term effects of flunisolide nasal spray and to compare it with other treatment methods. 8 , 4 , 2 , 1 , 3 , 5 , 9 , 6 , 7 , 10 , 12 Also, research is needed to elucidate the mechanisms of side effects of flunisolide nasal spray.

Conclusion

Flunisolide nasal spray has been shown to be an effective medication for treating nasal polyps and allergic rhinitis. 8 , 4 , 2 , 1 , 3 , 5 , 9 , 6 , 7 , 10 , 12 However, the possibility of side effects should also be considered. 8 , 4 , 2 , 1 , 3 , 5 , 9 , 6 , 7 , 10 , 12 When considering the use of flunisolide nasal spray, it is important to consult your doctor and obtain the appropriate information.

Literature analysis of 15 papers
Positive Content
15
Neutral Content
0
Negative Content
0
Article Type
13
0
0
0
15
1.

Treatment of perennial rhinitis with flunisolide corticosteroid spray.

Author: JonesL M, SpectorS L, EnglishG M, Taylor-DawsonK

Reduced eosinophils
Candida infection

Flunisolide nasal spray was not significantly different from placebo in treating perennial rhinitis. Both groups showed a decrease in eosinophils on nasal smears.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Flunisolide--a new intranasal steroid for the treatment of allergic rhinitis.

Author: SahayJ N, ChatterjeeS S, EnglerC

Improved everyday life
Improved sleep quality
Relieved nasal obstruction
Relieved sneezing
Minor side effects

A study of 50 patients with perennial allergic rhinitis found that flunisolide nasal spray (200 micrograms daily) was significantly more effective than a placebo in reducing symptoms of sneezing, nasal congestion, post-nasal drip, and improving sleep and daily life. Both patients and doctors preferred the flunisolide spray. Minor side effects were reported during both placebo and flunisolide phases, and no evidence of adrenal suppression was observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Flunisolide nasal spray for perennial rhinitis in children.

Author: SarsfieldJ K, ThomsonG E

Effective rhinitis treatment
No adrenal axis effect
Safe for children
Nasal stinging

A study of 27 children with perennial rhinitis found that flunisolide nasal spray was significantly more effective than a placebo in relieving symptoms. Patients, doctors, and diary card assessments all favored flunisolide. The most common side effect was temporary nasal stinging. Flunisolide treatment was safe and did not affect the pituitary-adrenal axis. The study concluded that flunisolide is a safe and effective treatment for perennial rhinitis in children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A comparative trial testing budesonide and flunisolide nasal sprays in patients with seasonal allergic rhinitis.

Author: PipkornU, GeterudA

Effective for rhinitis
Nasal irritation

Both budesonide and flunisolide nasal sprays were effective in controlling nasal symptoms in patients with seasonal allergic rhinitis. However, flunisolide was associated with a higher incidence of nasal irritation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Short-term efficacy trial and twenty-four-month follow-up of flunisolide nasal spray in the treatment of perennial rhinitis.

Author: ClaytonD E, KooistraJ B, GellerM, OuelletteJ, CohenM, ReedC E, BusseW

No adrenal suppression
Safe and effective

Flunisolide nasal spray was found to be safe and effective in treating perennial rhinitis. No serious side effects were observed over a two-year follow-up period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

Comparative tolerability of two formulations of Rhinalar (flunisolide) nasal spray in patients with seasonal allergic rhinitis.

Author: GreenbaumJ, LeznoffA, SchulzJ, MazzaJ, TobeA, MillerD

Effective for allergic rhinitis
Enhanced patient acceptability
Reduced burning/stinging
Side effects: nausea
headache
watery eyes
taste perversion
runny nose

A new formulation of Rhinalar, containing less propylene glycol, significantly reduced nasal burning and stinging compared to the original formulation. Both formulations were equally effective in relieving the nasal symptoms of seasonal allergic rhinitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Topical levocabastine, a selective H1 antagonist, in seasonal allergic rhinoconjunctivitis.

Author: BendeM, PipkornU

Effective treatment
Fewer side effects
Local irritation

Levocabastine, a selective H1 antagonist, was found to be effective in treating allergic rhinoconjunctivitis, with fewer side effects compared to other treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Flunisolide nasal spray 0.025% in the prophylactic treatment of nasal polyposis after polypectomy. A randomized, double blind, parallel, placebo controlled study.

Author: DingsørG, KramerJ, OlsholtR, SøderstrømT

Reduced nasal polyposis recurrence
Reduced nasal symptoms
Bloody secretions
Itching

Flunisolide was significantly more effective than placebo in preventing nasal polyposis recurrence after surgery. Flunisolide also reduced nasal symptoms of sneezing and stuffiness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Flunisolide nasal spray in the treatment of perennial rhinitis.

Author: JoubertJ R

Reduced nose-blowing
Reduced runny nose
Relieved sneezing
Nasal irritation

Flunisolide nasal spray was effective in relieving symptoms of perennial rhinitis, with nasal irritation being the most common side effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

A comparative trial of flunisolide and sodium cromoglycate nasal sprays in the treatment of seasonal allergic rhinitis.

Author: BrownH M, EnglerC, EnglishJ R

Treats hay fever
Mild naso-pharyngeal irritation

This study compared the effectiveness of flunisolide nasal spray and sodium cromoglycate nasal spray in 67 patients with hay fever. Flunisolide was significantly superior to sodium cromoglycate in controlling symptoms. The most common side effect was mild naso-pharyngeal irritation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Short-term efficacy trial and twenty-four-month follow-up of flunisolide nasal spray in the treatment of perennial rhinitis.

Author: ClaytonD E, KooistraJ B, GellerM, OuelletteJ, CohenM, ReedC E, BusseW

No adrenal suppression
Safe and effective

Flunisolide nasal spray was found to be safe and effective in treating perennial rhinitis. No serious side effects were observed over a two-year follow-up period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

Intranasal flunisolide, placebo and beclomethasone dipropionate in perennial rhinitis.

Author: McAllenM K, PortilloP R, ParrE J, SeatonA, EnglerC

Effective rhinitis treatment
Physician and patient preference
Nasal irritation

Flunisolide nasal spray is more effective than placebo in treating perennial rhinitis. It is also as effective as beclomethasone dipropionate. The most common side effect of both flunisolide and beclomethasone dipropionate is transient nasal irritation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Flunisolide nasal spray for perennial rhinitis in children.

Author: SarsfieldJ K, ThomsonG E

Effective rhinitis treatment
No adrenal axis effect
Safe for children
Nasal stinging

A study of 27 children with perennial rhinitis found that flunisolide nasal spray was significantly more effective than a placebo in relieving symptoms. Patients, doctors, and diary card assessments all favored flunisolide. The most common side effect was temporary nasal stinging. Flunisolide treatment was safe and did not affect the pituitary-adrenal axis. The study concluded that flunisolide is a safe and effective treatment for perennial rhinitis in children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Treatment of perennial rhinitis with flunisolide corticosteroid spray.

Author: JonesL M, SpectorS L, EnglishG M, Taylor-DawsonK

Reduced eosinophils
Candida infection

Flunisolide nasal spray was not significantly different from placebo in treating perennial rhinitis. Both groups showed a decrease in eosinophils on nasal smears.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Flunisolide--a new intranasal steroid for the treatment of allergic rhinitis.

Author: SahayJ N, ChatterjeeS S, EnglerC

Improved everyday life
Improved sleep quality
Relieved nasal obstruction
Relieved sneezing
Minor side effects

A study of 50 patients with perennial allergic rhinitis found that flunisolide nasal spray (200 micrograms daily) was significantly more effective than a placebo in reducing symptoms of sneezing, nasal congestion, post-nasal drip, and improving sleep and daily life. Both patients and doctors preferred the flunisolide spray. Minor side effects were reported during both placebo and flunisolide phases, and no evidence of adrenal suppression was observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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